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| 1 | Levels and distribution of brominated flame retardants in the soil of Harbin in China显示文摘This study reports the presence of brominated flame retardants in the topsoil in and around Harbin, a city in northeastern China. Samples of soil were collected from 17 locations in 2006, and the levels of 9 polybrominated diphenylethers (PBDEs 17, 28, 47, 66, 99, 100, 153, 154, and 183) ranged from 2.45 to 55.9 pg/g dry weight (dw) with a mean of 26.3 pg/g dw. These levels are very low comparing with those for some cities in Europe and USA. BDE 209 and hexabromocyclododecane were the two dominant congeners, with mean concentrations of 520 pg/g dw and 1750 pg/g dw, respectively. The concentrations of the total nine PBDE congeners clearly decreased from urban areas to background, but the compositions of individual congeners differed. Proportions of heavier congeners decreased while those of lighter congeners increased, along urban-rural-background transect, providing evidence for an urban fractionation effect. Correlation analysis indicated similar sources for PBDEs, hexabromocyclododecane, and 1,2-bis(2,4,6-tribromophenoxy)-ethane from urban areas but pentabromoethylbenzene was probably present due to long-range atmospheric transport. Principal component analysis was used to determine the characteristics of the relationships among these brominated flame retardants in the field. | WANG Xu REN Nanqi QI Hong MA Wanli LI Yifan | 2009 | Journal of Environmental Sciences2009，21，11： | 15 |
| 2 | Levels, distributions, and source identification of organochlorine pesticides in the topsoils in Northeastern China显示文摘Seventeen topsoil samples (9 urban, 4 suburban, 3 rural and 1 background) were collected in/around Harbin, a typical city in northeast of China, to measure concentration levels of organocholrine pesticides (OCPs) in topsoil of Northeastern China in 2006. Hexachlorohexanes (HCH), dichlorodiphenyltrichloroe thane (DDT), and hexachlorobenzene (HCB) were detected in soil samples with mean concentrations (in pg/g dry weight (dw)) of 7120, 5425, and 1039, respectively. The mean concentrations for other OCPs were very low, 4.8 pg/g dw for chlordane and 3.3 pg/g dw for endosulfan. Source identification analysis reveals that all OCPs found in soil samples were due to historical use of these chemicals or from other source regions through long- and short-range atmospheric transport. DDT was mainly used in the rural sites, whereas the sources of HCB, chlordane and endosulfan were mainly in the urban area. HCH was found almost equally in both urban and rural area. Soil concentrations of all detected OCPs, except HCHs, in and around Harbin were much lower than those in the southeast of China, which is expected since the use of these OCPs in the former was much lower than that in the latter, however higher HCH concentrations in and around Harbin than those found in most places of the Southeast China is not expected. It is suggested that high HCH concentration in soil of Northeast China was most likely due to long-range atmospheric transport (LRAT) from Southeast China and the cold condensation process. | WANG Xu REN Nanqi QI Hong MA Wanli LI Yifan | 2009 | Journal of Environmental Sciences2009，21，10： | 14 |
| 3 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 4 | Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19显示文摘The coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 was identified in December 2019.The symptoms include fever,cough,dyspnea,early symptom of sputum,and acute respiratory distress syndrome(ARDS).Mesenchymal stem cell(MSC)therapy is the immediate treatment used for patients with severe cases of COVID-19.Herein,we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19.MSC transplantation increases the immune indicators(including CD4 and lymphocytes)and decreases the inflammation indicators(interleukin-6 and C-reactive protein).High-flow nasal cannula can be used as an initial support strategy for patients with ARDS.With MSC transplantation,the fracrion of inspired O2(Fi02)of the two patients gradually decreased while the oxygen saturation(Sa02)and partial pressure of oxygen(P02)improved.Additionally,the patients9 chest computed tomography showed that bilateral lung exudate lesions were adsorbed after MSC infusion.Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19,particularly in patients with ARDS. | Lingling Tang Yingan Jiang Mengfei Zhu Lijun Chen Xiaoyang Zhou Chenliang Zhou Peng Ye Xiaobei Chen Baohong Wang Zhenyu Xu Qiang Zhang Xiaowei Xu Hainv Gao Xiaojun Wu Dong Li Wanli Jiang Jingjing Qu Charlie Xiang Lanjuan Li | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 5 | Effects of biochar on water movement characteristics in sandy soil under drip irrigation显示文摘Biochar addition can improve the physical and hydraulic characteristics of sandy soil.This study investigated the effects of biochar on water holding capacity and water movement in sandy soil under drip irrigation.By indoor simulation experiments,the effects of biochar application at five levels(0%,1%,2%,4%and 6%)on the soil water retention curve,infiltration characteristics of drip irrigation and water distribution were tested and analyzed.The results showed that biochar addition rate was positively correlated with water holding capacity of sandy soil and soil available water.Within the same infiltration time,with an increasing amount of added biochar,the diffusion distance of the horizontal wetting front(HWF)tended to decrease,while the infiltration distance of vertical wetting front(VWF)initially declined and then rose.The features of wetted bodies changed from'broad-shallow'to'narrow-deep'type.The relationship between the transport distances of HWF and VWF and the infiltration time was described by a power function.At the same distance from the point source,the larger the amount of added biochar,the higher the soil water content.Biochar had a great influence on the water content of the layer with biochar(0–200 mm)and had some effects at 200–250 mm without biochar;but it had less influence on the soil water content deeper than 250 mm.For the application rate of biochar of 4%,most water was retained within 0–250 mm soil layer.However,when biochar application amount was high(6%),it would be helpful for water infiltration.During the improvement of sandy soil,biochar application rate of 4%in the plow layer had the best effect. | PU Shenghai LI Guangyong TANG Guangmu ZHANG Yunshu XU Wanli LIPan FENG Guangping DING Feng | 2019 | Journal of Arid Land2019，11，5： | 6 |
| 6 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 7 | No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory显示文摘获得的免疫学的记忆是惹人注目的现象。致命的流行病通过 naï 扫; ve 人口,许多死但是幸存的那些从来不是 “攻击了 ― 两次;从未至少 fatally”,在 430 BCE 观察的历史学家修西得底斯。抗体记忆为对许多人的传染疾病的保护是批评的并且是的基础将近所有当前的人的疫苗。部分地,抗体记忆被编码为切换适应于不同地区生活的动物的免疫球蛋白(Ig ) 在对抗原的主要反应被产生并且产生的表示 G 记忆 B 房间快速,高亲密关系并且在有一样的抗原的挑战之上的 high-titered 抗体回答。IgG-B-cell 受体(BCR ) 并且导致抗原的 IgG-BCR 发信号怎么贡献记忆抗体回答,充分没被理解。在这评论,我们总结在抗体记忆在玩正在揭示细胞、分子的机制并且讨论怎么用不同试验性的途径学习的令人激动的新进展帮助将阐明 B 房间记忆的复杂现象。 | Yinsheng Xu Liling Xu Meng Zhao ChenGuang Xu Yilin Fan Susan K Pierce Wanli Liu | 2014 | Cell Research2014，24，6： | 4 |
| 8 | Influences of Film Thickness on the Electrical Properties of TaN_x Thin Films Deposited by Reactive DC Magnetron Sputtering显示文摘TaNx thin films were deposited on commercial polished Al2O3 ceramic substrates by reactive dc magnetron sputtering. The influences of the film thickness on the electrical properties of the samples were examined in detail. It is found that the film thickness does not influence the phase structures of the TaNx thin films. The sheet resistances of the samples shift from 173 Ω/sq. to 7.5 Ω/sq. with the film thickness shifting from 30 nm to 280 nm. With the increase of the film thickness from 30 nm to 280 nm, the temperature coefficient of resistance (TCR) of the samples shifts from negative value to positive value. When the film thickness is about 100 nm, TaNx thin films exhibits a near-zero TCR value (approximately -15×10-6/℃). This fact implies that TaNx thin films with a null TCR can be obtained by adjusting the film thickness. The variation in the electrical properties of the TaNx thin films with the film thickness can be qualitatively explained by the parallel connection of surface layer with high resistivity and negative TCR and TaNx layer with low resistivity and positive TCR. | Hongchuan Jiang Chaojie Wang Wanli Zhang Xu Si Yanrong Li | 2010 | Journal of Materials Science & Technology2010，26，7： | 3 |
| 9 | Effect of Substrate Movement Speed by Synchronous Rolling-casting Freeform Manufacturing for Metal on Microstructure and Mechanical Property of ZLl04 Aluminum Alloy Slurry显示文摘Synchronous rolling-casting freeform manufacturing for Metal(SRCFMM) means that the refined liquid metal is continuously pressed out from the bottom of crucible. There is a horizontal movable plate beneath the outlet. The clearance between the outlet and the plate is about several hundred micrometers. SRCFMM, similar to additive manufacturing, implies layer by layer shaping and consolidation of feedstock to arbitrary configurations, normally using a computer controlled movable plate. The primary dendritic crystal is easily crushed by movement of substrate in the rolling-casting area. ZL104 was used as the test materials, determining the control temperature by differential scanning thermal analysis(DSC), preparing a kind of samples by SR CFMM, then analyzing microstructures and mechanical property of the samples. Characteristics and distribution of the primary particles were assessed by optical microscopy(OM), scanning electron microscopy(SEM), energy dispersive spectrum(EDS) and image analysis software. Mechanical property of the samples was assessed by vickers hardness. The results show that the samples fabricated by SRCFMM have uniform structures and good performances with the velocity of the substrate controlled about 10 cm/s and temperature at about 580 ℃. | 罗晓强 李正阳 CHEN Guangnan XU Wanli 燕青芝 | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，5： | 3 |
| 10 | Electroacupuncture relieves irritable bowel syndrome by increasing expression of nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6 in water-avoidance stress mice显示文摘OBJECTIVE: To investigate the effect of electroacupuncture(EA) on irritable bowel syndrome(IBS) in mice through regulating nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6(NLRP6).METHODS: Water-avoidance stress(WAS) mice model was used to investigate the effects and the mechanism of EA. Abdominal withdrawal reflex test, open field test, and intestinal motility test were used to evaluate visceral sensitivity, anxiety,and intestinal motility in mice. The expressions of NLRP6, Mucin-2(MUC2) and E-cadherin were determined using immunofluorescence and Western blotting assays.RESULTS: EA significantly upregulated the expression of NLRP6 in the intestine of mice. Moreover, EA increased the expressions of MUC2 and E-cadherin in WAS mice.CONCLUSION: Our study found that the relief of IBS symptoms by EA may involve the increase in the expression of NLRP6 in WAS mice. | Song Yafang Geng Hao Chen Lu Wu Xiaoliang Yuan Mengqian Xu Wanli Guo Jing Sun Jianhua Pei Lixia | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 3 |
| 11 | Water erosion mechanism of mild carbon steels induced by micro-particles显示文摘To clarify the water erosion mechanism of the mild carbon steels, the water erosion experiments were performed by using deionized water as steam source. The results showed that under the damage threshold velocity of liquid impact, the material surface would not be destroyed. However, when the micro-particles were added into the steam, the pits appeared on the surface soon. By comparison, it is found that the pits are quite different from those induced by micro-particles impact without steam, but similar to those induced by cavitation erosion. The results indicated that the water erosion mechanism was similar to that of cavitation erosion under the damage threshold velocity. The micro-particles carry the micro-bubbles to approach the surface of the material, and the micro-bubbles collapse and generate micro-jet to impinge vertically on the surface, which lead to the produce of pits. | XU WanLi QIN Li WANG JiaDao CHEN HaoSheng CHEN DaRong | 2009 | Chinese Science Bulletin2009，54，24： | 1 |
| 12 | Unraveling Passivation Mechanism of Imidazolium-Based Ionic Liquids on Inorganic Perovskite to Achieve Near-Record-Efficiency CsPbI_(2)Br Solar Cells显示文摘The application of ionic liquids in perovskite has attracted wide-spread attention for its astounding performance improvement of perovskite solar cells(PSCs).However,the detailed mechanisms behind the improvement remain mysterious.Herein,a series of imidazolium-based ionic liquids(IILs)with different cations and anions is systematically investigated to elucidate the passivation mechanism of IILs on inorganic perovskites.It is found that IILs display the following advantages:(1)They form ionic bonds with Cs^(+)and Pb^(2+)cations on the surface and at the grain boundaries of perovskite films,which could effectively heal/reduce the Cs^(+)/I−vacancies and Pb-related defects;(2)They serve as a bridge between the perovskite and the hole-transport-layer for effective charge extraction and transfer;and(3)They increase the hydrophobicity of the perovskite surface to further improve the stability of the CsPbI_(2)Br PSCs.The combination of the above effects results in suppressed non-radiative recombination loss in CsPbI_(2)Br PSCs and an impressive power conversion efficiency of 17.02%.Additionally,the CsPbI_(2)Br PSCs with IILs surface modification exhibited improved ambient and light illumination stability.Our results provide guidance for an indepth understanding of the passivation mechanism of IILs in inorganic perovskites. | Jie Xu Jian Cui Shaomin Yang Yu Han Xi Guo Yuhang Che Dongfang Xu Chenyang Duan Wenjing Zhao Kunpeng Guo Wanli Ma Baomin Xu Jianxi Yao Zhike Liu Shengzhong Liu | 2022 | Nano-Micro Letters2022，14，1： | 1 |
| 13 | Stability mechanism of W/O crude oil emulsion stabilized by polymer and surfactant显示文摘 | Kang Wanli Xu Bin Wang Yongjian | 2011 | Colloids Surf A2011，384，3： | 1 |
| 14 | Stabilitymechanism of W/O crude oil emulsion stabilized by polymer andsurfactant显示文摘 | Kang Wanli Xu Bin Wang Yongjian | 2011 | Colloids Surf A2011，384，13： | 1 |
| 15 | rransmembrane domain dependent inhibitory unction of FcyRIIB显示文摘FcyRIIB,the only inhibitory IgG Fc receptor,functions to suppress the hyper-activation of immune cells.Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcyRIIB. However,later studies revealed that in addition to the ITIiVI,the transmembrane (TM)domain of FcyRIIB is also indispensable for its inhibitory function.Indeed,recent epidemiological studies revealed that a non-synonymous single nucleotide polymorphism (rs1050501) within the TM domain of FcyRIIB,responsible for the 1232T substitution,is associated with the susceptibility to systemic lupus erythematosus (SLE).In this review, we will summarize these epidemiological and functional studies of FcyRIIB-1232T in the past few years,and will further discuss the mechanisms accounting for the functional loss of FcyRIIB-1232T.Our review will help the reader gain a deeper understanding of the importance of the TM domain in mediating the inhibitory function of FcyRIIB and may provide insights to a new therapeutic target for the associated diseases. | Junyi Wang Zongyu Li Liling Xu Hengwen Yang Wanli Liu | 2018 | Protein & Cell2018，9，12： | 1 |
| 16 | Developing in situ electron paramagnetic resonance characterization for understanding electron transfer of rechargeable batteries显示文摘Electrochemical energy storage devices are pivotal in achieving“carbon neutrality”by enabling the storage of energy generated from renewable sources.To facilitate the development of these devices,it is important to gain insight into the underlying the single-/multi-electron transfer process.This can be achieved through in-time detection under operational conditions,but there are limited tools available for monitoring electron transfer under operando conditions.Electron paramagnetic resonance(EPR)is a powerful technique that can meet these expectations,as it is highly sensitive to unpaired electrons and can detect changes of paramagnetic centres.Despite the long history of in situ electrochemical EPR research,its potential has been surprisingly underutilized due to the need for strict operando cell design under special testing conditions.This review comprehensively summarizes recent efforts to understand energy storage mechanisms using in situ/operando EPR,with the aim of drawing researchers’attention to this powerful technique.After introducing the fundamental principles of EPR,we describe the critical advances made in detecting batteries using operando EPR,along with the remaining challenges and opportunities for future development of this technology in batteries.We emphasize the need for strict operando cell design and the importance of designing experiments that closely mimic real-world conditions.We believe that this review will provide innovative solutions to solve tough problems that researchers may encounter during their battery research,and ultimately contribute to the development of more efficient and sustainable energy storage devices. | Bin Wang Wanli Wang Kang Sun Yujie Xu Yi Sun Qiang Li Han Hu Mingbo Wu | 2023 | Nano Research2023，16，10： | 1 |
| 17 | New Semiconducting Polymer Based on Benzo[1,2-b:4,5-bldiselenophene Donor and Diketopyrrolopyrrole/Isoindigo Acceptor Unit: Synthesis, Characterization and Photovoltaics显示文摘 | Zhongjie Xu Guozheng Shi Jianyu Yuan Emily Glenn Hai-Qiao Wang Wanli Ma | 2015 | Chinese Journal of Chemistry2015，33，8： | 1 |
| 18 | Stability mechanism of W/O crude oil emulsion stabilized by polymer and surfactant显示文摘 | Wanli Kang Bin Xu Yongjian Wang Yuan Li Xiuhua Shan Faquan An Jiaheng Liu | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，，1： | 1 |
| 19 | Engineering of hollow polymeric nanosphere-supported imidazolium-based ionic liquids with enhanced antimicrobial activities显示文摘The design of stable,efficient and processable bactericidal materials represents a significant challenge for combating multidrugresistant bacteria in a variety of engineering fields.Herein,we report a facile strategy for the preparation of hollow polymeric nanosphere(HPN)-supported imidazolium-based ionic liquids(denoted as HPN-ILs)with superior antimicrobial activities.HPNILs were tailored by moderate Friedel−Crafts polymerization followed by the sequential covalent bonding of imidazole and bromoalkene.The resultant HPN-ILs have uniform hollow spherical morphology,an adequate surface area,and excellent physicochemical stability.Furthermore,they are highly active against both Gram-positive and Gram-negative bacteria and exhibit typical time/dosage-dependent antibacterial activities.The rational combination of porous HPNs and antibacterial ILs to generate an all-in-one entity may open new avenues for the design and fabrication of efficient bacteriostatic agents.Moreover,HPN-ILs have good biocompatibility and can also be loaded onto diverse matrices,and thus could extend their practical bactericidal application in the potential biomedical-active field. | Yu Zhang Shuwei Li Yixin Xu Xinyun Shi Mingxin Zhang Yingning Huang Ying Liang Yaqiong Chen Wanli Ji Jung Rae Kim Wenliang Song Deng-Guang Yu Il Kim | 2022 | Nano Research2022，15，6： | 1 |
| 20 | Engineering white blood cell membrane-camouflaged nanocarriers for inflammation-related therapeutics显示文摘White blood cells(WBCs)play essential roles against inflammatory disorders,bacterial infections,and cancers.Inspired by nature,WBC membrane-camouflaged nanocarriers(WBC-NCs)have been developed to mimic the“dynamic”functions of WBCs,such as transendothelial migration,adhesion to injured blood vessels,etc,which make them promising for diverse medical applications.WBC-NCs inherit the cell membrane antigens of WBCs,while still exhibiting the robust inflammation-related therapeutic potential of synthetic nanocarriers with excellent(bio)physicochemical performance.This review summarizes the proposed concept of cell membrane engineering,which utilizes physical engineering,chemical modification,and biological functionalization technologies to endow the natural cell membrane with abundant functionalities.In addition,it highlights the recent progress and applications of WBC-NCs for inflammation targeting,biological neutralization,and immune modulation.Finally,the challenges and opportunities in realizing the full potential of WBC-NCs for the manipulation of inflammation-related therapeutics are discussed. | Wanli Song Pengfei Jia Yaping Ren Junmiao Xue Bingqian Zhou Xinkai Xu Yansheng Shan Jing Deng Qihui Zhou | 2023 | Bioactive Materials2023，，5： | 1 |
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