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| 1 | SHRIMP zircon U-Pb dating in Jingshan 'migmatitic granite', Bengbu and its geological significance显示文摘The petrographic characteristics of Jingshan 'migmatitic granite' and the occurrence of the magmatic zircons indicate that the granite was formed by normal crystallization of felsic melts. All zircons in the granite have inherited cores and fine-scale oscillatory zoning rims of magmatic origin. It is realized that the granite was formed at 160.2±1.3 Ma through dating magmatic zircons. The generation of the granitic magma could be related to the lithospheric mantle and/or lower crust delamination after the ultrahigh pressure metamorphism (UHPM) in Triassic. Most inherited zircons yield the ages of 217.1±6.6 Ma, which is consistent with the peak UHPM in the Dabie-Sulu orogenic belt. Some of the inherited zircons (433-722 Ma) constitute a discordia line with the upper intercept age of 850+85/-68 Ma and a lower intercept age of 261+100/-140 Ma. These ages imply that the granite could be derived from the partial melting of the crustal materials of the South China Block that was intensively superimposed by the UHPM. The UHPM could be the reason for the major Pb loss at ±220 Ma. | XU Wenliang, WANG Qinghai, YANG Debin, LIU Xiaochun & GUO Jinghui College of Earth Sciences, Jilin University, Changchun 130061, China Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081, China Institute of Geology & Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2005 | Science China Earth Sciences2005，48，2： | 32 |
| 2 | Petrogenesis of Mesozoic High-Mg Diorites in Western Shandong: Evidence from Chronology and Petro-geochemistry显示文摘The high-Mg diorites, widely occurring in western Shandong, have important implications in the study of the relationship between the Mesozoic magmatism and the nature of the lithosphere and its thinning period in the eastern North China craton (NCC). The Tietonggou and Jinling intrusions are typically representatives. LA-ICP-MS zircon U-Pb dating, major and trace element and Sr-Nd isotopic compositions of the Mesozoic intrusive rocks from western Shandong, eastern China, were analyzed. The weighted mean 206Pb/ 238U ages from LA-ICP-MS zircon U-Pb dating results for early norite-diorite, late pyroxene-diorite from the Tietonggou intrusion and biotite-diorite from the Jinling intrusion are (131.4±4.9) Ma(n=15), (134.5±2.3) Ma(n=13), and (132.8±4.2) Ma(n=12), respectively, implying that they were formed in the Early Cretaceous. The weighted mean 207Pb/ 206Pb ages for round zircons from late pyroxene-diorite in the Tietonggou intrusion is (2 513±54) Ma(n=8), suggesting that the basement of the North China craton should exist in the research area. The high-Mg diorites are characterized by enrichment in MgO, Na2O, and light rare earth elements (LREE), and they are poor in heavy rare earth elements (HREE) and high field strength elements (HFSE), being similar to adakite. The existence of the mantle peridotite xenoliths with a high-Mg feature for these intrusive rocks implies that their primary magma should be derived from the upper mantle. However, Sr-Nd isotopic compositions (I sr: 0.704 75-0.707 15; ε Nd(130 Ma) values: -3.95 to -13.30), depletion in HFSE, and the occurrence of Archean inherited zircons suggest that crustal materials could be involved in the derivation of the primary magma. The compositional difference between the diorites from the Tietonggou and Jinling intrusions could be attributed to those of magma sources and degrees of partial melting. The Early Cretaceous high-Mg diorites are considered to have been formed by the mixed melting of the delaminated lithosphere (lithospheric mantle + crust) and asthenosphere, based on their geochemistry, the mantle-derived xenoliths, and the Early Mesozoic lithospheric evolutionary history of the eastern North China craton. | Yang Chenghai Xu Wenliang Yang Debin Liu Changchun Liu Xiaoming Hu Zhaochu | 2005 | Journal of China University of Geosciences2005，16，4： | 24 |
| 3 | Hydrology and water resources variation and its response to regional climate change in Xinjiang显示文摘Based on the surface runoff, temperature and precipitation data over the last 50 years from eight representative rivers in Xinjiang, using Mann-Kendall trend and jump detection method, the paper investigated the long-term trend and jump point of time series, the surface runoff, mean annual temperature and annual precipitation. Meanwhile, the paper analyzed the relationship between runoff and temperature and precipitation, and the flood frequency and peak flow. Results showed that climate of all parts of Xinjiang conformably has experienced an increase in temperature and precipitation since the mid-1980s. Northern Xinjiang was the area that changed most significantly followed by southern and eastern Xinjiang. Affected by temperature and precipitation variation, river runoff had changed both inter-annually and intra-annually. The surface runoff of most rivers has increased significantly since the early 1990s, and some of them have even witnessed the earlier spring floods, later summer floods and increasing flood peaks. The variation characteristics were closely related with the replenishment types of rivers. Flood frequency and peak flow increased all over Xinjiang. Climate warming has had an effect on the regional hydrological cycle. | XU Changchun CHEN Yaning YANG Yuhui HAO Xingming SHEN Yongping | 2010 | Journal of Geographical Sciences2010，20，4： | 17 |
| 4 | Effects of laser energy density on forming accuracy and tensile strength of selective laser sintering resin coated sands显示文摘Baozhu sand particles with size between 75 μm and 150 μm were coated by resin with the ratio of 1.5 wt.% of sands. Laser sintering experiments were carried out to investigate the effects of laser energy density(E = P/v), with different laser power(P) and scanning velocity(v), on the dimensional accuracy and tensile strength of sintered parts. The experimental results indicate that with the constant scanning velocity, the tensile strength of sintered samples increases with an increase in laser energy density; while the dimensional accuracy apparently decreases when the laser energy density is larger than 0.032 J·mm-2. When the laser energy density is 0.024 J·mm-2, the tensile strength shows no obvious change; but when the laser energy density is larger than 0.024 J·mm-2, the sample strength is featured by the initial increase and subsequent decrease with simultaneous increase of both laser power and scanning velocity. In this study, the optimal energy density range for laser sintering is 0.024-0.032 J·mm-2. Moreover, samples with the best tensile strength and dimensional accuracy can be obtained when P = 30-40 W and v = 1.5-2.0 m·s-1. Using the optimized laser energy density, laser power and scanning speed, a complex coated sand mould with clear contour and excellent forming accuracy has been successfully fabricated. | Xu Zhifeng Liang Pei Yang Wei Li Sisi Cai Changchun | 2014 | China Foundry2014，11，3： | 17 |
| 5 | The research progress on lateral shift of reflected electromagnetic wave at the interface of two conductive media显示文摘In this paper the research status of lateral shift of reflected electromagnetic wave at the interface of conductive media was reviewed, the lateral shift and the lateral delay were analyzed, and the charac-teristic of lateral shift curves varying with the angle of incidence was introduced in detail. For electro-magnetic wave logging, the error correction method of lateral shift was stressed in this paper, the magnitude of measured errors caused by the lateral shift was established. It is noticed that the longer wavelength, the larger error of measured results. With respect to the effect of lateral shift, the problem which still needs to be settled in the measurement of electromagnetic wave, as well as prospects on the further research and applications of lateral shift are described. | LIU FuPing WANG AnLing CHEN Qiang LI RuiZhong CHEN HuiGuo YANG ChangChun | 2008 | Chinese Science Bulletin2008，53，7： | 15 |
| 6 | Effects of Current Frequency on the Microstructure and Wear Resistance of Ceramic Coatings Embedded with SiC Nano-particles Produced by Micro-arc Oxidation on AZ91D Magnesium Alloy显示文摘To improve the surface wear resistance of the ceramic coating fabricated by micro-arc oxidation (MAO) on AZ91D magnesium alloy,ceramic coatings embedded with SiC nano-particles at different current frequency (500 Hz,700 Hz,and 900 Hz) were produced during the MAO process.The morphology and phase composition of the coatings were investigated by scanning electron microscopy (SEM),field emission scanning electron microscopy (FESEM),and X-ray diffraction (XRD).The surface roughness of the coatings was characterized by confocal laser scanning microscopy (CLSM).Simultaneously,the tribological properties of the composite coatings were evaluated by using a universal materials tester (UMT).The results shows that the wear resistance of the ceramic coatings with SiC nano-particles was improved significantly compared to the ceramic coatings without SiC nano-particles.Furthermore,the composite coating formed at current frequency 900 Hz showed the better wear resistance than the others. | Yue Yang and Hua Wu Key Laboratory of Advanced Structural Materials,Ministry of Education,Changchun University of Technology,Changchun 130012,China | 2010 | Journal of Materials Science & Technology2010，26，10： | 14 |
| 7 | A novel mutation at the JK locus causing Jknull phenotype in a Chinese family显示文摘Urea transporters are a group of proteins that facilitate urea movement across biological membranes. Kidd blood group (JK antigen) and urea transporter of human erythrocytes are carried by the same protein UT-B. To investigate the molecular basis of the Jknull phenotype in the Chinese population, blood samples from Chinese individuals were screened using the 2 mol/L urea solution hemolysis test. Urea and water permeability of erythrocytes membrane was measured by stopped-flow light scattering. Genomic DNA was extracted from lymphocytes. UT-B gene of Jknull's family was analyzed using genomic PCR by primers designed to cover sequences of all exons and exon-intron boundaries in human UT-B gene. One Jknull subject was found from twenty thousand screened Chinese individuals, and it was confirmed that this individual did not express the erythrocyte urea transporter. Genomic sequence analysis of the Jknull individual showed that there were two point mutations, G→C, which is novel, and G→A, at the 3(-acceptor splice site (AG) of intron 5 of UT-B gene. Exon 6 is spliced out in the UT-B transcript due to either of these mutations. Water permeability in Jknull erythrocytes (Pf, ~0.00037 cm/s) was significantly lower than that in normal erythrocytes (Pf, ~0.00062 cm/s) after HgCl2 incubation, providing evidence for UT-B facilitated water transport in human erythrocytes. | MENG Yan1, ZHOU Xueyan2, LI Yang1, ZHAO Dan1, LIANG Shuyuan2, ZHAO Xuejian1, YANG Baoxue1,3 1. Department of Pathophysiology, School of Medical Science, Jilin University, Changchun 130021, China 2. The Third Hospital of Jilin University, Changchun 130031, China 3. Departments of Medicine, University of California, San Francisco, CA, 94143-0521, USA | 2005 | Science China(Life Sciences)2005，48，6： | 13 |
| 8 | Relationship between genetic polymorphism of cytochrome P450IIE1 and fatty liver显示文摘AIM: To study the correlation between genetic polymorphism of cytochrome P450IIE1 (CYPIIE1) and fatty liver.METHODS: Peripheral blood mononuclear cells were collected in 56 patients with fatty liver, 26 patients without fatty liver and 20 normal controls. Then PCR-RFLP was used to analyze genetic polymorphism of CYPIIE1 in monocytes on the region of Pst I and Rsa I.RESULTS: The frequency of homozygotic C1 gene in patients with alcoholic fatty liver (28.6 %), obese fatty liver (38.5 %), or diabetic fatty liver (33.3 %) was significantly lower than that of the corresponding patients without fatty liver (100 %, 100 % and 80 % respectively), while the frequency of C2 genes, including C1/C2 and C2/C2, was significantly higher (71.4 %/0 %, 61.5 %/0 %, and 66.7 %/20 %) (P<0.01). The frequency distribution of the above genes of non-fatty liver patients (100 %/0, 100 %/0, and 80 %/20 %) was not significantly different from that of the normal controls (85 %/15 %) (P>0.05).CONCLUSION: The genetic polymorphism of CYPIIE1 on the position of Pst I and Rsa I is related to the susceptibility of fatty liver. Besides, C2 gene may play a key role in the pathogenesis of fatty liver. | Yun-Feng Piao Jing-Tao Li Yang Shi, Department of Gastroenterology, First Hospital, Jilin University, Changchun 130021, Jilin Province, China | 2003 | World Journal of Gastroenterology2003，9，11： | 12 |
| 9 | Experimental remolding on the caprock's 3D strain field of the Indosinian-Yanshanian epoch in Tongling deposit concentrating area显示文摘Based on field observations and rheology analysis, we perform one analogue experiment and remold the 3D structural frame of Tongling deposit concentrating area firstly. Then we disassemble and dialyze the 3D structures of the model using the methods of 'slicing' and 'stripping'. A series of sliced planes vertical to the fold hinges show similar landscapes of that in the drill hole profiles. Meanwhile, layer stripping analysis indicates that the deformation features of each layer in the model are qualitatively analogical to those obtained from field observations. Through contrasting the 3D structure between the experimental model and the field phenomena, we verify the following 3D deformation features of the caprock in this area: (1) the Tongling area mainly consists of three series of NE S-typed fold groups; (2) in the uniform stress field, the incoherent folds universally develop in different positions, along different axes as well as in different strata; (3) the faults propagate upward which are mostly inter-bedded detachment faults, while the fold amplitudes decrease while going deeper; and (4) the folds and cleavages are highly developed in the Silurian System indicating that the deformation effect of the Indosin-ian-Yanshanian structural layer terminates at this layer, which suggests that the Silurian System is the crucial layer for the inversion between brittle and plastic deformation domains and the underlying strata are subject to the control of another deformation system with distinct properties. | DENG Jun1,HUANG Dinghua2,WANG Qingfei1,WAN Li1,SUN Zhongshi3,YANG Liqiang1 & GAO Bangfei1 1. State Key Laboratory of Geological Processes and Mineral Resources,China University of Geosciences,Beijing 100083,China 2. Faculty of Earth Sciences,China University of Geosciences,Wuhan 430074,China 3. Department of Earth Sciences,Jilin University,Changchun 130061,China | 2005 | Science China Earth Sciences2005，48，7： | 12 |
| 10 | Studies on Absorption and Tansport of Limoninoids from Fructus Evodiae in Caco-2 Cell Monolayer Model显示文摘Objective To study the intestinal absorption and transepithelial transport of three limoninoids: evodol (EVO), limonin (LIM), and shihulimonin A (SHIA), isolated from Fructus Evodiae [the unripe fruit of Evodia rutaecarpa and Evodia rutaecarpa var. bodinieri] in the human intestine. Methods The in vitro cultured human colon carcinoma cell line, Caco-2 cell monolayer model, was applied to studying the absorption and transepithelial transport of the three limoninoids from apical (AP) to basolateral (BL) side and from BL to AP side. The three limoninoids were measured by reversed-phase high performance liquid chromatography coupled with ultraviolet absorption detector. Transport parameters and apparent permeability coefficients (Papp) were then calculated and compared with those of Propranolol as a control substance of high permeability and Atenolol as a control substance of poor permeability. Results The Papp value of EVO and LIM from AP to BL side for absorption and transport were 1.78 × 10-5 cm/s and 1.16 × 10-5 cm/s, respectively, which was comparable to that of Propranolol with Papp 2.18 × 10-5 cm/s. Conclusion The absorption and transport of both EVO and LIM are main passive diffusion as the dominating process in Caco-2 cell monolayer model, and they were estimated to be high absorbed compounds. SHIA in Caco-2 cell monolayer model may be involved in metabolism in the transport processes. | YANG Xiu-wei1*, TENG Jie1, ZHAO Bo2, ZHANG Lian-xue2 1. State Key Laboratory of Natural and Biomimetic Drugs (Peking University), School of Pharmaceutical Sciences, Peking University, Beijing 100191, China 2. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China | 2009 | Chinese Herbal Medicines2009，1，1： | 10 |
| 11 | Inhibitory effect of all-trans retinoic acid on human hepatocellular carcinoma cell proliferation显示文摘AIM: To study the inhibitory effect of all-trans retinoic acid on human hepatocellular carcinoma cell line SMMC-7721and to explore the mechanism of its effect.METHODS: SMMC-7721 cells were divided into two groups, one treated with all-trans retinoic acid (ATRA) for 5 days and the other as a control group. Light microscope and electron microscope were used to observe the morphological changes. Telomerase activity was analyzed with silver-stained telomere repeated assay protocal (TRAP). Expression of Caspase-3 was demonstrated with western blot.RESULTS: ATRA-treated cells showed differentiation features including small and pyknotic nuclei, densely stained chromatin and fewer microvilli. Besides, ATRA could inhibit the activity of telomerase, promote the expression of Caspase-3 and its activation.CONCLUSION: Telomerase activity and Caspase-3expression are changed in human hepatocellular carcinoma cell line SMMC-7721 treated with all-trans retinioc acid.The inhibition of telomerase activity and the activation of Caspase-3 may be the key steps through which ATRA inhibits the proliferation of SMMC-7721 cell line. | Yun-Feng Piao Yang Shi Pu-Jun Gao Department of Gastroenterology,the First Hospital of Jilin University,Changchun,130021,Jilin Province,China | 2003 | World Journal of Gastroenterology2003，9，9： | 9 |
| 12 | Study on the stability and 3-dimensional character for natural convection in a rectangular cavity heated from below显示文摘Natural convection of air is numerically simulated in a 3-dimensional rectangular cavity heated from below using SIMPLE algorithm with a QUICK scheme.The results suggest that when all lateral walls are adiabatic,the fluid rolls occur along the long axis.When the Rayleigh number is smaller,the flow is of 2-dimensional character,and the rolls shapes are similar.The average Nusselt numbers in the central part of the cavity are similar.The average Nusselt numbers in the part near by the cavity are different.According to the comparison of 3-dimensional results with 2-dimensional results,the flow patterns and heat transfer in the central part of the cavity can be assumed as a 2-dimensional flow,While those in the part near by the cavity can not.With increasing Rayleigh number,the flow is 3-dimensional characteristic.The 3-dimensional result accords with the experimental result.When all lateral walls are adiabatic,the ten rolls occur along the long axis.But when lateral walls are heated or cooled,the rolls disappear along the long axis and two rolls occur along the short axis.The rotation direction of the rolls is reversed.When Rayleigh number is over some critical value,flow and heat transfer will be asymmetry,indicating unsteady oscillation occurs.By nonlinear analyses,it is shown that with increasing Rayleigh number,flow and heat transfer will change from steady state to unsteady state through HOPF bifurcation,and transition to chaos will occur through multi-periodical oscillation. | ZHAN NaiYan1,2,XU PeiWei1,SUN ShiMei,YANG Mo2 & LIU Jun3 1 Scool of Municipal and Environmental Engineering,Jilin Institute of Architectural and Civil Engineering,Changchun 130021,China 2 College of Power Engineering,University of Shanghai for Science and Technology,Shanghiai 200093,China 3 College of Power Engineering,Jilin University,Changchun 130000,China | 2010 | Science China(Technological Sciences)2010，53，6： | 9 |
| 13 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 14 | Spectral element analysis on the characteristics of seismic wave propagation triggered by Wenchuan M_s8.0 earthquake显示文摘The 2008 Wenchuan earthquake occurred in an active earthquake zone, i.e., Longmenshan tectonic zone. Seismic waves triggered by this earthquake can be used to explore the characteristics of the fault rupture process and the hierarchical structure of the Earth's interior. We employ spectral element method incorporated with large-scale parallel computing technology, to investigate the characteristics of seismic wave propagation excited by Wenchuan earthquake. We calculate synthetic seismograms with one-point source model and three-point source model respectively. The AK135 model is employed as a prototype of our numerical global Earth model. The Earth's ellipticity, Earth’s medium attenuation, and topography data are taken into consideration. These wave propagation processes are simulated by solving three-dimensional elastic wave governing equations. Three-dimensional visualization of our numerical results displays the profile of the seismic wave propagation. The three-point source, which is proposed from the latest investigations through field observation and reverse estimation, can better demonstrate the spatial and temporal characteristics of the source rupture process than the one-point source. We take comparison of synthetic seismograms with observational data recorded at 16 observatory stations. Primary results show that the synthetic seismograms calculated from three-point source agree well with the observations. This can further reveal that the source rupture process of Wenchuan earthquake is a multi-rupture process, which is composed by at least three or more stages of rupture processes. | YAN ZhenZhen ZHANG Huai YANG ChangChun SHI YaoLin | 2009 | Science China Earth Sciences2009，52，6： | 9 |
| 15 | ^40Ar/^39Ar dating of Daqingshan thrust显示文摘The Daqingshan thrust system, to the south of the Shiguai Mesozoic basin, is a complex system of top-to- the-north thrusting tectonic sheets. The thrust system has a complicated evolution due to multi-stage thrusting. In order to date the thrusting events, syntectonic muscovite and bio-tite grains are respectively analyzed with normal 40Ar/39Ar dating and laser 40Ar/39Ar dating, which yield 2 isochron ages, i.e. 193.74 3.88 Ma and 121.6 1.6 Ma. These ages suggest that faults within the Daqingshan thrust system formed dur-ing 2 stages of thrusting, one the early Indosinian and the other the late Yanshanian. The isotopic dating is consistent with field geological relations. Indosinan deformation is evi-denced by top-to-the-north thrusting, with the occurrence of a series of large-scale east-west trending thrust faults and folds, while the Yanshanian thrusting is characterized by top-to-the-NNW thrusting. It is superposed on and modifies early Indosinian thrust faults. | LIU Zhenghong, XU Zhongyuan & YANG Zhensheng College of Earth Sciences, Jilin University, Changchun 130061, China Correspondence should be addressed to Liu Zhenghong (e-mail: liuzhenghong@jlu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，24： | 9 |
| 16 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 17 | The Effect of Tide on the Global Climate Change显示文摘The differential rotation between the solid and fluid spheres caused by tidal force could explain the 1500 to 1800-year cycle of the world's temperature. Strong tide increases the vertical and horizontal mixing of water in the oceans, drawing the cold Pacific water from the depths to the surface and the warm water from the west to the east, where it cools or warms the atmosphere above, absorbs or releases CO2 to decrease or increase greenhouse effect and to make La Nina or El Nino occur in the global. The moon's declination and obliquity of the ecliptic affect the tidal intensity. The exchange of tidal energy and tide-generating force caused by the sun, moon and major planets makes the earth's layers rotate in different speeds. The differenti-al rotation between solid and fluid of the earth is the basic reason for El Nino and global climate change. | YANG Xuexiang, CHEN Zhen and CHEN Dianyou( College of Ceo - exploration Science and Technology, Jilin University, Changchun 130026, P. R. China)Qiao Qiyuan(National Astronomical Observatory, Chinese Academy of Science, Beijing 100012, P. R. China) | 2002 | Global Geology2002，7，1： | 7 |
| 18 | Sedimentary Characteristics of the Cretaceous in the Songliao Basin显示文摘The rupture of the lithosphere in Late Jurassic brought about the eruption of basaltic magma in the Songliao Basin. The evolution of the basin in Cretaceous progressed through six stages: pre-rift doming, extensional fracturing, fault subsidence, fault downwarping, downwarping and shringkage, resulting in the deposition of terrstrial facies nearly 10,000 m thick. There are different depositional sequences in these stages: the depositional period of the Early Cretaceous Shahezi and Yincheng Formations is the development stage of the down-faulted basin, forming a volcanic rock-alluvial fan-fan delta-lacustrine (intercalated with episodic turbidites)-swamp facies sequences; the period of the Early Cretaceous Dengluku Formation is the transformation stage of fault subsidence into fault downwarping of the basin, forming a sequence mainly of alluvial plain-lacustrine facies; the depositional period of the Early Cretaceous Quantou Formation-Late Cretaceous Nenjiang Formation is the downwarping stage of the basin, forming an alluvial plain-delta-lacustrine facies sequence; the period of the Late Cretaceous Sifangtai Formation-Mingshui Formation is the shringkage stage of the basin, forming again a sequence mainly of alluvial plain-alluvial fan and small relict lacustrine facies. These vertical depositional sequences fully display the sedimentary characteristics of a failed continental rift basin. Many facts indicate that the two large-scale lake invasions, synchronous with the global rise of sea level, which took place in the downwarping stage of the basin development, led to the connection between the lake and sea. | Liu Zhaojun, Wang Dongpo, Liu Li, Liu Wanzhu, Wang Pujun, Du Xiaodi and Yang Guang Changchun University of Earth Sciences, Changchun, Jilin Sun Sheping | 1993 | Acta Geologica Sinica(English Edition)1993，67，2： | 7 |
| 19 | EFFECTS OF AGRICULTURE RECLAMATION ON THE HYDROLOGIC CHARACTERISTICS IN THE SANJIANG PLAIN, CHINA显示文摘The Sanjiang Plain is the largest and most concentrated wetland region in China, the total area is about 1.088×107ha with rich marsh resources and biodiversity. Before 1949, the Sanjiang Plain was a large untravelled wild plant and waterfowl habitat, and there were some rare swans, red-crowned cranes and thousands of hydrophytes. From 1950, the local government began to reclaim the marsh in the Sanjiang Plain, built the commodity grain base of Northeast China, and developed the industry of grain processing, animal husbandry, etc. Up to now, there are 54 farms which control 3.5087×106ha agriculture field. The marsh areas are reduced by 1/2; many rare animals and plants are near extinction. The human activities and agriculture reclamation made a great change on the environment, especially made water balance change and regional climate change. So to study and protect the wetland ecosystem and marsh resource are extremely urgent. This paper focus on the hydrology change and climate change before and after marsh reclamation, including evapotranspiration, run off, soil character, micro-climate on both marsh and agriculture field, and the reason that cause seasonal drought, waterlogging and degeneration of marsh. | WANG Yi-yong, YANG Yong-xing (Changchun Institute of Geography, the Chinese Academy of Sciences,Changchun 130021,P. R. China) | 2001 | Chinese Geographical Science2001，11，2： | 6 |
| 20 | Detection and characterization of diverse alpha-and betacoronaviruses from bats in China显示文摘Bats have been implicated as important reservoir hosts of alpha- and betacoronaviruses. In this study, diverse coronaviruses(CoVs) were detected in 50 of 951(positive rate 5.3%) intestinal specimens of eight bat species collected in four provinces and the Tibet Autonomous Region of China by pan-coronavirus RT-PCR screening. Based on 400-nt RNA-dependent RNA polymerase(Rd RP) sequence analysis, eight belonged to genus Alphacoronavirus and 42 to Betacoronavirus.Among the 50 positive specimens, thirteen gave rise to CoV full-length Rd RP gene amplification for further sequence comparison, of which three divergent sequences(two from a unreported province) were subjected to full genome sequencing. Two complete genomes of betacoronaviruses(JTMC15 and JPDB144) and one nearly-complete genome of alphacoronavirus(JTAC2) were sequenced and their genomic organization predicted. The present study has identified additional numbers of genetically diverse bat-borne coronaviruses with a wide distribution in China. Two new species of bat CoV, identified through sequence comparison and phylogenetic analysis, are proposed. | Lin Xu Fuqiang Zhang Weihong Yang Tinglei Jiang Guanjun Lu Biao He Xingyu Li Tingsong Hu Gang Chen Yun Feng Yuzhen Zhang Quanshui Fan Jiang Feng Hailin Zhang Changchun Tu | 2016 | Virologica Sinica2016，31，1： | 6 |
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