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| 1 | Protocol liver biopsy is the only examination that can detect mid-term graft fibrosis after pediatric liver transplantation显示文摘AIM:To assessed the clinical significance of protocol liver biopsy(PLB)in pediatric liver transplantation(LT).METHODS:Between July 2008 and August 2012,89and 55 PLBs were performed in pediatric patients at two and five years after LT,respectively.We assessed the histopathological findings using the Metavir scoring system,including activity(A)and fibrosis(F),and we identified factors associated with scores of≥A1 and≥F1.Our results clarified the timing and effectiveness of PLB.RESULTS:The incidences of scores of≥A1 and≥F1 were 24.7%and 24.7%,respectively,at two years after LT and 42.3%and 34.5%,respectively,at five years.Independent risk factors in a multivariate analysis of a score of≥A1 at two years included≥2 h ofcold ischemic time,no acute cellular rejection and an alanine amino transaminase(ALT)level of≥20 IU/L(P=0.028,P=0.033 and P=0.012,respectively);however,no risk factors were identified for a score of≥F1.Furthermore,no independent risk factors associated with scores of≥A1 and≥F1 at five years were identified using multivariate analysis.A ROC curve analysis of ALT at two years for a score of≥A1 demonstrated the recommended cutoff value for diagnosing≥A1 histology to be 20 IU/L.The incidence of scores of≥A2 or≥F2 at two years after LT was 3.4%(three cases),and all patients had an absolute score of≥A2.In contrast to that observed for PLBs at five years after LT,the incidence of scores of≥A2 or≥F2 was 20.0%(11 cases),and all patients had an absolute score of≥F2.In all cases,the dose of immunosuppressants was increased after the PLB,and all ten patients who underwent a follow-up liver biopsy improved to scores of≤A1 or F1.CONCLUSION:PLB at two years after LT is an unnecessary examination,because the serum ALT level reflects portal inflammation.In addition,immunosuppressive therapy should be modulated to maintain the ALT concentration at a level less than 20 IU/L.PLB at five years is an excellent examination for the detection of early reversible graft fibrosis because no serum markers reflect this finding. | Yukihiro Sanada Koshi Matsumoto Taizen Urahashi Yoshiyuki Ihara Taiichi Wakiya Noriki Okada Naoya Yamada Yuta Hirata Koichi Mizuta | 2014 | World Journal of Gastroenterology2014，20，21： | 5 |
| 2 | characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases显示文摘AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP. | Yusuke Sekino Masahiko Inamori Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Hiroshi Iida Kunihiro Hosono Hiroki Endo Takashi Nonaka Hirokazu Takahashi Tomoko Koide Yasunobu Abe Eiji Gotoh Shigeru Koyano Yoshiyuki Kuroiwa Shin Maeda Atsushi Nakajima | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 3 | Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report显示文摘This is the first report of living donor liver transplantation(LDLT) for congenital hepatic fibrosis(CHF) using a mother's graft with von Meyenburg complex. A 6-year-old girl with CHF, who suffered from recurrent gastrointestinal bleeding, was referred to our hospital for liver transplantation. Her 38-year-old mother was investigated as a living donor and multiple biliary hamartoma were seen on her computed tomography and magnetic resonance imaging scan. The mother's liver function tests were normal and she did not have any organ abnormality, including polycystic kidney disease. LDLT using the left lateral segment(LLS) graft from the donor was performed. The donor LLS graft weighed 250 g; the graft recipient weight ratio was 1.19%. The operation and post-operative course of the donor were uneventful and she was discharged on post-operative day(POD) 8. The graft liver function was good, and the recipient was discharged on POD 31. LDLT using a graft with von Meyenburg complex is safe and useful. Long-term follow-up is needed with respect to graft liver function and screening malignant tumors. | Naoya Yamada Yukihiro Sanada Takumi Katano Masahisa Tashiro Yuta Hirata Noriki Okada Yoshiyuki Ihara Atsushi Miki Hideki Sasanuma Taizen Urahashi Yasunaru Sakuma Koichi Mizuta | 2016 | World Journal of Gastroenterology2016，22，44： | 2 |
| 4 | Rescue case of low birth weight infant with acute hepatic failure显示文摘We report a case involving a rescued low birth weight infant(LBWI) with acute liver failure. Case: The patient was 1594 g and 32^(3/7) gestational wk at birth. At the age of 11 d, she developed acute liver failure due to gestational alloimmune liver disease. Exchange transfusion and high-dose gamma globulin therapy were initiated, and body weight increased with enteral nutrition. Exchange transfusion was performed a total of 33 times prior to living donor liver transplantation(LDLT). Her liver dysfunction could not be treated by medications alone. At 55 d old and a body weight of 2946 g, she underwent LDLT using an S2 monosegment graft from her mother. Three years have passed with no reports of intellectual disability or liver dysfunction. LBWIs with acute liver failure may be rescued by LDLT after body weight has increased to over 2500 g. | Noriki Okada Yukihiro Sanada Taizen Urahashi Yoshiyuki Ihara Naoya Yamada Yuta Hirata Takumi Katano Kentaro Ushijima Shinya Otomo Shujiro Fujita Koichi Mizuta | 2017 | World Journal of Gastroenterology2017，23，40： | 2 |
| 5 | Kyoto classification in patients who developed multiple gastric carcinomas after Helicobacter pylori eradication显示文摘BACKGROUND Endoscopic Kyoto classification predicts gastric cancer risk;however,the score in the patients with primary gastric cancer after Helicobacter pylori(H.pylori)eradication therapy is unknown.AIM To elucidate the Kyoto classification score in patients with both single gastric cancer and multiple gastric cancers developed after H.pylori eradication.METHODS The endoscopist recorded the Kyoto classification at the endoscope and the Kyoto classification score at the time of the first diagnosis of gastric cancer after H.pylori eradication.The score was compared between single gastric cancer group and multiple gastric cancers group.RESULTS The Kyoto score at the time of diagnosis of 45 cases of gastric cancer after H.pylori eradication was 4.0 points in average.The score was 3.8 points in the single gastric cancer group,and 5.1 points in the multiple gastric cancers group.The multiple group had a significantly higher score than the single group(P=0.016).In the multiple gastric cancers group,all the patients(7/7)had 5 or higher Kyoto score,while in single gastric cancer group,the proportion of patients with a score of 5 or higher was less than half,or 44.7%(17/38).CONCLUSION Patients diagnosed with gastric cancer after H.pylori eradication tended to have advanced gastritis.In particular,in cases of multiple gastric cancers developed after H.pylori eradication,the endoscopic Kyoto classification score tended to be 5 or higher in patients with an open type atrophic gastritis and the intestinal metaplasia extended to the corpus. | Kosuke Sakitani Toshihiro Nishizawa Akira Toyoshima Shuntaro Yoshida Tatsuya Matsuno Tomoharu Yamada Masatoshi Irokawa Yoshiyuki Takahashi Yousuke Nakai Osamu Toyoshima Kazuhiko Koike | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，9： | 2 |
| 6 | The prognostic significance of overexpression of the decoy receptor for Fas ligand (DcR3) in patients with gastric carcinomas显示文摘 | Yasushi Takahama Yukishige Yamada Koji Emoto Heisuke Fujimoto Tomoyoshi Takayama Masatoh Ueno Hideki Uchida Shuya Hirao Takashi Mizuno Yoshiyuki Nakajima | 2002 | Gastric Cancer2002，，2： | 1 |
| 7 | Management of the late effects of disconnected pancreatic duct syndrome: A case report显示文摘BACKGROUND There have been few reports about the late effects of disconnected pancreatic duct syndrome(DPDS). Although few reports have described the recurrence interval of pancreatitis, it might be rare for recurrence to occur more than 5 years later.Herein, we describe a case of recurrence in an 81-year-old man after the treatment of walled-off necrosis(WON) with pancreatic transection 7 years ago.CASE SUMMARY An 81-year-old man visited our hospital with chief complaints of fever and abdominal pain 7 years after the onset of WON due to severe necrotic pancreatitis. His medical history included an abdominal aortic aneurysm(AAA),hypertension, dyslipidemia, and chronic kidney disease. Computed tomography(CT) scan showed that the pancreatic fluid collection(PFC) had spread to the aorta with inflammation surrounding it, and CT findings suggested that bleeding occurred from the vasodilation due to splenic vein occlusion. First, we attempted to perform transpapillary drainage because of venous dilation around the residual stomach and the PFC. However, pancreatic duct drainage failed because of complete main pancreatic duct disruption. Second, we performed endoscopic ultrasound-guided drainage. After transmural drainage, the inflammation improved and stenting for the AAA was performed successfully. The inflammation was resolved, and he has been free from infection for more than 2 years after the procedure.CONCLUSION This case highlights the importance of continued follow-up of patients for recurrence after the treatment of WON with pancreatic transection. | Reiko Yamada Yuhei Umeda Yasunori Shiono Hiroaki Okuse Naoki Kuroda Junya Tsuboi Hiroyuki Inoue Yasuhiko Hamada Kyosuke Tanaka Noriyuki Horiki Yoshiyuki Takei | 2019 | World Journal of Clinical Cases2019，7，9： | 1 |
| 8 | Alloy development of high eoughness Mg-Gd-Y-Zn-Zr alloys 显示文摘 | Kentaro Yamada Yoshiyuki Okubo Masashi Shiono | 2006 | Materials Transactions2006，47，4： | 1 |
| 9 | Pattern of Recurrence after Resection for Intraductal Papillary Mucinous Tumors of the Pancreas显示文摘 | Masayuki Sho Yoshiyuki Nakajima Hiromichi Kanehiro Michiyoshi Hisanaga Kazushi Nishio Mitsuo Nagao Naoya Ikeda Hideki Kanokogi Takatsugu Yamada Hiroshige Nakano | 1998 | World Journal of Surgery1998，，8： | 1 |
| 10 | ANTI-INTERLEUKIN 6 (IL-6) RECEPTOR ANTIBODY SUPPRESSES CASTLEMAN’S DISEASE LIKE SYMPTOMS EMERGED IN IL-6 TRANSGENIC MICE显示文摘 | Asao Katsume Hiroyuki Saito Yoshiki Yamada Keigo Yorozu Otoya Ueda Ken-Ichi Akamatsu Norihiro Nishimoto Tadamitsu Kishimoto Kazuyuki Yoshizaki Yoshiyuki Ohsugi | 2002 | Cytokine2002，，6： | 1 |
| 11 | Alloy development of high eoughness Mg-Gd-Y-Zn-Zr alloys 显示文摘 | Kentaro Yamada Yoshiyuki Okubo Masashi Shiono | 2006 | Materials Transactions2006，47，4： | 1 |
| 12 | Imperfection - senstive overall buckling of single - layer latticed domes 显示文摘 | Seishi Yamada Akiko Takeuchi Yoshiyuki Tada | 2001 | Journal of Engineering Mechanics2001，，4： | 1 |
| 13 | Extracellular signal-regulated kinase and Akt activation play a criticalrole in the process of hepatocyte growth factor-induced epithelial-mesenchymaltransition显示文摘 | Toshiyuki Tanahashi Shinji Osada Atsuko Yamada Junko Kato Kazunori Yawata Ryutaro Mori Hisashi Imai Yoshiyuki Sasaki Shiro Saito Yoshihiro Tanaka Kenichi Nonaka Kazuhiro Yoshida | 2013 | International Journal of Oncology2013，，2： | 1 |
| 14 | Inflammation of the gastric remnant after gastrectomy: mucosal erythema is associated with bile reflux and inflammatory cellular infiltration is associated with Helicobacter pylori infection显示文摘 | Youngho Lee Akira Tokunaga Takashi Tajiri Gotaro Masuda Takeshi Okuda Itsuo Fujita Teruo Kiyama Toshiro Yoshiyuki Shunji Kato Norio Matsukura Nobutaka Yamada | 2004 | Journal of Gastroenterology2004，，6： | 1 |
| 15 | Extracellular signal-regulated kinase and Akt activation play a criticalrole in the process of hepatocyte growth factor-induced epithelial-mesenchymaltransition显示文摘 | Toshiyuki Tanahashi Shinji Osada Atsuko Yamada Junko Kato Kazunori Yawata Ryutaro Mori Hisashi Imai Yoshiyuki Sasaki Shiro Saito Yoshihiro Tanaka Kenichi Nonaka Kazuhiro Yoshida | 2013 | International Journal of Oncology2013，，2： | 1 |
| 16 | Comparison of Corneal and Aqueous Humor Penetration of Moxifloxacin, Gatifloxacin and Levofloxacin during Keratoplasty显示文摘 | Masahiko Fukuda Masakazu Yamada Shigeru Kinoshita Tsutomu Inatomi Yuichi Ohashi Toshihiko Uno Jun Shimazaki Yoshiyuki Satake Naoyuki Maeda Yuichi Hori Kohji Nishida Akira Kubota Toru Nakazawa Yoshikazu Shimomura | 2012 | Advances in Therapy2012，，4： | 1 |
| 17 | Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction显示文摘 | Mako Nakaya Masao Yamasaki Yoshiyuki Miyazaki Hirofumi Tachibana Koji Yamada | 2003 | In Vitro Cellular & Developmental Biology - Animal (-)2003，，8： | 1 |
| 18 | Use of proteomics to identify novel virulence determinants that are required for Edwardsiella tarda pathogenesis显示文摘 | Yoshiyuki Yamada P S Tan Y P | 2004 | Molecular Microbiology2004，53，2： | 1 |
| 19 | Brain metastasis from colorectal cancer: Prognostic factors and survival显示文摘 | Shingo Noura Masayuki Ohue Tatsushi Shingai Ayako Fujiwara Shinya Imada Toshinori Sueda Terumasa Yamada Yoshiyuki Fujiwara Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2012 | J. Surg. Oncol2012，，2： | 1 |
| 20 | Diagnosis of intrahepatic metastasis and multicentric carcinogenesis by microsatellite loss of heterozygosity in patients with multiple and recurrent hepatocellular carcinomas显示文摘 | Osakuni Morimoto Hiroaki Nagano Masato Sakon Yoshiyuki Fujiwara Terumasa Yamada Hidewaki Nakagawa Atsushi Miyamoto Motoi Kondo Isao Arai Tameyoshi Yamamoto Hideo Ota Keizo Dono Koji Umeshita Shoji Nakamori Yo Sasaki Osamu Ishikawa Shingi Imaoka Morito Mon | 2003 | Journal of Hepatology2003，，2： | 1 |
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