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| 1 | Origin and phylogenetic analysis of Tibetan Mastiff based on the mitochondrial DNA sequence显示文摘At present,the Tibetan Mastiff is the oldest and most ferocious dog in the world. However,the origin of the Tibetan Mastiff and its phylogenetic relationship with other large breed dogs such as Saint Bernard are unclear. In this study,the primers were designed accord-ing to the mitochondrial genome sequence of the domestic dog,and the 2,525 bp mitochondrial sequence,containing the whole sequence of Cytochrome b,tRNA-Thr,tRNA-Pro,and control region of the Tibetan Mastiff,was obtained. Using grey wolves and coyotes as out-groups,the Tibetan Mastiff and 12 breeds of domestic dogs were analyzed in phylogenesis. Tibetan Mastiff,domestic dog breeds,and grey wolves were clustered into a group and coyotes were clustered in a group separately. This indicated that the Tibetan Mastiff and the other domestic dogs originated from the grey wolf,and the Tibetan Mastiff belonged to Carnivora,Canidae,Canis,Canis lupus,Canis lupus familiaris on the animal taxonomy. In domestic dogs,the middle and small breed dogs were clustered at first; German Sheepdog,Swedish Elkhound,and Black Russian Terrier were clustered into one group,and the Tibetan Mastiff,Old English Sheepdog,Leonberger,and Saint Bernard were clustered in another group. This confirmed the viewpoint that many of the famous large breed dogs worldwide such as Saint Bernard possibly had the blood lineage of the Tibetan Mastiff,based on the molecular data. According to the substitution rate,we concluded that the approximate divergence time between Tibetan Mastiff and grey wolf was 58,000 years before the present (YBP),and the approximate divergence time between other domestic dogs and grey wolf was 42,000 YBP,demonstrating that the time of origin of the Tibetan Mastiff was earlier than that of the other domestic dogs. | Qifa Li Zhenshan Liu Yinxia Li Xingbo Zhao Liyan Dong Zengxiang Pan Yuanrong Sun Ning Li Yinxue Xu Zhuang Xie | 2008 | Journal of Genetics and Genomics2008，35，6： | 15 |
| 2 | Comparison of basic features and origins of oolitic shoal reservoirs between carbonate platform interior and platform margin locations in the Lower Triassic Feixianguan Formation of the Sichuan Basin,southwest China显示文摘The oolitic shoal reservoirs of the Lower Triassic Feixianguan Formation carbonates in the Sichuan Basin of southwest China are an important target for gas exploration in the basin.Their occurrence,like other cases worldwide,can be divided into two locations in general,i.e.,platform interior and platform margin locations.Their differences of reservoir features and origins,however,have not been investigated comprehensively due to different exploration degrees.This issue is addressed in this paper,to provide basic data and information for the basin's hydrocarbon exploration and for the study of carbonate platform sedimentology and reservoir geology worldwide.We compared the features of these two types of reservoirs in detail,including the depositional and diagenetic features,pore types and petrophysical features.Based on the comparison,the origin of the reservoirs was further discussed.It is shown that the reservoirs in platform interior and platform margin locations differ significantly.The interior carbonates were deposited in moderate to high energy settings and the dominant lithologic type was limestone,which was weakly compacted and intensely cemented and has undergone meteoric dissolution.Pore types include intragranular dissolution and moldic pores,with low porosities(<6%) and low permeabilities(<0.1 mD).By contrast,the platform margin carbonates were deposited in relatively high energy settings and mainly consisted of dolostones with some limestones.The rocks were strongly compacted but incompletely cemented.As a result,some primary intergranular pores were preserved.Both meteoric solution and burial solution have taken place.There are various types of pore spaces including intergranular and intercrystalline solution pores and residual intergranular pores.This type of reservoir generally has better petrophysical properties(>9% porosity and >0.1 mD permeability) and pore-throat structures than the interior reservoirs.These differences were influenced by both primary depositional features and secondary diagenesis.For the interior carbonate reservoirs,early meteoric dissolution,weak compaction and strong cementation are important controlling factors.By contrast,the factors controlling the formation of the margin carbonate reservoirs mainly include dolomitization,preservation of primary pores and burial dissolution. | Tan Xiucheng Zhao Luzi Luo Bing Jiang Xingfu Cao Jian Liu Hong Li Ling Wu Xingbo Nie Yong | 2012 | Petroleum Science2012，9，4： | 9 |
| 3 | The phylogenetic status of typical Chinese native pigs: analyzed by Asian and European pig mitochondrial genome sequences显示文摘China is one of the most diverse countries, which have developed 88 indigenous pig breeds. Several studies showed that pigs were independently domesticated in multiple regions of the world. The purpose of this study was to investigate the origin and evolution of Chinese pigs using complete mitochondrial genomic sequences (mtDNA) from Asian and European domestic pigs and wild boars. Thirty primer pairs were designed to determine the mtDNA sequences of Xiang pig, Large White, Lantang, Jinhua and Pietrain. The phylogenetic status of Chinese native pigs was investigated by comparing the mtDNA sequences of complete coding regions and D-loop regions respectively amongst Asian breeds, European breeds and wild boars. The analyzed results by two cluster methods contributed to the same conclusion that all pigs were classified into two major groups, European clade and Asian clade. It revealed that Chinese pigs were only recently diverged from each other and distinctly different from European pigs. Berkshire was clustered with Asian pigs and Chinese pigs were involved in the development of Berkshire breeding. The Malaysian wild boar had distant genetic relationship with European and Asian pigs. Jinhua and Lanyu pigs had more nucleotide diversity with Chinese pigs although they all belonged to the Asian major clade. Chinese domestic pigs were clustered with wild boars in Yangtze River region and South China. | Guanghui Yu Hai Xiang Jikun Wang Xingbo Zhao | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 7 |
| 4 | Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed Han sheep显示文摘Background: In farm animals, mitochondrial DNA(mtDNA) effect on economic performance remains hot-topic for breeding and genetic selection. Here, 53 maternal lineages of Small-tailed Han sheep were used to investigate the association of mitochondrial DNA variations and the lambing litter size.Results: Sequence sweeping of the mitochondrial coding regions discovered 31 non-synonymous mutations, and the association study revealed that T7719G in mt DNA t RNA-Lys gene was associated with litter size(P < 0.05),manifesting 0.29 lambs per litter between the G and T carriers. Furthermore, using the mixed linear model, we assayed the potential association of the ovine litter size and haplogroups and multiple-level mtDNA haplotypes,including general haplotypes, assembled haplotypes of electron transport chain contained sequences(H-ETC),mitochondrial respiratory complex contained sequences(H-MRC) and mitochondrial genes(H-gene, including polypeptide-coding genes, rRNA genes and tRNA genes). The strategy for assembled mitochondrial haplotypes was proposed for the first time in mtDNA association analyses on economic traits, although none of the significant relations could be concluded(P > 0.05). In addition, the nuclear major gene BMPR1B was significantly correlated with litter size in the flock(P < 0.05), however, did not interact with mtDNA T7719G mutation(P > 0.05).Conclusions: Our results highlight mutations of ovine mitochondrial coding genes, suggesting T7719G in tRNA-Lys gene be a potentially useful marker for selection of sheep litter size. | Xiaoyong Chen Dan Wang Hai Xiang Weitao Dun Dave O.H.Brahi Tao Yin Xingbo Zhao | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 4 |
| 5 | microRNA-21 overexpression contributes to cell proliferation by targetingPTEN in endometrioid endometrial cancer显示文摘 | Xiaoyan Qin Lei Yan Xingbo Zhao Chunyan Li Yibing Fu | 2012 | Oncology Letters2012，，： | 2 |
| 6 | Genetic analysis on 3'- terminal flanking region of uncoupling protein 3 in different pig breeds显示文摘The 3’-terminal flanking region of porcine uncoupling protein 3 (UCP3) was cloned, the sequence data revealed 15 nucleotide substitutions among Landrace and three Chinese native pig breeds named Neijiang, Minpig and Erhualian. The continuous 9 polymorphic sites were checked by PCR-RFLP, the results indicated that Erhualian had extraordinary gene frequency, presented most significant difference by x2 test compared with Landrace, Largewhite, Neijiang and Minpig respectively, significant level compared with Meishan; and Meishan also had significant difference compared with Landrace and Minpig respectively. These results can be concluded that Taihu pigs have special genetic characteristics among pig breeds. | FANG Meiying, ZHAO Xingbo, LI Ning & WU ChangxinCollege of Animal Science and Technology, China Agricultural University, Beijing 100094, China State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, China | 2002 | Chinese Science Bulletin2002，47，18： | 2 |
| 7 | Removal of roosters alters the domestic phenotype and microbial and genetic profile of hens显示文摘Hens are raised apart from roosters in modern poultry production, a substantial change from their natural social structure. We compared productivity, injuries, behavior, physiology, microbiome and transcriptome of hens housed with(R+) or without(R–)roosters to quantify the effects of this change in social structure. Hens were raised free-range from 70 to 280 days when 30 birds per treatment were assigned to battery cages until Day 315(R+C vs. R–C), while 30 birds per treatment remained in free-range pens(R+F vs. R–F). Response to a novel environment and object, behavioral time budgets, cecum microbiome, blood composition and transcriptomic sequencing of thigh muscle and spleen were analyzed. Hens housed without roosters showed better survival, consumed less food, produced more eggs and had better feed conversion. R+F hens clustered around the rooster and were less mobile in the novel environment and object tests. R+F hens displayed the richest microbiome, and the presence of roosters resulted in differentially expressed genes related to muscle development, cellular processes, environmental information processing and immune function. Removing roosters from housed hens intensified desirable characteristics favored by domestication probably operating by deprivation of mating behavior and reduced fear, along with altered microbial and genetic function. | Hai Xiang Siyu Chen Hui Zhang Xu Zhu Dan Wang Huagui Liu Jikun Wang Tao Yin Langqing Liu Minghua Kong Jian Zhang Hua Li Simon Turner Xingbo Zhao | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 8 | ZIF-7@carbon composites as multifunctional interlayer for rapid and durable Li-S performance显示文摘The notorious'shuttle effect'of polysulfide during charge-discharge process induces grievous capacity fading,while the sluggish polysulfide conversion kinetics significantly hinders the development of practically viable lithium-sulfur(Li-S)batteries.In this study,a novel ZIF-7@carbon composite with ZIF-7 sheets vertically rooted on carbon cloth was developed as multifunctional interlayer to address these issues.The composite shows directional layered structure with outstanding compactness,and thus can provide massive active sites for accelerated redox reactions.The pore channels are perpendicular to the square surface,resulting in extremely high utilization of one-dimensional channels.Therefore,this structure can not only maintain the structural stability during the charge-discharge process by providing enough space for volume expansion,but also contribute to efficient exposure and utilization of active sites for the physical/chemical adsorption and catalytic conversion of polysulfide.As a result,Li-S batteries with the as-developed interlayer deliver a considerable areal capacity of 4.75 mAh cm^(-2) at an elevated sulfur loading of 5.5 mg cm^(-2),and an impressive cyclability with an extremely low capacity-fading rate of merely 0.04%per cycle over 500 cycles at 1 C. | Xingbo Wang Yan Zhao Feichao Wu Shuming Liu Zisheng Zhang Zhaoyang Tan Xiaohang Du Jingde Li | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 9 | Complete sequence of the yak (Bos grunniens) mitochondrial genome and its evolutionaryrelationship with other ruminants显示文摘 | Gu Zhiliang Zhao Xingbo Li Ning | 2007 | Molecular Phylogenetics and Evolution2007，42，： | 1 |
| 10 | Dual-specificity phosphatase 6 (Dusp6), a negative regulator of FGF2/ERK1/2 signaling, enhances 17β-estrodial-induced cell growth in endometrial adenocarcinoma cell显示文摘 | Hui Zhang Qiufen Guo Chong Wang Lei Yan Yibing Fu Mingjun Fan Xingbo Zhao Mingjiang Li | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
| 11 | microRNA-21 overexpression contributes to cell proliferation by targetingPTEN in endometrioid endometrial cancer显示文摘 | Xiaoyan Qin Lei Yan Xingbo Zhao Chunyan Li Yibing Fu | 2012 | Oncology Letters2012，，6： | 1 |
| 12 | Dual-specificity phosphatase 6 (Dusp6), a negative regulator of FGF2/ERK1/2 signaling, enhances 17β-estrodial-induced cell growth in endometrial adenocarcinoma cell显示文摘 | Hui Zhang Qiufen Guo Chong Wang Lei Yan Yibing Fu Mingjun Fan Xingbo Zhao Mingjiang Li | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
| 13 | Sequences and polymorphisms of exons 3 and 4 in porcine UCP_2 gene显示文摘Uncoupling proteins are mitochondrial membrane transporters, which regulate metabolic pathways of energy balance, and are associated with biological traits of animal body weight, resting metabolic rates and energy conversion. In this study, a region of the exons 3 and 4 of pig UCP2 gene was cloned and analyzed, and a new single nucleotide polymorphic site was detected by PCR-SSCP in five pig breeds. This newfound polymorphism results from a T to G substitution at the position of nucleotide 272, which is located in intron3. | FANG Meiying, LIU Chousheng, ZHAO Xingbo, LI Ning and WU Changxin(1. College of Animal Science and Technology, China Agricultural University, Beijing 100094, China 2. National Laboratory for A-gribiotechnology, China Agricultural University, Beijing 100094, China 3. Gansu Institute of Animal and Veterinary Science, Pingliang 744000, China) | 2002 | Progress in Natural Science:Materials International2002，12，7： | 1 |
| 14 | Allergic bronchopulmonary aspergillosis coexists with hereditary bisalbuminemia显示文摘The electrophoresis of a patient's serum proteins occasionally reveals two distinct fractions of serum albumin.This rare phenomenon is called bisalbuminemia.Bisalbuminemia can be classified into two types,a rare hereditary one and non-hereditary bisalbuminemia.There have been many reports about non-hereditary bisalbuminemia,which is mainly caused by the excess-use of antibiotics such as penicillin.Hereditary bisalbuminemia (or alloalbuminemia) is a rare,autosomal,and incomplete dominant hereditary condition characterized by the presence of two distinct fractions of serum albumin by electrophoresis.Scheurlen1 reported the first case of this disease in 1955.The first case of hereditary bisalbuminemia in China was reported by Ying et al2 in 1980.Since then,approximately 130 cases of bisalbuminemia from 21 different families have been reported in China.Here,we described a new family with hereditary bisalbuminemia,which was discovered with a patient complained of refractory asthma. | Chen Xin Li Jiang Zhao Xingbo | 2014 | Chinese Medical Journal2014，，7： | 0 |
| 15 | Molecular authentication of the traditional Chinese medicine Tongren Dahuoluo Wan and its alternative formulation显示文摘Tongren Dahuoluo Wan has been a popular traditional Chinese medicine in international pharmaceutical markets for hundreds of years. Leopard bone powder is the key element in its formulation. However, the leopard has been listed for wildlife conservation, which limits the use of the leopard bone supplies. Therefore, an alternative formulation which substitutes leopard bone with zokor bone in the formula of Tongren Dahuoluo Wan is now manufactured. To develop a simple and reliable molecular method for authenticating the two patent medicines,mitochondrial nucleotide polymorphic sites of 12 S rRNA,COI and Cytb genes were screened in leopard and zokor bones, and nine pairs of species-specific primers were verified for discriminating the two species. For the patent medicine authentication, we set up a molecular diagnostic assay to resolve the difficulties of low concentration of target DNAs and presence of PCR-inhibitory substances in this complex medicine, and successfully confirmed leopard or zokor content using the nine pairs of species-specific primers. We recommend a common technical strategy for authentication of species origins in traditional Chinese medicine, and discuss the experimental solutions for technical problems of molecular diagnostic assays. | Jikun WANG Jing DU Meng CAO Lu YAO Suhua XIE Jiafu CHEN Xingbo ZHAO | 2017 | Frontiers of Agricultural Science and Engineering2017，4，3： | 0 |
| 16 | Ancient mitochondrial genome depicts sheep maternal dispersal and migration in Eastern Asia显示文摘Sheep have been one of the most important groups of animals since ancient times.However,the knowledge of their migration routes and genetic relationships is still poorly understood.To investigate sheep maternal migration histories alongside Eurasian communications routes,in this study,we obtain mitochondrial genomes(mitogenomes)from 17 sheep remains in 6 Chinese sites and 1 Uzbekistan site dated 4429–3100 years before present(BP).By obtaining the mitogenomes from the sheep(4429–3556 BP)found in the Tongtian Cave site in Xinjiang,Altai region of northwest China,our results support the emergence of haplogroup C sheep in Xinjiang as early as 4429–3556 BP.The combined phylogenetic analyses with extant ancient and modern sheep mitogenomes suggest that the Uzbekistan-Altai region may have been a migration hub for early sheep in eastern Asia.At least two migration events have taken place for sheep crossing Eurasia to China,one passing by Uzbekistan and Northwest China to the middle and lower reaches of the Yellow River at approximately 4000 BP and another following the Altai region to middle Inner Mongolia from 4429 BP to 2500 BP.Overall,this study provides further evidence for early sheep utilization and migration patterns in Eastern Asia. | Liu Yang Xing Zhang Yaning Hu Piao Zhu Hua Li Zhenyu Peng Hai Xiang Xinying Zhou Xingbo Zhao | 2024 | Journal of Genetics and Genomics2024，51，1： | 0 |
| 17 | 通过基矢光前量子化计算轻介子部分子分布函数及其QCD演化显示文摘The basis light front quantization(BLFQ)is a nonperturbative approach for the light front wavefunctions(LFWFs)and the spectroscopy of the many body bound-state systems in quantum field theories[1−3].It is a Hamiltonian-based formalism with the advantages of light front dynamics[4].The LFWFs of the bound states are obtained as the eigenfunctions of the light front Schr¨odinger equation Heff|Ψ>=M2|Ψ>,where Heff is the effective Hamiltonian of the system. | Lan Jiangshan Mondal Chandan Xu Siqi Zhao Xingbo | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 18 | Heterometallic cluster-based organic frameworks as highly active electrocatalysts for oxygen reduction and oxygen evolution reaction:a density functional theory study显示文摘Recently,metal–organic frameworks are one of the potential catalytic materials for electrocatalytic applications.The oxygen reduction reaction and oxygen evolution reaction catalytic activities of heterometallic cluster-based organic frameworks are investigated using density functional theory.Firstly,the catalytic activities of heterometallic clusters are investigated.Among all heterometallic clusters,Fe_(2)Mn–Mn has a minimum overpotential of 0.35 V for oxygen reduction reaction,and Fe_(2)Co–Co possesses the smallest overpotential of 0.32 V for oxygen evolution reaction,respectively 100 and 50 mV lower than those of Pt(111)and RuO_(2)(110)catalysts.The analysis of the potential gap of Fe_(2)M clusters indicates that Fe_(2)Mn,Fe_(2)Co,and Fe_(2)Ni clusters possess good bifunctional catalytic activity.Additionally,the catalytic activity of Fe_(2)Mn and Fe_(2)Co connected through 3,3′,5,5′-azobenzenetetracarboxylate linker to form Fe_(2)M–PCN–Fe_(2)M is explored.Compared with Fe_(2)Mn–PCN–Fe_(2)Mn,Fe_(2)Co–PCN–Fe_(2)Co,and isolated Fe_(2)M clusters,the mixed-metal Fe_(2)Co–PCN–Fe_(2)Mn possesses excellent bifunctional catalytic activity,and the values of potential gap on the Mn and Co sites of Fe_(2)Co–PCN–Fe_(2)Mn are 0.69 and 0.70 V,respectively.Furthermore,the analysis of the electron structure indicates that constructing a mixed-metal cluster can efficiently enhance the electronic properties of the catalyst.In conclusion,the mixed-metal cluster strategy provides a new approach to further design and synthesize high-efficiency bifunctional electrocatalysts. | Xin Chen Liang Luo Shihong Huang Xingbo Ge Xiuyun Zhao | 2023 | Frontiers of Chemical Science and Engineering2023，17，5： | 0 |
| 19 | A Study of the Pion from BLFQ显示文摘We study the properties of the pion through the light-front wave function(LFWF)obtained from a basis lightfront quantization(BLFQ)approach[1−4].BLFQ is a nonperturbative approach to quantum field theory based on the Hamiltonian formalism.In order to make the numerical calaulation feasible. | Lan Jiangshan Chandan Mondal Zhao Hengfei Zhao Xingbo | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 20 | Proton Structure with Three Dynamical Quarks显示文摘Basis light-front quantization(BLFQ)as a nonperturbative approach has been successfully applied to QED and QCD systems[1–13].Treating the proton as a system of three dynamical quarks,we adopt a light-front effective Hamiltonian. | Xu Siqi Chandan Mondal Lan Jiangshan Zhao Xingbo Li Yang James P.Vary | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
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