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| 1 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 2 | State of China’s climate in 2021显示文摘2021年,中国气候暖湿特征明显,全国平均气温10.5℃,较常年偏高1.0℃,创下了1951年以来最高纪录;全国平均降水量672.1毫米,比常年偏多6.7%,其中北方地区平均降水量较常年偏多40.2%,为1961年以来第二多.汛期暴雨过程强度大,极端性显著,河南特大暴雨灾害影响重,黄河中下游流域秋汛明显;高温过程多,夏秋南方高温持续时间长;区域性,阶段性气象干旱明显,华南干旱影响较重;台风生成和登陆均偏少,“烟花”陆地滞留时间长,影响范围广;强对流天气强发,极端大风频发,局地致灾重;寒潮过程多,强度大,极端低温频现;沙尘天气出现早,强沙尘暴过程多. | Wei Li Shanshan Zhao Yu Chen Ling Wang Wei Hou Yundi Jiang Xukai Zou Shuai Shi | 2022 | Atmospheric and Oceanic Science Letters2022，15，4： | 2 |
| 3 | An Objective Identification Technique for Regional Extreme Events显示文摘 | Ren Fumin Cui Donglin Gong Zhiqiang Wang Yanjiao Zou Xukai Li Yiping Wang Shigong Wang Xiaoling | 2012 | EN2012，，20： | 1 |
| 4 | Catalytic ozonation of p-chlorobenzoic acid by activated carbon and nickel supported activated carbon prepared from petroleum coke显示文摘 | Xukai Li Qiuyun Zhang Lili Tang | 2009 | Journal of Hazardous Materials2009，163，： | 1 |
| 5 | State of the climate in the Three Gorges Region of the Yangtze River basin in 2020显示文摘2020年,长江三峡地区年平均气温17.2℃,接近常年;年平均降水量1530.8毫米,偏多29%,为1961年以来第二多,仅次于1998年.6月,7月降水量及年平均暴雨日数均为1961年以来第二多.平均风速较常年偏大;相对湿度略偏高;各月均无酸雨出现,近十余年酸雨强度呈现明显减弱趋势.2020年,三峡地区夏季暴雨洪涝灾害重.分析表明,冷空气频繁南下与西南暖湿水汽丰沛是造成三峡地区6–7月降水异常偏多的直接原因.2020年春季以来,印度洋海温持续偏暖导致西北太平洋副热带高压持续偏强偏南可能是造成6–7月长江流域气候异常的重要原因. | Tong Cui Xianyan Chen Xukai Zou Qiang Zhang Shuai Li Hongling Zeng | 2022 | Atmospheric and Oceanic Science Letters2022，15，2： | 1 |
| 6 | Catalytic ozonation ofp-chlorobenzoic acid by activated carbon and nickel supported activated carbon prepared from petroleum coke显示文摘 | Li Xukai Zhang Qiuyun Tang Lili | 2009 | J Hazard Mater2009，163，1： | 1 |
| 7 | An Objective Identification Technique for Regional Extreme Events显示文摘 | Ren Fumin Cui Donglin Gong Zhiqiang Wang Yanjiao Zou Xukai Li Yiping Wang Shigong Wang Xiaoling | 2012 | EN2012，，20： | 1 |
| 8 | Data-driven strategies for the computational design of enzyme thermal stability:trends,perspectives,and prospects显示文摘Thermal stability is one of the most important properties of enzymes,which sustains life and determines the potential for the industrial application of biocatalysts.Although traditional methods such as directed evolution and classical rational design contribute greatly to this field,the enormous sequence space of proteins implies costly and arduous experiments.The development of enzyme engineering focuses on automated and efficient strategies because of the breakthrough of high-throughput DNA sequencing and machine learning models.In this review,we propose a data-driven architecture for enzyme thermostability engineering and summarize some widely adopted datasets,as well as machine learning-driven approaches for designing the thermal stability of enzymes.In addition,we present a series of existing challenges while applying machine learning in enzyme thermostability design,such as the data dilemma,model training,and use of the proposed models.Additionally,a few promising directions for enhancing the performance of the models are discussed.We anticipate that the efficient incorporation of machine learning can provide more insights and solutions for the design of enzyme thermostability in the coming years. | Zhixin Dou Yuqing Sun Xukai Jiang Xiuyun Wu Yingjie Li Bin Gong Lushan Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 9 | Interactions of phenol and benzaldehyde in electrocatalytic upgrading process显示文摘Biomass pyrolysis oil can be improved effectively by electrocatalytic hydrogenation(ECH).However,the unclear interactions among different components lead to low bio-oil upgrading efficiency in the conversion process.Herein,benzaldehyde and phenol,as common compounds in bio-oil,were chosen as model compounds.The interactions between the two components were explored in the ECH process by combining experiments and theoretical calculations.Results showed that phenol could accelerate the conversion of benzaldehyde in the ECH.The selectivity of benzyl alcohol was increased from 60.9%of unadded phenol to 99.1%with 30 mmol/L phenol concentration at 5 h.Benzaldehyde inhibited the ECH of phenol.In the presence of benzaldehyde,the conversion rate of phenol was below 10.0%with no cyclohexanone and cyclohexanol formation at 5 h.The density functional theory(DFT)calculations revealed that the phenol could promote the adsorption of benzaldehyde and facilitate the targeted conversion of benzaldehyde on the active site by lowering the reaction energy barrier.The research on the interaction between phenol and benzaldehyde in the ECH provides a theoretical basis for the application of ECH in practical bio-oil upgrading. | Lan Liang Chuanbin Wang Xukai Lu Yunan Sun Beibei Yan Ning Li Guanyi Chen Li'an Hou | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 10 | State of China's climate in 2022显示文摘2022年我国气候暖干特征明显,年平均气温偏高0.62℃,位居1961年以来历史第二高;年降水量偏少5%,为2012年以来最少,冬春季降水偏多,夏秋季降水偏少.汛期(5-9月)降水量偏少11.9%,位居1961年以来第3少,中东部降水距平呈“北多南少”分布.雨季进程偏早,雨量空间差异大,华南前汛期,华北雨季,东北雨季降水量偏多,而长江中下游和江淮梅雨降水偏少.华南,东北洪涝灾害重,南方夏秋连旱严重,中东部遭遇最强高温过程,登录台风异常偏少. | Ling Wang Linhai Sun Wei Li Xianyan Chen Ying Li Xukai Zou Yundi Jiang | 2023 | Atmospheric and Oceanic Science Letters2023，16，6： | 0 |
| 11 | Expression of bcl-2 and survivin gene products in different stages of vessel differentiation in hemangiomas显示文摘 | Junlin Li Ye Xinping Qin Xingjun Wang Xukai | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 12 | Rhodium(Ⅲ)-catalyzed [3+2] annulative coupling between oximes and electron-deficient alkynes显示文摘Rhodium(III)-catalyzed coupling between ketoximes and alkynes via C–H activation and annulation typically followed the[4+2]selectivity to afford isoquinolines.By designing alkynes bearing a highly electron-withdrawing group and under substrate control,we have successfully switched the selectivity of the coupling between oximes and alkynes to the alternative[3+2]annulation,leading to the efficient synthesis of indenamines.This process features good regioselectivity for both substrates,high efficiency,broad substrate scope,and excellent functional group tolerance. | Xukai Zhou Songjie Yu Zisong Qi Xingwei Li | 2015 | Science China Chemistry2015，58，8： | 0 |
| 13 | Electro-catalytic activity of CeO_(x) modified graphite felt for carbamazepine degradation via E-peroxone process显示文摘E-peroxone(EP)was one of the most attractive AOPs for removing refractory organic compounds from water,but the high energy consumption for in situ generating H_(2)O_(2) and its low reaction efficiency for activating O_(3) under acidic conditions made the obstacles for its practical application.In this study,cerium oxide was loaded on the surface of graphite felt(GF)by the hydrothermal method to construct the efficient electrode(CeO_(x)/GF)for mineralizing carbamazepine(CBZ)via EP process.CeO_(x)/GF was an efficient cathode,which led to 69.4%TOC removal in CeO_(x)/GF-EP process with current intensity of 10 mA in 60 min.Moreover,CeO_(x)/GF had the flexible application in the pH range from 5.0 to 9.0,TOC removal had no obvious decline with decrease of pH.Comparative characterizations showed that CeO_(x)could enhance surface hydrophilicity and reduce the charge-transfer resistance of GF.About 5.4 mg/L H_(2)O_(2) generated in CeO_(x)/GF-EP process,which was 2.1 times as that in GF-EP process.The greater ozone utility was also found in CeO_(x)/GF-EP process.More O_(3) was activated into hydroxyl radicals,which accounted for the mineralization of CBZ.An interfacial electron transfer process was revealed,which involved the function of oxygen vacancies and Ce^(3+)/Ce^(4+)redox cycle.CeO_(x)/GF had the good recycling property in fifth times'use. | Xinyu Wang Ye Jin Weirui Chen Ruini Zou Jinxin Xie Yiming Tang Xukai Li Laisheng Li | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 0 |
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