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| 1 | A High-Density SNP Genotyping Array for Rice Biology and Molecular Breeding显示文摘一个高密度的单个核苷酸多型性(SNP ) 数组为遗传学者和分子的 breeders.With 是极其重要的 genomic 的巨大的数量的累积重新定序为精确 SNP 察觉的数据和可得到的技术,设计高密度、高质量的米饭 SNP 数组是可能的。这里,我们报导一个高密度的 riceSNP 数组和它的实用程序的开发。SNP 探针被屏蔽超过 10 设计从变化和一个数组说出 RiceSNP50 的 801 米饭的 re-sequencingdata 提取的 000 000 SNP loci 在 Illumina Infinium 站台上被生产。数组 contained51 478 个均匀地分布式的标记,其 68% 个在遗传因子的区域以内。有 parent/F1 relationshipswere 的几百米饭植物过去常为精确 SNP 打电话产生一个高质量的簇文件。应用程序测试证明这穿有的 highgenotyping 精确性,并且能被用于不同目的。例如,有好分辨率的精英米饭变化 wasclustered 的一个核心集合。染色体宽的协会研究(GWAS ) 分析正确地识别了描绘的 QTL.Further,这个数组成功地为变化确认和特点基因渗入被使用。作为一个精确 high-throughputgenotyping 工具, RiceSNP50 将在两功能的 genomics 学习和分子的 breeding.Key 词起一个重要作用: | Haodong Chen Weibo Xie Hang He Huihui Yu Wei Chen Jing Li Renbo Yu Yue Yao Wenhui Zhang Yuqing He Xiaoyan Tang Fasong Zhou Xing Wang Deng Qifa Zhang | 2014 | Molecular Plant2014，7，3： | 38 |
| 2 | RNA-Directed DNA Methylation Is Involved in Regulating Photoperiod-Sensitive Male Sterility in Rice显示文摘光周期敏感的男绝育(PSMS ) 是为混合米饭繁殖的珍贵 germplasm。最近,我们克隆 pms3,控制 PSMS 的一个地点,它编码称为在长天的条件下面为米饭植物的正常男富饶要求的 LDMAR 的长非编码的 RNA。在在 PSMS 米饭(Nongken 58S ) 相对的 LDMAR 的倡导者的增加的 methylation 野类型(Nongken 58 ) 减少了在长天的条件下面导致男绝育的 LDMAR 的表示。在这研究,我们鉴别 siRNA 在比在 Nongken 58 更充满 Nongken 58S 的 LDMAR 倡导者区域说出 PsiLDMAR。我们证明 PsiLDMAR 多半从 AK111270 被导出,与它让 110 底与 LDMAR 的 5 结束重叠的 3 结束从 LDMAR 倡导者的感觉海滨获得的一个抄本。在 Nongken 58S 的 Overexpressing AK111270 极大地充实 PsiLDMAR,它在 LDMAR 倡导者导致了指导 RNA 的 DNA methylation 并且镇压 LDMAR 的表示。在 Nongken 58S 的 LDMAR 的减小为富饶恢复改变了批评的天长度并且在短天的条件下面推迟了富饶恢复。这结果为 PSMS 增加了我们分子的机制的理解。 | Jihua Ding Jianqiang Shen Hailiang Mao Weibo Xie Xianghua Li Qifa Zhang | 2012 | Molecular Plant2012，5，6： | 33 |
| 3 | Rice 2020: A Call For An International Coordinated Effort In Rice Functional Genomics显示文摘我们在在一个工程形式的功能的 genomics 说出 RICE2020 的米饭为一个国际协调努力描述一个电话。工程的使命将是:在一年 2020 在米饭染色体决定每基因的功能,从米饭的主要基因水池的有用基因研究基因改进为农业上识别等位基因的功能的差异,并且使用功能的 genomics 的调查结果到米饭。 | Qifa Zhang Jiayang Li Yongbiao Xue Bin Han Xing Wang Deng | 2008 | Molecular Plant2008，1，5： | 30 |
| 4 | Origin and phylogenetic analysis of Tibetan Mastiff based on the mitochondrial DNA sequence显示文摘At present,the Tibetan Mastiff is the oldest and most ferocious dog in the world. However,the origin of the Tibetan Mastiff and its phylogenetic relationship with other large breed dogs such as Saint Bernard are unclear. In this study,the primers were designed accord-ing to the mitochondrial genome sequence of the domestic dog,and the 2,525 bp mitochondrial sequence,containing the whole sequence of Cytochrome b,tRNA-Thr,tRNA-Pro,and control region of the Tibetan Mastiff,was obtained. Using grey wolves and coyotes as out-groups,the Tibetan Mastiff and 12 breeds of domestic dogs were analyzed in phylogenesis. Tibetan Mastiff,domestic dog breeds,and grey wolves were clustered into a group and coyotes were clustered in a group separately. This indicated that the Tibetan Mastiff and the other domestic dogs originated from the grey wolf,and the Tibetan Mastiff belonged to Carnivora,Canidae,Canis,Canis lupus,Canis lupus familiaris on the animal taxonomy. In domestic dogs,the middle and small breed dogs were clustered at first; German Sheepdog,Swedish Elkhound,and Black Russian Terrier were clustered into one group,and the Tibetan Mastiff,Old English Sheepdog,Leonberger,and Saint Bernard were clustered in another group. This confirmed the viewpoint that many of the famous large breed dogs worldwide such as Saint Bernard possibly had the blood lineage of the Tibetan Mastiff,based on the molecular data. According to the substitution rate,we concluded that the approximate divergence time between Tibetan Mastiff and grey wolf was 58,000 years before the present (YBP),and the approximate divergence time between other domestic dogs and grey wolf was 42,000 YBP,demonstrating that the time of origin of the Tibetan Mastiff was earlier than that of the other domestic dogs. | Qifa Li Zhenshan Liu Yinxia Li Xingbo Zhao Liyan Dong Zengxiang Pan Yuanrong Sun Ning Li Yinxue Xu Zhuang Xie | 2008 | Journal of Genetics and Genomics2008，35，6： | 15 |
| 5 | Rice Functional Genomics Research: Past Decade and Future显示文摘瑞斯(Oryza sativa ) 是为世界范围的超过 35 亿个人的主要主食食物庄稼。在米饭理解复杂农学的特点的规章的机制为全球食物安全是批评的。瑞斯也是为单子叶植物的 genomics 研究的模型植物。由于功能的 genomic 技术的快速的发展,控制重要农学的特点的超过 2000 基因被克隆,并且他们的分子的生物机制也是部分描绘了。这里,我们简短在米饭考察进展功能的 genomics 研究在过去的 10 年期间包括功能的 genomics 平台的一篇摘要,基因 ? 并且调整重要农学的特点的分子的规章的网络,并且 ? 为基因鉴定的最新发达的工具。在功能的 genomics 研究做的这些成就将极大地便于发展 ? 绿超级米饭。我们也讨论未来挑战和米饭的前景功能的 genomics 研究。 | Yan Li Jinghua Xiaot Lingling Chen Xuehui Huang Zhukuan Cheng Bin Han Qifa Zhang Changyin Wu | 2018 | Molecular Plant2018，11，3： | 14 |
| 6 | Origination and Establishment of a Trigenic Reproductive Isolation System in Rice显示文摘 | Yidan Ouyang Guangwei Li Jiaming Mi Conghao Xu Hongyi Du Chengjun Zhang Weibo Xie Xianghua Li Jinghua Xiao Huazhi Song Qifa Zhang | 2016 | Molecular Plant2016，9，11： | 7 |
| 7 | Artificial Selection in Domestication and Breeding Prevents Speciation in Rice显示文摘Speciation has long been regarded as an irreversible process once the reproductive barriers had been established.However,unlike in natural populations,artificial selection might either accelerate or prevent speciation processes in domesticated species.Asian cultivated rice is a target crop for both domestication and artificial breeding;it contains two subspecies of indica and japonica,which usually produce sterile inter-subspecific hybrids due to reproductive barriers.In this study,we constructed the evolutionary trajectory of a reproductive isolation system S5,which regulates fertility in indica-japonica hybrids via three adjacent genes,based on the data of 606 accessions including two cultivated and 11 wild rice species.Although hybrid sterility haplotypes at S5 lead to establishment of a killer-protector reproductive barrier,origin of wide-compatibility haplotypes by complex hybridization and recombination provides an opposing force to reproductive isolation and thus prevents speciation during domestication.Analysis in a diallel set of 209 crosses involving 21 parents showed that the wide-compatibility genotypes largely rescued fertility of indica-japonica hybrids,indicating that the wide-compatibility gene would enable gene flow to maintain species coherence.This counteracting system indicates that combined effects of natural evolution and artificial selection may result in reversible processes of speciation in rice,which may also have implications for genetic improvement of rice. | Jiaming Mi Guangwei Li Conghao Xu Jiangyi Yang Huihui Yu Gongwei Wang Xianghua Li Jinghua Xiao Huazhi Song Qifa Zhang Yidan Ouyang | 2020 | Molecular Plant2020，13，4： | 6 |
| 8 | From Green Super Rice to green agriculture:Reaping the promise of functional genomics research显示文摘Producing sufficient food with finite resources to feed the growing global population while having a smaller impact on the environment has always been a great challenge.Here,we review the concept and practices of Green Super Rice(GSR)that have led to a paradigm shift in goals for crop genetic improvement and models of food production for promoting sustainable agriculture.The momentous achievements and global deliveries of GSR have been fueled by the integration of abundant genetic resources,functional gene discoveries,and innovative breeding techniques with precise gene and whole-genome selection and efficient agronomic management to promote resource-saving,environmentally friendly crop production systems.We also provide perspectives on new horizons in genomic breeding technologies geared toward delivering green and nutritious crop varieties to further enhance the development of green agricul-ture and better nourish the world population. | Sibin Yu Jauhar Ali Shaochuan Zhou Guangjun Ren Huaan Xie Jianlong Xu Xinqiao Yu Fasong Zhou Shaobing Peng Liangyong Ma Dingyang Yuan Zefu Li Dazhou Chen Ruifeng Zheng Zhigang Zhao Chengcai Chu Aiqing You Yu Wei Susong Zhu Qiongyao Gu Guangcun He Shigui Li Guifu Liu Changhua Liu Chaopu Zhang Jinghua Xiao Lijun Luo Zhikang Li Qifa Zhang | 2022 | Molecular Plant2022，15，1： | 6 |
| 9 | b-DAZL:A novel gene in bovine spermatogenesis显示文摘DAZL 基因在 gametogenesis 起一个重要作用。这基因的 Microdeletion 和变化经常在脊椎动物和无脊椎动物与绝育被联系了。这里,包含 DAZL 基因的完全的开的读物框架的 cDNA,它编码通常认为的 RRM RNA 有约束力的蛋白质,被 RT-PCR 从牛的纸巾孤立。孤立的基因被叫作 b-DAZL。基于计算机的地点分析证明 b-DAZL 在染色体 1 的结束附近被定位。b-DAZL 基因和它的脊椎动物相当或相同事物分享了高核苷酸类似(90 94%) 在编码区域并且在 genomic 组织,每由 10 前 ons 和 9 introns 组成。他们的蛋白质产品包含了一个高度保存的 RNA 有约束力的主题,一次唯一的 DAZ 重复,和 PUM2 和 PABP 交往领域。RT-PCR 试金表明 b-DAZL 在睾丸和卵巢被表示。然而,没有信号在无菌的雄的牛牦牛的睾丸被检测。不育的男性的睾丸的微观结构显示出很少的 spermatocytes 但是主要体的房间。这些观察与有有缺点的 DAZL 表示的睾丸的典型显型一致。随后的基因察觉研究显示那抄写拘捕可能在牛牦牛的睾丸导致一个 b-DAZL 抄本缺点。我们的结果建议 b-DAZL 可以涉及精子发生,并且基因的那抄写拘捕在牛牦牛与男绝育被联系。 | Qingbo Zhang Qifa Li Jiahuang Li Xinfu Li Zhenshan Liu Dawei Song Zhuang Xie | 2008 | Progress in Natural Science:Materials International2008，18，10： | 6 |
| 10 | Analysis of IGF2 mRNA expression and its methylation status between cattle yaks and their parents显示文摘Cattle yaks are an F1 hybrid between cattle and yaks and exhibit significant hybrid vigor. However, cattle yaks are sterile males. To study the epigenetic aspects of this reproductive isolation, IGF2 mRNA expression in cattle yaks and their parents and the patterns of the IGF2 differentially methylated regions (DMR) were examined in blood and testes. The results showed that IGF2 expression in cattle yaks' testes was lower than in their parents (P < 0.01). The IGF2 DMR was highly methylated (above 90%) in blood and testes of cattle yaks, yaks and cattle, with the highest level in cattle yaks (P > 0.05). Our study showed that IGF2 plays an important role in bovine spermato-genesis and might be involved in cattle-yak male sterility. The methylation level of the IGF2 DMR was irrelevant to the lower expression of IGF2 in cattle yaks; other factors perhaps play roles in its expression. | Zhenshan Liu Qifa Li Qingbo Zhang Xuguang Qu Liyan Dong Chamba Yang-zom Zhuang Xie Honglin Liu | 2009 | Progress in Natural Science:Materials International2009，19，9： | 5 |
| 11 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 12 | Ultrabithorax is a key regulator for the dimorphism of wings,a main cause for the outbreak of planthoppers in rice显示文摘Rice planthoppers,the most devastating rice pests,occur in two wing forms:the short-wing form for rapid population growth and long-wing form for long-distance migration,which together create the mechanism for outbreak.Here we show that Ultrabithorax(Ubx)is a key regulator for switching between the long-and short-wing forms of rice planthoppers.Ubx is expressed in both forewing and hindwing pads,which is different from the canonical model of Ubx expression.In brown planthoppers,expression of Ubx(Nl Ubx)is regulated by nutritional status of the rice host.High-quality young plants induce Nl Ubx expression leading to the short-wing form;low-quality ripe plants reduce Nl Ubx expression resulting in long-wing form.We also showed that Nl Ubx is regulated by the insulin receptors Nl In R1 and Nl In R2.The default expression of Nl In R1 inhibits Nl Ubx resulting in long-wings,while high-quality hosts induce Nl In R2 expression,which represses Nl In R1 thus promoting Nl Ubx expression to produce short-wings. | Fangzhou Liu Xiang Li Muhua Zhao Mengjian Guo Kehong Han Xinxin Dong Jing Zhao Wanlun Cai Qifa Zhang Hongxia Hua | 2020 | National Science Review2020，7，7： | 5 |
| 13 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 14 | Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair显示文摘Peripheral nerve regeneration requires stepwise and well-organized establishment of microenvironment.Since local delivery of VEGF-A in peripheral nerve repair is expected to promote angiogenesis in the microenvironment and Schwann cells(SCs)play critical role in nerve repair,combination of VEGF and Schwann cells may lead to efficient peripheral nerve regeneration.VEGF-A overexpressing Schwann cells were established and loaded into the inner wall of hydroxyethyl cellulose/soy protein isolate/polyaniline sponge(HSPS)conduits.When HSPS is mechanically distorted,it still has high durability of strain strength,thus,can accommodate unexpected strain of nerve tissues in motion.A 10 mm nerve defect rat model was used to test the repair performance of the HSPS-SC(VEGF)conduits,meanwhile the HSPS,HSPS-SC,HSPS-VEGF conduits and autografts were worked as controls.The immunofluorescent co-staining of GFP/VEGF-A,Ki67 and MBP showed that the VEGF-A overexpressing Schwann cells could promote the proliferation,migration and differentiation of Schwann cells as the VEGF-A was secreted from the VEGF-A overexpressing Schwann cells.The nerve repair performance of the multifunctional and flexible conduits was examined though rat behavioristics,electrophysiology,nerve innervation to gastrocnemius muscle(GM),toluidine blue(TB)staining,transmission electron microscopy(TEM)and NF200/S100 double staining in the regenerated nerve.The results displayed that the effects on the repair of peripheral nerves in HSPS-SC(VEGF)group was the best among the conduits groups and closed to autografts.HSPS-SC(VEGF)group exhibited notably increased CD31+endothelial cells and activation of VEGFR2/ERK signaling pathway in the regenerated nerve tissues,which probably contributed to the improved nerve regeneration.Altogether,the comprehensive strategy including VEGF overexpressing Schwann cells-mediated and HSPS conduit-guided peripheral nerve repair provides a new avenue for nerve tissue engineering. | Ping Wu Zan Tong Lihua Luo Yanan Zhao Feixiang Chen Yinping Li Céline Huselstein Qifa Ye Qingsong Ye Yun Chen | 2021 | Bioactive Materials2021，6，10： | 4 |
| 15 | Rapid genome evolution in Pms1 region of rice revealed by comparative sequence analysis显示文摘Pms1, a locus for photoperiod sensitive genic male sterility in rice, was identified and mapped to chromosome 7 in previous studies. Here we report an effort to identify the candidate genes for Pms1 by comparative sequencing of BAC clones from two cultivars Minghui 63 and Nongken 58, the parents for the initial mapping population. Annotation and comparison of the sequences of the two clones resulted in a total of five potential candidates which should be functionally tested. We also conducted com-parative analysis of sequences of these two cultivars with two other cultivars, Nipponbare and 93-11, for which sequence data were available in public databases. The analysis revealed large differences in sequence composition among the four genotypes in the Pms1 region primarily due to retroelement activity leading to rapid recent growth and divergence of the genomes. High levels of polymorphism in the forms of indels and SNPs were found both in intra- and inter-subspecific comparisons. Dating analysis using LTRs of the retroelements in this region showed that the substitution rate of LTRs was much higher than reported in the literature. The results provided strong evidence for rapid genomic evolution of this region as a consequence of natural and artificial selection. | YU JinSheng FAN YouRong LIU Nan SHAN Yan LI XiangHua ZHANG QiFa | 2007 | Chinese Science Bulletin2007，52，7： | 4 |
| 16 | Haploidentical hematopoietic cell transplantation for severe acquired aplastic anemia: a case-control study of post-transplant cyclophosphamide included regimen vs. anti-thymocyte globulin & colony-stimulating factor-based regimen显示文摘Dear Editor,Haploidentical allogeneic hematopoietic stem cell transplantation(haplo-HSCT),a curative therapy for severe aplastic anemia(SAA)patients,has been used clinically for decades.Two models,not involving ex vitro T-cell depletion,have been adopted for haplo-HSCT in patients with SAA.The first is referred to as the'Beijing protocol'(Xu et al.,2017),and comprises a conditioning regimen using busulfex(BU),cyclophosphamide(CY). | Lanping Xu Bin Fu Wenjing Wang Yajing Xu Depei Wu Shunqing Wang Qifa Liu Linghui Xia Sujun Gao Ming Jiang Jianmin Wang Xi Zhang Hai Bai Huiren Chen Chunfu Li Xiaojun Huang | 2020 | Science China(Life Sciences)2020，63，6： | 3 |
| 17 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 18 | Bract suppression regulated by the miR156/529-SPLs-NL1-PLA1 module is required for the transition from vegetative to reproductive branching in rice显示文摘Reproductive transition of grasses is characterized by switching the pattern of lateral branches,featuring the suppression of outgrowth of the subtending leaves(bracts)and rapid formation of higher-order branches in the inflorescence(panicle).However,the molecular mechanisms underlying such changes remain largely unknown.Here,we show that bract suppression is required for the reproductive branching in rice.We identified a pathway involving the intrinsic time ruler microRNAI56/529,their targets SQUAMOSA PROMOTER BINDING PROTEIN LIKE(SPL)genes,NECK LEAF1(NL1),and PLASTOCHRON1(PLA1),which regulates the bract outgrowth and thus affects the pattern switch between vegetative and reproductive branching.Suppression of the bract results in global reprogramming of transcriptome and chromatin accessibility following the reproductive transition,while these processes are largely dysregu-lated in the mutants of these genes.These discoveries contribute to our understanding of the dynamic plant architecture and provide novel insights for improving crop yields. | Lei Wang Luchang Ming Keyan Liao Chunjiao Xia Shengyuan Sun Yu Chang Hongkai Wang Debao Fu Conghao Xu Zhengji Wang Xu Li Weibo Xie Yidan Ouyang Qinglu Zhang Xianghua Li Qinghua Zhang Jinghua Xiao Qifa Zhang | 2021 | Molecular Plant2021，14，7： | 2 |
| 19 | Comparative analysis of gene expression at early seedling stage between a rice hybrid and its parents using a cDNA microarray of 9198 uni-sequences显示文摘Using a cDNA microarray consisting of 9198 expressed sequence tags,we surveyed the gene expression profiles in shoots and roots of a rice hybrid,Liangyoupei 9 and its parents Peiai 64s and 93-11 at 72 h after germination. A total of 8587 sequences had detectable signals in both shoots and roots of the three genotypes. A total of 1571 sequences exhibited significant (P<0.01) expression differences in shoots or roots among the three genotypes,of which 121 showed expression poly-morphisms in both shoots and roots,and 870 revealed significant expression differences between the hybrid and one of the parents. The expression polymorphism of the sequences was associated with the functional categories of the sequences. They occurred more frequently in categories of carbohy-drate,energy and lipid metabolisms and stress response than expected,while less frequently in categories of amino acid metabolism,transcription and translation regulation,and signal transduction. A total of 214 sequences exhibited significant (P<0.05) mid-parent heterosis in expression,of which 117 had homology to genes with known functions,assigned in the categories of basic metabolism,genetic information processing,cell growth and death,signal transduction,transportation and stress response. The results may provide useful information for exploring the relationship between gene expression polymorphism and phenotypic variation,and for characterizing the molecular mechanism of seedling development and heterosis in rice. | HUANG Yi LI Lihua CHEN Ying LI Xianghua XU Caiguo WANG Shiping ZHANG Qifa | 2006 | Science China(Life Sciences)2006，49，6： | 2 |
| 20 | Understanding the genetic and molecular constitutions of heterosis for developing hybrid rice显示文摘The wide adoption of hybrid rice has greatly increased rice yield in the last several decades.The utilization of heterosis facilitated by male sterility has been a common strategy for hybrid rice development.Here,we summarize our efforts in the genetic and molecular understanding of heterosis and male sterility together with the related progress from other research groups.Analyses of F1 diallel crosses show that strong heterosis widely exists in hybrids of diverse germplasms,and inter-subspecific hybrids often display higher heterosis.Using the elite hybrid Shanyou 63 as a model,an immortalized F2 population design is conducted for systematic characterization of the biological mechanism of heterosis,with identification of loci controlling heterosis of yield and yield component traits.Dominance,overdominance,and epistasis all play important roles in the genetic basis of heterosis;quantitative assessment of these components well addressed the three classical genetic hypotheses for heterosis.Environment-sensitive genic male sterility(EGMS)enables the development of two-line hybrids,and long noncoding RNAs often function as regulators of EGMS.Inter-subspecific hybrids show greatly reduced fertility;the identification and molecular characterization of hybrid sterility genes offer strategies for overcoming inter-subspecific hybrid sterility.These developments have significant implications for future hybrid rice improvement using genomic breeding. | Yidan Ouyang Xu Li Qifa Zhang | 2022 | Journal of Genetics and Genomics2022，49，5： | 2 |
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