4篇
您的检索式：作者名="Xinlong Lan"
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| 1 | Self-assembly with varying hydrophobic centers:Synthesis of red blood cell-like basic magnesium carbonate microspheres显示文摘Basic magnesium carbonate microspheres with a red blood cell(RBC)-like appearance and diameters of ~3μm were synthesized by amphiphilic molecule-participated self-assembly under hydrothermal conditions.In the self-assembly,sodium dodecyl benzene sulfonate served as a template for the formation of Mg(OH)_2 spherical micelles and also as a reactant precursor that releases CO_2 to react with Mg(OH)_2.The growth of the microspheres is driven by the continuous generation of new hydrophobic centers because of the consumption of hydrophilic poles(—SO_3^-).The surfactant-directed self-assembly can be applied to the synthesis of other carbonate or metallic oxide self-assemblies,indicating that it is a universal self-assembly method for amphiphilic molecules. | Xinlong Ma Guoqing Ning Bing Chen Chuanlei Qi Xingying Lan Jinsen Gao | 2015 | Particuology2015，13，5： | 2 |
| 2 | Supramolecular isomerism with polythreaded topology based on ^4- isomers显示文摘 | Lan Yaqian Li Shunli Wang Xinlong | 2008 | Inorganic Chemistry2008，47，2： | 1 |
| 3 | Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A_(2A/2B)receptors in tolerogenic dendritic cells显示文摘Tolerogenic dendritic cells(tol DCs)facilitate the suppression of autoimmune responses by differentiating regulatory T cells(Treg).The dysfunction of immunotolerance results in the development of autoimmune diseases,such as rheumatoid arthritis(RA).As multipotent progenitor cells,mesenchymal stem cells(MSCs),can regulate dendritic cells(DCs)to restore their immunosuppressive function and prevent disease development.However,the underlying mechanisms of MSCs in regulating DCs still need to be better defined.Simultaneously,the delivery system for MSCs also influences their function.Herein,MSCs are encapsulated in alginate hydrogel to improve cell survival and retention in situ,maximizing efficacy in vivo.The three-dimensional co-culture of encapsulated MSCs with DCs demonstrates that MSCs can inhibit the maturation of DCs and the secretion of pro-inflammatory cytokines.In the collagen-induced arthritis(CIA)mice model,alginate hydrogel encapsulated MSCs induce a significantly higher expression of CD39^(+)CD73^(+)on MSCs.These enzymes hydrolyze ATP to adenosine and activate A_(2A/2B)receptors on immature DCs,further promoting the phenotypic transformation of DCs to tol DCs and regulating naive T cells to Tregs.Therefore,encapsulated MSCs obviously alleviate the inflammatory response and prevent CIA progression.This finding clarifies the mechanism of MSCs-DCs crosstalk in eliciting the immunosuppression effect and provides insights into hydrogel-promoted stem cell therapy for autoimmune diseases. | Gaona Shi Yu Zhou Wenshuai Liu Chengjuan Chen Yazi Wei Xinlong Yan Lei Wu Weiwei Wang Lan Sun Tiantai Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 4 | Construction of EMS-Induced Peanut Mutant Libraries and Identification of Pod-Related Traits Mutant Lines显示文摘Peanut(Arachis hypogaea L.)is an oil and economic crop of vital importance,and peanut pod is the key organ influencing the yield and processing quality.Hence,the Pod-related traits(PRTs)are considered as important agronomic traits in peanut breeding.To broaden the variability of PRTs in current peanut germplasms,three elite peanut cultivars were used to construct Ethyl methane sulfonate(EMS)-induced mutant libraries in this study.The optimal EMS treatment conditions for the three peanut varieties were determined.It was found that the median lethal dose(LD50)of EMS treatment varied greatly among different genotypes.Finally,the EMS-induced peanut mutant libraries were constructed and a total of 124 mutant lines for PRTs were identified and evaluated.Furthermore,“M-8070”,one of the mutant lines for pod constriction,was re-sequenced via high-throughput sequencing technology.The genome-wide variations between“M-8070”and its wild parent“Fuhua 8”(FH 8)were detected.2994 EMS-induced single nucleotide polymorphisms(SNPs)and 1188 insertion-deletions(InDels)between“M-8070”and its wild parent were identified.The predominant SNP mutation type was C/G to T/A transitions,while the predominant InDel mutation type was“1-bp”.We analyzed the distribution of identified mutations and annotated their functions.Most of the mutations(91.68%of the SNPs and 77.69%of the InDels)were located in the intergenic region.72 SNPs were identified in the exonic region,leading to 27 synonymous,43 nonsynonymous and 2 stop-gain variation for gene structure.13 Indels were identified in the exonic region,leading to 4 frame-shift,8 non-frame-shift and 1 stop-gain variations of genes.These mutations may lead to the phenotypic variation of“M-8070”.Our study provided valuable resources for peanut improvement and functional genomic research. | Hao Chen Faqian Xiong Rilong Xu Xiangyu Chen Haifeng Zhong Yumei Zhang Xinlong Lan Hong Zhang Yuhua Chen Runfang Hu Guoqiang Lin Zhaoxiu Tang | 2023 | Phyton-International Journal of Experimental Botany2023，92，2： | 0 |
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