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| 1 | Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer显示文摘因为高发生和高死亡,肺癌症是在中国的最致命的癌症之一。Cyclooxygenase-2 (COX-2 ) 和容器 endothelial 生长因素 C (VEGF-C ) 被发现在恶意的肿瘤的 lymphangiogenesis 起一个重要作用。在这研究,我们调查了淋巴的 microvessel 密度(LMVD ) 是否与在非小的房间肺癌症(NSCLC ) 的预后有关是 COX-2 和 VEGF-C 的病人,和表情以便在 NSCLC lymphangiogenesis 决定 COX-2 和 VEGF-C 的可能的角色。嵌入的织物 NSCLC 取样的 65 修理福尔马林的石蜡被染色的 immunohistochemical 为 COX-2 和 VEGF-C 评估。估计肿瘤 lymphangiogenesis, LMVD 被 immunohistochemical 染色 VEGFR-3 polyclonal 决定抗体。在 COX-2 和 VEGF-C 表示, LMVD,和 clinicopathologic 参数之中的关系被分析。在 65 件样品之中,高 LMVD 显著地与淋巴节点转移和差的幸存被联系。Multivariate 幸存分析证明那 LMVD 价值和淋巴节点转移是独立预示的因素。COX-2 和 VEGF-C 的表示水平比邻近的纸巾的那些显著地高。在 NSCLC 的 COX-2 和 VEGF-C 表情显著地与淋巴节点转移,然而并非与耐心的性,年龄,肿瘤尺寸,或肿瘤相关,节点,转移分类舞台。COX-2- 或 VEGF-C-positive 肿瘤的吝啬的 LMVD 价值比 COX-2- 或 VEGF-C-negative 肿瘤的高。重要关联在 COX-2 和 VEGF-C 的表情之间被发现。这研究建议 LMVD 可以是为 NSCLC 病人的重要预示的因素之一。VEGF-C 可能在 COX-2 lymphangiogenic 小径起一个重要作用。COX-2 和 VEGF-C 可以由刺激 lymphangiogenesis 在肿瘤前进起一个重要作用。lymphangiogenesis, COX-2,或 VEGF-C 活动的抑制可以在 NSCLC 的控制有一个重要治疗学的好处。 | Xufeng Guo Yongbing Chen Zhonghua Xu Zhonghen Xu Yongyue Qian Xueyan Yu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 34 |
| 2 | Exosome-functionalized magnesium-organic framework-based scaffoldswith osteogenic, angiogenic and anti-inflammatory properties foraccelerated bone regeneration显示文摘Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown potential as an effectivetherapeutic tool for repairing bone defects. Although metal-organic framework (MOF) scaffolds are promisingstrategies for bone tissue regeneration, their potential use for exosome loading remains unexplored. In this study,motivated by the potential advantages of hADSCs-Exos and Mg-GA MOF, we designed and synthesized anexosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, taking using of thebenefits of hADSCs-Exos, Mg2+, and gallic acid (GA) to construct unique nanostructural interfaces to enhanceosteogenic, angiogenic and anti-inflammatory capabilities simultaneously. Our in vitro work demonstrated thebeneficial effects of PLGA/Exo-Mg-GA MOF composite scaffolds on the osteogenic effects in human bonemarrow-derived mesenchymal stem cells (hBMSCs) and angiogenic effects in human umbilical endothelial cells(HUVECs). Slowly released hADSCs-Exos from composite scaffolds were phagocytosed by co-cultured cells,stabilized the bone graft environment, ensured blood supply, promoted osteogenic differentiation, and acceleratedbone reconstruction. Furthermore, our in vivo experiments with rat calvarial defect model showed thatPLGA/Exo-Mg-GA MOF scaffolds promoted new bone formation and satisfactory osseointegration. Overall, weprovide valuable new insights for designing exosome-coated nanocomposite scaffolds with enhanced osteogenesisproperty. | Yue Kang Chang Xu Ling’ao Meng Xufeng Dong Min Qi Daqing Jiang | 2022 | Bioactive Materials2022，7，12： | 11 |
| 3 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 4 | A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells显示文摘Breast cancer is one of the most malignant tumors and is associated with high mortality rates among women.Lycium barbarum polysaccharide(LBP)is an extract from the fruits of the traditional Chinese herb,L.barbarum.LBP is a promising anticancer drug,due to its high activity and low toxicity.Although it has anticancer properties,its mechanisms of action have not been fully established.Ferroptosis,which is a novel anticancer strategy,is a cell death mechanism that relies on iron-dependent lipid reactive oxygen species(ROS)accumulation.In this study,human breast cancer cells(Michigan Cancer Foundation-7(MCF-7)and MD Anderson-Metastatic Breast-231(MDA-MB-231))were treated with LBP.LBP inhibited their viability and proliferation in association with high levels of ferroptosis.Therefore,we aimed to ascertain whether LBP reduced cell viability through ferroptosis.We found that the structure and function of mitochondria,lipid peroxidation,and expression of solute carrier family 7 member 11(SLC7 A11,also known as x CT,the light-chain subunit of cystine/glutamate antiporter system X_(c)^(-))and glutathione peroxidase 4(GPX4)were altered by LBP.Moreover,the ferroptosis inhibitor,Ferrostatin-1(Fer-1),rescued LBP-induced ferroptosis-associated events including reduced cell viability and glutathione(GSH)production,accumulation of intracellular free divalent iron ions and malondialdehyde(MDA),and down-regulation of the expression of x CT and GPX4.Erastin(x CT inhibitor)and RSL3(GPX4 inhibitor)inhibited the expression of x CT and GPX4,respectively,which was lower after the co-treatment of LBP with Erastin and RSL3.These results suggest that LBP effectively prevents breast cancer cell proliferation and promotes ferroptosis via the x CT/GPX4 pathway.Therefore,LBP exhibits novel anticancer properties by triggering ferroptosis,and may be a potential therapeutic option for breast cancer. | Xing DU Jingjing ZHANG Ling LIU Bo XU Hang HAN Wenjie DAI Xiuying PEI Xufeng FU Shaozhang HOU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 10 |
| 5 | Potential and Suitability Evaluation of CO_2 Geological Storage in Major Sedimentary Basins of China,and the Demonstration Project in Ordos Basin显示文摘From 2010 to 2012, the China Geological Survey Center for Hydrogeology and Environmental Geology Survey(CHEGS) carried out the project 'Potential evaluation and demonstration project of CO2 Geological Storage in China'. During this project, we developed an evaluation index system and technical methods for the potential and suitability of CO2 geological storage based on China's geological conditions, and evaluated the potential and suitability of the primary basins for CO2 geological storage, in order to draw a series of regional scale maps(at a scale of 1:5000000) and develop an atlas of the main sedimentary basins in China. By using these tools, we delineated many potential targets for CO2 storage. We also built techniques and methods for site selection and the exploration and assessment of CO2 geological storage in deep saline aquifers. Furthermore, through cooperation with the China Shenhua Coal to Liquid and Chemical Co., Ltd., we successfully constructed the first coal-based demonstration project for CO2 geological storage in deep saline aquifers in the Yijinhuoluo Banner of Ordos in the Inner Mongolia Autonomous Region, which brought about the basic preliminary theories, techniques, and methods of geological CO2 storage in deep saline aquifers under China's geological conditions. | GUO Jianqiang WEN Dongguang ZHANG Senqi XU Tianfu LI Xufeng DIAO Yujie JIA Xiaofeng | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 8 |
| 6 | Genome-wide Analysis of Transcriptional Variability in a Large Maize-Teosinte Population显示文摘基因表示规定在控制植物显型和改编起一个重要作用。这里,我们报导对通过 transcriptome 的基因表示变化的一个全面评价大 maize-teosinte 分析试验性的人口。染色体宽的印射识别了 25 ? 660 表示为 17 的量的特点 loci (eQTL )? 311 基因,捕获表示变化的一个崭新的范围。我们发现本地 eQTL 更经常被印射到邻近的基因,显示表示 piggybacking 的一个模式,它因而创造了共同调整的基因簇。在共同调整的基因簇以内的基因趋于有相关功能和分享的染色质修正。远 eQTL 与他们显著地在特定的功能的范畴充实的目标形成了 125 个重要远 eQTL 热点。由集成信息的不同来源,我们为许多新陈代谢的小径识别了通常认为的 trans- 管理者。我们证明 bHLH 抄写因素 R1 和 hexokinase HEX9 可能分别地为 flavonoid 生合成和 glycolysis 充当关键管理者。而且,我们证明驯服或改进显著地影响了全球基因表示,与选择指向的许多基因。特别兴趣,为生合成可能经历了的 benzoxazinoid 的 Bx 基因协调了在玉米和 teosinte 之间的 cis 规章的分叉,并且当玉米与一个不同草食动物社区传播了进适度的环境,使 Bx12 失去活性的 transposon 插入在强壮的选择下面。 | Xufeng Wang Qiuyue Chen Yaoyao Wu Zachary H. Lemmon Guanghui Xu Cheng Huang Yameng Liang Dingyi Xu Dan Li John F. Doebley Feng Tian | 2018 | Molecular Plant2018，11，3： | 7 |
| 7 | Scalable microfabrication of three-dimensional porous interconnected graphene scaffolds with carbon spheres for high-performance all carbon-based micro-supercapacitors显示文摘As one of the most important micro energy storage devices(MESDs),graphene-based micro-supercapacitors(G-MSCs)possess the advantages of excellent flexibility,long cycle life,affordability and high reliability.In most cases,constructing three-dimensional(3D)graphene networks is widely utilized to promote the permeation of electrolyte and enhance the utilization of active materials.In this work,conventional freeze-drying process is utilized in the fabrication of G-MSCs to constitute 3D interconnected networks micro-electrodes,and further by regulating the composition of inks,carbon spheres(CSs)at different mass loadings are introduced into the graphene scaffolds to further increase the active sites of the micro-electrodes.The fabricated all carbon-based MSC with the optimal mass loading of CSs(0.406 mg cm^(-2))exhibits a high specific areal capacitance of 17.01mF cm^(-2)at the scan rate of 10mV s^(-1)and a capacitance retention of 93.14%after 10000 cycles at the scan rate of 500 mV s^(-1).The proposed microfabrication process is facile and fully compatible with modern microtechnologies and will be highly suitable for large-scale production and integration. | Yiming Chen Minghao Guo Liang He Wei Yang Lin Xu Jiashen Meng Xiaocong Tian Xinyu Ma Qiang Yu Kaichun Yang Xufeng Hong Liqiang Mai | 2019 | Journal of Materiomics2019，5，2： | 6 |
| 8 | Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation显示文摘大多数前列腺癌症(PCas ) 作为 acinar 类型被分类(常规) 有包括雄激素受体(AR ) 和前列腺特定的抗原(PSA ) 的表示的钠区别的肿瘤房间镇静的腺癌。在腺癌的每种情况中有也散布的 neuroendocrine (NE ) 房间。NE 房间是 quiesecent,不表示 AR 或 PSA,并且他们的功能仍然保持不清楚。我们证明了那条 IL8-CXCR2-P53 小径提供一个生长禁止的信号并且把 NE 房间放在良性的前列腺和腺癌静止。有趣地,在神经质的治疗,和如此的肿瘤由是的纯 NE 房间组成以后,有腺癌的历史的一些病人与小房间 neuroendocrine 癌(SCNC ) 复发高度 proliferative 并且好攻击,由于 P53 变化和 IL8-CXCR2-P53 小径的 inactivation。SCNC 的发生将多半由于进一步禁止 AR 功能或 intratumoral 雄激素合成的新奇的药的普遍使用增加。阶段 II 试用证明了基于铂的化疗可能为如此的导致治疗的肿瘤是有用的。 | Julia Lipianskaya Alexa Cohen Clark J Chen Elaine Hsia Jill Squires Zhen Li Yaqun Zhang Wei Li Xufeng Chen Hua Xu Jiaoti Huang | 2014 | Asian Journal of Andrology2014，16，4： | 6 |
| 9 | Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model显示文摘Chaperone-mediated autophagy(CMA)is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases.However,the mechanisms that regulate CMA are not fully understood.Here,using unbiased drug screening approaches,we discover Metformin,a drug that is commonly the first medication prescribed for type 2 diabetes,can induce CMA.We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA,Hsc70,and its activation.Notably,we find that amyloid-beta precursor protein(APP)is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent manner.The inhibition of CMA-mediated degradation of APP enhances its cytotoxicity.Importantly,we find that in the APP/PS1 mouse model of Alzheimer's disease(AD),activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβplaque levels and reverses the molecular and behavioral AD phenotypes.Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases,such as AD,where such therapeutic intervention could be beneficial. | Xiaoyan Xu Yaqin Sun Xufeng Cen Bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng Zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia | 2021 | Protein & Cell2021，12，10： | 5 |
| 10 | Partial cooperative spectrum sensing schedule in cognitive network显示文摘Cognitive radio has emerged as a promising technology for maximizing the utilization efficiency of the limited spectrum resources while accommodating the increasing amount of services and applications in wireless networks. One of the most important and critical components of the cognitive radio is spectrum sensing and accordingly, detection of primary users. Considering the hardware constraints existing in cognitive devices, based on the coarse estimation of channel occupancy, partial cooperative spectrum sensing with adaptive spectrum schedule scheme is proposed to increase the possibility to discover more spectrum opportunities promptly. Simulation results show the gain of sensing performance and the energy-saving feature of partial spectrum sensing. Special security scheme is designed to protect the reliability of sensing result from the false message attack. For the scenarios tested, the proposed scheme is shown to increase opportunities by up to 15 percent. | XU FangMin ZHENG XuFeng LI XiaoQiang ZHOU Zheng | 2009 | Science in China(Series F)2009，52，12： | 5 |
| 11 | In vitro immunomodulation of magnesium on monocytic cell toward anti-inflammatory macrophages显示文摘Biodegradable magnesium(Mg)has shown great potential advantages over current bone fixation devices and vascular scaffold technologies;however,there are few reports on the immunomodulation of corrosive Mg products,the micron-sized Mg particles(MgMPs).Human monocytic leukemia cell line THP-1 was set as the in vitro cell model to estimate the immunomodulation of MgMPs on cell proliferation,apoptosis,polarization and inflammatory reaction.Our results indicated highconcentration of Mg^2+ demoted the proliferation of the THP-1 cells and,especially,THP-1-derived macrophages,which was a potential factor that could affect cell function,but meanwhile,cell apoptosis was almost not affected by Mg^2+.In particular,the inflammation regulatory effects of MgMPs were investigated.Macrophages exposed to Mg^2+ exhibited down-regulated expressions of M1 subtype markers and secretions of pro-inflammatory cytokines,up-regulated expression of M2 subtype marker and secretion of anti-inflammatory cytokine.These results indicated Mg^2+ could convert macrophages from M0 to M2 phenotype,and the bioeffects of MgMPs on human inflammatory cells were most likely due to the Mg^2+-induced NF-jB activation reduction.Together,our results proved Mg^2+ could be used as a new anti-inflammatory agent to suppress inflammation in clinical applications,which may provide new ideas for studying the immunomodulation of Mg-based implants on human immune system. | Lei Sun Xiaoyu Li Menghan Xu Fenghe Yang Wei Wang Xufeng Niu | 2020 | Regenerative Biomaterials2020，7，4： | 3 |
| 12 | Rare earth elements and yttrium in ferromanganese deposits from the South China Sea:distribution,composition and resource considerations显示文摘Ferromanganese nodules and crusts contain relatively high concentration of rare earth elements(REE) and yttrium(REY),with a growing interest in exploitation as an alternative to land-based REY resources.On the basis of comprehensive geochemical approach,the abundance and distribution of REY in the ferromanganese nodules from the South China Sea are analyzed.The results indicate that the REY contents in ferromanganese deposits show a clear geographic regularity.Total REY contents range from 69.1×10^(–6) to 2 919.4×10^(–6),with an average value of 1 459.5×10^(–6).Especially,the enrichment rate of Ce content is high,accounting for almost 60% of the total REY.This REE enrichment is controlled mainly by the sorption of ferromanganese oxides and clay minerals in the nodules and crusts.Moreover,the total REY are higher in ferromanganese deposits of hydrogenous origin than of diagenetic origin.Finally,Light REE(LREE) and heavy REE(HREE) oxides of the ferromanganese deposits in the study area can be classified into four grades: non-enriched type,weakly enriched type,enriched type,and extremely enriched type.According to the classification criteria of rare earth resources,the Xisha and Zhongsha platform-central deep basin areas show a great potential for these rare earth metals. | ZHONG Yi CHEN Zhong GONZALEZ Francisco Javier ZHENG Xufeng LI Gang LUO Yun MO Aibin XU Antao WANG Shuhong | 2018 | Acta Oceanologica Sinica2018，37，7： | 3 |
| 13 | Glossy15 Plays an Important Role in the Divergence of the Vegetative Transition between Maize and Its Progenitor, Teosinte显示文摘 | Dingyi Xu Xufeng Wang Cheng Huang Guanghui Xu Yameng Liang Qiuyue Chen Chenglong Wang Dan Li Jinge Tian Lishuan Wu Yaoyao Wu Li Guo Xuehan Wang Weihao Wu Weiqiang Zhang Xiaohong Yang Feng Tian | 2017 | Molecular Plant2017，10，12： | 3 |
| 14 | A novel technique for automatic seismic data processing using both integral and local feature of seismograms显示文摘A novel technique for automatic seismic data processing using both integral and local feature of seismograms was presented in this paper.Here,the term integral feature of seismograms refers to feature which may depict the shape of the whole seismograms.However,unlike some previous efforts which completely abandon the DIAL approach,i.e.,signal detection,phase identification,association,and event localization,and seek to use envelope cross-correlation to detect seismic events directly,our technique keeps following the DIAL approach,but in addition to detect signals corresponding to individual seismic phases,it also detects continuous wave-trains and explores their feature for phase-type identification and signal association.More concrete ideas about how to define wave-trains and combine them with various detections,as well as how to measure and utilize their feature in the seismic data processing were expatiated in the paper.This approach has been applied to the routine data processing by us for years,and test results for a 16 days' period using data from the Xinjiang seismic station network were presented.The automatic processing results have fairly low false and missed event rate simultaneously,showing that the new technique has good application prospects for improvement of the automatic seismic data processing. | Ping Jin Chengliu Zhang Xufeng Shen Hongchun Wang Changzhou Pan Na Lu Xiong Xu | 2014 | Earthquake Science2014，27，3： | 3 |
| 15 | Thermal and luminescent properties of 2 μm emission in thulium-sensitized holmium-doped silicate-germanate glass显示文摘In this paper, we present the luminescent properties of Tm^(3+)∕Ho^(3+)co-doped new glass. A series of silicategermanate glass was prepared by the conventional melt-quenching method. In the Tm^(3+)∕Ho^(3+)co-doped silicategermanate glass, a strong emission of 2 μm originating from the Ho^(3+):~5I_7→~5I_8transition can be observed under conventional 808 nm pumping. The characteristic temperatures, structure, and absorption spectra have been measured. The radiative properties of Ho^(3+)in the prepared glass were calculated. The emission cross section of Ho^(3+)ions transition can reach 4.78 × 10^(-21)cm^2 around 2 μm, and the FWHM is as high as 153 nm. The energy transfer efficiency between Ho^(3+)and Tm^(3+)has a large value(52%), which indicates the Tm^(3+)∕Ho^(3+)co-doped silicategermanate glass is a suitable candidate for the 2 μm laser. Moreover, the energy transfer mechanism between Tm^(3+)and Ho^(3+)ions was investigated. | Rong Chen Ying Tian Bingpeng Li Xufeng Jing Junjie Zhang Shiqing Xu Hellmut Eckert Xianghua Zhang | 2016 | Photonics Research2016，4，6： | 2 |
| 16 | A proteomic analysis of Bcl-2 regulation of cell cycle arrest:insight into the mechanisms显示文摘B cell lymphoma 2(Bcl-2)is an important antiapoptotic gene that plays a dual role in the maintenance of the dynamic balance between the survival and death of cancer cells.In our previous study,Bcl-2 was shown to delay the G0/G1 to S phase entry by regulating the mitochondrial metabolic pathways to produce lower levels of adenosine triphosphate(ATP)and reactive oxygen species(ROS).However,the detailed molecular mechanisms or pathways by which Bcl-2 regulates the cell cycle remain unknown.Here,we compared the effects of Bcl-2 overexpression with an empty vector control in the NIH3T3 cell line synchronized by serum starvation,and evaluated the effects using proteomic analysis.The effect of Bcl-2 on cell cycle regulation was detected by monitoring Bcl-2 and p27 expression.The result of subsequent proteomic analysis of Bcl-2 overexpressing cells identified 169 upregulated and 120 downregulated proteins with a 1.5-fold change.These differentially expressed proteins were enriched in a number of signaling pathways predominantly involving the ribosome and oxidative phosphorylation,according to the data of Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses.These results indicated that Bcl-2 potentially acts at the translation level to influence proteins or enzymes of the respiratory chain or in the ribosome,and thereby regulates the cell cycle.Additionally,differentially expressed proteins involved in oxidative phosphorylation were determined to account for most of the effects of Bcl-2 on the cell cycle mediated by the mitochondrial pathway investigated in our previous study.These results can provide assistance for additional in-depth studies on the regulation of the cell cycle by Bcl-2.The results of the proteomic analysis determined the mechanism of Bcl-2-dependent delay of the cell cycle progression.In summary,the results of this study provide a novel mechanistic basis for identifying the key proteins or pathways for designing and developing precisely targeted cancer drugs. | Xing DU Jingjing XIAO Xufeng FU Bo XU Hang HAN Yin WANG Xiuying PEI | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，10： | 2 |
| 17 | Enhanced perovskite electronic properties via A-site cation engineering显示文摘Organic-inorganic halide perovskites have emerged as excellent candidates for low-cost photovoltaics and optoelectronics.While the predominant recent trend in designing perovskites for efficient and stable solar cells has been to mix different A-site cations,the role of A-site cations is still limited to tune the lattice and bandgap of perovskites.Herein we compare the optoelectronic properties of acetamidinum(Ace)and guanidinium(Gua)mixed methylammonium lead iodide perovskites and shed a light on the hidden role of A-site cation on the carrier mobility of mixed-cation lead iodide perovskites.The cations do not affect the bandgap of the perovskites since the orbitals from Ace and Gua do not contribute to the band edges of the material.However,the mobility of the Ace mixed perovskite is significantly enhanced to be an order of magnitude higher than that of the pristine perovskite.We apply the Ace mixed perovskite in hole-conductor-free printable mesoscopic perovskite solar cells and obtain a stabilized PCE of over 18%(certified 17.7%),which is the highest certified efficiency so far. | Xufeng Xiao Yanmeng Chu Chunyu Zhang Zhihui Zhang Zexiong Qiu Cheng Qiu Huaixing Wang Anyi Mei Yaoguang Rong Gengzhao Xu Yue Hu Hongwei Han | 2021 | Fundamental Research2021，1，4： | 2 |
| 18 | Preparation and properties of hollow fibre nanofiltration membrane with continuous coffee-ring structure显示文摘Polyamide(PA)hollow fibre composite nanofiltration(NF)membranes with a coffee-ring structure and beneficial properties were prepared by adding graphene oxide(GO)into the interfacial polymerization process.The presentation of the coffee-ring structure was attributed to the heterogeneous,finely dispersed multiphase reaction system and the“coffee-stain”effect of the GO solution.When the piperazine concentration was 0.4 wt-%,the trimesoyl chloride concentration was 0.3 wt-%,and the GO concentration was 0.025 wt-%,the prepared NF membranes showed the best separation properties.The permeate flux was 76 L·m^(−2)·h^(−1),and the rejection rate for MgSO4 was 98.6%at 0.4 MPa.Scanning electron microscopy,atomic force microscopy,and attenuated total reflectance-Fourier transform infrared spectroscopy were used to characterize the chemical structure and morphology of the PA/GO NF membrane.The results showed that GO was successfully entrapped into the PA functional layer.Under neutral operating conditions,the PA/GO membrane showed typical negatively charged NF membrane separation characteristics,and the rejection rate decreased in the order of Na2SO_(4)>MgSO_(4)>MgCl_(2)>NaCl.The PA/GO NF membrane showed better antifouling performance than the PA membrane. | Xiuzhen Wei Xufeng Xu Yi Chen Qian Zhang Lu Liu Ruiyuan Yang Jinyuan Chen Bosheng Lv | 2021 | Frontiers of Chemical Science and Engineering2021，15，2： | 2 |
| 19 | Polymerization of n - hexyl i-socyanate with rare earth catalyst composed of Nd ( P2 04 ) 3/Al ( i -Bu)3 显示文摘 | Xu Xiaoyan Ni Xufeng Shen Zhiquan | 2005 | Polymer Bulletin2005，53，2： | 1 |
| 20 | Copolymerization of phenyliso-cyanate and e - caprolactone with rare earth chloride systems显示文摘 | Ni Xufeng Xu Xiaoyan Shen Zhiquan | 2007 | Jour-nal of Applied Polymer Science2007，103，4： | 1 |
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