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| 1 | Safety and Efficacy of Physical Thermal Ablation Combined Sorafenib for Hepatocellular Carcinoma:A Meta-analysis显示文摘Background and Aims:To compare the efficacy and safety of physical thermal ablation(PTA),including radiofrequency ablation(RFA)and microwave ablation(MWA),combined with sorafenib and physical thermal ablation alone for the control and treatment of hepatocellular carcinoma(HCC)according to the available literature.Methods:Comprehensive searches were performed on PubMed,Embase,CNKI,the Cochrane Library,China Biomedical Literature Database(known as CBM),Weipu Journal,and Wanfang Database.Meta-analysis was performed using Revman 5.3 software.Results:A total of 15 studies,consisting of 2,227 HCC patients,were selected and included in this meta-analysis.Compared with the RFA-alone group,the patients in the RFA+sorafenib group had longer 1-,2-,and 3-year overall survival(all p<0.05),better overall efficacy(p<0.0001),longer radiofrequency interval(p<0.001),and lower 2-year recurrence rate(p=0.02).The 1-year overall survival(p=0.003)and overall efficacy(p=0.002)of the MWA+sorafenib group were also higher than those of the MWA-alone group.The incidences of adverse reactions in the RFA+sorafenib group,such as hand-foot skin reactions(p<0.001),diarrhea and constipation(p=0.0001),hypertension(p=0.009),and alopecia(p<0.001),were significantly higher than those in the RFA-alone group.Conclusions:RFA or MWA combined with sorafenib has produced a better therapeutic effect on HCC than physical thermal ablation alone;however,adverse reactions have been obvious.It is necessary to evaluate the safety of combination therapy,and pay close attention to the adverse reactions that develop in patients. | Mengdi Jin Qiong Yu Yahui Liu Weiling Xu Xueqi Fu Bai Ji | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 6 |
| 2 | SOD1^(G93A) Induces a Unique PSAP-Dependent Mitochondrial Apoptosis Pathway via Bax-Bak Interaction显示文摘Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly understood.The B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS development.The death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6.Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced apoptosis.In this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in vitro.The data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax translocation.PSAP,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction. | HAN NIU XIN CHEN XUEQI FU JINGTIAN ZHANG GUODONG LI YUXIANG WANG JIAYUE SONG XUETING MA CHEN HU XUEMIN XU FUQIANG ZHANG LINLIN ZENG | 2021 | BIOCELL2021，45，4： | 2 |
| 3 | Simultaneous nitrification and denitrification by aerobic granular sludge membrane bioreactor for high concentration ammonium nitrogen wastewater显示文摘 | Rui CHEN Xiaoli WANG Yonggang ZHANG Xueqi FU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 2 |
| 4 | Occurrence of endocrine-disrupting compounds in reclaimed water from Tianjin, China显示文摘 | Yuqiu Wang Wei Hu Zhonghong Cao Xueqi Fu Tan Zhu | 2005 | Analytical and Bioanalytical Chemistry2005，，5： | 1 |
| 5 | Occurrence of endocrine-disrupting compounds in reclaimed water from Tianjin, China显示文摘 | Yuqiu Wang Wei Hu Zhonghong Cao Xueqi Fu Tan Zhu | 2005 | Analytical and Bioanalytical Chemistry2005，，5： | 1 |
| 6 | Quantitation of yeast ceramides using high performance liquid chromatography-evaporative light-scattering detection显示文摘 | ZHOU Quan ZHANG Lin FU Xueqi | 2002 | J Chromatogr B Analyt Technol Biomed Life Sci2002，780，1： | 1 |
| 7 | Effect of so lution chemistry on membrane resistance and flux decline显示文摘 | Li Xiufen Fu Xueqi | 2002 | Filtration &Separation2002，10，39： | 1 |
| 8 | Exploration of Zinc(II)Complexes as Potent Inhibitors Against Protein Tyrosine Phosphatase IB显示文摘Although protein tyrosine phosphatases(PTPs)do not contain any metals,their activities can be inhibited by some metal complexes.Here we investigated the inhibition of two zinc complexes with Schiff base ligands against PTPs activity to explore their effect on the cellular metabolism.It has been found that they are potent inhibitors against four recombinant PIPs5 including protein tyrosine phosphatase 1B(PTP1B),T cell protein tyrosine phosphatase(TCPTP),megakaryocyte protein tyrosine phosphatase 2(PTP-MEG2)S and Src-homology phosphatase 1(SHP-1),with exception of Src-homology phosphatase 2(SHP-2).Moreover,tlaey showed moderate selective inhibition against PTP1B with the IG50 values of 0.15 and 0.36μmol/L.Meanwhile,the complexes also inhibited cellular phosphatase activities efficiently.Comparing the inhibitory potency over PTPs mediated by the zinc ion,we found that zinc complexes might be easily developed into potent and selective inhibitors against certain PTP by rationally modifying the organic ligands moieties. | LI Xinhua YUAN Caixia LU Liping ZHU Miaoli XING Shu FU Xueqi | 2019 | Chemical Research in Chinese Universities2019，35，2： | 1 |
| 9 | Simulation investigations on the marble deterioration by sulphur dioxide显示文摘This paper deals with investigations on corrosion of marble SO2. We have simulated oxidation of SO2 by photochemical process in the atmosphere. The experiments indicate that formation of SO3 aerosols is related to the concentration of SO2, the UV light intensity, the time of irradiation and the humidity of the air. The corrosion feature of surfaces of the marble and the depth profiles of sulphur were obtained by SEM (Scanning electron microscope), EDXA (Energy-dispersive X-ray analyzer) and SIMS (Secondary ion mass spectrometer). The results of experiments show the corrosive extent of marble depends on its compositions and microareas of marble, which contain lower silicon content can be easily corroded by SO2. | Gan Weitang, Dai Shugui, Liu Youying, Liu Zhaomeng, Zhang Qingmin,Zhou Xingdi, Su Shengpei, Liu Xiao, Zhu RuiZhi,Fu Xueqi and R. J. ChengDepartment of Chemistry,Nankai University,Tianjin 300071,ChinaAtmospheric Science Ressarch Center,State University of New York,Albany,N.Y.12222,USA | 1991 | Journal of Environmental Sciences1991，3，1： | 0 |
| 10 | Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease显示文摘Exosomes are extracellular vesicles with a 30–150 nm diameter originating from endosomes.In recent years,scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease(AD)across the blood-brain barrier due to their nanoscale size and low immunogenicity.A large amount of evidence shows that exosomes are rich in biomarkers,and it has been found that the changes in biomarker content in blood,cerebrospinal fluid,and urine are often associated with the onset of AD patients.In this paper,some recent advances in the use of exosomes in the treatment of AD are reviewed,and various exosome markers and some latest detection methods are summarized to provide some evidence for the detection or treatment of AD by exosomes. | XIANGYU QUAN XUETING MA GUODONG LI XUEQI FU JIANGTAO LI LINLIN ZENG | 2023 | BIOCELL2023，47，10： | 0 |
| 11 | Loss of tyrosine phosphatase SHP2 activity promotes growth of colorectal carcinoma HCT-116 cells显示文摘Dear Editor,Tyrosine phosphatase SHP2/PTPN11 plays an important role in cell signaling.Activation mutation of SHP2 causes cancer,which makes the enzyme an anti-cancer drug target.Several selective and potent SHP2 inhibitors have been discovered.SHP099,the best known SHP2 inhibitor currently in clinical trials,has been shown to be effective for receptor tyrosine kinase-driven and oncogenic KRAS-driven cancers1,2.We employed a colorectal cancer cell line HCT-116 that carries a KRAS-G13D mutation in this study.Interestingly,SHP2 inhibitors failed to inhibit HCT-116 growth and ERK1/2 activation but in contrast had the opposite effect.We then generated SHP2 knockout cells by using the CRISPR technique and provided further evidence that loss of SHP2 activity promotes growth of HCT-116 cells in vitro and in vivo.Our study suggests that targeting SHP2 may have adverse effects on certain cancers,which may have major implications for further development of anti-cancer drugs targeting SHP2. | Xin Chen Xueqi Fu Wanke Zhao Wan-Ting Tina Ho Shu Xing Zhizhuang Joe Zhao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 12 | Application of membrane technology for water treatment: Ultrasound-associated cleaning of fouled microfiltration membranes显示文摘 | Rui CHEN Xiaoli WANG Yonggang ZHANG Xueqi FU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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