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| 1 | The effects of EGR and ignition timing on emissions of GDI engine显示文摘The effects of EGR and ignition timing on engine emissions and combustion were studied through an experiment carried out on an air-guided GDI engine.The test results showed that the ignition timing significantly affected the GDI engine emissions,that the NOx emissions significantly reduced when the ignition timing was retarded,and that NOx emissions decreased with the EGR level increasement.A higher EGR rate could reduce CO emissions while the CO emissions were less affected by the ignition timing.The HC emissions decreased at a lower EGR rate.At 2500 r/min,an appropriate EGR rate could cut down CO emissions.The exhaust gas temperature could significantly decrease with improving the EGR rate,and the exhaust gas temperature at 2500 r/min was clearly higher than that at 1850 r/min.The nucleation mode particles increased clearly,the accumulation mode particle number decreased gradually with the increase of EGR rate,and the typical particle size of nucleation mode particle was in the range of 10–25 nm. | ZHAO LiFeng YU XiuMin QIAN DingChao DONG Wei SUN Ping HE Ling YANG Song | 2013 | Science China(Technological Sciences)2013，56，12： | 5 |
| 2 | Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications显示文摘Dear Editor Diabetes is a chronic metabolic disease that has become a major epidemic worldwide. High blood glucose is thought to be the primary cause of most devastating long-term complications of diabetes. In addition to strict glycemic control,a number of therapeutics have been used to slow down the progression of diabetic complications. However,a majority of current therapies for most diabetic complications have shown disappointing results in clinical trials.Because these complications arise from a number of pathological processes,targets for early interventions that could lead to effective treatments are largely unknown. | Fan Yu Song Guo Te Li Jie Ran Wei Zhao Dengwen Li Min Liu Xiumin Yan Xiaoyong Yang Xueliang Zhu Jun Zhou | 2019 | Cell Research2019，29，2： | 3 |
| 3 | Modeling Regional and Local-scale Permafrost Distribution in Qinghai-Tibet Plateau Using Equivalent-elevation Method显示文摘This study proposes an equivalent-elevation method to evaluate the integrated effects of latitude and elevation on regional and local-scale permafrost distribution in the Qinghai-Tibet Plateau,and to model the general permafrost-distribution patterns in regional and local-scale area.It is found that the Gaussian curve―an empirical model describing the relation between variations of altitudinal permafrost lower limit (PLL) and latitude in the Northern Hemisphere―could be applied in regional-and local-scale areas in the Qinghai-Tibet Plateau in a latitude-sensitive interval of 30°-50°N.The curve was then used to evaluate the latitudinal effect on permafrost distribution through transforming the latitudinal effect into a kind of altitudinal difference of PLL.This study then calculated the local equivalent-elevation value by overlaying the altitudinal difference of PLL onto real elevation at a certain location.The equivalent-elevation method was verified in an experimental subwatershed of the Qinghai-Tibet Plateau.However,feasibility of the method should be further tested in order to extend for future studies.The use of equivalent-elevation values can build a platform for comparing the regional general permafrost distribution in the plateau,and for basing further evaluations of local factors' effects on regional permafrost distribution. | LI Jing SHENG Yu WU Jichun WANG Jie ZHANG Bo YE Baisheng ZHANG Xiumin QIN Xiang | 2012 | Chinese Geographical Science2012，22，3： | 3 |
| 4 | AVP(4-8) Improves Cognitive Behaviors and Hippocampal Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease显示文摘Memory deficits with aging are related to the neurodegeneration in the brain, including a reduction in arginine vasopressin(AVP) in the brain of patients with Alzheimer’s disease(AD). AVP(4-8), different from its precursor AVP, plays memory enhancement roles in the CNS without peripheral side-effects. However, it is not clear whether AVP(4-8) can improve cognitive behaviors and synaptic plasticity in the APP/PS1 mouse model of AD. Here, we investigated for the first time the neuroprotective effects of AVP(4-8) on memory behaviors and in vivo long-term potentiation(LTP) in APP/PS1-AD mice.The results showed that:(1) APP/PS1-AD mice had lower spontaneous alternation in the Y-maze than wild-type(WT) mice, and this was significantly reversed by AVP(4-8);(2) the prolonged escape latency of APP/PS1-AD mice in the Morris water maze was significantly decreased by AVP(4-8), and the decreased swimming time in target quadrant recovered significantly after AVP(4-8) treatment;(3) in vivo hippocampal LTP induced by high-frequency stimulation had a significant deficit in the AD mice, and this was partly rescued by AVP(4-8);(4) AVP(4-8)significantly up-regulated the expression levels of postsynaptic density 95(PSD95) and nerve growth factor(NGF)in the hippocampus of AD mice. These results reveal the beneficial effects of AVP(4-8) in APP/PS1-AD mice,showing that the intranasal administration of AVP(4-8)effectively improved the working memory and long-term spatial memory of APP/PS1-AD mice, which may be associated with the elevation of PSD95 and NGF levels in the brain and the maintenance of hippocampal synaptic plasticity. | Xiumin Zhang Fang Zhao Chenfang Wang Jun Zhang Yu Bai Fang Zhou Zhaojun Wang Meina Wu Wei Yang Junhong Guo Jinshun Qi | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
| 5 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 6 | Calculating model of driving force of natural cycel for evaporators, Eleventh Internatinal Conference on Computational Methods and Experiments 显示文摘 | Yu Xiumin Yu Tianlan Pen Deqi | 2003 | (5): 12 - 142003，，5： | 1 |
| 7 | Research on twisted strip with asymmetric oblique teeth显示文摘 | Yu Tianlan Peng Deqi Yu Xiumin | 2004 | Enhanced Heat Transfer2004，11，4： | 1 |
| 8 | Research on vertical water-cooled condensers of fluidized-bed of internal circulation with bubble cap plate显示文摘 | Deqi PENG XiaoHeng ZHI XiuMin YU | 2004 | The 3rd International Symposium On Heat Transfer Enhancement And Energy Conser ration2004，，： | 1 |
| 9 | Reserch on Twisted Strip with Asymmetric Oblique Teeth显示文摘 | Tianlan Yu Deqi Peng Xiumin Yu | 2004 | Enhanced Heat Transfer2004，11，4： | 1 |
| 10 | Experimental Investigation of SO2and NOx Emission from Huadian Oil Shale During Circulating Fluidized Bed Combustion显示文摘 | Jiang Xiumin Yu Lijun Yan Che | 2004 | Oil Shale2004，21，3： | 1 |
| 11 | Significance of β-tubulin Expression in Breast Premalignant Lesions and Carcinomas显示文摘OBJECTIVE To explore the expression of β-tubulin in premalignant lesions and carcinomas of the breast,and to observe the relationship of its expression with breast cancer pathological features. METHODS The expression of β-tubulin was detected immunohistochemically in 50 specimens of premalignant lesions of the breast(ADH and Peri-PM with ADH),50 specimens of breast in situ ductal carcinomas(DCIS),and 50 specimens of invasive ductal carcinomas(IDC).Thirty specimens of normal breast tissues served as a control group. RESULTS Immunohistochemical analysis showed that:the differences among the 4 groups(normal breast tissues,breast premalignant lesions,DCIS and IDC,P<0.05)were significant, and there were also statistically significant differences between any 2 groups(P<0.05)except for the β-tubulin positive expression comparing DCIS versus IDC(P>0.05).In addition,β-tubulin was expressed at a higher level in Peri-PM with ADH compared to ADH(P<0.05).Following the degree of breast epithelial hyperplasia involved,and its development into carcinoma,the β-tubulin positive expression displayed an elevating tendency. We also found a significant positive relationship of β-tubulin expression with lymph node metastasis(P<0.05),but no significant correlation with histological grading and nuclear grade. CONCLUSION Centrosome defects may be an early event in the development of breast cancer and they can also promote tumor progression.Studies of aberrations of centrosomal proteins provide a new way to explore the mechanism of breast tumorigenesis. | Yuxia Gao Yun Niu Xiumin Ding Yong Yu | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 0 |
| 12 | Differentially expressed whey proteins of donkey and bovine colostrum revealed with a label-free proteomics approach显示文摘This study aimed to analyze and compare the differentially expressed whey proteins(DEWPs)of donkey and bovine colostrum using high-performance liquid chromatography with tandem mass spectrometry-based proteomics.A total of 620 and 696 whey proteins were characterized in the donkey and bovine colostrum,respectively,including 383 common whey proteins.Among these common proteins,80 were identified as DEWPs,including 21 upregulated and 59 downregulated DEWPs in donkey colostrum compared to bovine colostrum.Gene Ontology analysis revealed that these DEWPs were mainly related to cellular components,such as extracellular exosome,plasma membrane,and mitochondrion;biological processes,such as oxidation-reduction process,cell-cell adhesion,and small guanosine triphosphate(GTP)ase-mediated signal transduction;and molecular functions,such as GTP binding,GTPase activity,and soluble N-ethylmaleimide-sensitive factor(NSF)attachment protein receptor activity.Metabolic pathway analysis suggested that the majority of the DEWPs were associated with soluble NSF factor attachment protein receptor interactions in vesicular transport,fatty acid biosynthesis,and estrogen signaling pathways.Our results provide a vital insight into the differences between donkey and bovine colostrum,along with important information on the significant components as nutritional and functional factors to be included in infant formula based on multiple milk sources. | Mohan Li Qilong Li Haikun Yu Xiumin Zhang Dehao Li Wanying Song Yan Zheng Xiqing Yue | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 13 | Performance Development Target Setting of Passenger Car Diesel Engine显示文摘Setting engine emission targets to meet diesel car requirements is particularly important in engine performance development phase. Many researches are focused on associating vehicle performance with engine targets, but most work is done by testing, which is time and cost consuming, furthermore, the relationship of vehicle and engine will change when either engine or vehicle changes. A GT-Drive model to simulate New European Driving Cycle (NEDC) for passenger car is developed and calibrated by testing data, model precision is controlled within 5%. Time distribution of engine operating conditions when car running NEDC cycle has been analyzed, 10 critical major engine operating points are summarized according to running time proportion. Emission of NOx and smoke control regions containing these 10 points for target engine are set. Vehicle emissions are simulated and evaluated during engine development after engine performance test data are got, and engine combustion system layout and calibration are adjusted until vehicle targets are met. Vehicle is tested in chassis dynamometer finally, the testing results show a good agreement with the simulated results with an error of less than 5%, which proves that the emission value exchange of vehicle and engine is reliable. Performance target decomposition method for passenger car diesel presented can greatly shorten the development cycle and save costs. | ZHENG Guangyong YU Xiumin LIU Jiangwei SONG Tao LI Wenxiang | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 0 |
| 14 | O-GIcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis显示文摘Dear Editor,O-GIcNAcylation is a nutrient sensor that is particularly sensitive to environmental glucose(Hardiville and Hart,2014).Glucose can be converted to UDP-GIcNAc through the hexosamine biosynthetic pathway,providing a substrate for O-GIcNAcylation.Two enzymes participate in this reversible modification,O-GIcNAc transferase(OGT),which adds a single GIcNAc residue to the serine/threonine sites of proteins,and O-GIcNAcase(OGA),which removes the residue(Yang and Qian,2017). | Fan Yu Te Li Yanchao Sui Qingxia Chen Song Yang Jia Yang Renjie Hong Dengwen Li Xiumin Yan Wei Zhao Xueliang Zhu Jun Zhou | 2020 | Protein & Cell2020，11，11： | 0 |
| 15 | Preliminary Study on the Expression and the Significance of S-Phase Kinase Associated Protein 2 in Atypical Ductal Hyperplasia and Breast Cancer显示文摘OBJECTIVE To explore the relationship of high S-phase kinase associ- ated protein 2 (Skp2) expression with the characteristics of breast cancer. METHODS Using a immunohistochemical method, Skp2 expression was detected and evaluated in 30 normal tissues, 30 atypical ductal hy- perplasias (ADH), 30 ductal carcinomas in situ (DCIS) and 56 invasive carcinomas (including invasive specific carcinoma and invasive nonspe- cific carcinoma). The relationship between Skp2 expression and the characteristics of breast cancer was analyzed. RESULTS Skp2 expression varied among normal tissue, ADH, DCIS and invasive carcinomas (χ2=54.02, P<0.005). The positive level of Skp2 ex- pression in DCIS was higher than that of normal tissue (χ2=21.82, P< 0.005) and there was a significant difference in Skp2 between DCIS and ADH (χ2=5.08, P<0.025) as well as between invasive carcinomas and DCIS (χ2=6.52, P<0.01). The positive expression level of Skp2 in invasive carcinomas with positive lymph nodes was remarkably higher compared to those with negative lymph nodes. A significant difference in Skp2 ex- pression was found between combined histological Grades I and II ver- sus Grade III of invasive carcinomas (χ2=6.66, P<0.01). CONCLUSION High Skp2 expression may play an important role in car- cinogenesis and biological behavior of breast cancer. | Yan Lu Yun Niu Xiumin Ding Xuqi Xiao Yong Yu | 2006 | Chinese Journal of Clinical Oncology2006，3，3： | 0 |
| 16 | Main Components and Antioxidant Activity of Callisia repens Extracts显示文摘To study the main active components and antioxidant activity in vitro of extracts from Callisia repens , the contents of main active components such as total flavonoids, total anthocyanin and total sugar in the extracts were studied by spectrophotometry. The components and content of 18 kinds of metals were determined by ICP-MS mass spectrometry. Finally, the oxidative activity of the extract was evaluated by spectrophotometry. Results showed that the content of flavonoids, the total protein, the total sugar and the total anthocyanin in C. repens extract powder were 2.04%, 1.83%, 55.2% and 7.2%, respectively. Beneficial trace elements such as Ca, Mn, Mg in C. repens extracts were higher, while harmful heavy metals such as Pb, Hg, Ag, Co, Ge were very tiny or not detected at all. The IC 50 of C. repens was 0.265 mg/mL for scavenging DPPH·, and 1.16 mg/mL for scavenging ·OH free radical, the total reducing power of 1 mg extract was equivalent to that of 39 μg of Vc, and the extract showed no regular chelating power to ferrous ions. In conclusion, C. repens extracts have high content of natural active components, but extremely low content of the harmful heavy metals, and C. repens extract has good antioxidant capacity. Its antioxidant activity is realized by a variety of active factors through a synergistic mechanism. Thus, C. repens extract has great potential for developing into functional foods. | Bo LENG Shaoru CAI Xiumin LI Jiafu HUANG Yu XUE Zhichao LIN Wensong CHEN Chunxian LI Yutian PAN | 2019 | Asian Agricultural Research2019，11，7： | 0 |
| 17 | Discussion on possibilities of taking ground ice in permafrost as water sources on the Qinghai-Tibet Plateau during climate warming显示文摘Large amounts of ground ice are born with permafrost on the Qinghai-Tibet Plateau.Degradation of permafrost resulted from the climate warming will inevitably lead to melting of ground ice.The water released from the melting ground ice enters hydrologic cycles at various levels,and changes regional hydrologic regimes to various degrees.Due to difficulties in monitoring the perma-frost-degradation-release-water process,direct and reliable evidence is few.The accumulative effect of releasing water,however,is remarkable in the macro-scale hydrologic process.On the basis of the monitoring results of water-levels changes in some lakes on the Qinghai-Tibet Plateau,and combined with the previous results of the hydrologic changing trends at the regional scale,the authors preliminarily discussed the possibilities of the degrading permafrost on the Qinghai-Tibet Plateau as a potential water source during climate warming. | JiChun Wu,Yu Sheng,QingBai Wu,Jing Li,XiuMin Zhang State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental Engineering Research Institute,Chinese Academy of Sciences,Lanzhou,Gansu 730000,China. | 2009 | Research in Cold and Arid Regions2009，1，4： | 0 |
| 18 | The Mutagenicity of the Lyophilized Agkistrodon Haly (pallas) Venom显示文摘 | Xiumin Hu Bingbing Zhang Lixia Yu Zeshi Wang | 2005 | Journal of US-China Medical Science2005，2，6： | 0 |
| 19 | A Secure Supply of Antiretroviral Medicines for People Living with HIV During the COVID-19 Pandemic—China’s Experience显示文摘The occurrence of acute infectious diseases or severe natural disasters has a negative impact on the medical system(1).A survey of 105 countries by the World Health Organization(WHO)from March to June 2020 found that health services were disrupted in 90%of countries due to the coronavirus disease 2019(COVID-19)pandemic,with low-and middle-income countries being the most affected.Human immunodeficiency virus(HIV)treatment continuity and healthcare service delivery were also affected by the COVID-19 pandemic(2–3). | Yan Zhao Mengjie Han Yuting Lian Qiang Wang Xiumin Gan Lan Yu Chuntao Ma | 2022 | China CDC weekly2022，4，38： | 0 |
| 20 | Clonal Analysis of Peripheral Papilloma and Cancerous Cells of the Breast显示文摘OBJECTIVE Because almost al malignancies represent monoclonal proliferations,we have studied the clonal status of peripheral papil omas (peri-PM),ductal carcinomas in situ(DCIS),and normal breast tissues to explore a reliable way to distinguish benign and malignant(or pre-malignant) cases previously diagnosed morphologically. METHODS Twenty-six cases of peri-PM,25 cases of peri-PM with atypical ductal hyperplasia(ADH),27 cases of DCIS,16 cases of developed canceration and 20 specimens of normal tissue were examined in the study.The clonal status of these tissues was studied using an assay based on inactivation mosaicism of the lenth-polymorphic X-chromosomes at the androgen receptor(AR)locus. RESULTS Loss of polymorphism at the AR locus was found in all DCIS cases and 10 cases(10/25,40.0%)of peri-PM with ADH,indicating the monoclonality of the tumors.Twenty-four out of 26(92.3%)cases with peri-PM and 19 specimens of normal tissue were shown to be polyclonal.In 16 cases of developed canceration,identical X chromosome inactivation(monoclonal alterations)was observed from both the peri-PM with ADH part,and the DCIS part in each case. CONCLUSION These results contribute to the understanding of the genetic changes of peri-PM,and confirm the peri-PM withADH as a precancerous lesion of the breast.Clonal analysis might be a useful modality to screen high-risk cases from precancerous lesions or to distinguish between benign hyperplasia and early carcinoma. | Qi Yu Yun Niu Yong Yu Xiumin Ding Yurong Shi | 2007 | Chinese Journal of Clinical Oncology2007，4，6： | 0 |
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