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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 4 | Western blotting of RSV gene products in rice and insects显示文摘 | Qu Z C Shen D L Xu Y N | 1999 | Chinese Journal of Genetics1999，26，4： | 1 |
| 5 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 6 | Stochastic decomposition in the M/M/1 queue with working vacation显示文摘 | LIU W Y XU X L TIAN N S | 2008 | Applied Mathematics and Computation2008，204，1： | 1 |
| 7 | Registration of 70 common spring wheat germplasm lines resistant to stripe rust显示文摘 | Wang M N Chen X M Xu L S | | 0，，01： | 1 |
| 8 | Tetraena mongolica Maxim can accumulate large amounts of triacylglycerol in phloem cells and xylem parenchyma of stems显示文摘 | WANG G L LIN Q Q XU Y N | | 0，，： | 1 |
| 9 | Formation of white layer during labora- tory abrasive wear testing of ferrous alloys显示文摘 | Xu L Q Kennon N F | 1992 | Material Fo- rum1992，16，： | 1 |
| 10 | Effect of Y con- centration on the microstructure and mechanical prop- erties of as-cast Mg-Zn-Y-Zr alloys 显示文摘 | XU D K TANG W N LIU L | 2007 | Journal of Al- loys and Compounds2007，432，12： | 1 |
| 11 | Chemical ablation of the gallbladder显示文摘 | Xu Z Wang L Zhang N | 2005 | Surgical Endoscopy&Other Interventional Techniques2005，19，5： | 1 |
| 12 | Postoperative severe pneumonia in adult liver transplant recipients显示文摘 | Xia D Yan L N Xu L | 2006 | Transplant Proc2006，38，9： | 1 |
| 13 | Dielectric resonator antenna element and subarray with unequal crossstub 显示文摘 | ZHANG L N ZHONG S S Xu S Q | 2008 | Microwave and Optical Technology Letters2008，50，8： | 1 |
| 14 | 显示文摘 | XU F GAO M N WANG L | 2001 | Talanta2001，55，2： | 1 |
| 15 | Multidimensional Least squares Fitting with a fuzzy Model显示文摘 | Xu R N Li C L | 2001 | Fuzzy Sets and Systems2001，119，： | 1 |
| 16 | J Chemom显示文摘 | Cao D SiLiang Y Z Xu Q S Zhang L X Hu Q N Li H D | 2011 | 25(4):2012011，25，4： | 1 |
| 17 | CD4 T-cell activation for immunotherapy of malignancies using Ii-Key/MHC class II epitope hybrid vaccines 显示文摘 | Xu M Kallinteris N L yon Hofe E | 2012 | Vaccine2012，30，18： | 1 |
| 18 | Lipid-binding proteins:a fam-ily of fatty acid and retinoid transport proteins 显示文摘 | Banaszak L Winter N Xu Z | 1994 | Adv ProteinChem1994，45，： | 1 |
| 19 | Simultaneous determination of Cd(Ⅱ)and Pb(Ⅱ)using square wave anodic stripping voltammetry at a gold nanoparticle-graphenecysteine composite modified bismuth film electrode显示文摘 | Zhu L Xu L L Jia N M | 2014 | Electrochimica Acta2014，115，： | 1 |
| 20 | What is more important for enhancing nu- trient bioavailability with biochar application into a sandy soil:Direct or indirect mechanism?显示文摘 | Xu G Wei L L Sun J N | 2013 | Ecological Engineering2013，52，： | 1 |
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