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| 1 | Impact of metastatic lymph node ratio in node-positive colorectal cancer显示文摘Colorectal cancer(CRC) is one of the most common malignant diseases in the world.Presently,the most widely used staging system for CRC is the tumor nodes metastasis classification system,which classifies patients into prognostic groups according to the depth of the primary tumor,presence of regional lymph node(LN) metastases,and evidence of distant metastatic spread.The number of LNs with confirmed metastasis is related to the severity of the disease,but this number depends on the number of LNs retrieved,which varies depending on patient age,tumor grade,surgical extent,and tumor site.Numerous studies and a recent structured review have demonstrated associated improvements in the survival of CRC patients with increasing numbers of LNs retrieved for examination.Hence,the impact of lymph node ratio(LNR),defined as the number of metastatic LNs divided by the number of LNs retrieved,has been investigated in various malignancies,including CRC.In this editorial,we review the literature demonstrating the clinicopathological significance of LNR in CRC pati-ents.Some reports have indicated the advantage of considering the LNR compared to the number of LNs retrieved and/or LN status.When the LNR is taken into consideration for survival analysis,the number of LNs retrieved and/or the LN status is not always found to be a prognostic factor.The cut-off points for LNRs were proposed in numerous studies.However,optimal thresholds for LNRs have not yet received consensus.It is still unclear whether the LNR has more prognostic validity than N stage.For all these reasons,the potential advantages of LNRs in the staging system should be investigated in large prospective data sets. | Shingo Noura Masayuki Ohue Shingo Kano Tatsushi Shingai Terumasa Yamada Isao Miyashiro Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 7 |
| 2 | Clinical benefit of surgery for stage IV colorectal cancer with synchronous peritoneal metastasis显示文摘 | Hirotoshi Kobayashi Kenjiro Kotake Kimihiko Funahashi Kazuo Hase Koichi Hirata Tsuneo Iiai Shingo Kameoka Yukihide Kanemitsu Koutarou Maeda Akihiko Murata Masayuki Ohue Kazuo Shirouzu Keiichi Takahashi Toshiaki Watanabe Hideaki Yano Toshimasa Yatsuoka Yoj | 2014 | Journal of Gastroenterology2014，，4： | 2 |
| 3 | Transarterial chemoembolization with miriplatin-lipiodol emulsion for neuroendocrine metastases of the liver显示文摘Miriplatin,a cisplatin derivative with a high affinity for iodized oil,is a novel chemotherapeutic agent designed for use in the transarterial treatment of hepatocellular carcinoma.This case report describes our experience with transarterial chemoembolization(TACE) using miriplatin in 2 patients with neuroendocrine liver metastases.A 38-year-old man with multiple neuroendocrine liver metastases was treated by whole liver chemoembolization,and a 35-year-old woman with a single hepatic lesion was treated by superselective chemoembolization.No serious adverse events were noted during the interventional procedures,or during the observation period of 3 mo in either patient.Sufficient iodized oil uptake was observed in the hypervascular lesions on the unenhanced computed tomography(CT) at 7 d after the procedure.Contrast-enhanced CT obtained at 3 mo after chemoembolization revealed that all hepatic lesions were substantially reduced in size irrespective of tumor vascularity or degree of cystic degeneration,although iodized oil accumulation was only marginal for lesions with cystic degeneration.Thus,TACE with miriplatin can be a safe and effective therapeutic option for the treatment of neuroendocrine metastases of the liver. | Jin Iwazawa Shoichi Ohue Keigo Yasumasa Takashi Mitani | 2010 | World Journal of Radiology2010，2，12： | 2 |
| 4 | 对有静脉内的提高对比的 C 手臂的肝肿瘤的脱离边缘评价计算了断层摄影术显示文摘 AIM:To evaluate the feasibility of intravenous contrastenhanced C-arm computed tomography(CT) for assessing ablative areas and margins of liver tumors.METHODS:Twelve patients(5 men,7 women;mean age,69.5 years) who had liver tumors(8 hepatocellular carcinomas,4 metastatic liver tumors;mean size,16.3 mm;size range,8-20 mm) and who underwent percutaneous radiofrequency ablations(RFAs) with a flatdetector C-arm system were retrospectively reviewed.Intravenously enhanced C-arm CT and multidetector computed tomography(MDCT) images were obtained at the end of the RFA sessions and 3-7 d after RFA to evaluate the ablative areas and margins.The ablated areas and margins were measured using axial plane images acquired by both imaging techniques,with prior contrast-enhanced MDCT images as the reference.The sensitivity,specificity,and positive and negative predictive values of C-arm CT for detecting insufficient ablative margins(< 5 mm) were calculated.Statistical differences in the ablative areas and margins evaluated with both imaging techniques were compared using a paired t-test.RESULTS:All RFA procedures were technically successful.Of 48 total ablative margins,19(39.6%) and 20(41.6%) margins were found to be insufficient with C-arm CT and MDCT,respectively.Moreover,there were no significant differences between these 2 imaging techniques in the detection of these insufficient ablative margins.The sensitivity,specificity,and positive and negative predictive values for detecting insufficient margins by C-arm CT were 90.0%,96.4%,94.7% and 93.1%,respectively.The mean estimated ablative areas calculated from C-arm CT(462.5 ± 202.1 mm 2) and from MDCT(441.2 ± 212.5 mm 2) were not significantly different.The mean ablative margins evaluated by C-arm CT(6.4 ± 2.2 mm) and by MDCT(6.0 ± 2.4 mm) were also not significantly different.CONCLUSION:The efficacy of intravenous contrastenhanced C-arm CT in assessing the ablative areas and margins after RFA of liver tumors is nearly equivalent to that of MDCT. | Jin Iwazawa Shoichi Ohue Naoko Hashimoto Takashi Mitani | 2012 | World Journal of Radiology2012，4，3： | 2 |
| 5 | Cone index prediction of compacted soils显示文摘 | Raghavan G S V Mckyes E | 1988 | Transactions of ASAE1988，31，2： | 1 |
| 6 | High concentration of E-cadherin in portal drainage vein of colorectal cancer patients may predict metachronous liver metastasis显示文摘 | Ohue M Takahashi K Yamaguchi T | 2002 | Gan To Kagaku Ryoho2002，29，12： | 1 |
| 7 | Multi-institutional study of risk factors of liver metastasis from colorectal cancer: correlation with CD10 expression显示文摘 | Shin Fujita Hirokazu Taniguchi Takashi Yao Tadakazu Shimoda Hideki Ueno Takashi Hirai Masayuki Ohue | 2010 | International Journal of Colorectal Disease2010，，6： | 1 |
| 8 | Surgical management of brainstem cavernomas:selection of approaches and microsurgical techniques显示文摘 | Ohue S Fukushima T Kumon Y | 2010 | Neurosurg Rev2010，33，3： | 1 |
| 9 | Cytokine production in five tumor cell lines with activity to induce cancer cachexia syndrome in nude mice 显示文摘 | Iseki H Kajimura N Ohue C | 1995 | Jpn J Cancer Res1995，86，6： | 1 |
| 10 | Diagnosis of tooth surface failure by wavelet transform of dynamic characteristics显示文摘 | Yoshida A Ohue Y Ishikawa H | 2000 | Tribology International2000，，33： | 1 |
| 11 | Feasibility of autonomic nerve-preserving surgery for advanced rectal cancer based on analy- sis ofmicrometastases显示文摘 | Matsumoto T Ohue M Sekimoto M | 2005 | Br J Surg2005，92，11： | 1 |
| 12 | Development of a simple and highly sensitive enzyme immonoassay for hepatitis C virus core antigen显示文摘 | Aoyagi K Ohue C Iida K | 1999 | J Clin Microbiol1999，37，6： | 1 |
| 13 | Feasibility of autonomic nerve-preserving surgery for advanced rectal cancer based on analysis of micrometastases显示文摘 | Matsumoto T Ohue M Sekimoto M | 2005 | Br J Surg2005，92，11： | 1 |
| 14 | High-speed scaled-down self-aligned SEG SiGe HBTs显示文摘 | WASHIO K OHUE E HAYAMI R | 2003 | IEEE Trans on Electron Devices2003，50，3： | 1 |
| 15 | Single-incision laparoscopic cecectomy for low-grade appendiceal mucinous neoplasm after laparoscopic rectectomy显示文摘In this case report,we discuss single-incision laparoscopic cecectomy for low-grade appendiceal neoplasm after laparoscopic anterior resection for rectal cancer.The optimal surgical therapy for low-grade appendiceal neoplasm is controversial;currently,the options include appendectomy,cecectomy,right hemicolectomy,and open or laparoscopic surgery.Due to the risk of pseudomyxoma peritonei,complete resection without rupture is necessary.We have encountered 5 cases of lowgrade appendiceal neoplasm and all 5 patients had no lymph node metastasis.We chose the appendectomy or cecectomy without lymph node dissection if preoperative imaging studies did not suspect malignancy.In the present case,we performed cecectomy without lymph node dissection by single-incision laparoscopic surgery(SILS),which is reported to be a reduced port surgery associated with decreased invasiveness and patient stress compared with conventional laparoscopic surgery.We are confident that SILS is a feasible alternative to traditional surgical procedures for borderline tumors,such as low-grade appendiceal neoplasms. | Shiki Fujino Norikatsu Miyoshi Shingo Noura Tatsushi Shingai Yasuhiko Tomita Masayuki Ohue Masahiko Yano | 2014 | World Journal of Gastrointestinal Surgery2014，6，5： | 1 |
| 16 | The indications for a diverting stoma in low anterior resection for rectal cancer:a prospective muhicentre study of 222 patients from Japanese cancercenler:显示文摘 | Shiomi A Ito M Saito N Hirai T Ohue M | 2011 | Colorectal Dis2011，13，12： | 1 |
| 17 | A case of apocrine adenocarcinoma suspected as an axillary lymph node metastasis from cecal cancer显示文摘 | Ogino T Noura S Ohue M | | 0，，： | 1 |
| 18 | Identifying feeding arteries during TACE of hepatic tumors: comparison of C arm CT and digital subtraction angiography显示文摘 | Iwazawa J Ohue S Mitani T | 2009 | Am J Roentgenol2009，192，10： | 1 |
| 19 | CEA-Antigen and SCC-Antigen mRNA Expression in Peripheral Blood Predict Hematogenous Recurrence After Resection in Patients with Esophageal Cancer显示文摘 | Koji Tanaka Masahiko Yano Masaaki Motoori Kentaro Kishi Isao Miyashiro Tatsushi Shingai Kunihito Gotoh Shingo Noura Hidenori Takahashi Masayuki Ohue Terumasa Yamada Hiroaki Ohigashi Takashi Yamamoto Tomoyuki Yamasaki Yuichiro Doki Osamu Ishikawa | 2010 | Annals of Surgical Oncology2010，，： | 1 |
| 20 | Treatment for patients with liver metastasis from colorectal cancer--expansion of hepatic arterial infusion therapy 显示文摘 | Mori T Takahashi K Ohue M | 2002 | Gan To Kagaku Ryoho2002，29，6： | 1 |
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