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| 1 | 低剂量三联疗法根除幽门螺杆菌的多中心临床研究显示文摘本研究对根除幽门螺杆菌(Hp)的三联疗法进行改良,减少其中阿莫西林及甲硝唑的剂量,对Hp阳性的173例慢性胃炎患者及267例十二指肠溃疡患者进行Hp根除治疗。用药方法为胶体次枸橼酸铋(德诺,CBS)120mg,阿莫西林250mg,及甲硝唑200mg同服,每日4次,连服14天,Hp根除率为86.8%。此外,对49例慢性胃炎及107例十二指肠溃疡Hp阳性者减少服药次数,采用每日2次给药,连服14天,Hp根除率89.1%。研究证明,低剂量三联疗法Hp根除率高,不良反应少,有较好的依从性。每日2次服药与每日4次服药临床疗效相似,Hp根除率差异无显著性(P>0.05)。 | Liu Xinguang,Jia Boqi.Department of Gastroenterology, FirstTeaching Hospital, Beijing Medical University, Beijing l00034 | 1996 | 中华消化杂志1996，16，4： | 36 |
| 2 | 知识、态度、社会规范对青少年新型毒品使用的影响研究显示文摘目的研究知识、态度和社会规范与青少年新型毒品使用之间的关系并构建影响模式。方法采用分层随机整群抽样的方法进行抽样。来自武汉市初中、高中、职业高中和大学的共3018名学生参加了问卷调查,调查是无记名和自愿的。采用确证性因子分析构建测量模型,采用结构方法模型进行评价、修正以确定最佳模型。结果武汉市青少年新型毒品的滥用率为3.28%,其中男女生分别为4.81%和1.94%,普通初中、高中、职业高中和大学生的毒品滥用率分别为1.80%、2.91%、7.83%和3.25%。模型拟和效果较好。模型结果显示:知识、态度、社会规范影响青少年使用新型毒品,其中态度、社会规范直接影响青少年吸毒或吸毒倾向,而知识通过态度、社会规范的中介作用发挥效应。结论对新型毒品的了解不足、对待毒品的态度不正确以及吸毒社会规范不强增加青少年使用新型毒品的风险。 | 龚洁 曾晶 Xinguang Chen 李芳 周敦金 王增珍 | 2007 | 中华流行病学杂志2007，28，10： | 18 |
| 3 | 吸毒社会规范及吸毒倾向对青少年药物滥用的影响显示文摘目的研究青少年吸毒社会规范、吸毒倾向与药物滥用的关系,为预防青少年吸毒提供指导。方法采用分层随机整群抽样方法,抽取武汉市初中、高中、职业高中和大学学生共3018名进行问卷调查,调查是无记名和自愿的。采用多因素Logistic回归分析模型进行分析。结果武汉市青少年药物滥用率为3.58%,其中男、女生分别为5.37%和2.0%。控制性别、学校类型和年龄的影响,Logistic回归分析结果显示,吸毒社会规范、吸毒倾向与青少年吸毒有很强的联系,OR值分别为1.723和14.608。结论吸毒社会规范、吸毒倾向可能增加青少年吸毒的风险,提示在青少年吸毒预防中,应提高他们对毒品的认识,帮助他们树立良好的社会规范,降低吸毒倾向。 | 龚洁 曾晶 Xinguang Chen 李芳 周敦金 王增珍 | 2008 | 中国学校卫生2008，29，1： | 17 |
| 4 | Double role of Fas ligand in the apoptosis of intervertebral disc cells in vitro显示文摘船边交货 ligand (FasL ) 可以在维持 intervertebral 圆盘(IVD ) 的有免疫力的特权起一个重要作用。而且,它是仔细与退化圆盘房间的 apoptosis 有关。现在,大量报告关于 FasL 的矛盾的效果描述了,尽管 IVD 房间上的 FasL 的效果仍然在争论下面。在这研究,我们试着在船边交货表示上并且在原子核 pulposus (NP ) 的 apoptosis 上调查 FasL 的效果在 SpragueDawley 老鼠的房间。结果证明在 NP 房间的船边交货的表示被 recombinant FasL 显著地增加。同时, NP 房间的 apoptosis 以一种 FasL 剂量依赖者方式显著地增加了。有趣地, RNA 干扰结果显示船边交货表示和以前描述的 NP 房间 apoptosis 的增加被船边交货 siRNA 禁止,建议 RNA 干扰可能是阻止 IVD 房间 apoptosis 的新奇策略之一。 | Dunfu Han Yue Ding Shang-Li Liu Gang Wang In-Cheong Si Xinguang Wang Liyang Cui Dongshang Huang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，11： | 14 |
| 5 | Anomaly Detection of User Behavior Based on Shell Commands and Homogeneous Markov Chains显示文摘 | TIAN Xinguang DUAN Miyi LI Wenfa SUN Chunlai | 2008 | Chinese Journal of Electronics2008，17，2： | 12 |
| 6 | 武汉市青少年应激性生活事件和吸烟行为的关系显示文摘目的 :了解武汉市青少年应激性生活事件及其与吸烟的关系。方法 :采用匿名的方式 ,在武汉市 11个区随机抽取 2 2所中学初一至初三的学生 6994名 ,进行问卷调查。应激性生活事件的测量采取记数的方式 ,分别统计家庭、学校和小伙伴三个方面的正性和负性生活事件数 ,作为生活事件得分 ;吸烟的测量采用 4个变量 ,即尝试吸烟 ,30天吸烟 ,7天吸烟和是否吸 10 0支烟 (吸烟习惯 )。采取单因素 χ2 检验和多因素Logistic回归模型进行分析。结果 :武汉市青少年吸烟主要与家庭和学校方面的负性生活事件正相关 ,而与学校方面的正性生活事件呈负相关。结论 :应激性生活事件与青少年吸烟有关 ,提示我们应大力提高青少年应对生活事件的能力 ,预防和减少青少年吸烟。 | 李燕 Jennifer Unger 龚洁武汉市卫生防疫站 Xinguang Chen Chihping Chou C.Anderson Johnson | 2003 | 中国心理卫生杂志2003，17，2： | 11 |
| 7 | Early prediction of pathological outcomes to neoadjuvant chemotherapy in breast cancer patients using automated breast ultrasound显示文摘Objective: Early assessment of response to neoadjuvant chemotherapy(NAC) for breast cancer allows therapy to be individualized.The optimal assessment method has not been established.We investigated the accuracy of automated breast ultrasound(ABUS) to predict pathological outcomes after NAC.Methods: A total of 290 breast cancer patients were eligible for this study.Tumor response after 2 cycles of chemotherapy was assessed using the product change of two largest perpendicular diameters(PC) or the longest diameter change(LDC).PC and LDC were analyzed on the axial and the coronal planes respectively.Receiver operating characteristic(ROC) curves were used to evaluate overall performance of the prediction methods.Youden's indexes were calculated to select the optimal cut-off value for each method.Sensitivity, specificity,positive and negative predictive values(PPV and NPV) and the area under the ROC curve(AUC) were calculated accordingly.Results: yp T0/is was achieved in 42 patients(14.5%) while yp T0 was achieved in 30 patients(10.3%) after NAC.All four prediction methods(PC on axial planes, LDC on axial planes, PC on coronal planes and LDC on coronal planes) displayed high AUCs(all>0.82), with the highest of 0.89 [95% confidence interval(95% CI), 0.83–0.95]when mid-treatment ABUS was used to predict final pathological complete remission(p CR).High sensitivities(85.7%–88.1%) were observed across all four prediction methods while high specificities(81.5%–85.1%) were observed in two methods used PC.The optimal cut-off values defined by our data replicate the WHO and the RECIST criteria.Lower AUCs were observed when mid-treatment ABUS was used to predict poor pathological outcomes.Conclusions: ABUS is a useful tool in early evaluation of p CR after NAC while less reliable when predicting poor pathological outcomes. | Xinguang Wang Ling Huo Yingjian He Zhaoqing Fan Tianfeng Wang Yuntao Xie Jinfeng Li Tao Ouyang | 2016 | Chinese Journal of Cancer Research2016，28，5： | 11 |
| 8 | Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset显示文摘Objective Intravenous tissue plasminogen activator(tPA)is the standard therapy for patients with acute ischaemic stroke(AIS)within 4.5 hours of onset.Recent trials have expanded the endovascular treatment window to 24 hours.We investigated the efficacy and safety of using multimodal MRI to guide intravenous tPA treatment for patients with AIS of unknown time of onset(UTO).Methods Data on patients with AIS with UTO and within 4.5 hours of onset were reviewed.Data elements collected and analysed included:demographics,National Institutes of Health Stroke Scale(NIHSS)score at baseline and 2 hours,24 hours,7 days after thrombolysis and before discharge,the modified Rankin Scale(mRS)score at 3 months after discharge,imaging findings and any adverse event.results Forty-two patients with UTO and 62 in control group treated within 4.5 hours of onset were treated with intravenous tPA.The NIHSS scores after thrombolysis and/or before discharge in UTO group were significantly improved compared with the baseline(p<0.05).Between the two groups,no significant differences in NIHSS score were observed(p>0.05).Utilising the non-inferiority test,to compare mRS scores(0-2)at 3 months between the two groups,the difference was 5.2%(92%CI,OR 0.196).Patients in the UTO group had mRS scores of 0-2,which were non-inferior to the control group.Their incidence of adverse events was similar.Conclusions Utilising multimodal MRI to guide intravenous only thrombolysis for patients with AIS with UTO was safe and effective.In those patients with AIS between 6 and 24 hours of time of onset but without large arterial occlusion,intravenous thrombolysis could be considered an option. | Jie Zhao Hongmei Zhao Runtao Li Jiangtao Li Chang Liu Juan Lv Yanan Li Wei Liu Dongpu Ma Huaihai Hao Xinguang Xiao Junzhong Liu Yongfeng Yin Rongli Liu Qiaoyan Yu Yingjie Wei Pengyan Li Yue Wang Runqing Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 8 |
| 9 | Intrusion detection based on system calls and homogeneous Markov chains显示文摘A novel method for detecting anomalous program behavior is presented, which is applicable to host-based intrusion detection systems that monitor system call activities. The method constructs a homogeneous Markov chain model to characterize the normal behavior of a privileged program, and associates the states of the Markov chain with the unique system calls in the training data. At the detection stage, the probabilities that the Markov chain model supports the system call sequences generated by the program are computed. A low probability indicates an anomalous sequence that may result from intrusive activities. Then a decision rule based on the number of anomalous sequences in a locality frame is adopted to classify the program's behavior. The method gives attention to both computational effciency and detection accuracy, and is especially suitable for on-line detection. It has been applied to practical host-based intrusion detection systems. | Tian Xinguang Duan Miyi Sun Chunlai Li Wenfa | 2008 | Journal of Systems Engineering and Electronics2008，19，3： | 8 |
| 10 | Evaluation of groundwater quality in the Xinjiang Plain Area显示文摘Groundwater is the main source of drinking water for the urban and rural residents in the plain area of the Xinjiang Uygur Autonomous Region,China.The quality of groundwater has a direct relationship with human health.Thus,386 groundwater samples collected from April to August in 2003 were analyzed.The samples were collected in basic evaluation units which are determined on the basis of watersheds.Total dissolved solids,total hardness,pH value,NH3–N,C6H5OH,Chemiluminescence detection of permanganate index(CODMn)and intestinal germ group were evaluated according to the guidelines of Groundwater Quality Standard(GB/T14848-93).The quality of the groundwater in each evaluation unit was classified by using the One Veto Method(a unified approach stipulated by the Ministry of Water Resources).The results indicate that the groundwater in the mainstream area of the Tarim Basin and the Yerqiang River Sub-basin belongs to Category V;the groundwater in the Wulungu River Sub-basin,the KaiduKongque River Sub-basin,the Kashgar River Sub-basin,the Cherchen River Sub-basin and the Hotan River Subbasin belongs to Category IV;the groundwater in the Aibi Lake System belongs to Category II,and the groundwater of other evaluation units belongs to Category III.The causes of water quality formation were concisely analyzed.The results can be useful for the evaluation and management of water resources in the Xinjiang Plain Area. | Jinlong ZHOU Xinguang DONG Guomin LI Yiping WANG Xiaojing GUO | 2010 | Frontiers of Environmental Science & Engineering2010，4，2： | 8 |
| 11 | 35 W continuous-wave Ho:YAG single-crystal fiber laser显示文摘We report on a high-power Ho:YAG single-crystal fiber(SCF)laser inband pumped by a high-brightness Tm-fiber laser at 1908 nm.The Ho:YAG SCF grown by the micro-pulling-down technique exhibits a propagation loss of 0.05±0.005 cm^-1 at 2.09μm.A continuous-wave output power of 35.2 W is achieved with a slope efficiency of 42.7%,which is to the best of our knowledge the highest power ever reported from an SCF-based laser in the 2µm spectral range. | Yongguang Zhao Li Wang Weidong Chen Jianlei Wang Qingsong Song Xiaodong Xu Ying Liu Deyuan Shen Jun Xu Xavier Mateos Pavel Loiko Zhengping Wang Xinguang Xu Uwe Griebner Valentin Petrov | 2020 | High Power Laser Science and Engineering2020，8，2： | 7 |
| 12 | Different Dosages of Intravitreal Triamcinolone Acetonide Injections for Macular Edema Secondary to Central Retinal Vein Occlusion显示文摘Purpose:.To study the effect of intravitreal injections of triamcinolone acetonide (TA) for the treatment of macular edema secondary to central retinal vein occlusion.(CRVO).in a sample of Chinese patients from Shaanxi province. Methods:.The 50 eyes from 50 patients were separated into three TA treatment groups:.17 patients were given 4 mg/0.1 ml,.19 patients were given 8 mg/0.2 ml,.and 14 patients were given 16 mg/0.4 ml. Patients were followed up for 12 months. Foveal thickness, intraocular pressure (IOP), and best-corrected visual acuity (BCVA) were measured. Results:.Macular edema responded well both anatomically and functionally to the TA injections. After the initial intravitreal injection,.macular edema recurred at 2-4 months in the low-dose group.(4 mg),.at 3-5 months in the medium-dose group (8 mg), and at 6-9 months in the high-dose group (16 mg)..No significant difference in BCVA or in foveal thickness were observed between the first intravitreal injection and the re-injection. There was no increase in IOP after re-injection of 16 mg TA,.if the patient did not have an elevated IOP after the initial intravitreal injection of 4/8 mg TA. Conclusion: A low dosage of TA (4 mg) administered via intravitreal injection might be useful as an initial treatment for macular edema secondary to CRVO..A higher dosage of TA (16mg) can be used if there is no IOP elevation with the initial TA injection. | Yong Wei Huaizhou Wang Fenghua Chen Zhongqiao Zu Chuncao Bi Xinguang Yang | 2012 | Eye Science2012，27，3： | 6 |
| 13 | The next generation models for crops and agro-ecosystems显示文摘Growth in population, decrease in arable land area, and change in climate are endangering our food security. Precision agriculture has the potential to increase crop productivity thorough tailored agricultural practices for different growing areas. Many models of crops and agro-ecosystems capable of predicting interaction between plants and environments have been developed for precision agriculture. Currently, there are several representative categories of crop and agro-ecosystem models, including the de Wit school models, the DSSAT series models and the APSIM series models, which have contributed substantially to improvement of agricultural practices. However, these models are weak in predicting performances of crops under environmental and genetic perturbations are generally weak, which severely limits the application of these models in guiding precision agriculture. We need to develop the next generation crop and agro-ecosystems models with a high level of mechanistic basis, which can be integrated with high throughput data and can predict the heterogeneity of environmental factors inside canopy and dynamic canopy photosynthesis. In developing such a model close collaboration is inevitably required among scientists from different disciplines. The successful development and application of such models will undoubtedly advance precision agriculture through providing better agronomical practices tailored for different growing environments. These models will also form a basis to identify breeding targets for increased productivity at given location with given soil and climatic conditions. | ZHU XinGuang ZHANG GuiLian THOLEN Danny WANG Yu XIN ChangPeng SONG QingFeng | 2011 | Science China(Information Sciences)2011，54，3： | 6 |
| 14 | National guidelines for diagnosis and treatment of breast cancer 2022 in China(English version)显示文摘Contents 1. Breast cancer screening 1.1 Recommendations for females at normal risk 1.1.1 Age 20-39 years old 1.1.2 Age 40-69 years old 1.1.3 Age≥70 years old 1.2 Recommendations for females at increased risk 2. Diagnosis of breast cancer 2.1 Clinical manifestations 2.1.1 Breast lump 2.1.2 Nipple discharge 2.1.3 Skin changes 2.1.4 Abnormalities in nipple and areola 2.1.5 Enlarged axillary lymph nodes。 | 无 Xinguang Wang Xue Chen Dongfeng Niu Yang Yang Jingyi Zhao | 2022 | Chinese Journal of Cancer Research2022，34，3： | 5 |
| 15 | Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma显示文摘In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed.Methodologies included HPLC–PDA, HPLC–VWD and UHPLC–MSn, combined with principal component analysis(PCA) and partial least squares regression techniques(PLSR). The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated in vitro. PLSR analysis revealed significant positive correlations(R2= 0.5795) between the contents of triterpenes 10, 14, 15, 18 and 22 and the inhibitory effects of Alismatis Rhizoma. The present study establishes an effective method for simultaneous determination of multiple components, and identifies key bioactive triterpenes. These results can be used for systematic and novel analytical strategies for the quality control of Alismatis Rhizoma production. | Xiaoxv Gao Chengpeng Sun Zhenglong Yu Jian Cang Xiangge Tian Xiaokui Huo Lei Feng Xinguang Liu Chao Wang Baojing Zhang Xiaochi Ma | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 4 |
| 16 | Association between plasma brain natriuretic peptide/N-terminal pro-brain natriuretic peptide levels and atrial fibrillation: evidence from a meta-analysis显示文摘 | Liu Yaowu Xiao Yunyun Chen Xinguang Zhang Fengxiang | 2014 | Chinese Medical Journal2014，，15： | 4 |
| 17 | The interaction and migration of deformation twin in an eutectic high-entropy alloy AlCoCrFeNi2.1显示文摘An eutectic high-entropy alloy consisting Al, Co, Cr, Fe and Ni elements was prepared by vacuum directional solidification technology. The alloy exhibits excellent comprehensive mechanical performance during tension at temperature range of 600–700℃. The microstructure reveals the intersection of twintwin is the prevailing deformation mechanism and the twins play a dual role in strengthening and toughening the alloy in the thermomechanical process. The deformation twin variants I and were formed by the edge dislocation 112 and the mixed dislocation 211 on the {111} crystal planes, respectively. Besides, the dislocation jogs and kinks caused by twin intersection on the slip planes can strengthen the alloy, which may contribute to the high strength(the tensile strengths at the 600°and 700°tensile tests are respectively780 MPa and 630 MPa.). Moreover, the coherent twin boundary migration has the function of coordinating deformation and contributes to the high ductility of the alloy. | Yaoli Zhang Jinguo Li Xinguang Wang Yiping Lu Yizhou Zhou Xiaofeng Sun | 2019 | Journal of Materials Science & Technology2019，35，5： | 4 |
| 18 | Effect of thermal exposure on the microstructure and creep properties of a fourth-generation Ni-based single crystal superalloy显示文摘The effect of thermal exposure on microstructure and creep properties of a fourth-generation nickelbased single crystal superalloy was investigated.The thermal exposure of samples after the full heat treatment was carried out at 1000℃,1100℃ and 1140℃ for 100 h and 200 h.The γ’ coarsening,γ’ rafting and γ channel widening were observed in samples after thermal exposure.When the thermal exposure time was constant,the morphology of γ’ phase in the alloy evolved significantly with increasing aging temperature.The interracial dislocation networks in aged samples after creep ruptured gradually became irregular and sparse with the increase of exposure temperature.When the higher exposure temperature was used,enla rgement of the defect pores was observed in samples,the microcracks were more likely to initiate and propagate at the corner of these pores.After aging at 1000℃ for 100 h,the creep life at 1140℃/137 MPa was slightly longer than that of heat-treated sample,which could be attributed to the slightly coarsened γ’ phase,homogenization of refractor elements.In contrast,the creep life of sample exposed at 1140℃ for 100 h was greatly decreased.The decrease of creep life was dominated by the rafting of γ’phase,the irregular interfacial dislocation networks as well as the enlargement of homogenization pores. | Yeshun Huang Xinguang Wang Chuanyong Cui Zihao Tan Jinguo Li Yanhong Yang Jinlai Liu Yizhou Zhou Xiaofeng Sun | 2021 | Journal of Materials Science & Technology2021，，10： | 4 |
| 19 | On the γ' precipitates of the normal and inverse Portevin-Le Chatelier effect in a wrought Ni-base superalloy显示文摘The Portevin-Le Chatelier(PLC) effects in a wrought Ni-base superalloy with different γ' precipitates contents have been investigated. Detailed analysis on the serration type of the tensile curves indicates that the γ' precipitates have a decisive influence on the transformation from normal to inverse PLC behavior, which is rarely proposed in other works. It is considered that the γ' precipitates play the same role in PLC effect as temperature and strain rate for the investigated wrought Ni-base superalloy. | Xinguang Wang Guoming Han Chuanyong Cui Shuai Guan Jinguo Li Guichen Hou Yizhou Zhou Xiaofeng Sun | 2019 | Journal of Materials Science & Technology2019，35，1： | 3 |
| 20 | Effect of pyrophosphate on the light scatter in KDP crystal显示文摘Pyrophosphate doped potassium dihydrogen phosphate (KDP) crystal was grown from aqueous solution by the temperature lowering method. Light scatter in KDP crystal was detected with the ultramicroscopic method. The light scatter in KDP crystal was aggravated when pyro-phosphate was doped into the growth solution, which was distributed ununiformly in prism and pyramidal sectors of KDP crystal. Different effects of pyrophosphate on prism and pyramidal sectors of KDP crystal can explain this case. The transmission in this crystal was measured, showing that pyrophosphate affects the transmission evidently. | Xun Sun Xinguang Xu Youjun Fu Shenglai Wang Hong Zeng Yiping Li Zhangshou Gao | 2001 | Chinese Science Bulletin2001，46，5： | 3 |
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