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| 1 | Development of a New Index for Integrating Landscape Patterns with Ecological Processes at Watershed Scale显示文摘Understanding the relationship between landscape patterns and ecological processes has been a central yet challenging research theme in landscape ecology. Over the past decades,many landscape metrics have been proposed but few directly incorporated ecological processes. In this paper,we developed a landscape index,namely,location-weighted landscape index(LWLI) to highlight the role of landscape type in ecological processes,such as nutrient losses and soil erosion. Within the framework of the Lorenz curve theory,we develop this index by integrating landscape pattern and point-based measurements at a watershed scale. The index can be used to characterize the contribution of landscape pattern to ecological processes(e.g. nutrient losses) with respect to a specific monitoring point in a watershed. Through a case study on nutrient losses in an agricultural area in northeastern China,we found that nutrient losses tended to be higher for a watershed with a higher LWLI value,and vice versa. It implied that LWLI can be used to evaluate the potential risk of nutrient losses or soil erosion by comparing their values across watersheds. In addition,this index can be extended to characterize ecological processes,such as the effect of landscape pattern on wildlife inhabitation and urban heat island effect. Finally,we discuss several problems that should be paid attention to when applying this index to a heterogeneous landscape site. | CHEN Liding TIAN Huiying FU Bojie ZHAO Xinfeng | 2009 | Chinese Geographical Science2009，19，1： | 38 |
| 2 | Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens显示文摘Programmed cell death 1(PD-1)/programmed cell death 1 ligand(PD-L1) blockade has shown promising effects in cancer immunotherapy. Removing the so-called 'brakes' on T cell immune responses by blocking the PD-1/PDL1 check point should boost anti-tumor immunity and provide durable tumor regression for cancer patients.However, 30%–60% of patients show no response to PD-1/PD-L1 blockade. Thus, it is urgent to explore the underlying resistance mechanisms to improve sensitivity to anti-PD-1/PD-L1 therapy. We propose that the mechanisms promoting resistance mainly include T cell exclusion or exhaustion at the tumor site,immunosuppressive factors in the tumor microenvironment(TME), and a range of tumor-intrinsic factors. This review highlights the power of studying the cellular and molecular mechanisms of resistance to improve the rational design of combination therapeutic strategies that can be translated to the clinic. Here, we briefly discuss the development of PD-1/PD-L1 blockade agents and focus on the current issues and future prospects for potential combinatorial therapeutic strategies that include anti-PD-1/PD-L1 therapy, based upon the available preclinical and clinical data. | Mengjia Song Xinfeng Chen Liping Wang Yi Zhang | 2018 | Chinese Journal of Cancer Research2018，30，2： | 16 |
| 3 | Microstructure and Oxidation Behaviors of Nano-particles Strengthened NiCoCrAlY Cladded Coatings on Superalloys显示文摘Nano-particles which can largely improve the microstructure and oxidation resistance of materials are often used as a strengthening component in metal matrix composites. However, few studies were reported on its application in the bond coat of duplex structure thermal barrier coating(TBC). Three kinds of NiCoCrAlY coatings strengthened by different nano-particles with the same addition (1%, mass fraction) were prepared by the laser cladding technique on Ni-based superalloy substrates, aiming to study the effects of the nano-particles on microstructure and oxidation resistance of NiCoCrAlY coatings (the bond coat of the duplex structure thermal barrier coatings). Scanning electron microscope (SEM), X-ray diffractometer(XRD) and thermogravimetry were employed to investigate their morphologies, phases and cyclic oxidation behaviors in atmosphere at 1 050℃, compared with the coating without nano-particles. With the addition of nano-particles, the growth pattern of the grains at the interface changed from epitaxial growth to non-epitaxial growth or part-epitaxial growth; slender dendrites were broken and cellularized; cracks and pores were restrained; and the oxidation weight-gain and the stripping resistance of the oxide scale were improved as well. Among the three kinds of nano-particles, the SiC nano-particles showed the most improvement on microstructure, while the CeO2 nano-particles were insufficient, but its effects on the oxidation resistance are the same as those of the SiC nano-particles. Based on the discussions of the influence mechanism, it is believed that CeO2 nano-particles would show better improvement than SiC nano-particles if the proper amount is added and the proper preparation technique of micro-nanometer composite powders is adopted, with the synergistic action of nanometer effect and reactive element effect. | WANG Hongyu ZUO Dunwen CHEN Xinfeng YU Shouxin GU Yuanzhi | 2010 | Chinese Journal of Mechanical Engineering2010，23，3： | 11 |
| 4 | Understanding unusually high levels of peroxyacetyl nitrate(PAN) in winter in Urban Jinan,China显示文摘Peroxyacetyl nitrate(PAN), as a major secondary pollutant, has gained increasing worldwide attentions, but relevant studies in China are still quite limited. During winter of 2015 to summer of 2016, the ambient levels of PAN were measured continuously by an automatic gas chromatograph equipped with an electron capture detector(GC–ECD) analyzer at an urban site in Jinan(China), with related parameters including concentrations of O3, NO, NO_2, PM_(2.5), HONO,the photolysis rate constant of NO_2 and meteorological factors observed concurrently. The mean and maximum values of PAN concentration were(1.89 ± 1.42) and 9.61 ppbv respectively in winter, and(2.54 ± 1.44) and 13.47 ppbv respectively in summer. Unusually high levels of PAN were observed during severe haze episodes in winter, and the formation mechanisms of them were emphatically discussed. Study showed that high levels of PAN in winter were mainly caused by local accumulation and strong photochemical reactions during haze episodes, while mass transport played only a minor role. Accelerated photochemical reactions(compared to winter days without haze) during haze episodes were deduced by the higher concentrations but shorter lifetimes of PAN, which was further supported by the sufficient solar radiation in the photolysis band along with the high concentrations of precursors(NO_2, VOCs) and HONO during haze episodes. In addition, significant PAN accumulation during calm weather of haze episodes was verified by meteorological data. | Lu Liu Xinfeng Wang Jianmin Chen Likun Xue Wenxing Wang Liang Wen Dandan Li Tianshu Chen | 2018 | Journal of Environmental Sciences2018，30，9： | 10 |
| 5 | Performance of pond–wetland complexes as a preliminary processor of drinking water sources显示文摘Shijiuyang Constructed Wetland(110 hm^2) is a drinking water source treatment wetland with primary structural units of ponds and plant-bed/ditch systems. The wetland can process about 250,000 tonnes of source water in the Xincheng River every day and supplies raw water for Shijiuyang Drinking Water Plant. Daily data for 28 months indicated that the major water quality indexes of source water had been improved by one grade. The percentage increase for dissolved oxygen and the removal rates of ammonia nitrogen, iron and manganese were 73.63%, 38.86%, 35.64%, and 22.14% respectively. The treatment performance weight of ponds and plant-bed/ditch systems was roughly equal but they treated different pollutants preferentially. Most water quality indexes had better treatment efficacy with increasing temperature and inlet concentrations. These results revealed that the pond–wetland complexes exhibited strong buffering capacity for source water quality improvement. The treatment cost of Shijiuyang Drinking Water Plant was reduced by about 30.3%. Regional rainfall significantly determined the external river water levels and adversely deteriorated the inlet water quality, thus suggesting that the 'hidden' diffuse pollution in the multitudinous stream branches as well as their catchments should be the controlling emphases for river source water protection in the future. The combination of pond and plant-bed/ditch systems provides a successful paradigm for drinking water source pretreatment. Three other drinking water source treatment wetlands with ponds and plant-bed/ditch systems are in operation or construction in the stream networks of the Yangtze River Delta and more people will be benefited. | Weidong Wang Jun Zheng Zhongqiong Wang Rongbin Zhang Qinghua Chen Xinfeng Yu Chengqing Yin | 2016 | Journal of Environmental Sciences2016，28，1： | 10 |
| 6 | Size Distributions of Aerosol Sulfates and Nitrates in Beijing during the 2008 Olympic Games: Impacts of Pollution Control Measures and Regional Transport显示文摘为 2008 个奥运会,激烈的控制措施在二氧化物(SO2 ) ,氮氧化物(没有 x ) 和处理穷人的问题的另外的污染物质通风的硫的工业、城市的排出物上被实现在北京的质量。在微粒硫酸盐和硝酸盐集中以及他们的尺寸分布上调查 SO2 和没有 x 减小的效果,分离尺寸的喷雾器样品在照原尺寸的控制前后在北京在城市、顺风的农村地点用微孔的一致存款 impactors (MOUDI ) 被收集。在采样时期期间,在城市、农村的地点的好粒子(PM1.8 ) 的集体集中分别地是 94.0 和 85.9 g m3。超过 90% 硫酸盐和 60% 硝酸盐形成了同样好的粒子。得益于有益的气象学的条件和来源控制,硫酸盐在奥林匹克期间在相当低的集中并且首先在冷凝作用模式被观察。控制措施的效果独立被分析让北风和南方的 air-mass-dominated 天说明任何偏爱。在控制措施被实现以后,当在北方的空气群众占优势时,下午,硫酸盐,和硝酸盐显著地被减少,与在更大的粒子的减小的一个更高的百分比。在控制措施被实现以后,微滴模式粒子,在控制被实现以前,统治了硫酸盐和硝酸盐,显著地在集体集中被减少。但当弄脏的南方的空气群众占优势时,本地来源控制在北京测量,有效地没从北方中国平原由于庞大的地区性的贡献减少周围的硫酸盐集中。 | WANG Xinfeng WANG Tao Ravi Kant PATHAK Mattias HALLQUIST GAO Xiaomeit NIE Wei XUE Likun GAO Jian GAO Rui ZHANG Qingzhu WANG Wenxing WANG Shulan CHAI Fahe CHEN Yizhen | 2013 | Advances in Atmospheric Sciences2013，30，2： | 8 |
| 7 | Strong ozone production at a rural site in the North China Plain: Mixed effects of urban plumes and biogenic emissions显示文摘Regional ozone(O_3) pollution has drawn increasing attention in China over the recent decade, but the contributions from urban pollution and biogenic emissions have not been clearly elucidated. To better understand the formation of the regional O_3 problem in the North China Plain(NCP), intensive field measurements of O_3 and related parameters were conducted at a rural site downwind of Ji'nan, the capital city of Shandong province, in the summer of 2013. Markedly severe O_3 pollution was recorded, with the O_3 mixing ratios exceeding the Chinese national ambient air quality standard on 28 days(a frequency of 78%) and with a maximum hourly value of 198 ppbv. Extensive regional transport of wellprocessed urban plumes to the site was identified. An observation-constrained chemical box model was deployed to evaluate in situ photochemical O_3 production on two episodes.The results show that the in situ formation accounted for approximately 46% of the observed O_3 accumulation, while the remainder(~54%) was contributed by regional transport of the O_3-laden urban plumes. The in situ ozone production was in a mixed controlled regime that reducing either NOx or VOCs would lead to a reduction of ozone formation. Biogenic VOCs played an important role in the local ozone formation. This study demonstrates the significant mixed effects of both anthropogenic pollution from urban zones and biogenic emission in rural areas on the regional O_3 pollution in the NCP region,and may have general applicability in facilitating the understanding of the formation of secondary pollution over China. | Ruihan Zong Xue Yang Liang Wen Caihong Xu Yanhong Zhu Tianshu Chen Lan Yao Liwei Wang Junmei Zhang Lingxiao Yang Xinfeng Wang Min Shao Tong Zhu Likun Xue Wenxing Wang | 2018 | Journal of Environmental Sciences2018，30，9： | 8 |
| 8 | Perovskite quantum dot lasers显示文摘Owing to the excellent properties of perovskite quantum dots(QDs),such as an easy synthesis process,high photoluminescence quantum yields,high defect tolerance,and tunable bandgap with different elements,laser actions have been widely conducted.Over the past few years,several approaches have been used for successfully creating perovskite QD lasers.In this review,we summarize the progress of perovskite QD lasers from the aspects of laser theory,characteristics and applications of QD lasers,advantages of perovskite materials for lasers,factors influencing the QD laser threshold,two-photon pumped QD lasers,and perovskite QD laser stability.At the same time,aiming at existing problems,possible solutions and prospects are presented. | Jie Chen Wenna Du Jianwei Shi Meili Li Yue Wang Qing Zhang Xinfeng Liu | 2020 | InfoMat2020，2，1： | 6 |
| 9 | Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein显示文摘Dear Editor,The pandemic of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health and the economy.Up to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been established.We herein report that the hydrophilic compound Salvianolic acid C(Sal-C)from Danshen,a traditional Chinese medicine(TCM),potently inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(S)protein. | Chan Yang Xiaoyan Pan Xinfeng Xu Chen Cheng Yuan Huang Lin Li Shibo Jiang Wei Xu Gengfu Xiao Shuwen Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 10 | NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma显示文摘Objective:Esophageal squamous cell carcinoma(ESCC)has high morbidity and mortality rates worldwide.Cancer stem cells(CSCs)may cause tumor initiation,metastasis,and recurrence and are also responsible for chemotherapy and radiotherapy failures.Myeloid-derived suppressor cells(MDSCs),in contrast,are known to be involved in mediating immunosuppression.Here,we aimed to investigate the mechanisms of interaction of CSCs and MDSCs in the tumor microenvironment.Methods:ESCC tissues and cell lines were evaluated.Neural precursor cell expressed,developmentally downregulated 9(NEDD9)was knocked down and overexpressed by lentiviral transfection.Quantitative PCR,Western blot,immunohistochemistry,cell invasion,flow cytometry,cell sorting,multiplex chemokine profiling,and tumor growth analyses were performed.Results:Microarray analysis revealed 10 upregulated genes in esophageal CSCs.Only NEDD9 was upregulated in CSCs using the sphere-forming method.NEDD9 expression was correlated with tumor invasion(P=0.0218),differentiation(P=0.0153),and poor prognosis(P=0.0373).Additionally,NEDD9 was required to maintain the stem-like phenotype.Screening of chemokine expression in ESCC cells with NEDD9 overexpression and knockdown showed that NEDD9 regulated C-X-C motif chemokine ligand 8(CXCL8)expression via the ERK pathway.CXCL8 mediated the recruitment of MDSCs induced by NEDD9 in vitro and in vivo.MDSCs promoted the stemness of ESCC cells through NEDD9 via the Notch pathway.Conclusions:As a marker of ESCC,NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor,suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC. | Dongli Yue Shasha Liu Tengfei Zhang Yong Wang Guohui Qin Xinfeng Chen Huanyu Zhang Dong Wang Lan Huang Feng Wang Liping Wang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 11 | Support vector machine and ROC curves for modeling of aircraft fuel consumption显示文摘To estimate the fuel consumption of a civil aircraft,we propose to use the receiver operating characteristic(ROC)curve to optimize a support vector machine(SVM)model.The new method and procedure has been developed to build,train,validate,and apply an SVM model.A conceptual support vector network is proposed to model fuel consumption,and the flight data collected from routes are used as the inputs to train an SVM model.During the training phase,an ROC curve is defined to evaluate the performance of the model.To validate the applicability of the trained model,a case study is developed to compare the data from an aircraft performance manual and from the implemented simulation model.The investigated aircraft in the case study is a Boeing 737-800 powered by CFM-56 engines.The comparison has shown that the trained SVM model from the proposed procedure is capable of representing a complex fuel consumption function accurately for all phases during the flight.The proposed methodology is generic,and can be extended to reliably model the fuel consumption of other types of aircraft,such as piston engine aircraft or turboprop engine aircraft. | Xuhui Wang Xinfeng Chen Zhuming Bi | 2015 | Journal of Management Analytics2015，2，1： | 3 |
| 12 | Transplantation of low-power laser-irradiated olfactory ensheathing cells to promote repair of spinal cord injury in rats显示文摘BACKGROUND:Previous studies have demonstrated that low-power laser(LPL) irradiation can promote the regeneration of peripheral nerves and central nerves,as well as influence cellular proliferation.Therefore,it is thought to be a potential treatment for spinal cord injury. OBJECTIVE:Utilizing histological observations and behavioral evaluations,the aim of this study was to investigate the influence of transplanted olfactory ensheathing cells(OECs),irradiated by LPL,on functional repair of rats following transversal spinal cord injury. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the animal experimental center in the First Affiliated Hospital of Xinjiang Medical University between January 2007 and February 2008. MATERIALS:A total of 52 Sprague Dawley rats were included in this experiment.Twelve rats were used to harvest OECs,some of which were irradiated by LPL on days 3,5,and 7 in culture. The remaining 40 rats were used to establish T_(12) complete spinal cord transection injury. DMEM/F12 medium was purchased from Sigma,USA,Fluorogold was provided by Chemicon, USA,and the LY/JG650-D500-16 low-power laser was produced by Xi'an Lingyue Electromechanical Science And Technology Co.,Ltd.,China. METHODS:The successful rat models were randomly divided into three groups:OEC transplantation,LPL-irradiated OEC transplantation,and control.These animals were microinjected with OEC suspension,LPL-irradiated OEC suspension,and DMEM/F12 medium (10μL) respectively 4 weeks after spinal cord was completely transected at the T_(12) level. MAIN OUTCOME MEASURES:Spinal cord injury was observed using hematoxylin-eosin staining. Expression of nerve growth factor receptor p75 and glial fibrillary acidic protein were determined using immunohistochemical staining.Regeneration of spinal nerve fibers in rats was assayed by Fluorogold retrograde labeling method.Basso,Beattie and Bresnahan(BBB) scores were used to evaluate motor functions of rat lower limbs. RESULTS:Structural disturbances were observed following spinal cord injury in each group,and a large amount of scar tissue covered the broken ends,accompanied by porosis and inflammatory cell infiltration.Following OEC transplantation,the distal end connected to the proximal end.nerve growth factor receptor p75 and glial fibrillary acidic protein immunohistochemistry revealed positive OECs in the cephalad and caudal area of rats that received LPL-irradiated OEC transplantation.In the OECs group,only glial fibrillary acidic protein staining was observed.No staining was found in the control group.Neural fibers labeled with Fluorogold extended across the lesion area and into the cephalad and caudal area in the OECs and LPL-irradiated OECs groups, but were not present in the control group.BBB scores revealed statistically significant differences among the three groups(P<0.05):OECs irradiated by LPL group>OECs group>control group. CONCLUSION:Transplantation of OECs and LPL-irradiated OECs promoted functional repair in the injured spinal cord of rats,although LPL-irradiated OECs resulted in greater beneficial effects. | Haoxian Chen Xinfeng Zheng Weibin Sheng Qin Wei Tao Jiang Gele Jin | 2009 | Neural Regeneration Research2009，4，3： | 3 |
| 13 | An unexpected large continental source of reactive bromine and chlorine with significant impact on wintertime air quality显示文摘Halogen atoms affect the budget of ozone and the fate of pollutants such as hydrocarbons and mercury.Yet their sources and significances in polluted continental regions are poorly understood.Here we report the observation of unprecedented levels(averaging at 60 parts per trillion)of bromine chloride(BrCl)at a mid-latitude site in North China during winter.Widespread coal burning in rural households and a photo-assisted process were the primary source of BrCl and other bromine gases.BrCl contributed about 55%of both bromine and chlorine atoms.The halogen atoms increased the abundance of'conventional'tropospheric oxidants(OH,HO_(2) and RO_(2))by 26%-73%,and enhanced oxidation of hydrocarbon by nearly a factor of two and the net ozone production by 55%.Our study reveals the significant role of reactive halogen in winter atmospheric chemistry and the deterioration of air quality in continental regions where uncontrolled coal combustion is prevalent. | Xiang Peng Weihao Wang Men Xia Hui Chen A.R.Ravishankara Qinyi Li Alfonso Saiz-Lopez Pengfei Liu Fei Zhang Chenglong Zhang Likun Xue Xinfeng Wang Christian George Jinhe Wang Yujing Mu Jianmin Chen Tao Wang | 2021 | National Science Review2021，8，7： | 2 |
| 14 | Surface molecular imprinting on g-C3N4 photooxidative nanozyme for improved colorimetric biosensing显示文摘Graphitic carbon nitride(g-C3 N4),as a visible-light-active organic semiconductor,has attracted growing attentions in photocatalysis and photoluminescence-based biosensing.Here,we demonstrated the intrinsic photooxidase activity of g-C3 N4 and then surface molecular imprinting on g-C3 N4 nanozymes was achieved for improved biosensing.Upon blue LED irradiation,the g-C3 N4 exhibited superior enzymatic activity for oxidation of chromogenic substrate like 3,3’,5,5’-tetramethylbenzidine(TMB)without destructive H2 O2.The oxidation was mainly ascribed to ·O2^-that was generated during light irradiation.The surface molecular imprinting on g-C3 N4 can lead to an over 1000-fold alleviation in matrix-interference from serum samples,4-fold improved enzymatic activity as well as enhanced substrate specificity comparing with bare g-C3 N4 during colorimetric sensing.Also,the MIP-g-C3 N4 possesses a high affinity to TMB with a Km value of only 22 μmol/L,much lower than other comment nanozymes like AuNPs,Fe3 O4 NPs,etc.It was successfully applied for detection of cysteine in serum sample with satisfactory recoveries. | Yuanheng Wu Qiang Chen Shuang Liu Hua Xiao Menglin Zhang Xinfeng Zhang | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 15 | Synthesis and self-assembly of poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine)and their oxidation-sensitive polymersomes显示文摘Amphiphilic block copolymers poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine)(PEGb-PMeSPG)were synthesized via ring-opening polymerization of N-3-(methylthio)propyl glycine Nthiocarboxyanhydride(MeSPG-NTA)initiated by amino-terminated PEG.The self-assemblies of three PEG-b-PMeSPG copolymers with different PMeSPG block lengths were first prepared by nanoprecipitation method using THF and DMF,respectively,as the organic solvent,and their morphologies were studied by Cryo-EM and DLS.To prepare polymersomes loaded with glucose oxidase(GOx),double emulsion method followed by extrusion treatment was employed.The oxidation-responsive disruption of polymersomes was achieved upon the introduction of glucose because of the oxidants generated insitu by GOx/glucose. | Yangwei Deng Hui Chen Xinfeng Tao Sylvain Trepout Jun Ling Min-Hui Li | 2020 | Chinese Chemical Letters2020，31，7： | 2 |
| 16 | High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells显示文摘在导致的 pluripotent 干细胞(iPSCs ) 积累的反常 epigenetic 修正是否能最终影响 iPSC pluripotency,仍然保持争论。为了探查这个问题,有一样的基因背景的 iPSC 线和 proviral 集成地点,被建立,并且每根 iPSC 线的 pluripotency 状态用 tetraploid (4N ) 被描绘互补试金。随后,基因表示和 “ 的全球 epigenetic 修正; 4N-ON ”并且相应 “ 4N-OFF ”iPSC 线通过深定序 mRNA 表示,小 RNA 侧面, histone 修正(H3K27me3, H3K4me3,和 H3K4me2 ) ,和 DNA methylation 的分析被比较。我们发现了印的基因的那 methylation, Zrsr1,一致地与减少的 pluripotency 在 iPSC 线被破坏。而且,破坏 methylation 不能被改进文化条件或 iPSCs 的 subcloning 救。而且,在 iPSCs 的 Zrsr1 和 pluripotency 状态的 hypomethylation 之间的关系进一步在线从另外的 reprogramming 系统导出的独立 iPSC 被验证。 | Gang Chang Shuai Gao Xinfeng Hou Zijian Xu Yanfeng Liu Lan Kang Yu Tao Wenqiang Liu Bo Huang Xiaochen Kou Jiayu Chen Lei An Kai Miao Keqian Di Zhilong Wang Kun Tan Tao Cheng Tao Cai Shaorong Gao Jianhui Tian | 2014 | Cell Research2014，24，3： | 2 |
| 17 | Learning curve of totally thoracoscopic pulmonarysegmentectomy显示文摘Totally thoracoscopic pulmonary segmentectomy (TTPS) is a feasible and sale technique that requiresadvanced thoracoscopic skills and knowledge of pulmonary anatomy. However, data describing the learning curveof TTPS have yet to be obtained. In this study, 128 patients who underwent TTPS between September 2010 andDecember 2013 were retrospectively analyzed to evaluate the learning curve and were divided chronologically intothree phases, namely, ascending phase (A), plateau phase (B), and descending phase (C), through cumulativesummation (CUSUM) for operative time (OT). Phases A, B, and C comprised 39, 33, and 56 cases, respectively. OTand blood loss decreased significantly from phases A to C (P 〈 0.01), and the frequency of intraoperativebronchoscopy for target bronchus identification decreased gradually (A, 8/39; B, 4/33; C, 3/56; P = 0.06). Nosignificant differences were observed in demographic factors, conversion, complications, hospital stay, andretrieved lymph nodes among the three phases. Surgical outcomes and techniques improved with experience andvolume. CUSUMoT indicated that the learning curve of TTPS should be more than 72 cases. | Weibing Wu Jing Xu Wei Wen Yue Yu Xinfeng Xu Quan Zhu Liang Chen | 2018 | Frontiers of Medicine2018，12，5： | 1 |
| 18 | Co MParison of Extraction Methods for Analysis of Citrinin in Red Fermented Rice显示文摘 | WANG Weiping CHEN Qi ZHANG Xinfeng | 2014 | Food Chemistry2014，157，8： | 1 |
| 19 | Pattern of cerebrovascular atherosclerotic stenosis in older Chinese patients with stroke显示文摘 | Fang Yang Ling Liu Min Li Mingquan Li Qin Yin Ruibing Guo Yun Li Guanghui Chen Renliang Zhang Xinfeng Liu | 2013 | Journal of Clinical Neuroscience2013，，7： | 1 |
| 20 | Association between plasma homocysteine levels and obstructive sleep apnoea in patients with ischaemic stroke显示文摘 | Maogang Chen Bona Wu Xinchun Ye Zhiming Zhou Xuanye Yue Qizhang Wang Wanxiang Wang Yongjun Jiang Xuegan Lian Zhaoyao Chen Gelin Xu Xinfeng Liu | 2011 | Journal of Clinical Neuroscience2011，，11： | 1 |
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