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| 1 | Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury显示文摘In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury(SCI). Currently,however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation(SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations,classification, potential underlying etiology, and currentchallenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed. | Qian Huang Wanru Duan Eellan Sivanesan Shuguang Liu Fei Yang Zhiyong Chen Neil C.Ford Xueming Chen Yun Guan | 2019 | Neuroscience Bulletin2019，35，3： | 13 |
| 2 | Source apportionment of VOCs in a typical medium-sized city in North China Plain and implications on control policy显示文摘Characteristics of atmospheric VOCs(volatile organic compounds) have been extensively studied in megacities in China, however, they are scarcely investigated in medium/smallsized cities in North China Plain(NCP).A comprehensive research on possible sources of VOCs was conducted in a medium-sized city of NCP, from May to September 2019.A total of 143 canister samples of 8 sites in Xuchang city were collected, and 57 VOC species were detected.The average VOC concentrations were 42.6 ± 31.6 μg/m3, with 53.7 ± 31.0 μg/m3 and 32.1 ± 27.8 μg/m^(3), in the morning and afternoon, respectively.Alkenes and aromatics contributed 80% of the total ozone formation potential(OFP).Aromatics accounted for more than 95% of secondary organic aerosol potential(SOAP).VOCs were dominated by the local emission with significant transport from the southeast direction.PMF analysis extracted 6 sources, which were combustion(33.1%), LPG usage(19.3%), vehicular exhaust & fuel evaporation(15.8%), solvent usage(15.2%), industrial(9.11%) and biogenic(7.51%), respectively and they contributed 33.4%, 17.6%, 12.9%, 18.6%, 9.28% and 8.22% to the OFP, respectively.Combustion and LPG usage were the dominant VOC sources;and combustion, solvent usage and LPG usage were the main sources of OFP in Xuchang city, which were different to megacities in China with a high contribution from vehicular exhaust, solvent usage and industry,suggesting specific control strategies on VOCs need to be implemented in medium-sized city such as Xuchang city. | Juanjuan Qin Xiaobo Wang Yanrong Yang Yuanyuan Qin Shaoxuan Shi Peihua Xu Rongzhi Chen Xueming Zhou Jihua Tan Xinming Wang | 2021 | Journal of Environmental Sciences2021，33，9： | 6 |
| 3 | Effects of Tillage Management on Infiltration and Preferential Flow in a Black Soil, Northeast China显示文摘The impacts of no-tillage (NT) and moldboard plough (MP) managements on infiltration rate and preferential flow were characterized using a combined technique of double-ring device and dye tracer on a black soil (Mollisols) in Northeast China. The objective of this study is to evaluate how tillage practices enhance soil water infiltration and preferential flow in favor of soil erosion control in the study area. The steady infiltration rates under NT management are 1.6 and 2.1 times as high as those under MP management in the 6th and 8th years of the tillage management in place, while the infiltrated water amounts under NT management are 1.4 and 2.0 times as high as those under MP management, respectively. The depth of methylene blue penetrated into NT soil increases from 43cm in the 6th year to 57cm in the 8th year, which are 16cm and 19cm deeper than those in MP soil, respectively. The results of morphologic image show that more biological macro-pores occur in NT soil than in MP soil. These macro-pores play a key role in enhancing preferential flow in NT soil, which in turn promotes water infiltration through preferential pathways in NT soil. The results are helpful to policy-making in popularizing NT and have the implications for tillage management in regard to soil erosion control in black soil region of China. | FAN Ruqin ZHANG Xiaoping YANG Xueming LIANG Aizhen JIA Shuxia CHEN Xuewen | 2013 | Chinese Geographical Science2013，23，3： | 6 |
| 4 | DYNAMIC CHARACTERISTIC ANALY-SIS OF PRECISE LONG STROKE LINEAR MOTOR WITH AIR-BEARING IN OPTICAL LITHOGRAPHY显示文摘Dynamic characteristic is presented by identifying the model and the dynamic parameters of a precise long stroke linear motor (PLSLM) with the air-bearing in optical lithography.The PLSLM is supported by air-bearing on the stator,and is driven by on-board two large linear motors in a cross-configuration.Firstly,a model of the PLSLM is established by finite element method (FEM). Secondly,based on the model,the natural frequencies and model shapes are discussed.And the contribution of each active mode is evaluated by computing the modal participation factors (MPF), which indicates the major vibration direction.Furthermore,by the experimental modal analysis,the experimental results are in agreement with simulation results,which it is sure that the FEM is reasonable.What′s more,comparing with the effects on the frequency due to the air-bearing stiffness, the relations of the natural frequencies with the air-bearing stiffness are found.It is found that the frequency response curve is fluctuant with the air-bearing stiffness in each direction.Finally,it is conclusion that the natural frequency of the PLSLM is largely affected by the air-bearing stiffness variety.This research is contributed to the dynamic characteristics resulted from the air-bearing stiffness.Further work will include better optimization on the dynamic parameter in the controller design through the control algorithm for the precise long stroke motor. | CHEN Xuedong YU Xianzhong HE Xueming YAN Tianhong | 2008 | Chinese Journal of Mechanical Engineering2008，21，2： | 4 |
| 5 | Plasticity of language pathways in patients with low-grade glioma A diffusion tensor imaging study显示文摘Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively. | Gang Zheng Xiaolei Chen Bainan Xu Jiashu Zhang Xueming Lv Jinjiang Li Fangye Li Shen Hu Ting Zhang Ye Li | 2013 | Neural Regeneration Research2013，8，7： | 3 |
| 6 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 7 | Mechanism of chromatin remodeling revealed by the Snf2-nucleosome structure显示文摘Subject Code:C05With the support from the National Natural Science Foundation of China,a collaborative study by the research teams led by Chen Zhucheng(陈柱成)and Li Xueming(李雪明)at the School of Life Sciences,Tsinghua University,recently reported their work,titled“Mechanism of chromatin remodeling revealed | Chen Zhucheng (陈柱成) Li Xueming (李雪明) | 2017 | Science Foundation in China2017，25，3： | 2 |
| 8 | Intraoperative diffusion tensor imaging predicts the recovery of motor dysfunction after insular lesions显示文摘Insular lesions remain surgically challenging because of the need to balance aggressive resection and functional protection. Motor function deficits due to corticospinal tract injury are a common complication of surgery for lesions adjacent to the internal capsule and it is therefore essential to evaluate the corticospinal tract adjacent to the lesion. We used diffusion tensor imaging to evaluate the corticospinal tract in 89 patients with insular lobe lesions who underwent surgery in Chinese PLA General Hospital from February 2009 to May 2011. Postoperative motor function evaluation revealed that 57 patients had no changes in motor function, and 32 patients suffered motor dysfunction or aggravated motor dysfunction. Of the affected patients, 20 recovered motor function during the 6-12-month follow-up, and an additional 12 patients did not recover over more than 12 months of follow-up. Following reconstruction of the corticospinal tract, fractional anisotropy comparison demonstrated that preoperative, intraoperative and follow-up normalized fractional anisotropy in the stable group was higher than in the transient deficits group or the long-term deficits group. Compared with the transient deficits group, intraoperative normalized fractional anisotropy significantly decreased in the long-term deficits group. We conclude that intraoperative fractional anisotropy values of the corticospinal tracts can be used as a prognostic indicator of motor function outcome. | Jinjiang Li Xiaolei Chen Jiashu Zhang Gang Zheng Xueming Lv Fangye Li Shen Hu Ting Zhang Bainan Xu | 2013 | Neural Regeneration Research2013，8，15： | 2 |
| 9 | Boosted photoreduction of diluted CO_(2) through oxygen vacancy engineering in NiO nanoplatelets显示文摘Converting carbon dioxide(CO_(2))to diverse value-added products through photocatalysis can validly alleviate the critical issues of greenhouse effect and energy shortages simultaneously.In particular,based on practical considerations,exploring novel catalysts to achieve efficient photoreduction of diluted CO_(2) is necessary and urgent.However,this process is extremely challenging owing to the disturbance of competitive adsorption at low CO_(2) concentration.Herein,we delicately synthesize oxygen vacancy-laden NiO nanoplatelets(r-NiO)via calcination under Ar protection to reduce diluted CO_(2) through visible light irradiation(>400 nm)assisted by a Ru-based photosensitizer.Benefitting from the strongly CO_(2) adsorption energy of oxygen vacancies,which was confirmed by density functional calculations,the r-NiO catalysts exhibit higher activity and selectivity(6.28×10^(3)µmol·h^(−1)·g^(−1);82.11%)for diluted CO_(2)-to-CO conversion than that of the normal NiO(3.94×10^(3)µmol·h^(−1)·g^(−1);65.26%).Besides,the presence of oxygen vacancies can also promote the separation of electron-hole pairs.Our research demonstrates that oxygen vacancies could act as promising candidates for photocatalytic CO_(2) reduction,offering fundamental guidance for the actual photoreduction of diluted CO_(2) in the future. | Weiyi Chen Xueming Liu Bin Han Shujie Liang Hong Deng Zhang Lin | 2021 | Nano Research2021，14，3： | 2 |
| 10 | Epitaxy of rare earth element fluorcarbonate minerals from carbonatite dyke at Bayan Obo, Inner Mongolia, China显示文摘Rare earth element fluorocarbonate minerals such as bastnaesite and parisite are firstly discovered in carbonatite dykes from Bayan Obo, Inner Mongolia, China. Bastnaesite rarely occurs as homogeneously single crystal, but contains microfine phase of parisite. They form regular intergrowth along (0001) plane net, which is identified as epitaxy. This eptactic texture results from the variation of chemical composition of crystallizing agents of those minerals that crystallize directly from carbonatite magma. | Xueming Yang Peishan Zhang Kejie Tao Xiaoyong Yang Shuangxi Chen Minglong Zou M. J. Le Bas R. N. Wilson R. Ranson L. S. Campbell et al. | 1998 | Chinese Science Bulletin1998，43，13： | 2 |
| 11 | Tracing the location of powdery mildew resistance-related gene Stpk-V by FISH with a TAC clone in Triticum aestivum–Haynaldia villosa alien chromosome lines显示文摘Bacterial artificial chromosomes(BACs)or yeast artificial chromosomes(YACs)containing large inserts as probes for fluorescence in situ hybridization(FISH)have been used in the physical mapping of specific DNA sequences,especially for single-or low-copy sequences.Our earlier study identified Stpk-V,a powdery mildew resistance-related gene located on the 6VS chromosome arm of the wild grass Haynaldia villosa(tribe Triticeae),and obtained several Triticum aestivum–H.villosa alien chromosome lines carrying the Stpk-V gene.However,the precise physical location of the Stpk-V gene on chromosome 6VS is not known.In this study,we used TAC-FISH with TAC15 as the probe coupled with sequential genomic in situ hybridization(GISH)to determine the physical location of the Stpk-V gene in different T.aestivum–H.villosa 6V alien chromosome lines,including addition,substitution and translocation lines.The result indicated that the fraction length of the Stpk-V locus is 0.575±0.035 on the 6V chromosome short arm and this was confirmed by FISH using TAC15 as the probe for tracing the Stpk-V gene in other genetic stocks.The cytological mapping strategies used in this study will be of benefit for tracing the alien gene location in the course of introducing desirable traits from wild species. | YANG XueMing CAO AiZhong SUN YuLei CHEN PeiDu | 2013 | Chinese Science Bulletin2013，58，33： | 2 |
| 12 | Silencing myostatin gene by RNAi in sheep embryos显示文摘 | Dayun Tang Huabin Zhu Jianmin Wu Hanzhong Chen Yan Zhang Xueming Zhao Xiaoliang Chen Weihua Du Dong Wang Xiukun Lin | 2012 | Journal of Biotechnology2012，，3： | 2 |
| 13 | Separation of pollutants from restaurant wastewater by electrocoagulation 显示文摘 | Chen Xueming Chen Guohua Yue P L | 2000 | Separation Purification Technology2000，19，12： | 1 |
| 14 | In vitro srudy on the cloning and transduction of human O6-methylguanine-DNA methylt ransferase cDNA into human umbilical cord blood CD34+cells显示文摘 | Jishi Wang Zixing Chen Xueming Xia | 2000 | Chinese Journa l of Cancer Research2000，，12： | 1 |
| 15 | Improvement of combina tion chemotherapy tolerance by introduction of polycistronic retroviral vector d rug resistance genes MGMT and MDR1 into human umbilical cord blood CD34+ cells 显示文摘 | Jishi Wang Zixing Chen Xueming Xia | 2002 | Leukemia Research2002，26，： | 1 |
| 16 | Variable effects on the performance of continuous electrodeionization for the removal of Cr(Ⅵ)from wastewater 显示文摘 | XING Yunqing CHEN Xueming | 2009 | Separation and Purification Technology2009，68，3： | 1 |
| 17 | Capacitive properties of PANI/MnO 2 synthesized via simultaneous-oxidation route显示文摘 | Jie Zhang Dong Shu Tianren Zhang Hongyu Chen Haimin Zhao Yongsheng Wang Zhenjie Sun Shaoqing Tang Xueming Fang Xiufang Cao | 2012 | Journal of Alloys and Compounds2012，，： | 1 |
| 18 | Removal of chromium (Ⅵ) from wastewater by combined electrocoagulation electroflotation without a filter 显示文摘 | Gao Ping Chen Xueming Shen Feng | 2005 | Separation and Purification Technology2005，4，3： | 1 |
| 19 | Electrochemical removal of fluoride ions from industrial wastewater显示文摘 | Shen Feng Chen Xueming Gao Ping | 2003 | Chemical Engineering Science2003，58，3456： | 1 |
| 20 | Electrochemical removal of fluoride ions from industrial wastewater 显示文摘 | Shen Feng Chen Xueming Gao Ping | 2003 | Chemical Engineering Science2003，58，36： | 1 |
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