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| 1 | Prognostic significance of combined fibrinogen concentration and neutrophil-to-lymphocyte ratio in patients with resectable non-small cell lung cancer显示文摘Objective:Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival.In this study,we investigated the significance of the combination of preoperative fibrinogen and the neutrophil-to-lymphocyte ratio(NLR)in predicting the survival of patients with non-small cell lung cancer(NSCLC).Methods:We retrospectively enrolled 589 patients with NSCLC who underwent surgery.The univariate and multivariate Cox survival analyses were used to evaluate the prognostic indicators,including the combination of fibrinogen and NLR(F-NLR).The cut-off values for fibrinogen,NLR,and clinical laboratory variables were defined by the receiver operating characteristic(ROC)curve analysis.According to the ROC curve,the recommended cut-off values for fibrinogen and the NLR were 3.48 g/L and 2.30,respectively.Patients with both a high NLR(≥2.30)and hyperfibrinogenemia(≥3.48 g/L)were given a score of 2,whereas those with one or neither were scored as 1 or 0,respectively.Results:Our results showed that F-NLR was an independent prognostic indicator for disease-free survival(DFS)[hazard ratio(HR),1.466;95%confidence interval(CI),1.243–1.730;P<0.001]and overall survival(OS)(HR,1.512;95%CI,1.283–1.783;P<0.001).The five-year OS rates were 66.1%,53.5%,and 33.3%for the F-NLR=0,F-NLR=1,and F-NLR=2,respectively(P<0.001).Correspondingly,their five-year DFS rates were 62.2%,50.3%,and 30.4%,respectively(P<0.001).In the subgroup analyses of the pathological stages,the F-NLR level was significantly correlated with DFS and OS in stage I and IIIA cancers.Conclusions:Preoperative F-NLR score can be used as a valuable prognostic marker for patients with resectable early-stage NSCLC. | Wuhao Huang Shengguang Wang Hua Zhang Bin Zhang Changli Wang | 2018 | Cancer Biology & Medicine2018，15，1： | 27 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | A modified PANS model for computations of unsteady turbulence cavitating flows显示文摘A modification to the PANS(partially averaged Navier-Stokes) model is proposed to simulate unsteady cavitating flows. In the model, the parameter fk is modified to vary as a function of the ratios between the water density and the mixture density in the local flows. The objective of this study is to validate the modified model and further understand the interaction between turbulence and cavitation around a Clark-Y hydrofoil. The comparisons between the numerical and experiment results show that the modified model can be improved to predict the cavity evolution, vortex shedding frequency and the lift force fluctuating in time fairly well, as it can effectively modulate the eddy viscosity in the cavitating region and various levels of physical turbulent fluctuations are resolved. In addition, from the computational results, it is proved that cavitation phenomenon physically influences the turbulent level, especially by the vortex shedding behaviors. Also, the mean u-velocity profiles demonstrate that the attached cavity thickness can alter the local turbulent shear layer. | HU ChangLi WANG GuoYu CHEN GuangHao HUANG Biao | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，10： | 12 |
| 4 | Enhanced Invasive and Metastatic Potential Induced by Transforming Growth Factor-β1 Might be Correlated with Glutathione-S-transferase-π, Cofilin and Heat Shock Protein 27 in SGC-7901 Gastric Cancer Cells显示文摘在我们的以前的学习,我们发现转变生长因素(TGF )-beta1 提高了胃的癌症房间的变形、侵略的潜力。Proteomics 在这研究被采用进一步说明内在的分子的机制。Aftertwo 维的电气泳动,图象分析,点鉴定,蛋白质鉴定和数据库分析,三蛋白质也就是, glutathione-S-transferase-pi (GST-pi ) , cofilin 和热震惊蛋白质 27 (HSP27 ) ,被发现在 TGF-beta1 起来调整对待的 SGC-7901 房间。Thefindings 被蛋白质印迹分析进一步证实。这些结果建议 GST-pi, cofilin 和 HSP27 可能参予 TGF-beta1 导致的提高的侵略潜力。 | Kuansong WANG Jinghe LI Changli ZHEN Jianhua ZHOU Desheng XIAO Jie LIU Ying LIU Haiying JIANG Chen CHEN Jifang WEN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 11 |
| 5 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 6 | Sponge-like nickel phosphide-carbon nanotube hybrid electrodes for efficient hydrogen evolution over a wide pH range显示文摘经由水的电解的划算的氢生产为氢进化反应要求有效、持久的地球丰富的催化剂(她的) 在一个宽 pH 范围上。此处,我们报导像海绵的镍磷化物碳 nanotube (Ni x P/CNT ) 被非结晶的 Ni x P 催化剂到 threedimensional (3D ) 上多孔的 CNT 支持。这些混合物在酸、中立、基本的媒介为持续的氢进化展出优异催化活动。特别地, Ni x P/CNT 电极产生 10 和 100 mAapy 的 cathodic 水流,但是总是 regressed onanticoagulation。传单限制和最大的厚度的功课在二个组之间是显著地不同的( P ? P ?=? 0.005 )并且传单限制分数由一中部 1 [ quartiles 0 ; 2 ]( P ?=? 0.013 ),而在 anticoagulation 组,在 2.57 的最大的厚度 regressed ?甘油的 n 作为副产品。最后的紧张生产了 9.8 ? l 33 ?%( 从 205 ~ 272 ? mg/L ) 。直角的策略 inte?? | Shuying Wang Li Zhang Xiao Li Changli Li Rujing Zhang Yingjiu Zhang Hongwei Zhu | 2017 | Nano Research2017，10，2： | 8 |
| 7 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 8 | Dendritic cell-activated cytokine-induced killer cells enhance the anti-tumor effect of chemotherapy on non-small cell lung cancer in patients after surgery显示文摘 | Hui Li Changli Wang Jinpu Yu Shui Cao Feng Wei Weihong Zhang Ying Han Xiu-bao Ren | 2009 | Cytotherapy2009，，8： | 5 |
| 9 | Experimental Investigation on Cavitating Flow Shedding over an Axisymmetric Blunt Body显示文摘Nowadays,most researchers focus on the cavity shedding mechanisms of unsteady cavitating flows over different objects,such as 2D/3D hydrofoils,venturi-type section,axisymmetric bodies with different headforms,and so on.But few of them pay attention to the differences of cavity shedding modality under different cavitation numbers in unsteady cavitating flows over the same object.In the present study,two kinds of shedding patterns are investigated experimentally.A high speed camera system is used to observe the cavitating flows over an axisymmetric blunt body and the velocity fields are measured by a particle image velocimetry(PIV)technique in a water tunnel for different cavitation conditions.The U-type cavitating vortex shedding is observed in unsteady cavitating flows.When the cavitation number is 0.7,there is a large scale cavity rolling up and shedding,which cause the instability and dramatic fluctuation of the flows,while at cavitation number of 0.6,the detached cavities can be conjunct with the attached part to induce the break-off behavior again at the tail of the attached cavity,as a result,the final shedding is in the form of small scale cavity and keeps a relatively steady flow field.It is also found that the interaction between the re-entrant flow and the attached cavity plays an important role in the unsteady cavity shedding modality.When the attached cavity scale is insufficient to overcome the re-entrant flow,it deserves the large cavity rolling up and shedding just as that at cavitation number of 0.7.Otherwise,the re-entrant flow is defeated by large enough cavity to induce the cavity-combined process and small scale cavity vortexes shedding just as that of the cavitation number of0.6.This research shows the details of two different cavity shedding modalities which is worthful and meaningful for the further study of unsteady cavitation. | HU Changli WANG Guoyu HUANG Biao | 2015 | Chinese Journal of Mechanical Engineering2015，28，2： | 5 |
| 10 | Karst Collapse Mechanism and Criterion for Its Stability显示文摘Karst collapse, caused by natural or artificial abstraction of groundwater, has been a focus of environmental geological problems for its ever-increasing hazardousness. The potential erosion theory and vacuum suction erosion theory,which reveal the origin of karst collapse macroscopically, are popularly accepted. However, a mathematic prediction criterion for karst collapse cannot be established only by these two theories. From a new perspective, this paper attempts to explain the microcosmic mechanism of karst collapse on the basis of these two theories. When the shear stress surpasses the shear strength of soil, a certain point or a certain plane in the unconsolidated soil covering karst caves will fail under the mechanical effects of water and air as well as its load-pressure, and with the increase of damaged points, a breaking plane appears and the soil on karst caves is completely damaged; as a result, the karst ground collapses. On the basis of the MohrCoulomb failure theory and previous studies, the paper presents a prediction criterion of karst collapse. Finally, by taking,for example, nine typical cases of collapse caused by pumping tests in Guizhou, the paper gives the calculation process of the model and proves its reliability. | HE Keqiang LIU Changli WANG Sijing | 2001 | Acta Geologica Sinica(English Edition)2001，75，3： | 5 |
| 11 | Cisplatin resistance in lung cancer is mediated by MACC1 expression through PI3K/AKT signaling pathway activation显示文摘 | Qiang Zhang Bin Zhang Leina Sun Qingna Yan Yu Zhang Zhenfa Zhang Yanjun Su Changli Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 3 |
| 12 | PtNi-W/C with Atomically Dispersed Tungsten Sites Toward Boosted ORR in Proton Exchange Membrane Fuel Cell Devices显示文摘The performance of proton exchange membrane fuel cells is heavily dependent on the microstructure of electrode catalyst especially at low catalyst loadings.This work shows a hybrid electrocatalyst consisting of PtNi-W alloy nanocrystals loaded on carbon surface with atomically dispersed W sites by a two-step straightforward method.Single-atomic W can be found on the carbon surface,which can form protonic acid sites and establish an extended proton transport network at the catalyst surface.When implemented in membrane electrode assembly as cathode at ultra-low loading of 0.05 mgPt cm^(−2),the peak power density of the cell is enhanced by 64.4%compared to that with the commercial Pt/C catalyst.The theoretical calculation suggests that the single-atomic W possesses a favorable energetics toward the formation of*OOH whereby the intermediates can be efficiently converted and further reduced to water,revealing a interfacial cascade catalysis facilitated by the single-atomic W.This work highlights a novel functional hybrid electrocatalyst design from the atomic level that enables to solve the bottle-neck issues at device level. | Huawei Wang Jialong Gao Changli Chen Wei Zhao Zihou Zhang Dong Li Ying Chen Chenyue Wang Cheng Zhu Xiaoxing Ke Jiajing Pei Juncai Dong Qi Chen Haibo Jin Maorong Chai Yujing Li | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 13 | Silica Nanoparticles-mediated Stable Genetic Transformation in Nicotiana tabacum显示文摘 | FU Yuqin LI Luhua WANG Hui JIANG Yuan LIU Huijing CUI Xiyan WANG Piwu LU Changli | 2015 | Chemical Research in Chinese Universities2015，31，6： | 3 |
| 14 | Autologous cytokine-induced killer cell immunotherapy in lung cancer: a phase II clinical study显示文摘 | Runmei Li Changli Wang Liang Liu Chunjuan Du Shui Cao Jinpu Yu Shizhen Emily Wang Xishan Hao Xiubao Ren Hui Li | 2012 | Cancer Immunology Immunotherapy2012，，11： | 2 |
| 15 | Dual-metal single-atomic catalyst:The challenge in synthesis,characterization,and mechanistic investigation for electrocatalysis显示文摘Dual-metal single-atom catalysts(DACs),featuring high atomic utilization efficiency,excellent selectivity,and stability originating from the atomically dispersed nature,have emerged as a new frontier in heterogeneous electrocatalysis due to the synergistic effect between diversified metal active sites in promoting their catalytic activity.In this review,the recent progress and development on the syntheses,characterizations,theoretical uniqueness,and applications for various catalytic reactions and devices(oxygen reduction reaction,oxygen evolution reaction,hydrogen evolution reaction,CO_(2) reduction reaction,N2 reduction reaction,proton exchange membrane fuel cells)are summarized and reviewed.Specifically,the synergistic effect between the two metal centers and electronic structures of catalysts is systematically discussed.Moreover,the future challenges and prospects in developing practical DACs are proposed as a possible direction for further investigation. | Changli Chen Mengru Sun Kaixuan Wang Yujing Li | 2022 | SmartMat2022，3，4： | 2 |
| 16 | Superplastic Microforming of Zn-A122 Alloy Ribs显示文摘Research on microforming of fine-grained superplastic Zn-AI22 alloy was carried out in this paper by means of superplastic forming. With the selected material, microformability tests have been carried out with the specially developed evaluation method by using two kinds of stainless steel dies. With these dies, micro-extrusion tests have been carried out and the characteristics of microformability of the material have been clarified. Effects of processing parameters and die structure on forming have been analyzed. SEM and metallographic microscope have been used to analyze the formed specimens. Through analysis of flow lines of the formed specimen, behavior of material could be understood well. | Changli WANG, and Kaifeng ZHANGSchool of Materials Science arid Engineering, Harbin Institute of Technology, Harbin 150001, China | 2004 | Journal of Materials Science & Technology2004，20，2： | 2 |
| 17 | MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN显示文摘 | Boning Liu Xiang Wu Bin Liu Changli Wang Yunde Liu Qinghua Zhou Ke Xu | 2012 | BBA - Molecular Basis of Disease2012，，11： | 2 |
| 18 | Association schemes of quadratic forms over a finite field of characteristic two显示文摘For the association schemes of quadratic forms over a finite field of characteristic two, the parameters of this association scheme are discussed by using matrix skill. For n=2, 3 , all the parameters are computed. For n≥3 , the formulas of parameters P * 2 -2j+1 and related recursion formulas of the general parameters P * ** are obtained. | Yangxian Wang Chunsen Wang Changli Ma | 1998 | Chinese Science Bulletin1998，43，23： | 1 |
| 19 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 20 | Impact of the addition of a compound fertilizer on the dissolution of carbonate rock tablets: A column experiment显示文摘 | Song Chao Liu Changli Wang Junkun Zhang Yun Hou Hongbing | 2011 | Applied Geochemistry2011，，： | 1 |
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