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| 1 | NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma显示文摘Objective:Esophageal squamous cell carcinoma(ESCC)has high morbidity and mortality rates worldwide.Cancer stem cells(CSCs)may cause tumor initiation,metastasis,and recurrence and are also responsible for chemotherapy and radiotherapy failures.Myeloid-derived suppressor cells(MDSCs),in contrast,are known to be involved in mediating immunosuppression.Here,we aimed to investigate the mechanisms of interaction of CSCs and MDSCs in the tumor microenvironment.Methods:ESCC tissues and cell lines were evaluated.Neural precursor cell expressed,developmentally downregulated 9(NEDD9)was knocked down and overexpressed by lentiviral transfection.Quantitative PCR,Western blot,immunohistochemistry,cell invasion,flow cytometry,cell sorting,multiplex chemokine profiling,and tumor growth analyses were performed.Results:Microarray analysis revealed 10 upregulated genes in esophageal CSCs.Only NEDD9 was upregulated in CSCs using the sphere-forming method.NEDD9 expression was correlated with tumor invasion(P=0.0218),differentiation(P=0.0153),and poor prognosis(P=0.0373).Additionally,NEDD9 was required to maintain the stem-like phenotype.Screening of chemokine expression in ESCC cells with NEDD9 overexpression and knockdown showed that NEDD9 regulated C-X-C motif chemokine ligand 8(CXCL8)expression via the ERK pathway.CXCL8 mediated the recruitment of MDSCs induced by NEDD9 in vitro and in vivo.MDSCs promoted the stemness of ESCC cells through NEDD9 via the Notch pathway.Conclusions:As a marker of ESCC,NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor,suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC. | Dongli Yue Shasha Liu Tengfei Zhang Yong Wang Guohui Qin Xinfeng Chen Huanyu Zhang Dong Wang Lan Huang Feng Wang Liping Wang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 2 | The autocorrelation distribution of balanced Boolean function显示文摘 | Yu ZHOU Weiguo ZHANG Juan LI Xinfeng DONG Guozhen XIAO | 2013 | Frontiers of Computer Science2013，7，2： | 4 |
| 3 | Research on a Ka-Band MEMS Power Sensor Investigated with an MEMS Cantilever Beam显示文摘In this work, a novel high overload Ka-band power sensor with a Micro-electro-mechanical system(MEMS) cantilever beam is investigated in order to improve the measurement dynamic range and the bandwidth.The fabrication of the Ka-band power sensor is divided into front side and back side processing with a combination of surface and bulk micromachining of Ga As.The low-power measurement reveals that the terminating-type sensitivity is close to 0.081, 0.076 and0.072 m V/m W at 34, 35 and 36 GHz, respectively. The high-power measurement indicates that the capacitivetype sensitivity is around 4.9 f F/W at Ka-band. The overload power measurements show that the MEMS cantilever beam can improve the dynamic range by increasing the top end of the range into no less than200 m W, and enhance the bandwidth by increasing the top end of the range into no less than 36 GHz. There is an important reference value to achieve the high overload and wide frequency band for the thermoelectric microwave power sensors. | WANG Debo GU Xinfeng XIE Jiangcheng ZHANG Dong | 2020 | Chinese Journal of Electronics2020，29，2： | 2 |
| 4 | Biocrude oil production from Chlorella sp.cultivated in anaerobic digestate after UF membrane treatment显示文摘Algae cultivation in animal wastewater could recover nutrient resources,and harvest considerable amount of algae biomass for biofuel conversion.In this study,Chlorella sp.cultivated in ultrafiltration(UF)membrane treated anaerobic digestion effluent of chicken manure was converted into biocrude oil through hydrothermal liquefaction(HTL).The potential of biocrude production from grown Chlorella sp.was studied through changing the operational conditions of HTL,i.e.,holding temperature(HT,250℃-330℃),retention time(RT,0.5-1.5 h),and total solid(TS)(15 wt%-25 wt%)of the feedstock.The highest biocrude oil yield was 32.9%at 330℃,1.5 h and 20 wt%TS.The single factor experiments of HT also suggested that the biocrude oil yield decreased when the temperature was higher than 330℃.There were no significant differences of elemental contents in biocrude samples.The maximum higher heating values(HHV)of Chlorella sp.biocrude was 40.04 MJ/kg at HT of 330℃,RT of 1 h and TS of 15 wt%.This study suggests the great potential for energy recovery from Chlorella sp.cultivated in UF membrane treated anaerobic digestion effluent via HTL. | Wang Meng Wang Xinfeng Zhu Zhangbing Lu Jianwen Yuanhui Zhang Li Baoming Lu Haifeng Duan Na Zhang Dongming Dong Taili Liu Zhidan | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 1 |
| 5 | Microalgae cultivation and culture medium recycling by a two-stage cultivation system显示文摘Nutrients and water play an important role in microalgae cultivation.Using wastewater as a culture medium is a promising alternative to recycle nutrients and water,and for further developing microalgae-based products.In the present study,two species of microalgae,Chlorella sp.(high ammonia nitrogen tolerance)and Spirulinaplatensis (S.platensis,high growth rate),were cultured by using poultry wastewater through a two-stage cultivation system for algal biomass production.Ultrafiltration (UF)or centrifuge was used to harvest Chlorella-sp.from the first cultivation stage and to recycle culture medium for S.platensis growth in the second cultivation stage.Results showed the two-stage cultiyation system produced high microalgae biomass including 0.39g·L^-1 Chlorella sp.and 3.45g·L^-1 S.platensis in the first-stage and second-stage,respectively.In addition,the removal efficiencies of NH4+reached 19% and almost 100% in the first and the second stage,respectively. Total phosphorus (TP)removal reached 17% and 83%,and total organic carbon (TOC)removal reached 55% and 72% in the first and the second stage,respectively.UF and centrifuge can reeycle 96.8% and 100% water,respectively.This study provides a new method for the combined of pure microalgae cultivation and wastewater treatment with eulture medium recycling. | Xinfeng Wang Lu Lin Haifeng Lu Zhidan Liu Na Duan Taili Dong Hua Xiao Baoming Li Pei Xu | 2018 | Frontiers of Environmental Science & Engineering2018，12，6： | 1 |
| 6 | Identification of liver metastasis-associated genes in human colon carcinoma by mRNA profiling显示文摘Objective: Liver metastasis,which contributes substantially to high mortality,is the most common recurrent mode of colon carcinoma.Thus,it is necessary to identify genes implicated in metastatic colonization of the liver in colon carcinoma.Methods: We compared mRNA profiling in 18 normal colon mucosa(N),20 primary tumors(T) and 19 liver metastases(M) samples from the dataset GSE49355 and GSE62321 of Gene Expression Omnibus(GEO) database.Gene ontology(GO) and pathways of the identified genes were analyzed.Co-expression network and proteinprotein interaction(PPI) network were employed to identify the interaction relationship.Survival analyses based on The Cancer Genome Atlas(TCGA) database were used to further screening.Then,the candidate genes were validated by our data.Results: We identified 22 specific genes related to liver metastasis and they were strongly associated with cell migration,adhesion,proliferation and immune response.Simultaneously,the results showed that C-X-C motif chemokine ligand 14(CXCL14) might be a favorable prediction factor for survival of patients with colon carcinoma.Importantly,our validated data further suggested that lower CXCL14 represented poorer outcome and contributed to metastasis.Gene set enrichment analysis(GSEA) showed that CXCL14 was negatively related to the regulation of stem cell proliferation and epithelial to mesenchymal transition(EMT).Conclusions: CXCL14 was identified as a crucial anti-metastasis regulator of colon carcinoma for the first time,and might provide novel therapeutic strategies for colon carcinoma patients to improve prognosis and prevent metastasis. | Jianling Liu Dan Wang Chaoqi Zhang Zhen Zhang Xinfeng Chen Jingyao Lian Jinbo Liu Guixian Wang Weitang Yuan Zhenqiang Sun Weijia Wang Mengjia Song Yaping Wang Qian Wu Ling Cao Dong Wang Yi Zhang | 2018 | Chinese Journal of Cancer Research2018，30，6： | 1 |
| 7 | Off-hour effect is not significant in endovascular treatment for anterior circulation large vessel occlusion in a multicentre registry显示文摘Background and purpose Whether the off-hour effect has an impact on workflow and outcomes of endovascular treatment(EVT)for anterior circulation large vessel occlusion(AC-LVO)remains uncertain.This study aimed to compare the characteristics and outcomes of patients who presented or were treated during off-hour versus on-hour in a multi-center registry.Methods AC-LVO patients from 21 centres were categorised into the off-hour group and the on-hour group.Off-hour(weekends,holidays,and 18:00-7:59 on weekdays)and on-hour(8:00-17:59 on weekdays except for holidays)were defined according to arrival and groin-puncture time points,respectively.Subgroup comparisons between patients both arrived and treated during off-hour(true off-hour)and on-hour(true on-hour)were performed.The primary outcome was the 90-day modified Rankin Scale(mRS)score.Secondary outcomes included favourable outcome(mRS 0-2 at 90 days),EVT-related time metrics,and other clinical outcomes.Ordinary and binary logistic regression and linear regression were taken to adjust for confounding factors.Results Of all 698 patients enrolled,435(62.3%)and 456(65.3%)patients were categorised into the off-hour arrival and off-hour puncture group,respectively.Shorter onset to door time(adjustedßcoefficient:−21.56;95%CI−39.96 to−3.16;p=0.022)was noted in the off-hour arrival group.Ordinal and dichotomous mRS scores at 90 days were comparable between the off-hour group and the on-hour group regardless of off-hour definitions.Other time metrics and outcomes were comparable between the two groups.Of 595 patients both presented and were treated during off-hour or on-hour,394 patients were categorised into the true off-hour group and 201 into the true on-hour group.Time metrics and clinical outcomes were similar between the true off-hour and the true on-hour group.Conclusions The off-hour effect was not significant regarding clinical outcomes and in-hospital workflow in AC-LVO patients receiving EVT in this Chinese multicentre registry. | Mingming Zha Qingwen Yang Shuo Liu Kangmo Huang Xiaohao Zhang Min Wu Haodi Cai Qiushi Lv Rui Liu Dong Yang Xinfeng Liu | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 8 | Double-Stranded DNA Matrix for Photosensitization Switching显示文摘Photosensitization,originated from the activation of triplet states,is the basis of many photodynamic applications,but often competes with a series of nonradiative processes.Herein,we communicate a new function of double-stranded DNA(dsDNA)for label-free photosensitization switching.Up to∼70-fold singlet oxygen generation boosting was observed for SYBR Green I(SG)upon binding with dsDNA.Detailed photophysical and theoretical studies have revealed the role of dsDNA as a matrix,which could efficiently suppress the nonradiative transitions of SG. | Yanying Wang Hao Hu Tianyu Dong Hayam Mansour Xinfeng Zhang Feng Li Peng Wu | 2021 | CCS Chemistry2021，3，9： | 0 |
| 9 | Surrounding Problem of Multi-agent Systems Under Arbitrary Topology显示文摘This paper studies surrounding dynamically multi-targets with second-order integrator/nonlinear systems and continuous time-varying topology.The continuous time-varying topology refers to the continuous change of the topology rather than switching in several fixed topologies.Surrounding multi-targets is an extension of containment control.The distributed control algorithm is designed based on the containment control theory.By transforming the system of containment control into error stability,the condition that the error between multi-agent systems and multi-targets to be constant can be obtained by using the algebraic graph theory,matrix theory and Lyapunov function stability analysis.The multiagent systems can dynamically surround multi-targets by designing the deviation vector.Finally,simulation experiments verify the effectiveness of the proposed algorithm. | LIU Weifeng RU Xinfeng WEN Chenglin DONG Lijing | 2020 | Chinese Journal of Electronics2020，29，4： | 0 |
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