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25篇 您的检索式:作者名="Xingdong Wei"
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1Oral health in China: from vision to action显示文摘Chinese president Xi Jinping made clear at the National Health and Wellness Conference that health is the prerequisite for people's all-around development and a precondition for the sustainable development of China. Oral health is an indispensable component of overall health in humans. However, the long neglect of oral health in overall health agendas has made oral diseases an increasing concern. With this perspective, we described the global challenges of oral diseases, with an emphasis on the challenges faced by China. We also described and analyzed the recently released health policies of the Chinese government, which aim to guide midterm and long-term oral health promotion in China. More importantly, we called for specific actions to fulfill the larger goal of oral health for the nation. The implementation of primordial prevention efforts against oral diseases, the integration of oral health into the promotion of overall health, and the management of oral diseases in conjunction with other chronic non-communicable diseases with shared risk factors were highly recommended. In addition, we suggested the reform of standard clinical residency training, the development of domestic manufacturing of dental equipment and materials, the revitalization traditional Chinese medicine for the prevention and treatment of oral diseases, and integration of oral health promotion into the Belt and Road Initiative. We look forward to seeing a joint effort from all aspects of the society to fulfill the goal of Healthy China 2030 and ensure the oral health of the nation.Xuedong Zhou Xin Xu Jiyao Li Deyu Hu Tao Hu Wei Yin Yujiang Fan Xingdong Zhang 2018International Journal of Oral Science2018,10,1:7
2Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu 2017Cell Research2017,27,4:5
3Design and Implementation of An Active Multibeam Antenna System with 64 RF Channels and 256 Antenna Elements for Massive MIMO Application in 5G Wireless Communications显示文摘This paper focuses on the design and implementation of an active multibeam antenna system for massive MIMO applications in 5G wireless communications.The highly integrated active multibeam antenna system is designed and implemented at 5.8 GHz with 64 RF Channels and 256 antenna elements.The 64-channel highly integrated active multibeam antenna system provides a verification platform for digital beamforming algorithm and massive MIMO channel estimation for next generation wireless communications.PANG Xingdong HONG Wei YANG Tianyang LI Linsheng 2014China Communications2014,11,11:4
4Characteristics of plant calcium fractions for 25 species in Tengger Desert显示文摘Little attention has been paid to plant calcium fractions in the desert.To address the characteristic of the calcium fractions of desert plants,we collected 25 plant species in Tengger Desert,observed the calcium crystals using an optical microscope and determined water soluble calcium,acetic acid soluble calcium,and hydrochloric acid soluble calcium.To do so,we used sequential fractionation procedures to probe the relationships among different functional groups,different growth forms,or different successional stages.The results showed that the psammophyte,the late successional plants,and the drought-resistant shrub and semi-shrub all held considerable calcium oxalate crystal compared to the grassland plants,the early successional plants,and the perennial herb.With the proceeding succession,the acetic acid soluble calcium decreased gradually,and the hydrochloric acid soluble calcium increased gradually.The perennial herb had more water soluble calcium,while shrub held greater hydrochloric acid soluble calcium.The grassland plants held more water soluble calcium,while psammophyte had greater hydrochloric acid soluble calcium.This implies that the plants that are relatively sensitive to drought hold more calcium ion,while the drought-resistance plants hold more calcium oxalate.Thus,the plant calcium components are in close relation to plant drought-resistance,and of important significance in plant physiology of the desert.HuaCong Ci XingDong lie Rong Li Wei Wu PingPing Xue YuBao Gao HaLin Zhao 2010Research in Cold and Arid Regions2010,2,2:3
5Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants显示文摘So far,how to achieve the optimal regenerative repair of large load-bearing bone defects using artificial bone grafts is a huge challenge in clinic.In this study,a strategy of combining osteoinductive biphasic calcium phosphate(BCP)bioceramic scaffolds with intramedullary nail fixation for creating stable osteogenic microenvironment was applied to repair large segmental bone defects(3.0 cm in length)in goat femur model.The material characterization results showed that the BCP scaffold had the initial compressive strength of over 2.0 MPa,and total porosity of 84%.The cell culture experiments demonstrated that the scaffold had the excellent ability to promote the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells(BMSCs).The in vivo results showed that the intramedullary nail fixation maintained the initial stability and structural integrity of the implants at early stage,promoting the osteogenic process both guided and induced by the BCP scaffolds.At 9 months postoperatively,good integration between the implants and host bone was observed,and a large amount of newborn bones formed,accompanying with the degradation of the material.At 18 months postoperatively,almost the complete new bone substitution in the defect area was achieved.The maximum bending strength of the repaired bone defects reached to the 100% of normal femur at 18 months post-surgery.Our results demonstrated the good potential of osteoinductive BCP bioceramics in the regenerative repair of large load-bearing bone defects.The current study could provide an effective method to treat the clinical large segmental bone defects.Wei Zhi Xiaohua Wang Dong Sun Taijun Chen Bo Yuan Xiangfeng Li Xuening Chen Jianxin Wang Zhao Xie Xiangdong Zhu Kai Zhang Xingdong Zhang 2022Bioactive Materials2022,7,5:3
6Denoising method of X-ray phase contrast DR image for TRISO-coated fuel particles显示文摘TRISO(tristructural-isotropic) fuel is a type of micro fuel particles used in high-temperature gas-cooled reactors(HTGRs).Among the quality evaluation methods for such particles,in-line phase contrast imaging technique(PCI) is more feasible for nondestructive measurement.Due to imaging hardware limitations,high noise level is a distinct feature of PCI images,and as a result,the dimensional measurement accuracy of TRISO-coated fuel particles decreases.Therefore,we propose an improved denoising hybrid model named as NL P-M model which introduces non-local theory and retains the merits of the Perona-Malik(P-M) model.The improved model is applied to numerical simulation and practical PCI images.Quantitative analysis proves that this new anisotropic diffusion model can preserve edge or texture information effectively,while ruling out noise and distinctly decreasing staircasing artifacts.Especially during the process of coating layer thickness measurement,the NL P-M model makes it easy to obtain continuous contours without noisy points or fake contour segments,thus enhancing the measurement accuracy.To address calculation complexity,a graphic processing unit(GPU) is adopted to realize the acceleration of the NL P-M denoising.Min Yang Jianhai Zhang Fanyong Meng Sung-Jin Song Xingdong Li Wenli Liu Dongbo Wei 2013Particuology2013,11,6:2
7Effects of soil stoichiometry of the CaCO_3/available phosphorus ratio on plant density in Artemisia ordosica communities显示文摘In soil, CaCO3 can reduce the availability of phosphorus in arid and semi-arid regions, thereby influencing plant growth. However, the effects of soil stoichiometry of the CaCO3/available phosphorus ratio (CaCO3/AP ratio) on plant density are unknown. In this study, we examined 4 Artemisia ordosica communities located in arid and semi-arid regions, and performed a pot experiment with an orthogonal design to examine the relationships between the soil CaCO3/AP ratio and plant density. The results showed that the soil stoichiometry of the CaCO3/AP ratio had a greater effect on growth of A. ordosica than either CaCO3 or AP as single factor. The influence of the soil CaCO3/AP ratio on density of A. ordosica was related to the climatic zone and the types and/or amplitudes of increases in the soil CaCO3/AP ratio. When the soil CaCO3/AP ratio was within the same amplitude and was less than 2.5, the A. ordosica density increased in the semi-arid region, whereas the density decreased with increasing soil CaCO3/AP ratios in the arid region. In the semi-arid region, when the soil CaCO3/AP ratio was within the same amplitude and the increase in the soil CaCO3 content was greater than the increase in soil AP, the A. ordosica density increased with increasing soil CaCO3/AP ratios. This means that the relationship between the soil CaCO3/AP ratio and the A. ordosica density remained the same. In the arid region, an increase in the soil CaCO3/AP ratio as a result of increased soil CaCO3 content and decreased soil AP resulted in increased density of A. ordosica. Therefore, the relationship between soil CaCO3/AP ratios and density of A. ordosica was altered by these changes in soil chemistry. Thus, the soil stoichiometry of the CaCO3/AP ratio is an important factor affecting the density of A. ordosica in arid and semi-arid regions.ZHAO XueLai HE XingDong XUE PingPing ZHANG Ning WU Wei LI Rong CI HuaCong XU JingJing GAO YuBao ZHAO HaLin 2012Chinese Science Bulletin2012,57,5:2
8Wet-spinning fabrication of shear-patterned alginate hydrogel microfibers and the guidance of cell alignment显示文摘Native tissue is naturally comprised of highly-ordered cell-matrix assemblies in a multi-hierarchical way,and the nano/submicron alignment of fibrous matrix is found to be significant in supporting cellular functionalization.In this study,a self-designed wet-spinning device appended with a rotary receiving pool was used to continuously produce shear-patterned hydrogel microfibers with aligned submicron topography.The process that the flow-induced shear force reshapes the surface of hydrogel fiber into aligned submicron topography was systematically analysed.Afterwards,the effect of fiber topography on cellular longitudinal spread and elongation was investigated by culturing rat neuron-like PC12 cells and human osteosarcoma MG63 cells with the spun hydrogel microfibers,respectively.The results suggested that the stronger shear flow force would lead to more distinct aligned submicron topography on fiber surface,which could induce cell orientation along with fiber axis and therefore form the cell-matrix dual-alignment.Finally,a multi-hierarchical tissue-like structure constructed by dual-oriented cell-matrix assemblies was fabricated based on this wet-spinning method.This work is believed to be a potentially novel biofabrication scheme for bottom-up constructing of engineered linear tissue,such as nerve bundle,cortical bone,muscle and hepatic cord.You Yang Jing Sun Xiaolu Liu Zhenzhen Guo Yunhu He Dan Wei Meiling Zhong Likun Guo Hongsong Fan Xingdong Zhang 2017Regenerative Biomaterials2017,4,5:2
9Electron beam irradiation modification of collagen membrane显示文摘Bo Jiang Zhihong Wu Huichuan Zhao Fangyuan Tang Jian Lu Qingrong Wei Xingdong Zhang 2005Biomaterials2005,,:1
10A Novel MEMS Electromagnetic Actuator with Large Displacement 显示文摘Lv Xingdong Wei Weiwei Mao Xu 2015Sensors and Actuators A: Physical2015,221,:1
11A Novel MEMS Actuator with Large Lateral Stroke Driven by Lorentz Force 显示文摘Lv Xingdong Wei Weiwei Mao Xu 2015Journal of Micromeehanics and Mi- croengineering2015,25,25:1
12Effects of soil nitrate:ammonium ratio on plant carbon:nitrogen ratio and growth rate of Artemisia sphaerocephala seedlings显示文摘Can soil nitrate: ammonium ratios influence plant carbon: nitrogen ratios of the early succession plant? Can plant carbon: nitrogen ratios limit the plant growth in early succession? To address these two questions, we performed a two-factor (soil nitrate: ammonium ratio and plant density) randomized block design and a uniform-precision rotatable central composite design pot experiments to examine the relationships between soil nitrate: ammonium ratios, the carbon: nitrogen ratios and growth rate of Artemisia sphaerocephala seedlings. Under adequate nutrient status, both soil nitrate: ammonium ratios and plant density influenced the carbon: nitrogen ratios and growth rate of A. sphaerocephala seedlings. Under the lower soil nitrate: ammonium ratios, with the increase of soil nitrate: ammonium ratios, the growth rates of plant height and shoot biomass of A. sphaerocephala seedlings decreased significantly; with the increase of plant carbon: nitrogen ratios, the growth rates of shoot biomass of A. sphaerocephala seedlings decreased significantly. Soil nitrate: ammonium ratios affected the carbon: nitrogen ratios of A. sphaerocephala seedlings by plant nitrogen but not by plant carbon. Thus, soil nitrate: ammonium ratios influenced the carbon: nitrogen ratios of A. sphaerocephala seedlings, and hence influenced its growth rates. Our results suggest that under adequate nutrient environment, soil nitrate: ammonium ratios can be a limiting factor for the growth of the early succession plant.Rong Li XingDong He PingPing Xue HuaCong Ci Wei Wu YuBao Gao HaLin Zhao 2010Research in Cold and Arid Regions2010,2,5:1
13Effects of soil nitrogen:phosphorus ratio on growth rate of Artemisia ordosica seedlings显示文摘To address how the ratios of nitrogen and phosphorus (N:P ratios) in soil affect plant growth, we performed a two-factor (soil available N:P ratios and plant density) randomized block pot experiment to examine the relationships between soil N:P ratios, and the N:P ratios and growth rate of Artemisia ordosica seedlings. Under moderate water stress and adequate nutrient status, both soil N:P and plant density influenced the N:P ratios and growth rates of A. ordosica. With the increase of soil N:P ratios, the growth rates of A. ordosica seedlings decreased significantly. With the increase of soil N:P ratios, N:P ratios in A. ordosica seedlings increased significantly. While the nitrogen concentrations in the plant increased slightly, the phosphorus concentrations significantly decreased. With the increase of plant density, the shoot N:P ratios and growth rates significantly decreased, which resulted from soil N:P ratios. Thus, soil N:P ratios influenced the N:P ratios in A. ordosica seedlings, and hence, influenced its growth. Our results suggest that, under adequate nutrient environment, soil N:P ratios can be a limiting factor for plant growth.Wei Wu XingDong He HuaCong Ci Rong Li PingPing Xue YuBao Gao HaLin Zhao 2010Research in Cold and Arid Regions2010,2,4:1
14Synergy of in-situ heterogeneous interphases tailored lithium deposition显示文摘The implementation of a robust artificial solid electrolyte interphase(ASEI)to replace the unstable natural SEI can regulate lithium deposition behaviors and avoid the safety hazards caused by dendrites permeation in lithium metal batteries.Despite of devoted efforts in tailoring components of ASEI,the intrinsic mechanism of interfacial synergy within the heterogeneous interphases has not been well elucidated yet.Herein,we show that the lithium plating/striping behaviors can be substantially enhanced(over 900 h with an overpotential of less than 20 mV at 1 mA·cm^(−2)in Li|Li symmetric cells and 146 cycles in anode-free cells)by regulating the heterogeneous interphases.This favorable ASEI composed of LiF and Li_(3)N components can be in-situ generated during cycling by large-scale fabricated fluorinated boron nitride coatings.Further,the synergy of each heterogeneous component within ASEI was explored theoretically and experimentally.Li_(3)N has high adsorption energy and low ion diffusion barrier,which facilitates the transport of lithium ions and avoids its local accumulation to evolve into dendrites.Both the substrate and LiF are interfacially stable with high electron tunneling barriers,preventing the electrolyte decomposition and parasitic reactions.Finally,the high stiffness of the boron nitride also ensures lithium dendrites are suppressed once they grow,providing a stable environment for long-term cycling of lithium metal batteries.Yinuo Li Anjun Hu Xingdong Gan Miao He Jun Zhu Wei Chen Yin Hu Tianyu Lei Fei Li Yaoyao Li Yuxin Fan Fan Wang Mingjie Zhou An Wen Baihai Li 2023Nano Research2023,16,6:0
15Review of insulin-like growth factor 1 signaling pathway and its role in protection against brain diseases显示文摘Insulin-like growth factor 1(IGF-1) is a pluripotent growth factor,with multiple functions in the peripheral and central nervous systems. Increasing evidence suggests that IGF-1 fine-tunes the development of the central nervous system,ensuring proper neuronal differentiation,maturation,and connectivity. It supports neuronal survival and axon growth,and acts on myelinating Schwann cells and oligodendroglia. The biological functions of IGF-1 are modulated by the IGF-1 signaling pathway. Recent studies have proposed the modulation of the members of the IGF-1/IGF-1 signaling pathway as treatment for neuropathologies. In this study,we introduce the structure of IGF-1/2 and its receptors,with the intra-cellular interactions. Further,we review the therapeutic effects of IGF-1 in different models of brain diseases,via activation of different cellular mechanisms.Min Wei Lun Dong Hengzhu Zhang Zhenfei Teng Xiaodong Wang Zhengcun Yan Lei She Yuping Li Xingdong Wang 2017Translational Neuroscience and Clinics2017,3,4:0
16Regulatory perspectives of combination products显示文摘Combination products with a wide range of clinical applications represent a unique class of medical products that are composed of more than a singular medical device or drug/biological product.The product research and development,clinical translation as well as regulatory evaluation of combination products are complex and challenging.This review firstly introduced the origin,definition and designation of combination products.Key areas of systematic regulatory review on the safety and efficacy of device-led/supervised combination products were then presented.Preclinical and clinical evaluation of combination products was discussed.Lastly,the research prospect of regulatory science for combination products was described.New tools of computational modeling and simulation,novel technologies such as artificial intelligence,needs of developing new standards,evidence-based research methods,new approaches including the designation of innovative or breakthrough medical products have been developed and could be used to assess the safety,efficacy,quality and performance of combination products.Taken together,the fast development of combination products with great potentials in healthcare provides new opportunities for the advancement of regulatory review as well as regulatory science.Jiaxin Tian Xu Song Yongqing Wang Maobo Cheng Shuang Lu Wei Xu Guobiao Gao Lei Sun Zhonglan Tang Minghui Wang Xingdong Zhang 2022Bioactive Materials2022,7,4:0
17Anti-melanoma effect and action mechanism of a novel chitosan-based composite hydrogel containing hydroxyapatite nanoparticles显示文摘Hydroxyapatite nanoparticles(HANPs)have been increasingly regarded and reported due to their potential anti-tumor ability.Previously,we found that the rod-like HANPs had good application potential for cutaneous melanoma(CMM).To satisfy the actual requirements in repairing post-operative skin defects and inhibiting CMM recurrence after tumorectomy,we constructed a novel chitosan/alginate(CS/Alg)hydrogel containing the aforementioned HANPs.The in vitro cell experiments confirmed that activated mitochondrial-dependent apoptosis was tightly related to the anti-tumor ability of HANPs.Specifically,we further discovered several target proteins might be involved in abnormal activating Wnt,proteoglycans in cancer,oxidative phosphorylation and p53 signaling pathways.The in vivo animal experiments demonstrated that the HANPsloaded CS/Alg hydrogel(CS/Alg/HANPs)had a similar effect on inhibiting tumor growth as HANPs,and CS/Alg hydrogel as well as phosphate buffered saline(PBS)group(control)not showed any effect,proving the key role of HANPs.The immunohistochemical staining demonstrated a tumor inhibition via the mitochondria-mediated apoptosis pathway,consistent with the in vitro evaluation.Moreover,CS/Alg/HANPs exhibited no additional biosafety risk to the functions of major organs.Overall,this CS/Alg/HANPs hydrogel has substantial application potential for treating CMM.Kejia Xu Yifu Wang Yao Xie Xiaoyan Zhang Wei Chen Zhongtao Li Tingting Wang Xiao Yang Bo Guo Lin Wang Xiangdong Zhu Xingdong Zhang 2022Regenerative Biomaterials2022,9,1:0
18Waste-Derived Catalysts for Water Electrolysis:Circular Economy-Driven Sustainable Green Hydrogen Energy显示文摘The sustainable production of green hydrogen via water electrolysis necessitates cost-effective electrocatalysts.By following the circular economy principle,the utilization of waste-derived catalysts significantly promotes the sustainable development of green hydrogen energy.Currently,diverse waste-derived catalysts have exhibited excellent catalytic performance toward hydrogen evolution reaction(HER),oxygen evolution reaction(OER),and overall water electrolysis(OWE).Herein,we systematically examine recent achievements in waste-derived electrocatalysts for water electrolysis.The general principles of water electrolysis and design principles of efficient electrocatalysts are discussed,followed by the illustration of current strategies for transforming wastes into electrocatalysts.Then,applications of waste-derived catalysts(i.e.,carbon-based catalysts,transitional metal-based catalysts,and carbon-based heterostructure catalysts)in HER,OER,and OWE are reviewed successively.An emphasis is put on correlating the catalysts’structure-performance relationship.Also,challenges and research directions in this booming field are finally highlighted.This review would provide useful insights into the design,synthesis,and applications of waste-derived electrocatalysts,and thus accelerate the development of the circular economy-driven green hydrogen energy scheme.Zhijie Chen Sining Yun Lan Wu Jiaqi Zhang Xingdong Shi Wei Wei Yiwen Liu Renji Zheng Ning Han Bing-Jie Ni 2023Nano-Micro Letters2023,15,1:0
19Electrochemical converting ethanol to hydrogen and acetic acid for large scale green hydrogen production显示文摘Electrochemical coupling hydrogen evolution with biomass reforming reaction(named electrochemical hydrogen and chemical cogeneration(EHCC)),which realizes green hydrogen production and chemical upgrading simultaneously,is a promising method to build a carbon-neutral society.Herein,we analyze the EHCC process by considering the market assessment.The ethanol to acetic acid and hydrogen approach is the most feasible for large-scale hydrogen production.We develop AuCu nanocatalysts,which can selectively oxidize ethanol to acetic acid(>97%)with high long-term activity.The isotopic and in-situ infrared experiments reveal that the promoted water dissociation step by alloying contributes to the enhanced activity of the partial oxidation reaction path.A flow-cell electrolyzer equipped with the AuCu anodic catalyst achieves the steady production of hydrogen and acetic acid simultaneously in both high selectivity(>90%),demonstrating the potential scalable application for green hydrogen production with low energy consumption and high profitability.Yufeng Zhang Wei Zhu Jinjie Fang Zhiyuan Xu Yanrong Xue Jiajing Pei Rui Sui Xingdong Wang Xuejiang Zhang Zhongbin Zhuang 2024Nano Research2024,17,3:0
20Application of osteoinductive calcium phosphate ceramics in children’s endoscopic neurosurgery:report of five cases显示文摘This work aimed at investigating the possibility and effectiveness of osteoinductive calcium phosphate(CaP)ceramics to close the drilled skull holes and prevent the postoperative cerebrospinal fluid(CSF)leaking in children’s endoscopic neurosurgery.Five children patients(four boys and one girl,3-to 8-years old)underwent the surgery,in which the endoscopic third ventriculostomy(ETV)was operated in four cases of hydrocephalus,and biopsy and ETV were both performed in one case of pineal tumor.The drilled skull holes were filled with the commercial osteoinductive CaP ceramics.The patients were followed up by CT scan at 1,7 days,3 and 6 months postoperatively.All the five cases were successful,and the holes were closed well after filled with the ceramics.The follow-up survey showed that no CSF leaking or rejection reaction was found.The CT scan indicated that the drilled holes began healing at 7 days postoperatively,and a relatively complete healing happened at 6 months postoperatively.The excellent ability of the CaP ceramics to induce bone regeneration was also confirmed by repairing the skull defects in a monkey model.The results of μ-CT and histological analysis showed that a bony structure with irregular array occurred at the defect area,and the newly formed bone volume density reached 65.7%.In conclusion,the osteoinductive CaP ceramics could be an ideal material to treat the drilled skull holes in children’s endoscopic neurosurgery and prevent CSF leaking afterwards.However,further investigation with more cases and longer follow-up was required to evaluate the clinical effect.Jia Wei Hufei Qian Yu Liu Jiangang Liu Rui Zhao Xiao Yang Xiangdong Zhu Ruoping Chen Xingdong Zhang 2018Regenerative Biomaterials2018,5,4:0
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