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| 1 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 2 | CNN Feature Boosted SeqSLAM for Real-Time Loop Closure Detection显示文摘This paper proposes an efficient and robust Loop closure detection(LCD) method based on Convolutional neural network(CNN) feature. The primary method is called SeqCNNSLAM, in which both the outputs of the intermediate layer of a pre-trained CNN and the outputs of traditional sequence-based matching procedure are incorporated, making it possible to handle the viewpoint and condition variance properly. An acceleration algorithm for SeqCNNSLAM is developed to reduce the search range for the current image, resulting in a new LCD method called A-SeqCNNSLAM. To improve the applicability of A-SeqCNNSLAM to new environments, O-SeqCNNSLAM is proposed for online parameters adjustment in A-SeqCNNSLAM. In addition to the above work, we further put forward a promising idea to enhance Seq SLAM by integrating the both CNN features and VLAD's advantages called patch based Seq CNNSLAM(P-SeqCNNSLAM), and provide some preliminary experimental results to reveal its performance. | BAI Dongdong WANG Chaoqun ZHANG Bo YI Xiaodong YANG Xuejun | 2018 | Chinese Journal of Electronics2018，27，3： | 11 |
| 3 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 4 | UAV-Aided Networks for Emergency Communications in Areas with Unevenly Distributed Users显示文摘Nowadays,daily human life is closely intertwined with various networks.When natural disasters or malicious attacks break out,the failure of communication infrastructure due to direct destruction or indirect impact tends to cause a massive outage of communications.Emergency communication networks play a significant role in rescue operations.Recently,a flexible and efficient solution has been provided for emergency communications using unmanned aerial vehicles(UAVs).By means of their excellent characteristics,UAVs,serving as aerial base stations(ABSs),can be rapidly deployed to temporarily rebuild a damaged communication network to restore the users’connectivity.In this study,we investigate the use of UAVs as ABSs for an emergency communication scene where user equipment is unevenly distributed and the communication infrastructure has completely failed due to a severe disaster.Effective communication probability(ECP),which integrates throughput coverage and connectivity,is used to evaluate the performance of a communication network.Through simulations,we analyze communication improvements that can be obtained by the flexible deployment of ABSs.The results show a noticeable increase in ECP when some ABSs are deployed in optimal locations. | Gaozhao Peng Yongxiang Xia Xuejun Zhang Lin Bai | 2018 | Journal of Communications and Information Networks2018，3，4： | 1 |
| 5 | Intonation and respiration:apreliminary analysis显示文摘 | Shi Feng Zhang Jinyu Bai Xuejun | 2010 | Journal of Chinese Linguistics2010，38，2： | 1 |
| 6 | Genome-wide identification and expression analysis of NtbHLH gene family in tobacco(Nicotiana tabacum)and the role of NtbHLH86 in drought adaptation显示文摘The bHLH transcription factors play pivotal roles in plant growth and development,production of secondary metabolites and responses to various environmental stresses.Although the bHLH genes have been well studied in model plant species,a comprehensive investigation of the bHLH genes is required for tobacco with newly obtained high-quality genome.In the present study,a total of 309 NtbHLH genes were identified and can be divided into 23 subfamilies.The conserved amino acids which are essential for their function were predicted for the NtbHLH proteins.Moreover,the NtbHLH genes were conserved during evolution through analyzing the gene structures and conserved motifs.A total of 265 NtbHLH genes were localized in the 24 tobacco chromosomes while the remained 44 NtbHLH genes were mapped to the scaffolds due to the complexity of tobacco genome.Moreover,transcripts of NtbHLH genes were obviously tissue-specific expressed from the gene-chip data from 23 tobacco tissues,and expressions of 20 random selected NtbHLH genes were further confirmed by quantitative real-time PCR,indicating their potential functions in the plant growth and development.Importantly,overexpressed NtbHLH86 gene confers improve drought tolerance in tobacco indicating that it might be involved in the regulation of drought stress.Therefore,our findings here provide a valuable information on the characterization of NtbHLH genes and further investigation of their functions in tobacco. | Ge Bai Da-Hai Yang Peijian Chao Heng Yao MingLiang Fei Yihan Zhang Xuejun Chen Bingguang Xiao Feng Li Zhen-Yu Wang Jun Yang He Xie | 2021 | Plant Diversity2021，43，6： | 1 |
| 7 | Intonation and Respiration: a Preliminary Analysis 显示文摘 | FENG SHI XUEJUN BAI JINYU ZHANG | 2010 | Journal of Chinese Linguistics2010，38，2： | 1 |
| 8 | Hepatoprotective effect of cryptotanshinone from Salvia miltiorrhiza in d -galactosamine/lipopolysaccharide-induced fulminant hepatic failure显示文摘 | Quan Jin Shuang Jiang Yan-Ling Wu Ting Bai Yong Yang Xuejun Jin Li-Hua Lian Ji-Xing Nan | 2014 | Phytomedicine2014，，2： | 1 |
| 9 | Distribution of aromatic amines,phenols,chlorobenzenes,and naphthalenes in the surface sediment of the Dianchi Lake,China显示文摘Organic pollutants are widespread environmental pollutants with high toxicity,persistence,and bioaccumulation.Our aim was to investigate the distribution of aromatic amines,phenols,chlorobenzenes,and naphthalenes in the surface sediment of the Dianchi Lake,China.Nineteen surface sediment samples were collected from the Dianchi Lake,and 40 types of organic pollutants were analyzed via gas chromatography-mass spectrometry.The total organic pollutant concentrations in the surface sediment of the Dianchi Lake varied from 27.4 to 1.62×10^3 ng/g.The concentrations of phenols were much higher than those in other water bodies but still within a controllable range,whereas the concentrations of the other organic pollutant classes were similar or even lower.The detection ratio of 3-or 4-methylphenol was the highest(100.00%)among the pollutants.The average total organic pollutant concentrations decreased in the following order:Caohai(540 ng/g)>the middle of Waihai(488 ng/g)>the edge of Waihai(351 ng/g)>Haigeng Dam(90.4 ng/g).Pearson analysis showed a strong correlation among 1-methylnaphthalene,2-methylnaphthalene,1,3-dinitronaphthalene,and 1,4-dinitronaphthalene(P<0.01).Caohai,the north lakeshore of Waihai and the south of Waihai showed higher risk because of high concentration;meanwhile,1,4-dichlorobenzene,3-or 4-methylphenol and 1,2,4-trichlorobenzene were mor e likely to cause risks. | Xinyi Hu Ting Yang Chen Liu Jun Jin Bingli Gao Xuejun Wang Min Qi Baokai Wei Yuyu Zhan Tan Chen Hongtao Wang Yanting Liu Dongrui Bai Zhu Rao Nan Zhan | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 1 |
| 10 | The Effect of Word and Character Frequency on the Eye Movements of Chinese Readers显示文摘 | Guoli Yan Hongjie Tian Xuejun Bai | 2006 | British Journal of Psychology2006，97，2： | 1 |
| 11 | Material removal model of magnetorheological finishing based on dense granular flow theory显示文摘Magnetorheological finishing(MRF)technology is widely used in the fabrication of high-precision optical elements.The material removal mechanism of MRF has not been fully understood because MRF technology involves the integration of electromagnetics,contact mechanics,and materials science.In this study,the rheological properties of the MR polishing fluid in oscillation model have been investigated.We propose that the shear-thinned MR polishing fluid over the polishing area should be considered a dense granular flow,based on which a new contact model of MRF over the polishing area has been constructed.Removal function and processing force test experiments were conducted under different working gaps.The normal pressure and effective friction equations over the polishing area were built based on the continuous medium and dense granular flow theories.Then,a novel MRF material removal model was established.A comparison of the results of the theoretical model with actual polishing results demonstrated the accuracy of the established model.The novel model proposed herein reveals the generation mechanism of shear force over a polished workpiece and realizes effective decoupling of the main processing parameters that influence the material removal of MRF.The results of this study will provide new and effective theoretical guidance for the process optimization and technology improvement of MRF. | Yang Bai Xuejun Zhang Chao Yang Longxiang Li Xiao Luo | 2022 | Light(Advanced Manufacturing)2022，3，4： | 1 |
| 12 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 13 | A Least-Squares Solution to Nonlinear Steady-State Multi-Dimensional IHCP显示文摘ALeast-SquaresSolutiontoNonlinearSteady-StateMulti-DimensionalIHCPALeast-SquaresSolutiontoNonlinearSteady-StateMulti-Dimensio... | Bai Bofeng Guo Liejin Chen Xuejun (State Key Lab of Multiphase Flow in Power Engineering,Xi’an Jiao Tong University,Xi’an 710049,China) | 1996 | Journal of Thermal Science1996，5，1： | 0 |
| 14 | Mitoguardin通过调节MitoPLD调控线粒体融合及神经系统稳态显示文摘线粒体是细胞中的能量工厂和代谢中心,是人们最为熟悉的一种细胞器。在传统的细胞模式图中,线粒体被描绘为一个一个类似“豆子”的独立个体。 | Yongping Zhang Xiaoman Liu Jian Bai Xuejun Tian Xiaocui Zhao Wei Liu Xiuying Duan Weina Shang Heng-Yu Fan 佟超 | 2017 | 科学新闻2017，19，4： | 0 |
| 15 | PROGRESS ON IMPROVING AGRICULTURAL NITROGEN USE EFFICIENCY: UK−CHINA VIRTUAL JOINT CENTERS ON NITROGEN AGRONOMY显示文摘Two virtual joint centers for nitrogen agronomy were established between the UK and China to facilitate collaborative research aimed at improving nitrogen use efficiency(NUE)in agricultural production systems and reducing losses of reactive N to the environment.Major focus areas were improving fertilizer NUE,use of livestock manures,soil health,and policy development and knowledge exchange.Improvements to fertilizer NUE included attention to application rate in the context of yield potential and economic considerations and the potential of improved practices including enhanced efficiency fertilizers,plastic film mulching and cropping design.Improved utilization of livestock manures requires knowledge of the available nutrient content,appropriate manure processing technologies and integrated nutrient management practices.Soil carbon,acidification and biodiversity were considered as important aspects of soil health.Both centers identified a range of potential actions that could be taken to improve N management,and the research conducted has highlighted the importance of developing a systemslevel approach to assessing improvement in the overall efficiency of N management and avoiding unintended secondary effects from individual interventions.Within this context,the management of fertilizer emissions and livestock manure at the farm and regional scales appear to be particularly important targets for mitigation. | Tom MISSELBROOK Zhaohai BAI Zejiang CAI Weidong CAO Alison CARSWELL Nicholas COWAN Zhenling CUI David RCHADWICK Bridget EMMETT Keith GOULDING Rui JIANG Davey LJONES Xiaotang JU Hongbin LIU Yuelai LU Lin MA David POWLSON Robert MREES Ute SKIBA Pete SMITH Roger SYLVESTER-BRADLEY John WILLIAMS Lianhai WU Minggang XU Wen XU Fusuo ZHANG Junling ZHANG Jianbin ZHOU Xuejun LIU | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 0 |
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