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| 1 | The Effect of Chinese Tea on Occurrence of Esophageal Tumor Induced by N-Nitrosomethylbenzylamine in Rats显示文摘Five groups of rats (40 rats per group) were given five different varieties of Chinese tea (1 g/50 ml) and another two groups of rats (a positive control and a negative control) were given tap water as drinking water. Except for the negative control group, all the animals were intubated with A’-nitrosomethyibenzylamine (NMBzA, 5 mg/kg body wt/week). Half of the animals in each group were sacrificed after 6 weeks and the remaining animals at the end of 12 weeks. The incidences of esophageal mucosa lesions (16-59%) at the end of6 weeks were significantly lower in the tea-treated rats than in the positive control group (100%). The incidences of esophageal tumor at the end of 12 weeks (42-67%) were also significantly lower in the tea-treated groups than in the positive control group (90%). The same phenomenon was found with respect to the size and number of tumors in each tumor-bearing animal. The relative anticarcinogenic effects of the five varieties of Chinese tea were different. The Fujian oolong tea and jasmine tea exhibited the strongest effects. The results suggest that Chinese tea can effectively inhibit the carcinogenesis Caused by an N-nitroso compound. 1990 Academic Press.Inc. | HI AND XU YONG Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, China | 1990 | Biomedical and Environmental Sciences1990，3，1： | 11 |
| 2 | The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation显示文摘Among various immunoregulatory molecules,the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy.Antibodies targeting two B7 family co-inhibitory receptors,CTLA-4 and PD-1,have elicited long-term clinical outcomes in previously refractory cancer types and are considered a breakthrough in cancer therapy.Despite the success,the relatively low response rate(20–30%)warrants efforts to identify and overcome additional immune-suppressive pathways.Among the expanding list of T cell inhibitory regulators,V domain immunoglobulin suppressor of T cell activation(VISTA)is a unique B7 family checkpoint that regulates a broad spectrum of immune responses.Here,we summarize recent advances that highlight the structure,expression,and multi-faceted immunomodulatory mechanisms of VISTA in the context of autoimmunity,inflammation,and anti-tumor immunity. | Wenwen Xu TạMinh Hiếu Subramaniam Malarkannan Li Wang | 2018 | Cellular & Molecular Immunology2018，15，5： | 8 |
| 3 | Preparation, Characterization of Superacid SO_4^(2-)/ZrO_2-SiO_2 and Its Activity on Catalytic Synthesis of Methyl p-Nitrobenzoate显示文摘Solid superacid SO42-/Zr O2-SiO2 was prepared by dip-impregnation method, and its catalytic activity was tested with esterification of p-nitrobenzoic acid and methanol. The optimum conditions were also found, that is, the molar ratio between silica and zirconia was 10:1, the calcination temperature was 550 ℃ and the soaked consistency of H2SO4 was 1.0 mol?L-1. Under the conditions that the ratio of methanol to acid(m L/g) was 12:1, the amount of catalyst was 0.5 g, the reaction time was 5 h and the stirring speed was 800 r?min-1, the yield of methyl p-nitrobenzoate could reach up to 90.5%. Then the characterizations of cataslyst, including the acidity and types of acidic centers, specific surface area and surface structure was respectively examined by Hammett indicator, in-situ pyridine IR, BET method, FT-IR(KBr), transmission electron microscope(TEM), and X-ray diffraction(XRD). The results showed that the catalyst SO42-/Zr O2-SiO2 was superacid with high specific surface area due to Ho<-12.70. It contained acidic sites of Lewis and BrΦnsted, and its surface structure changed after esterification. The zirconia crystal was mainly tetragonal and silica crystal was not found. | 王刚 TAO Liya HOU Xin CAO Hi DONG Cheng NIE Wo XU Jun 张立庆 | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，5： | 2 |
| 4 | Expression of P-glycoproteinand multidrug resistance-associated protein is associated withmultidrug resistance in gastric cancer 显示文摘 | Xu HW Xu hi Hao JH | 2010 | J Int Med Res2010，38，1： | 1 |
| 5 | Iron toxicity in mice with collagenase-in- duced intracerebral hemorrhage显示文摘 | Wu HI Wu T Xu X | 2011 | J Cereb Blood Flow Metab2011，31，5： | 1 |
| 6 | Extracellular K^+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines 显示文摘 | Guo J Massaeli H Xu J et hi | 2009 | J Clin Invest2009，119，9： | 1 |
| 7 | Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and function显示文摘 | Liu W Xu D Yang H Xu H S hi Z Cao X Takeshita S L iu J Teale M Feng X | | 0，，： | 1 |
| 8 | A case - control study of risk fac tots for severe hand foot month disease among children in Ningbo China, 2010 - 2011显示文摘 | Yang TC Xu GZ I)ing HI | 2012 | Eur J Pediatr2012，171，9： | 1 |
| 9 | Molecular pharmacology of the interaction of anthracyclines with iron 显示文摘 | Xu X Persson HI Richardson DR | 2005 | Mol Pharmacol2005，68，2： | 1 |
| 10 | Effects of Modified Hyperbranched Poly- ester as a Curing Agent on Themorphology and Properties of Dynamically Cured Polypropylene/Polyurethane Blends显示文摘 | Xu N $hi W F | 2006 | Mater Sci2006，41，： | 1 |
| 11 | NOx control through rebuming 显示文摘 | Smoot L D Hill S C Xu Hi | 1998 | Progress in Energy and Combustion Science1998，24，5： | 1 |
| 12 | Enhanced tumor suppressor gene therapy via replication -deficient adenovirus vectors expressing an Nterminal truncated retinoblastoma protein 显示文摘 | Xu HI Zhou Y Seigne J Pemg GS Mixon M Zhang C Li J Benedict WF Hu SX | 1996 | Cancer Res1996，56，： | 1 |
| 13 | HuR post-transcriptionally regulates TNF-a-induced IL-6 expression in human pulmonary microvas- cularendothelial cells mainly via tristetraprolin 显示文摘 | hi JX Su X Xu J | 2012 | Respir Physi- ol Neurobiol2012，181，2： | 1 |
| 14 | Early response of endogenous adult neural progenitor cells to acute spinal cord injury in mice显示文摘 | Ke Y Hi L Xu R | 2012 | Stem Cells2012，24，4： | 1 |
| 15 | Mesenehymal stem cells ameliorate is- chemia-reperfnsion-induced renal dysfunction by improving the an- tioxidant/oxidant balance in the ischemic kidney 显示文摘 | Zhuo W Liao L Xu T et hi | 2011 | Urol lnt2011，86，2： | 1 |
| 16 | Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats显示文摘 | Xu HI Feng YP | 2000 | Acta Phannacol Sin2000，21，： | 1 |
| 17 | Do indoor environments influence on asthma and asthma - related symptoms among adults in homes? A review of the literature 显示文摘 | Yu J Noor HI Xu J | 2011 | Journal of the Formosan Medical Association2011，110，9： | 1 |
| 18 | Cell-specific and pH-ac- tivatable rubyrin-loaded nanoparticles for highly selective near-infrared photodynamic therapy against cancer 显示文摘 | Tian JW Ding L Xu HI | 2013 | Journal of the American Chemical Society2013，135，18： | 1 |
| 19 | The long non-coding RNA HI9- derived miR475 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1 显示文摘 | Zhuang hi GaoW Xu J | 2014 | Biochem Biophys Res Commun2014，448，3： | 1 |
| 20 | Optimal PN sequence design for quansisynchronous CDMA communication systems显示文摘 | Xu Duan Lin Kyung Hi Chang | 1997 | IEEE Trans on COM1997，45，2： | 1 |
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