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| 1 | Pharmacological effects of Astragaloside IV: a literature review显示文摘OBJECTIVE: To review the pharmacological effects and mechanisms of action of Astragaloside IV in Huangqi (Radix Astragali Mongolici). METHODS: Aticles focusing on Astragaloside IV in English and Chinese in databases were collected and reviewed in order to summarize the latest extraction separation, pharmacokinetics, and the pharmacological effects of astrageloside IV. RESULTS: Protective effects of Astrageloside IV on the cardiovascular system, immune, digestive, nervous system were identified, and the action mechanisms were associated with regulation of the calcium balance, anti-oxydant, antiapoptosis, antivirus, and so on. CONCLUSION: Astrageloside IV has broad application prospects, especially in cardiovascular diseases, digestive diseases, cancer and other modern high incidence, high-risk diseases, and could be developed as a medicine. | Shuang Ren Hua Zhang Yongping Mu Mingyu Sun Ping Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 57 |
| 2 | CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells显示文摘 | Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang | 2017 | Cell Research2017，27，1： | 40 |
| 3 | CFD simulation of particle suspension in a stirred tank显示文摘Particle suspension characteristics are predicted computationally in a stirred tank driven by a Smith turbine.In order to verify the hydrodynamic model and numerical method,the predicted power number and flow pattern are compared with designed values and simulated results from the literature,respectively.The effects of particle density,particle diameter,liquid viscosity and initial solid loading on particle suspension behavior are investigated by using the Eulerian-Eulerian two-fluid model and the standard k-s turbulence model.The results indicate that solid concentration distribution depends on the flow field in the stirred tank.Higher particle density or larger particle size results in less homogenous distribution of solid particles in the tank.Increasing initial solid loading has an adverse impact on the homogeneous suspension of solid particles in a low-viscosity liquid,whilst more uniform particle distribution is found in a high-viscosity liquid. | Nana Qi Hu Zhang Kai Zhang Gang Xu Yongping Yang | 2013 | Particuology2013，11，3： | 19 |
| 4 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 5 | Eco-environment range in the source regions of the Yangtze and Yellow rivers显示文摘Based on geographical and hydrological extents delimited, four principles are identified, as the bases for delineating the ranges of the source regions of the Yangtze and Yellow rivers in the paper. According to the comprehensive analysis of topographical characteristics, climate conditions, vegetation distribution and hydrological features, the source region ranges for eco-environmental study are defined. The eastern boundary point is Dari hydrological station in the upper reach of the Yellow River. The watershed above Dari hydrological station is the source region of the Yellow River which drains an area of 4.49×10 4 km 2 . Natural environment is characterized by the major topographical types of plateau lakes and marshland, gentle landforms, alpine cold semi-arid climate, and steppe and meadow vegetation in the source region of the Yellow River. The eastern boundary point is the convergent site of the Nieqiaqu and the Tongtian River in the upstream of the Yangtze River. The watershed above the convergent site is the source region of the Yangtze River, with a watershed area of 12.24×10 4 km 2 . Hills and alpine plain topography, gentle terrain, alpine cold arid and semi-arid climate, and alpine cold grassland and meadow are natural conditions in the source region of the Yangtze River. | DING Yongjian,YANG Jianping,LIU Shiyin,CHEN Rensheng,WANG Genxu,SHEN Yongping,WANG Jian,XIE Changwei,ZHANG Shiqing(Cold and Arid Regions Environmental and Engineering Research Institute, CAS, Lanzhou 730000, China) | 2003 | Journal of Geographical Sciences2003，13，2： | 18 |
| 6 | Influence of Gd_2O_3 and Yb_2O_3 Co-doping on Phase Stability,Thermo-physical Properties and Sintering of 8YSZ显示文摘The role of multicomponent rare earth oxides in phase stability, thermophysical properties and sintering for ZrO2-based thermal barrier coatings (TBCs) materials is investigated. 8YSZ codoped with 3 mol% Gd2O3 and 3 mol% Yb2O3 (GYb-YSZ) powders are synthesized by solid state reaction for 24 h at various temperatures. As temperature increases, stabilizers are dissolved into zirconia matrix gradually. Synthesized at 1 500 °C, GYb-YSZ is basically composed of cubic phase. GYb-YSZ exhibits excellent phase stability and sinters lower than 8YSZ by nearly three times. The thermal conductivity of GYb-YSZ is much lower than that of 8YSZ, and the thermal expansion coefficient of GYb-YSZ is comparable to that of 8YSZ. The influence of Gd2O3 and Yb2O3 co-doping on phase stability, thermal conductivity and sintering of 8YSZ is discussed. | ZHANG Yanli GUO Lei YANG Yongping GUO Hongbo ZHANG Hongju GONG Shengkai | 2012 | Chinese Journal of Aeronautics2012，25，6： | 17 |
| 7 | Effects of alternating magnetic field on the corrosion rate and corrosion products of copper显示文摘在 3.5% NaCl 答案,海水,和吸引的海水的铜的腐蚀形态学,腐蚀率,和腐蚀产品上的轮流出现的磁场的效果用电气化学的测试被调查,扫描电子显微镜学 / 精力 X 光检查(SEM/EDAX ) 的散分析系统,和 X 光检查衍射(XRD ) 。结果证明吸引的海水里的铜的腐蚀率是最小的。而且,吸引的海水里的标本的表面在 3.5% NaCl 答案和海水象与那些相比一致、紧缩。吸引的海水里的铜的腐蚀产品主要是 Cu2O 和 CuCl2。然而,海水里的腐蚀产品是 CuCl, Cu2Cl (哦) 3,并且由火花血浆 sintering 的 FeCl3ated。sintered 微观结构表明平均 WC 谷物缩放吗? | GUO Bin ZHANG Peng JIN Yongping CHENG Shukang | 2008 | Rare Metals2008，27，3： | 10 |
| 8 | Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens,a natural waste recycler显示文摘The black soldier fly(BSF),Hermetia illucens(Diptera:Stratiomyidae),is renowned for its bioconversion of organic waste into a sustainable source of animal feed.We report a high-quality genome of 1.1 Gb and a consensus set of 16,770 gene models for this beneficial species.Compared to those of other dipteran species,the BSF genome has undergone a substantial expansion in functional modules related to septic adaptation,including immune system factors,olfactory receptors,and cytochrome P450s.We further profiled midgut transcriptomes and associated microbiomes of BSF larvae fed with representative types of organic waste.We find that the pathways related to digestive system and fighting infection are commonly enriched and that Firmicutes bacteria dominate the microbial community in BSF across all diets.To extend its potential practical applications,we further developed an efficient CRISPR/Cas9-based gene editing approach and implemented this to yield flightless and enhanced feeding capacity phenotypes,both of which could expand BSF production capabilities.Our study provides valuable genomic and technical resources for optimizing BSF lines for industrialization. | Shuai Zhan Gangqi Fang Minmin Cai Zongqing Kou Jun Xu Yanghui Cao Liang Bai Yixiang Zhang Yongmao Jiang Xingyu Luo Jian Xu Xia Xu Longyu Zheng Ziniu Yu Hong Yang Zhijian Zhang Sibao Wang Jeffery K.Tomberlin Jibin Zhang Yongping Huang | 2020 | Cell Research2020，30，1： | 9 |
| 9 | CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells显示文摘 | Yongping Zhang Xingying Zhang Chen Cheng Wei Mu Xiaojuan Liu Na Li Xiaofei Wei Xiang Liu Changqing Xia Haoyi Wang | 2017 | Frontiers of Medicine2017，11，4： | 9 |
| 10 | A wideband combined transducer for measuring system in sound tube显示文摘为健全试管系统的一个宽带变换器被介绍,它联合纵的变换器和类 IV flextensional 变换器在低频率改进性能并且拓宽工作乐队。相等的电路被获得并且过去常分析在纵的变换器和 flextensional 变换器之间的联合机制。变换器的一个原型在由有限元素方法优化电声的表演以后被开发。在这个变换器刺激的健全试管的站的波浪被学习了,二件声学的材料样品的健全吸收系数用这个健全试管被测量,它证明变换器能满足声学的材料测量的要求,工作乐队从 1.4 kHz 到 23 kHz。 | PAN Yaozong MO Xiping LIU Yongping CUI Zheng ZHANG Tonggen | 2012 | Chinese Journal of Acoustics2012，31，2： | 9 |
| 11 | Thermo-flow characteristics and air flow field leading of the air-cooled condenser cell in a power plant显示文摘Special A-frame geometry of the air-cooled condenser cell and the complicated flow field at the exit of the axial flow fan bring on the air mal-distribution on the surface of the finned tube bundles and the deteriorated thermo-flow performances of a condenser cell.It is of benefit to the design and operation optimization of the direct dry cooling system in a power plant to investigate the thermo-flow characteristics of the condenser cell and propose the flow leading measures of cooling air.On the basis of the representative configuration of the air-cooled condenser cell in a 600 MW direct dry cooling power plant,the computational models of the air side fluid and heat flows are built,in which the actual fan blade geometric details are considered.Various flow field leading ways of cooling air are presented and the thermo-flow characteristics in the A-frame condenser cell and through the finned tube bundles are compared.Results show that the flow field leading measures can result in the increased volumetric flow rate and heat rejection,thus bringing on the improved performance of the condenser cell.The improvement of thermo-flow performances depends upon the geometric details of the flow guiding device. | ZHANG WanXi YANG LiJun DU XiaoZe YANG YongPing | 2011 | Science China(Technological Sciences)2011，54，9： | 8 |
| 12 | In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy显示文摘In this study,in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr(NZK) alloy were investigated to determine its suitability as a degradable medical biomaterial.Its corrosion properties were evaluated by static immersion test,electrochemical corrosion test,scanning electron microscopy(SEM),and energy dispersive spectroscopic(EDS) analysis,and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests.Pure magnesium was used as control.The results of static immersion test and electrochemical corrosion test in simulated body fluid(SBF) demonstrated that the addition of alloying elements could improve the corrosion resistance.The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%,which was lower than the safe value of 5%.The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC3T3-E1 cell viability.Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro.Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications. | WANG YongPing HE YaoHua ZHU ZhaoJin JIANG Yao ZHANG Jian NIU JiaLin MAO Lin YUAN GuangYin | 2012 | Chinese Science Bulletin2012，57，17： | 8 |
| 13 | Unique characteristics of the genetics epidemiology of amyotrophic lateral sclerosis in China显示文摘Continual discoveries of new genes and unraveling the genetic etiology in amyotrophic lateral sclerosis(ALS) have provided greater insight into the underlying pathogenesis in motor neuron degeneration, as well as facilitating the disease modeling and the testing of targeted therapeutics. While, the genetic etiology accounted for two-thirds of FALS and approximately 11% of SALS in Caucasians. However, the contributions of these causative genes to ALS vary among different populations. Furthermore, the prominent difference between Chinese population and other ethnics remains a source of ongoing debate. We systemically reviewed genetics literature of Chinese ALS populations and updated the mutation frequencies of the main ALS-implicated genes aiming to determine the genetic features of ALS in Chinese population. We also reviewed the associations between ALSimplicated single nucleotide polymorphisms(SNPs) and the risk of ALS in Chinese population. A total of 116 studies were included in this analysis(86 gene mutation study articles and 30 SNPs study articles). The results showed that the overall gene mutation rates of ALS-related causative genes were 55.0% in familial ALS(FALS) and 11.7% in sporadic ALS(SALS) in Chinese population. In Chinese FALS, the highest mutation frequency was found in SOD1 gene(25.6%), followed by FUS(5.8%), TARDBP(5.8%), DCTN1(3.6%) and C9 orf 72(3.5%). In Chinese SALS, the highest mutation frequency was also identified in SOD1 gene(1.6%), followed by ANXA11(1.4%), FUS(1.3%), SQSTM1(1.0%), OPTN(0.9%) and CCNF(0.8%).The associations between several SNPs and risk of ALS were also reported in Chinese population. The genetic features of ALS in Chinese population are significantly different from those in Caucasian population, indicating an association between genetic susceptibility and origin of population. Further explorations are required to understand the gene complexity of ALS, including the contribution of most minor genes and the molecular mechanisms in ALS pathologies. | Qianqian Wei Xueping Chen Yongping Chen Ruwei Ou Bei Cao Yanbing Hou Lingyu Zhang Hui-Fang Shang | 2019 | Science China(Life Sciences)2019，62，4： | 7 |
| 14 | Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed. | Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 7 |
| 15 | Relational pattern of urbanization and economic development:Parameter re-evaluation of the Chenery model显示文摘研究证明了在过去的 50 年在在都市化和经济开发之间的量的关系中有一个重要变化。由于这个变化, Chenery 模型不再能够执行这些参数的比较分析。我们根据 Chenery 模型执行了在都市化和经济开发之间的关系的正常表格的回归分析。我们从 1990 ~ 2009 从 149 个国家和区域使用了实验数据并且收养了双对数的模特儿,介绍为都市化的一个时间系列变量。从 1990 ~ 2009,与在美金 1000 和 10,000 之间留下的一项人均的粗野国家收入,都市化率从 17.78 ~ 60.36% 变化了,关系匹配数据因此变化了,尽管都市化的率的上面的限制在大约 75% 点留下了。在有一种更小的人口尺寸的国家的都市化是经济开发与大、中等的大小的人口在国家比都市化影响的更多。 | CHEN Mingxing TANG Zhipeng BAI Yongping ZHANG Xiaoping | 2015 | Journal of Geographical Sciences2015，25，8： | 7 |
| 16 | Numerical investigation on the cluster effect of an array of axial flow fans for air-cooled condensers in a power plant显示文摘The aerodynamic behavior of tens of axial flow fans incorporated with air-cooled condensers in a power plant is different from that of an individual fan.Investigation of the aerodynamic characteristics of axial flow fan array benefits its design optimization and running regulation.Based on a representative 2600 MW direct-dry cooling power plant,the flow rate of each fan and the overall flow rate of the fan array are obtained in the absence of ambient wind and at various wind speeds and directions,using CFD simulation.The cluster factor of each fan and the average cluster factor of the fan array are calculated and analyzed.Results show that the cluster factors are different from each other and that the cluster effect with ambient wind is significantly different from the cluster effect with no wind.The fan at the periphery of the array or upwind of the ambient wind generally has a small cluster factor.The average cluster factor of the array decreases with the increasing wind speeds and also varies widely with wind direction.The cluster effect of the axial flow fan array can be applied to optimize the design and operation of air-cooled condensers in a power plant. | YANG LiJun DU XiaoZe ZHANG Hui YANG YongPing | 2011 | Chinese Science Bulletin2011，56，21： | 6 |
| 17 | Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis显示文摘A preliminary clinical study by our group demonstrated Bushen Yisui Capsule(formerly called Erhuang Formula)in combination with conventional therapy is an effective prescription for the treatment of multiple sclerosis.However,its effect on axonal injury during early multiple sclerosis remains unclear.In this study,a MOG35–55-immunized C57BL/6 mouse model of experimental autoimmune encephalomyelitis was intragastrically administered Bushen Yisui Capsule.The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis.In addition,amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated.Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoimmune encephalomyelitis was mediated by amelioration of axonal damage and promotion of regeneration.But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction. | Ling Fang Qi Zheng Tao Yang Hui Zhao Qiuxia Zhang Kangning Li Li Zhou Haiyang Gong Yongping Fan Lei Wang | 2013 | Neural Regeneration Research2013，8，35： | 6 |
| 18 | INTERVENTIONAI DIAGNOSIS AND TREATMENT OF VASCULOGENEIC PULSATILE TINNITUS显示文摘Objective To retrospectively study clinical features and diagnostic imaging of vasculogeneic pulsatile tinnitus, and the feasibility and efficacy of transvascular interventional treatment for this condition. Methods Data from 82 cases of arterial or venous pulsatile tinnitus were reviewed. DSA characteristics and possible pathophysiological mechanisms of pulsatile tinnitus in these cases were studied. Diagnoses in this group included intracranial arterovenous fistula(AVF)(n=3), spontaneous skull base dural AVF(n=16), traumatic carotid-cavernous sinus fistula(n=5), subclavian artery stenosis(n=2), internal carotid artery stenosis(n=3), intracranial arterial stenosis(n=1), kinked and/or elongated vertebrobasilar artery(n=2), venous sinus diverticulum(n=2), venous sinus stenosis on the dominant drainage side(n=46) and occipital sinus stenosis(n=2).Treatments included embolization and stenting using coils, NBCA glue, Balt balloons, self-expansion stents and intracranial micro-stents via either the femoral artery or femoral vein. Results Procedures were successful in all cases with no surgery-related complications. Tinnitus disappeared within 2 days after the procedure in all cases. Follow up duration was 5-36 months. Recurrence occurred in 4 cases of arterial tinnitus within 3 months following the initial procedure, which improved after revision embolization or symptom management. There was no recurrence in venous tinnitus cases following stent plastic or stent-coiling embolization treatments. Conclusions Endovascular intervention provides a new approach to the diagnosis and treatment of intractable pulsatile tinnitus. It is also effective in differentiating and studying other types of tinnitus. | LI Baomin CAO Xiangyu LIU Xinfeng LI Sheng WANG Jun LIANG Yongping GE Aili ZHANG Alan FENG Huimin | 2014 | Journal of Otology2014，9，1： | 6 |
| 19 | Analysis on contact and flow features in CMP process显示文摘Contact pressure and flow features of chemical mechanical polishing/planarization (CMP) process were analyzed,taking advantage of the one-dimensional contact model of two layers and considering slurry flows. In this model,deformations of the bulk pad substrate and the asperities were considered. The deformations of the bulk pad sub- strate and the asperity layer,as well as the contact pressure and fluid pressure,were revealed with nu- merical methods. Numerical simulation results show a counterintuitive phenomenon: a diverging clear- ance is formed in the leading region of the wafer and thereby it gives rise to a suction pressure (subambi- ent pressure). A high stress concentration is pre- sented at the wafer edge and thereby over polishing can be introduced. The research provides some theoretical explanations for these two fundamental features of usual CMP processes. | ZHANG Chaohui LUO Jianbin LIU Jinquan DU Yongping | 2006 | Chinese Science Bulletin2006，51，18： | 5 |
| 20 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
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