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| 1 | Adventitious root formation in rice requires OsGNOM1 and is mediated by the OsPINs family显示文摘在谷物的含纤维的根系统包括首先偶然根(艺术) ,它在营养素和水举起起重要作用。关于位于 AR 开发下面的分子的机制的当前的知识仍然是有限的。我们这里报导四米饭(Oryza sativa L.) 的隔离异种从不同基因背景,所有哪个在 AR 是有缺点的形成。这些异种展出了侧面的根(LR ) 和 gravitropism 的部分损失的减少的数字。也显示的异种提高了敏感到 N-1-naphthylphthalamic 酸,极的植物生长素运输的一个禁止者(轻拍) ,显示变化影响了植物生长素运输。用四异种之一的位置的克隆表明它被一个 guanine 核苷酸交换因素的 loss-of-function 为 ADP-ribosylation 因素(OsGNOM1 ) 引起。转基因的植物显示出的 promoter::GUS 的 RT-PCR 和分析那 OsGNOM1 在 AR primordia,脉管的纸巾, LR,根尖端,叶子,花药和词根静脉被表示,与类似于植物生长素的一个分发模式。另外, OsPIN2, OsPIN5b 和 OsPIN9 的表情在异种被改变。一起拿,这些调查结果显示 OsGNOM1 通过调整影响艺术的形成轻拍。 | Shiping Liu Jirong Wang Lu Wang Xiaofei Wang Yanhong Xue Ping Wu Huixia Shou | 2009 | Cell Research2009，19，9： | 29 |
| 2 | IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome显示文摘Increased numbers of T follicular helper(Tfh)cells have been implicated in the development of autoimmune diseases including primary Sjögren’s syndrome(pSS),but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear.Here,we first found negative correlations between IL-10^(+)regulatory B(Breg)cell numbers and Tfh cell responses and disease activity in patients with pSS and mice with experimental Sjögren’s syndrome(ESS).Moreover,we detected high expression of IL-10 receptor on Tfh cells and their precursors in both humans and mice.In culture,IL-10 suppressed human and murine Tfh cell differentiation by promoting STAT5 phosphorylation.By using an adoptive transfer approach and two-photon live imaging,we found significantly increased numbers of Tfh cells with enhanced T cell homing into B cell follicles in the draining cervical lymph nodes of RAG-2−/−mice transferred with IL-10-deficient B cells during ESS development compared with those of RAG-2−/−mice transferred with wild-type B cells.In ESS mice,CD19^(+)CD1d^(hi)CD5^(+)Breg cells with decreased IL-10 production exhibited severely impaired suppressive effects on T cell proliferation.Consistently,CD19^(+)CD24^(+)CD38^(hi) Breg cells from pSS patients showed significantly reduced IL-10 production with defective inhibitory function in the suppression of autologous Tfh cell expansion.Furthermore,the adoptive transfer of IL-10-producing Breg cells markedly suppressed the Tfh cell response and ameliorated ESS progression in ESS mice.Together,these findings demonstrate a critical role for IL-10-producing Breg cells in restraining the effector Tfh cell response during pSS development. | Xiang Lin Xiaohui Wang Fan Xiao Kongyang Ma Lixiong Liu Xiaoqi Wang Dong Xu Fei Wang Xiaofei Shi Dongzhou Liu Yan Zhao Liwei Lu | 2019 | Cellular & Molecular Immunology2019，16，12： | 13 |
| 3 | Freeze-thaw Effects on Sorption/Desorption of Dissolved Organic Carbon in Wetland Soils显示文摘The effects of freeze-thaw cycles on sorption/desorption of dissolved organic carbon (DOC) in two wetland soils and one reclaimed wetland soil were investigated. DOC concentrations added were 0-600 mg/L. Laboratory incubations of sorption/desorption of DOC had been carried out at -15℃ for 10 h, and then at +5℃ for 13 h. Soil samples were refrozen and thawed subsequently for 5 cycles. Initial Mass model was used to describe sorption behavior of DOC. The results indicate that freeze-thaw cycles can significantly increase the sorption capacity of DOC and reduce the desorption capacity of DOC in the three soils. The freeze-thaw effects on desorption of DOC in soils increase with the increasing freeze-thaw cycles. The conversion of natural wetlands to soybean farmland can decrease the sorption capacity and increase the desorption capacity of DOC in soils. Global warming and reclamation may increase DOC release, and subsequently increase the loss of carbon and the emission of greenhouse gas. | YU Xiaofei ZHANG Yuxia ZHAO Hongmei LU Xianguo WANG Guoping | 2010 | Chinese Geographical Science2010，20，3： | 12 |
| 4 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 5 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 6 | Potential Benefits of Biochar in Agricultural Soils:A Review显示文摘Soil degradation,characterized by declines in nutrient status and simultaneous accumulation of pesticide residues,is a major problem affecting agricultural ecosystems.Previous studies indicate that biochar application to soil has promise as a practical method to alleviate these pressures:increasing crop yield and enhancing pesticide degradation.Here,we review the roles of biochar in both chemical and biological promotion of pesticide degradation and the potential benefits of biochar relating to the efficiency of fertilizer use,availability of nutrients,and nutrient exchange.Biochar typically has a high surface area featuring many functional groups,a high cation exchange capacity,and high stability.Major factors that impact on the nutrient retention characteristics of biochar(e.g.,feedstock,pyrolysis temperature,and application rate) are also discussed herein.Nonetheless,more studies of the long-term impacts on soil properties from biochar addition are still required before it can be possible to accurately quantify the sustainability of this approach to sequester carbon and restore soil function. | DING Yang LIU Yunguo LIU Shaobo HUANG Xixian LI Zhongwu TAN Xiaofei ZENG Guangming ZHOU Lu | 2017 | Pedosphere2017，27，4： | 10 |
| 7 | Field Capacity in Black Soil Region, Northeast China显示文摘In this work, 23 black soil profiles were surveyed and 113 soil samples were collected to determine the field capacity (FC) of the black soil in Northeast China. The effectiveness of three methods measuring FC, the Wilcox method (WM), the undisturbed soil pressure plate method (PUM) and the air-dried sieved soil pressure plate method (PDM) were compared to select a suitable laboratory measurement method. Results show that the FC values measured by PDM are greater than those measured by PUM, and the values measured by PUM are greater than those measured by WM. PUM is more suitable for the determination of FC in the study area. One regression equation between PUM and PDM has been established through which undisturbed soil can be replaced by air-dried sieved soil, which is easier to get, to measure FC. FCs vary from 23.50% to 37.00%, with an average of 31.65%, which differ greatly among the 23 black soil profiles. FC is found to be significantly positively correlated with the silt content, clay content and bulk density of the soil, but significantly negatively correlated with the sand content. An empirical pedotransfer function is established to estimate the FC using available soil physical and chemical properties. | DUAN Xingwu XIE Yun LIU Gang GAO Xiaofei LU Hongmei | 2010 | Chinese Geographical Science2010，20，5： | 9 |
| 8 | Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma显示文摘Glioblastoma(GBM)is an incurable and highly heterogeneous brain tumor,originating from human neural stem/progenitor cells(hNSCs/hNPCs)years ahead of diagnosis.Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels,the de novo gliomagenic path from hNSCs is largely unknown due to technical difficulties in early-stage sampling and preclinical modeling.Here,we established two highly penetrant hNSC-derived malignant glioma models,which resemble the histopathology and transcriptional heterogeneity of human GBM.Integrating time-series analyses of whole-exome sequencing,bulk and single-cell RNA-seq,we reconstructed gliomagenic trajectories,and identified a persistent NSC-like population at all stages of tumorigenesis.Through trajectory analyses and lineage tracing,we showed that tumor progression is primarily driven by multi-step transcriptional reprogramming and fate-switches in the NSC-like cells,which sequentially generate malignant heterogeneity and induce tumor phenotype transitions.We further uncovered stage-specific oncogenic cascades,and among the candidate genes we functionally validated C1QL1 as a new glioma-promoting factor.Importantly,the neurogenic-to-gliogenic switch in NSC-like cells marks an early stage characterized by a burst of oncogenic alterations,during which transient AP-1 inhibition is sufficient to inhibit gliomagenesis.Together,our results reveal previously undercharacterized molecular dynamics and fate choices driving de novo gliomagenesis from hNSCs,and provide a blueprint for potential early-stage treatment/diagnosis for GBM. | Xiaofei Wang Ran Zhou Yanzhen Xiong Lingling Zhou Xiang Yan Manli Wang Fan Li Chuanxing Xie Yiming Zhang Zongyao Huang Chaoqiong Ding Kaidou Shi Weida Li Yu Liu Zhongwei Cao Zhen-Ning Zhang Shengtao Zhou Chong Chen Yan Zhang Lu Chen Yuan Wang | 2021 | Cell Research2021，31，6： | 8 |
| 9 | Mesoproterozoic to Paleozoic Nd isotope stratigraphy of the South China continental nucleus and its geological significance显示文摘The Yangtze continental nucleus in South China is situated in the Huangling-Shennongjia area in western Hubei Province.It comprises the early Precambrian crystalline basement and generally successive Proterozoic to Phanerozoic sedimentary covers.This paper reports a comprehensive Nd isotope study of fine-grained sedimentary rocks from the regional Mesoproterozoic to early Paleozoic strata.The Nd model ages display a V-shaped variation from ~2.5-2.8 Ga during the late Mesoproterozoic through ~1.5-1.7 Ga during the Neoproterozoic Nanhua Period to ~1.8-2.1 Ga during the Paleozoic Ordovician,with corresponding Nd (t) ranges of 11 to 14,1.1 to 5.3,and 7.9 to 9.9,respectively.This evolutionary trend broadly resembles those documented in the sedimentary strata along the southeastern margin of the Yangtze Craton and within the Jiangnan orogenic belt,indicating that the whole South China block underwent a mantle-input related tectono-magmatic event at ~0.8 Ga or earlier.However,the Huangling-Shennongjia area is discriminated from the other two regions by highly variable model ages (~1.5-2.7 Ga) and Nd (t) values (1.38-12.0) of the early Mesoproterozoic strata.Combined with the Archean model ages of the late Mesoproterozoic strata,it is suggested that the Mesoproterozoic sedimentary provenance of the Yangtze continental nucleus was distinct from that of the southeastern Yangtze Craton,likely indicative of an intervening aulacogen (or rift zone) or oceanic basin.In addition,the high comparability in Neoproterozoic to Paleozoic Nd isotope stratigraphy between the Yangtze Craton and the Jiangnan orogenic belt infers that the whole South China block had shared the same sedimentary basin and provenance since the Yangtze-Cathaysia welding at ~0.9 Ga.Thus,it is proposed that the Yangtze Craton had comprised a collage of micro-continents during the pre-Neoproterozoic until the Rodinia assemblage when the primitive South China block was formed. | BAI Xiao LING WenLi DUAN RuiChun QIU XiaoFei LIU ChengXin KUANG Hua GAO YongJuan ZHOU Lian CHEN ZiWan LU Shah-Song | 2011 | Science China Earth Sciences2011，54，11： | 8 |
| 10 | A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice显示文摘Dear Editor,Since the beginning of this century,humanity has been struck three times by the coronavirus outbreak.The most recent one is caused by the SARS-CoV-2 virus,which was first reported in January 2020 and spread rapidly worldwide,developing into a global coronavirus disease pandemic coded COVID-19.1 By July 28,2020,SARS-CoV-2 has caused over sixteen million COVID-19 cases worldwide and 650,805 deaths.2 Such a grave situation has made the development of a COVID-19 vaccine imperative and urgent. | Jing Lu Guoliang Lu Shudan Tan Jia Xia Hualong Xiong Xiaofei Yu Qingqing Qi Xiang Yu Li Li Hang Yu Ningshao Xia Tianying Zhang Yingjie Xu Jinzhong Lin | 2020 | Cell Research2020，30，10： | 5 |
| 11 | Stability,Thermal Conductivity and Photothermal Conversion Performance of Water-Based ZnO Nanofluids显示文摘Water-based ZnO nanofluids were prepared via the two-step method,and the influences of dispersant type and mass fraction on the stability and particle size distribution of the nanofluids were investigated.The spectral transmittances of the nanofluids were obtained by a UV-Vis-NIR spectrophotometer.Thermal conductivities of the nanofluids with various mass fractions were measured at different temperatures and a fitted nonlinear correlated equation was established for low-concentration application and compared with existing models.The photothermal conversion performance of the nanofluids was evaluated by theoretical and experimental methods at three optical depths.The results showed that,CTAB as the dispersant provides better physical stability of water-based ZnO nanofluids than SDBS or GA does.Effect of the temperature on the nanofluid thermal conductivity is remarkable with the increase of nanoparticle mass fraction,especially in the range 55°C to 75°C.The maximum thermal conductivity of the studied nanofluids is 0.9488 W/(m·℃)at 75°C,43.61%higher than that of water.The minimum thermal conductivity of the studied nanofluids is 0.6376 W/(m·℃)at 25°C,5.16%higher than that of water.The photothermal conversion performance of the nanofluids is quite good with a maximum average absorption efficiency of 0.47,135%higher than that of water(η=0.2),and the maximum SAR is 527.5 W/g. | HAN Xiaofei LU Liwei YAN Suying YANG Xiaohong TIAN Rui ZHAO Xiaoyan | 2021 | Journal of Thermal Science2021，30，5： | 3 |
| 12 | Mesoporous iron oxide-silica supported gold catalysts for low-temperature CO oxidation显示文摘Mesoporous iron oxide-silica composite with a high silica content was synthesized by hydrothermal method,and another composite material with a high iron content was obtained by etching part of silica in alkaline solution.Gold catalysts were loaded onto both composites by a deposition-precipitation method,and used for CO oxidation.The samples were characterized by BrumauerEmmet-Teller(BET),X-ray diffraction(XRD),X-ray photoelectron spectra(XPS),transmission electron microscope(TEM)and scanning electron microscope(SEM)techniques.Both composites had high specific surface areas and were amorphous.The Au nanoparticles dispersed on the surface of the composites existed in metallic state.Composite with high silica content was not suitable for Au loading,and its supported gold catalyst showed poor performance in catalytic reaction.In contrast,composite with high iron content allowed efficient Au loading,and CO could be oxidized completely at low temperature on its supported gold catalyst.The effects of deposition-precipitation pH values on Au loading and activity of the catalyst were investigated,and the results indicated that Au loading was the highest and the catalyst was the most active for CO oxidation when the synthesis pH was adjusted to 8. | Weidong Zhang Xiaofei Lu Weili Zhou Feng Wu Jinjun Li | 2014 | Chinese Science Bulletin2014，59，31： | 3 |
| 13 | Genotypic variation in spatiotemporal distribution of canopy light interception in relation to yield formation in cotton显示文摘Background: Within-canopy interception of photosynthetically active radiation(PAR) impacts yield and other agronomic traits in cotton(Gossypium hirsutum L.). Field experiments were conducted to investigate the influence of 6 cotton varieties(they belong to 3 different plant types) on yield, yield distribution, light interception(LI), LI distribution and the relationship between yield formation and LI in Anyang, Henan, in 2014 and 2015.Result: The results showed that cotton cultivars with long branches(loose-type) intercepted more LI than did cultivars with short branches(compact-type), due to increased LI in the middle and upper canopy. Although loose-type varieties had greater LI, they did not yield significantly higher than compact-type varieties, due to decreased harvest index. Therefore, improving the harvest index by adjusting the source-to-sink relationship may further increase cotton yield for loose-type cotton. In addition, there was a positive relationship between reproductive organ biomass accumulation and canopy-accumulated LI, indicating that enhancing LI is important for yield improvement for each cultivar. Furthermore, yield distribution within the canopy was significantly linearly related to vertical LI distribution.Conclusion: Therefore, optimizing canopy structure of different plant type and subsequently optimizing LI distribution within the cotton canopy can effectively enhance the yield. | XING Fangfang HAN Yingchun FENG Lu ZHI Xiaoyu WANG Guoping YANG Beifang FAN Zhengyi LEI Yaping DU Wenli WANG Zhanbiao XIONG Shiwu LI Xiaofei Ll Yabing | 2018 | Journal of Cotton Research2018，1，3： | 3 |
| 14 | Thiocyanate-induced labilization of schwertmannite: Impacts and mechanisms显示文摘Schwertmannite is an amorphous iron(III)-oxyhydroxysulfate that forms in acid mine drainage(AMD) environments. The characteristic of high heavy metal adsorption capability makes schwertmannite a potentially useful, environmentally friendly material in wastewater treatment. Unstable schwertmannite is prone to recrystallization.Understanding the mechanisms that induce schwertmannite labilization and affect its capacity to remove heavy metals are of great environmental and geochemical significance.Thiocyanate(SCNˉ) is a hazardous pseudohalide that is also normally found in AMD.However, little is known about the impact of Fe(III)-binding ligand SCNˉ on schwertmannite stability and its subsequent capacity to bind trace elements. Here, we investigated the adsorption of SCNˉ on schwertmannite and subsequent mineral transformation to characterize this little-known process. The appearance of Fe2+indicated that the interactions between schwertmannite and SCNˉ may involve complexation and reduction reactions. Results showed that the majority of the adsorbed-SCNˉ was immobilized on schwertmannite during the 60-days transformation. The transformation rates of schwertmannite increased with increasing concentrations of SCNˉ. Goethite was detected as the dominant transformation product with or without SCNˉ. The mechanisms of SCNˉ-promoted dissolution of schwertmannite can be described as follows:(1) formation of Fe(III)–NCS complexes on the schwertmannite surface and in solution, a process which increases the reactivity of solid phase Fe(III);(2) the extraction of Fe(III) from schwertmannite by SCNˉ and subsequent schwertmannite dissolution; and(3) the formation of secondary minerals from extracted Fe(III). These findings may improve AMD treatment strategies and provide insight into the use and potential reuse of schwertmannite as a trace element sorbent. | Cong Fan Chuling Guo Junhui Zhang Cui Ding Xiaofei Li John R.Reinfelder Guining Lu Zhenqing Shi Zhi Dang | 2019 | Journal of Environmental Sciences2019，31，6： | 3 |
| 15 | An adaptive switching scheme for iterative computing in the cloud显示文摘 | Yu ZHANG Xiaofei LIAO Hai JIN Li LIN Feng LU | 2014 | Frontiers of Computer Science2014，8，6： | 2 |
| 16 | Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1显示文摘Bone regeneration remains a great clinical challenge. Low intensity near-infrared(NIR) light showed strong potential to promote tissue regeneration, offering a promising strategy for bone defect regeneration. However, the effect and underlying mechanism of NIR on bone regeneration remain unclear. We demonstrated that bone regeneration in the rat skull defect model was significantly accelerated with low-intensity NIR stimulation. In vitro studies showed that NIR stimulation could promote the osteoblast differentiation in bone mesenchymal stem cells(BMSCs) and MC3T3-E1 cells, which was associated with increased ubiquitination of the core circadian clock protein Cryptochrome 1(CRY1) in the nucleus. We found that the reduction of CRY1 induced by NIR light activated the bone morphogenetic protein(BMP) signaling pathways, promoting SMAD1/5/9 phosphorylation and increasing the expression levels of Runx2 and Osterix. NIR light treatment may act through sodium voltage-gated channel Scn4a, which may be a potential responder of NIR light to accelerate bone regeneration. Together, these findings suggest that low-intensity NIR light may promote in situ bone regeneration in a CRY1-dependent manner, providing a novel, efficient and non-invasive strategy to promote bone regeneration for clinical bone defects. | Jinfeng Peng Jiajia Zhao Qingming Tang Jinyu Wang Wencheng Song Xiaofeng Lu Xiaofei Huang Guangjin Chen Wenhao Zheng Luoying Zhang Yunyun Han Chunze Yan Qian Wan Lili Chen | 2022 | International Journal of Oral Science2022，14，4： | 2 |
| 17 | A Breeding Method for New Lodging Resistant Rice Varieties Based on Phenotype显示文摘The concept of lodging resistance core traits and their screening principles were first proposed on the basis of previous research.Afterwards,a lodging resistance breeding method based on phenotypic trait index was proposed based on a case study of screening lodging resistant aromatic rice by Yuehesimiao and Xiangyaxiangzhan.In other words,the materials that meet the breeding goals could be selected quickly by constructing breeding population and referring to lodging resistance core traits in each generation.Eventually,the advantages and disadvantages of the method were analyzed in combination with the actual situation,in order to provide the reference for rice breeding researchers. | Wang Xiaofei He Xiuying Lu Zhanhua Liu Wei Lu Dongbai Wang Shiguang Xue Jiao | 2020 | Plant Diseases and Pests2020，11，4： | 2 |
| 18 | The expanding functional diversity of plasma cells in immunity and inflammation显示文摘The generation and function of plasma cells have been well recognized as the central events in humoral immunity.In particular,long-lived plasma cells,characterized by a long lifespan and the lack of cell division,persistently secrete high-affinity antibodies to maintain serum antibody titers in the immune response and autoimmune inflammation.Although the significant expansion of plasma cells is observed during the aging process,autoimmune diseases and chronic infections,the expanding functional diversity and underlying mechanisms of plasma cells remain incompletely understood.Here,we describe recent advances in revealing new functional subsets and phenotypic features of plasma cells in aging and autoimmunity. | Kongyang Ma Xiaohui Wang Xiaofei Shi Xiang Lin Fan Xiao Xin Ma Dongzhou Liu Liwei Lu | 2020 | Cellular & Molecular Immunology2020，17，4： | 2 |
| 19 | hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cells显示文摘 | Xinyu Zhu Min Li Xiaojun Xu Rui Zhang Xiaofei Zhang Zhuo Ma Jingze Lu Tao Xu Junjie Hou Eli Song | 2018 | Protein & Cell2018，9，10： | 2 |
| 20 | Establishment of two-dimensional gel electrophoresis for soybean protein isolate and its application显示文摘To optimize the conditions for the establishment of two-dimensional gel electrophoresis(2-DE)of soybean protein isolate(SPI),we investigated Ampholine mixture,anodic and cathodic electrolytes,loading amount of sample,acrylamide concentration,p H gradient and gel staining method in twodimensional gel electrophoresis to optimize the protein imaging conditions in two-dimensional gel.The results of mixed-level design experiments showed that Ampholine,loading amount and gel staining method had significant effect(P<0.05)on 2-DE of SPI.The optimal conditions were Ampholine mixture(pH 3–10+pH 5–7 or pH 4–6+pH 5–7),loading amount of 2 mg sample and silver staining.Although the acrylamide concentration of the gel,the p H gradient,the anodic and cathodic electrolyte solutions had significant statistical effects on the protein separation degree,the complexity of the protein composition and the visibility of the gel images were more inclined to the 12%gel,the 3–10 pH gradient and the H3PO4/NaOH electrolyte.According to the established conditions,the hydrolyzed products of SPI emulsion were determined by 2-DE,and the dynamic changes of protein in the process of enzymatic hydrolysis were described. | Xinkai Lu Yaoming Cui Junjun Guan Xue Liu Hao Zhu Xuyang Ji Jianzhang Zheng Yunlong Cheng Xiaofei Fu | 2020 | Grain & Oil Science and Technology2020，3，3： | 2 |
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