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| 1 | Understanding nano effects in catalysis显示文摘Catalysis, as a key and enabling technology, plays an increasingly important role in ields ranging from energy, environment and agriculture to health care. Rational design and synthesis of highly eicient catalysts has become the ultimate goal of catalysis research. hanks to the rapid development of nanoscience and nanotechnology, and in particular a theoretical understanding of the tuning of electronic structure in nanoscale systems, this element of design is becoming possible via precise control of nanoparticles' composition, morphology, structure and electronic states. At the same time, it is important to develop tools for in situ characterization of nanocatalysts under realistic reaction conditions, and for monitoring the dynamics of catalysis with high spatial, temporal and energy resolution. In this review, we discuss coninement efects in nanocatalysis, a concept that our group has put forward and developed over several years. Taking the conined catalytic systems of carbon nanotubes, metal-conined nano-oxides and 2D layered nanocatalysts as examples, we summarize and analyze the fundamental concepts, the research methods and some of the key scientiic issues involved in nanocatalysis. Moreover, we present a perspective on the challenges and opportunities in future research on nanocatalysis from the aspects of:(1) controlled synthesis of nanocatalysts and rational design of catalytically active centers;(2) in situ characterization of nanocatalysts and dynamics of catalytic processes;(3) computational chemistry with a complexity approximating that of experiments; and (4) scale-up and commercialization of nanocatalysts. | Fan Yang Dehui Deng Xiulian Pan Qiang Fu Xinhe Bao | 2015 | National Science Review2015，2，2： | 9 |
| 2 | Gas-phase electrocatalytic reduction of carbon dioxide using electrolytic cell based on phosphoric acid-doped polybenzimidazole membrane显示文摘Carbon dioxide transformation to fuels or chemicals provides an attractive approach for its utilization as feedstock and its emission reduction.Herein, we report a gas-phase electrocatalytic reduction of CO_2 in an electrolytic cell, constructed using phosphoric acid-doped polybenzimidazole(PBI) membrane, which allowed operation at 170°C. Pt/C and Pt Mo/C with variable ratio of Pt/Mo were studied as the cathode catalysts. The results showed that Pt Mo/C catalysts significantly enhanced CO formation and inhibited CH_4 formation compared with Pt/C catalyst. Characterization by X-ray diffraction, X-ray photoelectron spectroscopy and transmission electron microscopy revealed that most Mo species existed as MoO_3 in Pt Mo/C catalysts and the interaction between Pt and MoO_x was likely responsible for the enhanced CO formation rate although these bicomponent catalysts in general had a larger particle size than Pt/C catalyst. | Dunfeng Gao Fan Cai Qinqin Xu Guoxiong Wang Xiulian Pan Xinhe Bao | 2014 | Journal of Energy Chemistry2014，23，6： | 2 |
| 3 | Catalytic conversion of syngas into C2 oxygenates over Rh-based catalysts effect of carbon supports显示文摘 | FAN Zhongli CHEN Wei PAN Xiulian | 2009 | Catalysis Today2009，147，： | 1 |
| 4 | Enhanced ethanol production inside carbon-nanotube reactors containing catalytic particles 显示文摘 | XiuLian Pan Zhongli Fan Wei Chen | 2007 | Nature2007，11，： | 1 |
| 5 | Phosphatidic acid-enabled MKL1 contributes to liver regeneration:Translational implication in liver failure显示文摘Liver regeneration following injury aids the restoration of liver mass and the recovery of liver function.In the present study we investigated the contribution of megakaryocytic leukemia 1(MKL1),a transcriptional modulator,to liver regeneration.We report that both MKL1 expression and its nuclear translocation correlated with hepatocyte proliferation in cell and animal models of liver regeneration and in liver failure patients.Mice with MKL1 deletion exhibited defective regenerative response in the liver.Transcriptomic analysis revealed that MKL1 interacted with E2F1 to program pro-regenerative transcription.MAPKAPK2 mediated phosphorylation primed MKL1 for its interaction with E2F1.Of interest,phospholipase d2 promoted MKL1 nuclear accumulation and liver regeneration by catalyzing production of phosphatidic acid(PA).PA administration stimulated hepatocyte proliferation and enhanced survival in a MKL1-dependent manner in a pre-clinical model of liver failure.Finally,PA levels was detected to be positively correlated with expression of pro-regenerative genes and inversely correlated with liver injury in liver failure patients.In conclusion,our data reveal a novel mechanism whereby MKL1 contributes to liver regeneration.Screening for small-molecule compounds boosting MKL1 activity may be considered as a reasonable approach to treat acute liver failure. | Jiawen Zhou Xinyue Sun Xuelian Chen Huimin Liu Xiulian Miao Yan Guo Zhiwen Fan Jie Li Yong Xu Zilong Li | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 6 | Liposomal codelivery of inflammation inhibitor and collagen protector to the plaque for effective anti-atherosclerosis显示文摘Plaque plays a central role in atherosclerosis(AS)progression,whereas inflammation and destruction of the plaque microenvironment contribute to plaque advancement.As a result,a therapy regime,which combines anti-inflammation and inhibition-degradation of plaque matrix,appears to be a promising strategy to combat AS.Herein,we report a p H-sensitive liposome co-loading with the anti-inflammatory agent(oridonin,ORD)and plaque-collagen protector(marimastat)for anti-AS therapy.ORD was first conjugated with hyaluronic acid(HA)to target the inflammation contributor,pro-inflammatory macrophages.Then,the conjugate assembled onto the MATT-loaded liposomes.The co-loaded system(150 nm)significantly improved pharmacokinetics over the liposomes without anchoring the conjugate and accumulated effectively in the plaque.The preparation administration allowed efficient anti-AS activities in high-fat diet(HFD)-Apoe-/-mice by decreasing the pro-inflammatory cytokine expression in the serum,lessening the lesion area,alleviating the plaque collagen degradation,promoting macrophage polarization from phenotypic M1 to M2,reducing T helper(Th)17 cells(Th17)/T regulatory cells(Tregs)and Th1/Th2 ratio,etc.Furthermore,the serum determination in AS patients demonstrated high expression of the inflammatory cytokines,indicating our finding may offer a potential guideline for clinical practice. | Xiaotong Li Jiayi Gu Qingqing Xiao Ying Liu Ping Zhou Lifang Fan Xiulian Zhang Xiang Lu Jun Wu Zhengxia Liu Wei He | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 7 | Achieving 1.2 fm/Hz^(1/2)Displacement Sensitivity with Laser Interferometry in Two-Dimensional Nanomechanical Resonators:Pathways towards Quantum-Noise-Limited Measurement at Room Temperature显示文摘Laser interferometry is an important technique for ultrasensitive detection of motion and displacement.We push the limit of laser interferometry through noise optimization and device engineering.The contribution of noises other than shot noise is reduced from 92.6%to 62.4%,demonstrating the possibility towards shotnoise-limited measurement.Using noise thermometry,we quantify the laser heating effect and determine the range of laser power values for room-temperature measurements.With detailed analysis and optimization of signal transduction,we achieve 1.2 fm/Hz^(1/2)displacement measurement sensitivity at room temperature in twodimensional(2D)Ca Nb_(2)O_(6)nanomechanical resonators,the best value reported to date among all resonators based on 2D materials.Our work demonstrates a possible pathway towards quantum-noise-limited measurement at room temperature. | Jiankai Zhu Luming Wang Jiaqi Wu Yachun Liang Fei Xiao Bo Xu Zejuan Zhang Xiulian Fan Yu Zhou Juan Xia Zenghui Wang | 2023 | Chinese Physics Letters2023，40，3： | 0 |
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