|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats显示文摘Aging is an inevitably spontaneous process of the creature.With the increase of age,physical function is degraded in the elderly.One of the most common degradation is memory loss and cognitive impairment in brain function.Neuron loss and neurofibrillary tangles formation contributes to brain dysfunction.Neuron loss is associated with neuronal cell apoptosis.Apoptosis is a process | Guoliang Fang Jiexiu Zhao Pengfei Li Liang Li Tao Yu Xingya Yang Zihong He Ye Tian | 2017 | Science Bulletin2017，62，11： | 7 |
| 3 | Real-variable characterizations of anisotropic product Musielak-Orlicz Hardy spaces显示文摘Let A :=(A_1, A_2) be a pair of expansive dilations and φ : R^n×R^m×[0, ∞) → [0, ∞) an anisotropic product Musielak-Orlicz function. In this article, we introduce the anisotropic product Musielak-Orlicz Hardy space H~φ_A(R^n× R^m) via the anisotropic Lusin-area function and establish its atomic characterization, the g-function characterization, the g_λ~*-function characterization and the discrete wavelet characterization via first giving out an anisotropic product Peetre inequality of Musielak-Orlicz type. Moreover, we prove that finite atomic decomposition norm on a dense subspace of H~φ_A(R^n× R^m) is equivalent to the standard infinite atomic decomposition norm. As an application, we show that, for a given admissible triplet(φ, q, s), if T is a sublinear operator and maps all(φ, q, s)-atoms into uniformly bounded elements of some quasi-Banach spaces B, then T uniquely extends to a bounded sublinear operator from H~φ_A(R^n× R^m) to B. Another application is that we obtain the boundedness of anisotropic product singular integral operators from H~φ_A(R^n× R^m) to L~φ(R^n× R^m)and from H~φ_A(R^n×R^m) to itself, whose kernels are adapted to the action of A. The results of this article essentially extend the existing results for weighted product Hardy spaces on R^n× R^m and are new even for classical product Orlicz-Hardy spaces. | FAN XingYa HE JianXun LI BaoDe YANG DaChun | 2017 | Science China Mathematics2017，60，11： | 5 |
| 4 | Structural charaeterization of iridoid glucosides by ultra-performance liquid chromatography/electrospray ionization quadrupole time-of flight randem mass spectrometry显示文摘 | Li CunMan Zhang XiuLi Xue XingYa | 2008 | Rapid Commun Mass Spectrom2008，22，12： | 1 |
| 5 | Structural Characterization of Iridoid Glucosides by Ultra-performance Liquid Chromatography/electrospray Ionization Quadrupole Time of Flight Tandem Mass Spectrometry显示文摘 | LI Cunman ZHANG Xiuli XUE Xingya | 2008 | Rapid Commun Mass Spectrom2008，22，12： | 1 |
| 6 | Analysis of Iridoid Glucosides in Hedyotis Diffusa by High-performance Liquid Chromatography/electrospray Ionization Tandem Mass Spectrometry显示文摘 | LI Cunman XUE Xingya ZHOU Dayong | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，48，： | 1 |
| 7 | Analysis of iridoid glucosides in Hedyotis diffusa by high-perform- ance liquidchromatography/electrospray ionization tan- dem mass spectrometry显示文摘 | Cunman Li Xingya Xue Dayong Zhou | 2008 | J Pharmaceut Biomed Anal2008，48，： | 1 |
| 8 | Identification of prenyl flavonoid glycosides and phenolic acids in Epimedium koreanum Nakai by Q-TOF-MS combined with selective enrichment on “click oligo (ethylene glycol)” column显示文摘 | Yaqin Wang Zhimou Guo Yu Jin Xiuli Zhang Li Wang Xingya Xue Xinmiao Liang | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员