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| 1 | In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite显示文摘AZ31 magnesium alloy fibers reinforced poly(lactic-co-glycolic acid)(PLGA) composites were prepared and their mechanical property,immersion corrosion behavior and biocompatibility were studied.The tensile test showed that with the addition of AZ31 fibers,the composites had a significant increment in tensile strength and elongation.For the direct cell attachment test,all the cells showed a healthy morphology and spread well on the experimental sample surfaces.The immersion results indicated that pH values of the immersion medium increased with increasing AZ31 fiber contents.All the in vitro experimental results indicated that this new kind of magnesium alloy fibers reinforced PLGA composites show a potential for future biomedical applications. | Y.H.Wu N.Li Y.Cheng Y.F.Zheng Y.Han | 2013 | Journal of Materials Science & Technology2013，29，6： | 8 |
| 2 | Nanocrystalline Ti49.2Ni50.8 shape memory alloy as orthopaedic implant material with better performance显示文摘Ti Ni alloys, with their unique shape memory effects and super elastic properties, occupy an indispensable place in the family of metallic biomaterials. In the past years, surface treatment is the main technique to improve the bioinert nature of microcrystalline Ti Ni alloys and inhibit on the release of toxic nickel ions to obtain excellent osteogenesis and osseointegration function. In the present study, nanocrystalline Ti49.2Ni50.8 alloy has been fabricated via equal channel angular pressing(ECAP), and the in vitro and in vivo studies revealed that it had enhanced cell viability, adhesion, proliferation, ALP(Alkaline phosphatase)activity and mineralization, and increased periphery thickness of new bone, in comparison to the commercial coarse-grained counterpart. These findings indicate that the reduction of grain size is beneficial to increasing the biocompatibility of Ti49.2Ni50.8 shape memory alloy. | H.F.Li F.L.Nie Y.F.Zheng Y.Cheng S.C.Wei R.Z.Valiev | 2019 | Journal of Materials Science & Technology2019，35，10： | 4 |
| 3 | Can progesterone be a better alternative to dexamethasone for use in routine brain surgery?显示文摘Can progesterone be a better alternative to dexamethasone for use in routine brain surgery?Surgical brain injury(SBI)is a form of brain trauma caused by various forms of neurosurgical interventions including brain tumor excision,evacuation of intracerebral hemorrhage and brain lobectomy(e.g.,in epilepsy surgery).Cerebral edema and brain swelling typically occurs soon after SBI and commonly peaks on post-operative days 3 to 7.SBI may | Stephen Y.Cheng Gilberto K.K.Leung | 2015 | Neural Regeneration Research2015，10，9： | 2 |
| 4 | 明潭抽水蓄能电站地下厂房洞室设计显示文摘明潭(Mingtan)地下厂房洞室是台湾最大的地下厂房之一.洞室的最佳方位及形状是根据地质、应力分析和施工条件确定的.洞顶出露的平行粘土夹层采用高压水射流冲洗软弱夹层井用不收缩的砂浆回填的方法,在总体开挖前从一些小的平洞中进行处理的.同时,为了加固洞顶,在开挖前从平洞中安装了具有防腐波形护套的高强度预应力锚索.岩石锚杆、预应力锚索及钢纤维喷混凝土组成的柔性支护系统在整个洞室周围形成自支撑岩体,大型地下洞室开挖中采用这种支护系统在台湾尚属首次. | S.C.Liu Y.Cheng C.T.Chang 刘琦凤 | 1991 | 西北水电1991，0，1： | 1 |
| 5 | High‐Power Alkaline Zn–MnO显示文摘 | F.?Y.Cheng J.Chen X.?L.Gou P.?W.Shen | 2005 | Adv Mater2005，，22： | 1 |
| 6 | Mean Shift, Mode Seeking, and Clustering显示文摘 | Y.Cheng | | 0，，08： | 1 |
| 7 | Microsomal prostaglandin E synthase‐1 inhibition in cardiovascular inflammatory disease显示文摘 | M.Wang W.‐L.Song Y.Cheng G. A.FitzGerald | 2008 | Journal of Internal Medicine2008，，5： | 1 |
| 8 | Efficacy of Cetylpyridinium Chlorine on Salmonella Typhimurium and Escherichia coli O157:H7 in Immersion Spray Treatment of Fresh‐Cut Lettuce显示文摘 | H.Yang Y.Cheng B.L.Swem Y.Li | 2006 | Journal of Food Science2006，，3： | 1 |
| 9 | Growth factor release from a chemically modified elastomeric poly(1,8‐octanediol‐co‐citrate) thin film promotes angiogenesis in vivo显示文摘 | Arun K.Sharma Matthew I.Bury Natalie J.Fuller Dorota I.Rozkiewicz Partha V.Hota David M.Kollhoff Matthew J.Webber NatalieTapaskar Jay W.Meisner Patrick J.Lariviere SamanthaDeStefano DeliWang Guillermo A.Ameer Earl Y.Cheng | 2012 | J Biomed Mater Res2012，，3： | 1 |
| 10 | Nitric oxide is involved in phosphorus deficiency‐induced cluster‐root development and citrate exudation in white lupin显示文摘 | B. L.Wang X. Y.Tang L. Y.Cheng A. Z.Zhang W. H.Zhang F. S.Zhang J. Q.Liu Y.Cao D. L.Allan C. P.Vance J. B.Shen | 2010 | New Phytologist2010，，4： | 1 |
| 11 | Size-controllable synthesis of monodispersed colloidal silica nanoparticles via hydrolysis of elemental silicon显示文摘 | J.Guo X.Liu Y.Cheng Y.Li G.Xu P.Cui | | 0，，： | 1 |
| 12 | Ceramic–Polymer Composites with High Dielectric Constant显示文摘 | M.Arbatti X.Shan Z.‐Y.Cheng | 2007 | Adv Mater2007，，10： | 1 |
| 13 | P38 MAPK inhibition enhancing ATO‐induced cytotoxicity against multiple myeloma cells显示文摘 | JianguoWen Haiyun Y.Cheng YongdongFeng LawrenceRice ShangfengLiu AlbertMo JamesHuang YouliZu Douglas J.Ballon Chung‐CheChang | 2007 | British Journal of Haematology2007，，2： | 1 |
| 14 | Incidence and risk of herpes zoster in patients with ulcerative colitis and Crohn’s disease in the USA显示文摘Background:Patients with inflammatory bowel disease(IBD)are at increased risk of herpes zoster(HZ).We evaluated the incidence of HZ in ulcerative colitis(UC)and Crohn’s disease(CD)patients and compared this with HZ incidence in a non-IBD population.Methods:We conducted a retrospective cohort study(GSK study identifier:VEO-000043)of adults aged18 years with UC and CD and without IBD who were identified from claims recorded in a US healthcare database between October 2015 and February 2020.Crude HZ incidence rates/1,000 person-years(PY)were calculated,and comparisons of HZ incidence rates between UC or CD and non-IBD cohorts were made using adjusted generalized linear models.Results:The study population comprised a total of 29,928 UC,25,959 CD,and 11,839,329 non-IBD patients.Crude overall HZ incidence rates were 13.64/1,000 PY(UC),15.94/1,000 PY(CD),and 7.95/1,000 PY(non-IBD).UC and CD patients had increased HZ incidence rates,with adjusted incidence rate ratios of 1.35(95%confidence interval[CI],1.26–1.44)and 1.66(95%CI,1.56–1.77),respectively,compared with non-IBD patients.Stratified analysis indicated increased relative rates of HZ in progressively younger age strata in the UC and CD patients compared with non-IBD patients.HZ incidence rates were higher in UC and CD patients who had previously received thiopurines or methotrexate,TNF-inhibitors,or corticosteroids than in UC and CD patients who did not take those medicines.Conclusion:UC and CD patients had increased HZ incidence rates compared with patients without IBD,demonstrating the importance of HZ prevention in IBD patients. | David Singer Philippe Thompson-Leduc Deepshekhar Gupta Wendy Y.Cheng Sara Poston Siyu Ma John E.Pawlowski Mei Sheng Duh Eric D.Morris Francesca Devine Francis A.Farraye | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 15 | KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression显示文摘Background:Histone deacetylases(HDACs)engage in the regulation of various cellular processes by controlling global gene expression.The dysregulation of HDACs leads to carcinogenesis,making HDACs ideal targets for cancer therapy.However,the use of HDAC inhibitors(HDACi)as single agents has been shown to have limited success in treating solid tumors in clinical studies.This study aimed to identify a novel downstream effector of HDACs to provide a potential target for combination therapy.Methods:Transcriptome sequencing and bioinformatics analysis were performed to screen for genes responsive toHDACi in breast cancer cells.The effects of HDACi on cell viability were detected using the MTT assay.The mRNA and protein levels of genes were determined by quantitative reverse transcription-PCR(qRT-PCR)andWestern blotting.Cell cycle distribution and apoptosis were analyzed by flow cytometry.The binding of CREB1(cAMP-response element binding protein 1)to the promoter of the KDELR(The KDEL(Lys-Asp-Glu-Leu)receptor)gene was validated by the ChIP(chromatin immunoprecipitation assay).The association between KDELR2 and protein of centriole 5(POC5)was detected by immunoprecipitation.A breast cancer-bearing mouse model was employed to analyze the effect of the HDAC3-KDELR2 axis on tumor growth.Results:KDELR2 was identified as a novel target of HDAC3,and its aberrant expression indicated the poor prognosis of breast cancer patients.We found a strong correlation between the protein expression patterns of HADC3 and KDELR2 in tumor tissues from breast cancer patients.The results of the ChIP assay and qRT-PCR analysis validated that HDAC3 transactivated KDELR2 via CREB1.The HDAC3-KDELR2 axis accelerated the cell cycle progression of cancer cells by protecting the centrosomal protein POC5 from proteasomal degradation.Moreover,the HDAC3-KDELR2 axis promoted breast cancer cell proliferation and tumorigenesis in vitro and in vivo.Conclusion:Our results uncovered a previously unappreciated function of KDELR2 in tumorigenesis,linking a critical Golgi-the endoplasmic reticulum traffic transport protein to HDAC-controlled cell cycle progression on the path of cancer development and thus revealing a potential therapeutical target for breast cancer. | Haoran Wei Wenhao Ma Xiaofei Lu Haiying Liu Kashuai Lin Yinghui Wang Zijian Ye Linchong Sun Zhitong Huang Tingting Pan Zilong Zhou Eric Y.Cheng Huafeng Zhang Ping Gao Xiuying Zhong | 2021 | Cancer Communications2021，41，9： | 0 |
| 16 | Optimal placement of dampers and actuators based on stochastic approach显示文摘A general method is developed for optimal application of dampers and actuators by installing them at optimal location on seismic-resistant structures. The study includes development of a statistical criterion, formulation of a general optimization problem and establishment of a solution procedure. Numerical analysis of the seismic response in time-history of controlled structures is used to verify the proposed method for optimal device application and to demonstrate the effectiveness of seismic response control with optimal device location. This study shows that the proposed method for the optimal device application is simple and general, and that the optimally applied dampers and actuators are very efficient for seismic response reduction. | Franklin Y.Cheng Hongping Jiang Xiaozhe Zhang | 2002 | Earthquake Engineering and Engineering Vibration2002，1，2： | 0 |
| 17 | Smurfs have“fused”into the asymmetric division of stem cells显示文摘The asymmetric cell division is the way in which a stem cell divides into one daughter stem cell and one differentiated daughter cell.This process is one of the key principles of developmental biology that ensures the perpetual supply of stem cells while allowing a particular cell lineage to be populated.During Drosophila oogenesis,the fate of the daughter stem cell produced from the asymmetric division of germline stem cells(GSCs)is specified by Decapentaplegic(Dpp),but the other daughter cell has almost equal access to the Dpp signal.How Dpp signaling is inactivated in the differentiated daughter cell has been a deep mystery until a recent study,led by Dahua Chen of the Institute of Zoology,China(Xia et al.,2010),showed that the Dpp receptor,Thick vein(Tkv),is degraded specifically in the differentiated daughter cell by an HECT-domain ubiquitin E3 ligase,Smurf,in conjunction with a serine-threonine kinase Fused(Fu).This finding is as much revealing as it is surprising,because up until now Fu is considered a core member of the Hedgehog signaling pathway. | Steven Y.Cheng Ying E.Zhang | 2011 | Protein & Cell2011，2，1： | 0 |
| 18 | 基于“张衡一号”卫星的GRO掩星载荷数据分析显示文摘'张衡一号'电磁卫星于2018年2月2日成功发射,该卫星搭载的全球导航卫星系统无线电掩星(GRO)接收机具备了全球定位系统(GPS)卫星和北斗导航系统(BD)卫星的掩星观测功能。对在轨测试期间数据进行分析,GRO掩星电离层反演结果合理、趋势正确,每天能够探测600个左右的电离层掩星事件。对连续2个多月共3万多个GRO掩星事件进行全球覆盖性分析,并与美国COSMIC掩星反演结果对比,GRO掩星与COSMIC掩星均能实现全球覆盖并且N_mF_2和H_mF_2的全球分布情况相近,随着纬度而变化明显。利用不同纬度的3个数字测高仪对时空一致的GRO掩星数据进行对比验证和分析,GRO掩星的N_mF_2相对数字测高仪的相对RM_SE优于9.41%,相关系数优于0.868 2。H_mF_2的相对RM_SE优于7.80%,相关系数优于0.706 6。 | Y.Cheng J.Lin X.H.Shen X.Wan X.X.Li W.J.Wang 程艳(译) 林剑(校) | 2019 | 世界地震译丛2019，50，4： | 0 |
| 19 | Identification of four novel prognosis biomarkers and potential therapeutic drugs for human colorectal cancer by bioinformatics analysis显示文摘Colorectal cancer(CRC)is one of the most deadly cancers in the world with few reliable biomarkers that have been selected into clinical guidelines for prognosis of CRC patients.In this study,mRNA microarray datasets GSE113513,GSE21510,GSE44076,and GSE32323 were obtained from the Gene Expression Omnibus(GEO)and analyzed with bioinformatics to identify hub genes in CRC development.Differentially expressed genes(DEGs)were analyzed using the GEO2 R tool.Gene ontology(GO)and KEGG analyses were performed through the DAVID database.STRING database and Cytoscape software were used to construct a protein-protein interaction(PPI)network and identify key modules and hub genes.Survival analyses of the DEGs were performed on GEPIA database.The Connectivity Map database was used to screen potential drugs.A total of 865 DEGs were identified,including 374 upregulated and 491 downregulated genes.These DEGs were mainly associated with metabolic pathways,pathways in cancer,cell cycle and so on.The PPI network was identified with 863 nodes and 5817 edges.Survival analysis revealed that HMMR,PAICS,ETFDH,and SCG2 were significantly associated with overall survival of CRC patients.And blebbistatin and sulconazole were identified as candidate drugs.In conclusion,our study found four hub genes involved in CRC,which may provide novel potential biomarkers for CRC prognosis,and two potential candidate drugs for CRC. | Zhen Sun Chen Liu Steven Y.Cheng | 2021 | The Journal of Biomedical Research2021，35，1： | 0 |
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