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| 1 | Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice显示文摘Advanced maternal age is characterized by declines in the quantity and quality of oocytes in the ovaries,and the aging process is accompanied by changes in gut microbiota composition.However,little is known about the relationship between gut microbiota and ovarian aging.By using fecal microbiota transplantation(FMT)to transplant material from young(5-week-old)into aged(42-week-old)mice,we find that the composition of gut microbiota in FMT-treated mice presents a“younger-like phenotype”and an increase of commensal bacteria,such as Bifidobacterium and Ruminococcaceae.Moreover,the FMT-treated mice show increased anti-inflammatory cytokine IL-4 and decreased pro-inflammatory cytokine IFN-γ.Fertility tests for assessing ovarian function reveal that the first litter size of female FMT-treated mice is significantly higher than that of the non-FMT group.Morphology analysis demonstrates a dramatic decrease in follicle atresia and apoptosis as well as an increase in cellular proliferation in the ovaries of the FMT-treated mice.Our results also show that FMT improves the immune microenvironment in aged ovaries,with decreased macrophages and macrophage-derived multinucleated giant cells(MNGCs).These results suggest that FMT from young donors could be a good choice for delaying ovarian aging. | Li Xu Qiankun Zhang Xiaowei Dou Yipeng Wang Jianwei Wang Yong Zhou Xingyin Liu Jing Li | 2022 | Journal of Genetics and Genomics2022，49，11： | 2 |
| 2 | Novel nondelay-based reservoir computing with a single micromechanical nonlinear resonator for high-efficiency information processing显示文摘Reservoir computing is a potential neuromorphic paradigm for promoting future disruptive applications in the era of the Internet of Things,owing to its well-known low training cost and compatibility with hardware.It has been successfully implemented by injecting an input signal into a spatially extended reservoir of nonlinear nodes or a temporally extended reservoir of a delayed feedback system to perform temporal information processing.Here we propose a novel nondelay-based reservoir computer using only a single micromechanical resonator with hybrid nonlinear dynamics that removes the usually required delayed feedback loop.The hybrid nonlinear dynamics of the resonator comprise a transient nonlinear response,and a Duffing nonlinear response is first used for reservoir computing.Due to the richness of this nonlinearity,the usually required delayed feedback loop can be omitted.To further simplify and improve the efficiency of reservoir computing,a self-masking process is utilized in our novel reservoir computer.Specifically,we numerically and experimentally demonstrate its excellent performance,and our system achieves a high recognition accuracy of 93%on a handwritten digit recognition benchmark and a normalized mean square error of 0.051 in a nonlinear autoregressive moving average task,which reveals its memory capacity.Furthermore,it also achieves 97.17±1%accuracy on an actual human motion gesture classification task constructed from a six-axis IMU sensor.These remarkable results verify the feasibility of our system and open up a new pathway for the hardware implementation of reservoir computing. | Jie Sun Wuhao Yang Tianyi Zheng Xingyin Xiong Yunfei Liu Zheng Wang Zhitian Li Xudong Zouu | 2021 | Microsystems & Nanoengineering2021，7，5： | 2 |
| 3 | Prognostic role of plasma levels ofγ-glutamyl transpeptidase in patients with advanced gastric cancer treated with anti-PD-1 immunotherapy显示文摘Objective Antibodies targeting programmed cell death protein 1(PD-1)have become the mainstay of treatment for chemotherapy-refractory gastric cancer,characterized by high levels of programmed cell death ligand-1(PDL-1)expression.However,the routine clinical implementation of PDL-1 testing is currently limited by the lack of robust detection methods.In this regard,the role of plasmaγ-glutamyl transpeptidase(GGT),an N-terminal nucleophilic hydrolase,as an independent predictor of the efficacy of anti-PD-1 therapy remains unknown.In this study,we aimed to assessed the prognostic role of changes in plasma GGT levels(6 weeks vs.baseline)in patients with advanced gastric cancer treated with anti-PD-1 immunotherapy.Methods We retrospectively analyzed data from 57 patients with gastric cancer treated with anti-PD-1 antibodies(camrelizumab,sintilimab,nivolumab,tislelizumab,and toripalimab)at the Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China,from July 2018 to February 2021.Results We found that after 6 weeks of treatment,there were significant differences between responders and non-responders with respect to plasma GGT levels(P<0.001).Multivariate logistic regression analysis revealed that the continuous value of the 6-week difference in GGT levels(OR=1.437,95%CI=1.116-1.849,P=0.005)and 6-week difference in GGT≥0 or<0(OR=53.675,95%CI=6.379-451.669,P<0.001)were independent predictors of disease control.Survival analysis indicated that a reduction in plasma GGT6 levels during treatment was significantly associated with a favorable progression-free survival(PFS)and overall survival(P<0.001).Consistently,univariate and multivariate Cox regression analyses revealed that a reduction in plasma GGT6 levels during treatment was an independent predictor of PFS(HR=1.033,95%CI=1.013-1.053,P=0.001).Conclusion Alterations in plasma GGT levels during treatment can be used as a predictor of disease progression and survival in patients with advanced gastric cancer undergoing treatment with anti-PD-1 antibodies. | Shaojie Xu Yiming Feng Xingyin Li Zaozao Huang Hewei Li Ganxin Wang | 2022 | Oncology and Translational Medicine2022，8，3： | 0 |
| 4 | Luminescence Characteristics and Energy Transfer Machanismof LaOBr:Tb^(3+) (Dy^(3+))显示文摘The rare earth luminescence materials LaOBrfTb3+(Dy3+) were synthesized at high temperature,and the structure and luminescence characteristics were studied. The co-doping Dy3+ may make the energy of 5D3 of Tb3+ transfer to 5D4 level, which makes the emission of 5D4-7FJ (J=0,1... 6), specially of 5D4-7F5, enhance obviously, and the total brightness is increased by about 40% in comparison with the samples without Dy3+ cations, as a result of the energy transfer of dipole-dipole interaction. | Jinghai YANG Chunzhong MIN and Zhanguo ZONG(Institute of Solid State Physics, Siping Normal University, Siping 136000, China)Yongji LI(Siping Teachers College, Siping 136000, China)Xingyin LIU(Changchun Institute of Physics, Chinese Academy of Sciences, | 1997 | Journal of Materials Science & Technology1997，13，6： | 0 |
| 5 | A decouple-decomposition noise analysis model for closed-loop mode-localized tilt sensors显示文摘The development of mode-localized sensors based on amplitude output metrics has attracted increasing attention in recent years due to the potential of such sensors for high sensitivity and resolution.Mode-localization phenomena leverage the interaction between multiple coupled resonant modes to achieve enhanced performance,providing a promising solution to overcome the limitations of traditional sensing technologies.Amplitude noise plays a key role in determining the resolution of mode-localized sensors,as the output metric is derived from the measured AR(amplitude ratio)within the weakly coupled resonator system.However,the amplitude noise originating from the weakly coupled resonator's closed-loop circuit has not yet been fully investigated.This paper presents a decouple-decomposition(DD)noise analysis model,which is applied to achieve high resolution in a mode-localized tilt sensor based on a weakly coupled resonator closed-loop circuit.The DD noise model separates the weakly coupled resonators using the decoupling method considering the nonlinearity of the resonators.By integrating the decoupled weakly coupled resonators,the model decomposes the weakly coupled resonator's closed-loop circuit into distinct paths for amplitude and phase noise analyses.The DD noise model reveals noise effects at various circuit nodes and models the system noise in the closed-loop circuit of the weakly coupled resonators.MATLAB/Simulink simulations verify the model's accuracy when compared to theoretical analysis.At the optimal operating point,the mode-localized tilt sensor achieves an input-referred instability of 3.91×10^(-4°)and an input-referred AR of PSD of 2.01×10^(-4°)⁄√Hz using the closed-loop noise model.This model is also applicable to other varieties of mode-localized sensors. | Kunfeng Wang XingYin Xiong Zheng Wang Liangbo Ma BoWen Wang WuHao Yang Xiaorui Bie ZhiTian Li XuDong Zou | 2023 | Microsystems & Nanoengineering2023，9，6： | 0 |
| 6 | BACTERIAL SWOLLEN STEM CANKER ON POPLAR:THE DISEASE AND ITS CAUSES显示文摘The bacterial swollen stem canker of poplar is prevalent in planted poplars ofnortheast China.Serious damage occurs in the form of necrosis,putridity,cankers,swollen stemsand discolored wood of trunks and branches of young and mature trees.Tests of allergic reaction,pathogenicity,culture characteristic,Gram stain and anaerobic culture revealed that the pathogen isErwinia sp.Its occurrence depends mainly on the predisposing factors of the disease among whichthe susceptibility of poplars is the most important one.The disease becomes widespread in associa-tion with low-lying and high-humidity terrain,frost injury,node wounds,insect damage,and prun-ing and other mechanical wounds.Harmful factors promote the disease. | Xiang Cunti Sun Haifeng Li GuishengNortheast Forestry UniversityWu Xingyin Li Zhuo DangWenqiang Zhang Jinghua Zou XipinAcheng Forest Bureau of Heilongjiang Province | 1991 | Journal of Northeast Forestry University1991，2，1： | 0 |
| 7 | CONTROL TECHNIQUE OF BACTERIAL CANKER OF POPLAR显示文摘The poplar bacterial canker caused by Erwinia sp is a serious disease spreading inmost parts of Northeast China,where poplars are cultivalted.The disease seriously infects thosepoplars belonging to section Aigeiros or the intersection hybrids of section Tacamahaca and section Aigeiros and their clones.Five fine poplar cultivars resistant to the bacterial canker have been ob-tained by screening tests.They are Lz2(Populus simonii×nigra var.italica),A15(P.×sp.)613(P.×sp.),A102and A98(P.simonii×sp.)T following chemicals are obviously effective,such as:50%DT germicide ,40% XF-136 and 10% C.C.M.A.or 12.5% ramphencol and 50,000 ppm/mlvalidamycin,with which the stems or roots can be watered. | Wu Xingyin Zhang JinghuaForest Pest Control and Quarantine Station of Archeng City of Heilongjiang ProvinceXiang Cunti Li Guisheng ’ Shao Zhongwen Liu Xiaoguang Ma LiyaNortheast Forestry UniversityZhang Xianwen Li Zhuo Xie Guicai Dang WenqiangArcheng Forestry Bureau of Heilongjiang Province | 1991 | Journal of Northeast Forestry University1991，2，2： | 0 |
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