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| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | Synergistic effect of MXene on the flame retardancy and thermal degradation of intumescent flame retardant biodegradable poly(lactic acid)composites显示文摘The effect of Ti3C2 MXene nanosheets on the intumescent flame retardant(IFR)poly(lactic acid)(PLA)composites was investigated among a series of PLA/IFR/MXene,which were prepared by melt blending 0-2.0 wt%MXene,10.0 wt%-12.0 wt%IFR and PLA together.The results of limiting oxygen index(LOI)and vertical burning(UL-94)discover that the combination of 0.5 wt%MXene and 11.5 wt%IFR synergistically improves the fire safety of PLA to reach UL-94 V-0 rating with LOI value of 33.0%.The PLA/IFR/MXene composites perform an obvious reduction in peak of heat release rate(HRR)in cone calorimeter tests(CCTs).Furthermore,the carbon residues after CCTs were characterized by scanning electron microscope(SEM),laser Raman spectroscopy(LRS),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS).It is demonstrated that both the titanium composition of the MXene structure and the characteristics of the two-dimensional material enhance the PLA/IFR/MXene composite materials’ability to produce a dense barrier layer to resist burnout during thermal degradation. | Haowei Huang Dexuan Dong Weijie Li Xinya Zhang Li Zhang Ying Chen Xinxin Sheng Xiang Lu | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 7 |
| 3 | Superior anti-corrosion and self-healing bi-functional polymer composite coatings with polydopamine modified mesoporous silica/graphene oxide显示文摘In this article,graphene oxide(GO)and benzotriazole-loaded mesoporous silica nanoparticles(BTA/MSNs)are combined on micro scale through the in situ polymerization of polydopamine(PDA),preparing a selfhealing bi-functional GO(fGO)used as nano-fillers for anti-corrosion enhancement of waterborne epoxy(WEP)coatings.Scanning electronic microscopy(SEM)images show that the BTA/MSNs are uniformly distributed on the surface of high aspect ratio GO nanosheets to endow GO nanocontainer characteristics.UV-vis profiles demonstrate that fGO has p H-controlled release function.Modulus at lowest frequency is generally used for comparing the corrosion resistance of organic coatings.Modulus at lowest frequency(1.42×10^(5)Ωcm^(2))after 30 days immersion in 3.5 wt.%Na Cl solution revealed 2 orders of magnitude higher that of blank WEP(1.17×10^(7)Ωcm^(2)).With artificial cracks on its coatings,fGO/WEP had no obvious rust compared with blank WEP after 240 h of immersion.We anticipate that self-healing and physical barrier bi-functional nanocontainers improve the traditional anticorrosion coating efficiency with better,longer-lasting performance for shipping,oil drilling or bridge maintenance. | Yanqi Ma Haowei Huang Hongda Zhou Michael Graham James Smith Xinxin Sheng Ying Chen Li Zhang Xinya Zhang Elena Shchukina Dmitry Shchukin | 2021 | Journal of Materials Science & Technology2021，，36： | 4 |
| 4 | Kinetics for chlorination of maleic anhydride grafted polypropylene显示文摘 | Fu Heqing Huang Hong Zhang Xinya | 2007 | Journal of Appied Polymer Science2007，106，1： | 1 |
| 5 | A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers显示文摘Mutations of the RAS oncogene are found in around 30%of all human cancers yet direct targeting of RAS is still considered clinically impractical except for the KRAS^(G12C)mutant.Here we report that RAS-ON(RASON),a novel protein encoded by the long intergenic non-protein coding RNA 00673(LINC00673),is a positive regulator of oncogenic RAS signaling.RASON is aberrantly overexpressed in pancreatic ductal adenocarcinoma(PDAC)patients,and it promotes proliferation of human PDAC cell lines in vitro and tumor growth in vivo.CRISPR/Cas9-mediated knockout of Rason in mouse embryonic fibroblasts inhibits KRAS-mediated tumor transformation.Genetic deletion of Rason abolishes oncogenic KRAS-driven pancreatic and lung cancer tumorigenesis in LSL Kras^(G12D);Trp53R172H/+mice.Mechanistically,RASON directly binds to KRAS^(G12D)/V and inhibits both intrinsic and GTPase activating protein(GAP)-mediated GTP hydrolysis,thus sustaining KRAS^(G12D/V)in the GTP-bound hyperactive state.Therapeutically,deprivation of RASON sensitizes KRAS mutant pancreatic cancer cells and patient-derived organoids to EGFR inhibitors.Our findings identify RASON as a critical regulator of oncogenic KRAS signaling and a promising therapeutic target for KRAS mutant cancers. | Rongjie Cheng Fanying Li Maolei Zhang Xin Xia Jianzhuang Wu Xinya Gao Huangkai Zhou Zhi Zhang Nunu Huang Xuesong Yang Yaliang Zhang Shunli Shen Tiebang Kang Zexian Liu Feizhe Xiao Hongwei Yao Jianbo Xu Chao Yan Nu Zhang | 2023 | Cell Research2023，33，1： | 1 |
| 6 | Influence of carboxyl groups on the particle size and rheological properties of polyacrylate latices显示文摘 | Xinya Zhang Heqing Fu Hong Huang Huanqin Chen | 2010 | Journal of Wuhan University of Technology - Mater Sci Ed2010，，3： | 1 |
| 7 | Iron-bound organic carbon dynamics in peatland profiles:The preservation equivalence of deep and surface soil显示文摘More than half of the carbon pools in peatlands are stored in the soil layers below 30 cm,yet little is known about the carbon stabilizing factors at these depths.Although iron oxide minerals are considered to be important for stabilizing organic carbon(OC),their role in the preservation of OC in peatlands,especially in the deep layers,is poorly understood.Here,we collected 1 m soil profiles from six peatlands in Central and West China to quantitatively study the vertical distribution characteristics of iron-bound OC(Fe-bound OC),and the influencing physicochemical properties of the soil.The results showed that the content of reactive iron(FeR)was enriched in the top layer and decreased gradually with depth.While Fe-bound OC was positively correlated with FeR,its concentration did not decrease with depth in the peat profile.There were no obvious trends in the distributions of FeR and Fe-bound OC with water level fluctuations in the peat profile.In addition,the proportion of Fe-bound OC to soil organic carbon in the deep peat(31 to 100 cm)was equivalent to that in the surface peat(0 to 30 cm),indicating that iron oxide mineral provides comparable protection of OC in both layers.According to upper estimates of global peatland carbon storage(612 Pg),it could be predicted that 23.81±11.75 Pg of OC is protected by association with FeR.These results indicated that iron oxide minerals are the effective'rusty sink'of OC sequestration in peatland,and a key factor for its long-term preservation.The results from this study make a valuable contribution to the carbon dynamics knowledgebase for peatlands,and provide a basis for improved predictive simulations. | Xinya Huang Xinwei Liu Liangshuai Chen Yanfen Wang Huai Chen | 2023 | Fundamental Research2023，3，6： | 1 |
| 8 | Progressive Fusion Network Based on Infrared Light Field Equipment for Infrared Image Enhancement显示文摘Dear Editor,3×3 Infrared imaging,generally,of low quality,plays an important role in security surveillance and target detection.In this letter,we improve the quality of infrared images by combining both hardware and software.To this end,an infrared light field imaging enhancement system is built for the first time,including a infrared light field imaging device,a large-scale infrared light field dataset(IRLF-WHU),and a progressive fusion network for infrared image enhancement(IR-PFNet). | Yong Ma Xinya Wang Wenjing Gao You Du Jun Huang Fan Fan | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 1 |
| 9 | Influence of carboxyl groups on the particle size and rheological properties of polyacrylate latices显示文摘 | Xinya Zhang Heqing Fu Hong Huang Huanqin Chen | 2010 | Journal of Wuhan University of Technology - Mater Sci Ed2010，，3： | 1 |
| 10 | Synthesis of Acrylate Microemulsion Modified by Alkoxy Silane显示文摘一个压克力吃了乳剂被增加 vinyltriisopropoxy 矽烷(商号 C-1706 ) 修改。由增加由组成的多重 emulsifier 一离子的 emulsifier,钠十二烷基苯磺酸盐(SDBS ) 和非离子的 emulsifier,辛基酉分的二乙烯氧化物(OP-10 ) , acrylosilane 微乳液被播种乳液聚合综合。包括类型和 emulsifiers 和烷氧基矽烷和对微乳液的性质的影响被调查的增加的方法的单体变化的增加的数量的有影响的因素。它为乳液聚合与 1:1 的集体比率和 2.5%3.5% 罐头作用于合作效果的增加的数量被发现那 SDBS 和 OP-10 同样多重的 emulsifiers。C-1706 拥有能在聚合过程期间减少水解作用反应的笨重 isopropoxy 取代者,以便不仅顺利做这个过程而且推进乳剂的店稳定性。而且, C-1706 的后者增加模式能在乳剂的聚合过程期间制止它的水解作用活动和缩聚作用反应。结构,电影十字节,粒子尺寸和它微乳液的分发被红外线的光线光谱(FTIR ) ,扫描电子显微镜学(SEM ) 和一个粒子缩放的 Fourier 变换分析分析器分别地。结果证明修改微乳液的粒子直径能在 50 和 70 nm 之间被控制,它的电影坚硬是 7.3。仅仅补充说进乳液聚合罐头的系统的 1.5% C-1706 显然改进微乳液的捱过的抵抗,它与色差(ΔE ) 经历降级在 QUV 老化的 3 600 个小时以后是 1.6。 | SUN Zhijuan ZHANG Xinya HUANG Hong FU Heqing CHEN Huanqin | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，2： | 0 |
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