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| 1 | Genome-wide signatures of the geographic expansion and breeding of soybean显示文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding. | Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 2 | Five new mononuclear complexes of 2-(5-methyl-lH-pyrazol-3-yl)pyri-dine :synthesis, crystalline architectures through supramolecular interactions and spectroscopy 显示文摘 | Zhu Guangzhou Xing Beibei Yang Fenglei | 2014 | Polyhedron2014，81，1： | 1 |
| 3 | Stoichio- metric characteristics and responses of submerged macro- phytes to eutrophication in lakes along the middle and lower reaches of the Yangtze River显示文摘 | XING Wei WU Haoping HAO Beibei | 2013 | Ecological Enginee- ring2013，54，： | 1 |
| 4 | Five new mononuclear complexes of 2-(5-methyl-1 H-pyrazol-3-yl)pyri- dine:synthesis, crystalline architectures through supramolecular interactions and spectroscopy显示文摘 | Zhu Guangzhou Xing Beibei Yang Fenglei | 2014 | Polyhedron2014，81，1： | 1 |
| 5 | Stoichiometric characteristics and responses of submerged macrophytes to eutrophication in lakes along the middle and lower reaches of the Yangtze River显示文摘 | XING Wei WU Haoping HAO Beibei | 2013 | Ecological Engineering2013，54，： | 1 |
| 6 | Expression of the mouse metallothionein mutant ββ-cDNA in the lettuces (Lactuca sativa L.)显示文摘Mouse metallothionein (MT) domain mutant ββ-cDNA gene has been inserted into the plant expression vector pGPTVd35S which has herbicide (PPT)-resistance gene bar as a selective marker. The chimeric gene was introduced into the lettuce (Lactuca sativa L. cv Salinas 88) by Agrobacterium-mediated transformation. PCR and Southern blot analysis of some putative transformants indicated that the introduced ββ-cDNA was integrated into lettuce genome and inheritted by sexual reproduction. The expression of ββ gene in lettuce plants was demonstrated by Northern and Western blot analysis. Meanwhile, the zinc content of the transformed lettuce plants is up to 400 μg/g dry weight, remarkably higher than the control plants. | Zuo Xiaofeng Zhang Yukun Wu Beibei Chang Xing Ru Binggen | 2002 | Chinese Science Bulletin2002，47，7： | 1 |
| 7 | New Technology of Multidirectional Loading Rotary Extrusion显示文摘To satisfy the requirements for the precise formation of large-scale high-performance lightweight components with inner ring reinforcement, a new multidirectional loading rotary extrusion forming technology is developed to match the linear motion with the rotary motion and actively increases the strong shear force. Its principle is that the radial force and rotating torque increase when the blank is axially extruded and loaded. Through the synergistic action of axial, radial, and rotating motions, the orderly fow of metal is controlled, and the cumulative severe plastic deformation (SPD) of an“uplift-trowel” micro-area is generated. Consequently, materials are uniformly strengthened and toughened. Simultaneously, through the continuous deformation of a punch “ellipse-circle,” a high reinforcement component is grown on the cylinder wall to achieve the high-quality formation of cylindrical parts or the inner-ring-reinforcement components. Additionally, the efective strain increases with rotation speed, and the maximum intensity on the basal plane decreases as the number of revolutions increase. The punch structure also afects the axial extrusion loading and equivalent plastic strain. Thus, the proposed technology enriches the plastic forming theory and widens the application feld of plastic forming. Furthermore, the formed large-scale high-performance inner-ring-stifened magnesium components have been successfully verifed in aerospace equipment, thereby solving the problems of integral forming and severe deformation strengthening and toughening. The developed technology has good prospects for mass production and application. | Zhimin Zhang Yong Xue Xing Zhang Beibei Dong Mei Cheng Zhe Chen | 2023 | Chinese Journal of Mechanical Engineering2023，36，5： | 0 |
| 8 | BGB-A445,a novel non-ligand-blocking agonistic anti-OX40 antibody,exhibits superior immune activation and antitumor effects in preclinical models显示文摘t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T cells.The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation and also promotes dendritic cells to mature to enhance their cytokine production.Therefore,the use of agonistic anti-Ox40 antibodies for cancer immunotherapy has gained great interest.However,most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited efficacy.Here,we discovered that BGB-A445,a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation,induced optimal T cell activation without impairing dendritic cell function.In addition,BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular cytotoxicity.In the MC38 syngeneic model established in humanized OX40 knock-in mice,BGB-A445 demonstrated robust and dose-dependent antitumor efficacy,whereas the ligand-competitive anti-Ox40 antibody showed antitumor efficacy characterized by a hook effect.Furthermore,BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.Taken together,our findings show that BGB-A445,which does not block OX40-OX40L interaction in contrast to clinical-stage anti-OX40 antibodies,shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation. | Beibei Jiang Tong Zhang Minjuan Deng Wei Jin Yuan Hong Xiaotong Chen Xin Chen Jing Wang Hongjia Hou Yajuan Gao Wenfeng Gong Xing Wang Haiying Li Xiaosui Zhou Yingcai Feng Bo Zhang Bin Jiang Xueping Lu Lijie Zhang Yang Li Weiwei Song Hanzi Sun Zuobai Wang Xiaomin Song Zhirong Shen Xuesong Liu Kang Li Lai Wangl Ye Liu | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 9 | FOXK2激发广泛的转录抑制并阻遏缺氧反应和乳腺癌发生发展显示文摘临床上,严重智力障碍、West综合征、Dandy-Walker畸形和并指等临床表现与转录因子FOXK2功能障碍密切相关,然而目前FOXK2的具体生物学作用尚不明确。 | Lin Shan Xing Zhou Xinhua Liu Yue Wang Dongxue Su Yongqiang Hou Na Yu Chao Yang Beibei Liu Jie Gao Yang Duan Jianguo Yang Wanjin Li Jing Liang Luyang Sun Kexin Chen Chenghao Xuan Lei Shi Yan Wang 尚永丰 | 2017 | 科学新闻2017，19，4： | 0 |
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