|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ulinastatin for acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis显示文摘AIM: To investigate the efficacy and safety of ulinastatin for patients with acute lung injury(ALI) and those with acute respiratory distress syndrome(ARDS).METHODS: A systematic review of randomized controlled trials(RCTs) of ulinastatin for ALI/ARDS was conducted. Oxygenation index, mortality rate [intensive care unit(ICU) mortality rate, 28-d mortality rate] and length of ICU stay were compared between ulinastatin group and conventional therapy group. Meta-analysis was performed by using Rev Man 5.1.RESULTS: Twenty-nine RCTs with 1726 participants were totally included, the basic conditions of which were similar. No studies discussed adverse effect. Oxygenation index was reported in twenty-six studies(1552 patients). Ulinastatin had a significant effect in improving oxygenation [standard mean difference(SMD) = 1.85, 95%CI: 1.42-2.29, P < 0.00001, I2 = 92%]. ICUmortality and 28-d mortality were respectively reported in eighteen studies(987 patients) and three studies(196 patients). We found that ulinastatin significantly decreased the ICU mortality [I2 = 0%, RR = 0.48, 95%CI: 0.38-0.59, number needed to treat(NNT) = 5.06, P < 0.00001], while the 28-d mortality was not significantly affected(I2 = 0%, RR = 0.78, 95%CI: 0.51-1.19, NNT = 12.66, P = 0.24). The length of ICU stay(six studies, 364 patients) in the ulinastatin group was significantly lower than that in the control group(SMD =-0.97, 95%CI:-1.20--0.75, P < 0.00001, I2 = 86%). CONCLUSION: Ulinastatin seems to be effective for ALI and ARDS though most trials included were of poor quality and no information on safety was provided. | Yu-Xin Leng Shu-Guang Yang Ya-Han Song Xi Zhu Gai-Qi Yao | 2014 | World Journal of Critical Care Medicine2014，3，1： | 61 |
| 2 | The TanSat mission: preliminary global observations显示文摘The Chinese global carbon dioxide monitoring satellite (Tan Sat) was launched successfully in December2016 and has completed its on-orbit tests and calibration. Tan Sat aims to measure the atmospheric column-averaged dry air mole fractions of carbon dioxide (XCO_2) with a precision of 4 ppm at the regional scale, and in addition, to derive global and regional CO2fluxes. Progress towards these objectives is reviewed and the first scientific results from Tan Sat measurements are presented. Tan Sat on-orbit tests indicate that the Atmospheric Carbon dioxide Grating Spectrometer is in normal working status and is beginning to produce L1B products. The preliminary Tan Sat XCO_2products have been retrieved by an algorithm and compared to NASA Orbiting Carbon Observatory-2 (OCO-2) measurements during an overlapping observation period. Furthermore, the XCO_2retrievals have been validated against eight groundsite measurement datasets from the Total Carbon Column Observing Network, for which the preliminary conclusion is that Tan Sat has met the precision design requirement, with an average bias of 2.11 ppm.The first scientific observations are presented, namely, the seasonal distributions of XCO_2over land on a global scale. | Yi Liu Jing Wang Lu Yao Xi Chen Zhaonan Cai Dongxu Yang Zengshan Yin Songyan Gu Longfei Tian Naimeng Lu Daren Lyu | 2018 | Science Bulletin2018，63，18： | 23 |
| 3 | Genome Analysis of the Ancient Tracheophyte Selaginella tama#scina Reveals Evolutionary Features Relevant to the Acquisition of Desiccation Tolerance显示文摘 | Zhichao Xu Tianyi Xin Dorothea Bartels Ying Li Wei Gu Hui Yao Sai Liu Haoying Yu Xiangdong Pu Jianguo Zhou Jiang Xu Caicai xi Hetian Lei Jingyuan song Shilin Chen | 2018 | Molecular Plant2018，11，7： | 20 |
| 4 | Early changes of procalcitonin predict bacteremia in patients with intensive care unit-acquired new fever显示文摘 | SHI Yan DU Bin XU Ying-chun RUI Xi DU Wei WANG Yao | 2013 | Chinese Medical Journal2013，，10： | 18 |
| 5 | Effects of Xinfeng capsule on pulmonary function based on treg-mediated notch pathway in a rat model of adjuvant arthritis显示文摘OBJECTIVE:To observe the impact of xinfeng xapsule(XFC) on pulmonary function in a rat model of adjuvant arthritis(AA) and to investigate the mechanism of action.METHODS:Forty rats were randomly divided into four groups of ten:normal control(NC);model control(MC);tripterygium glycosides tablet(TPT);and xinfeng capsule(XFC).Except for the NC group,AA was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw on the 19th day.NC and MC groups were given(0.9%) physiological saline.The TPT and XFC groups were given TPT(10 mg/kg) and XFC(1.2 g/kg),respectively.Thirty days after administration,changes in paw edema(E),the arthritis index(AI),pulmonary function,levels of regulatory T-cells(Treg),ultrastructure of lung tissue,and expression of Notch receptors and ligands in lung tissue were observed.RESULTS:In the MC group,E and the AI were increased and pulmonary function significantly decreased;the structure of alveolar type-II cells was damaged;ratios of Treg in peripheral blood were reduced;and expression of Notch receptors such as Notch3 and Notch4 and ligands such as Delta1 in lung tissue were significantly increased whereas expression of Notch1,Jagged1 and Jagged2 were significantly decreased.After intervention with XFC,E and the AI were decreased;pulmonary function was enhanced;the structure of alveolar type-II cells was improved;and expression of Treg,Notch1,Jagged1,Jagged2 was elevated,whereas that of Notch3,Notch4 and Delta1 was reduced.CONCLUSION:XFC can not only inhibit E and the AI and improve joint symptoms,it can also improve pulmonary function and reduce inflammation in lung tissue.These actions could be carried out through increases in the expression of Treg,Notch receptors(Notch1) and ligands(Jagged1,Jagged2),and reductions in the expression of Notch3,Notch4 and Delta1.These phenomena would reduce the deposition of immune complexes and the inflammatory response in lung tissue,thereby improving joint symptoms and pulmonary function. | Lei Wan Jian Liu Chuanbing Huang Yuan Wang Xi Shen Wandong Zhang Guizheng Wang Haixia Fan Yao Ge Ruilian Chen Yunxiang Cao Ruikai Zong Li Lei | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 17 |
| 6 | First Global Carbon Dioxide Maps Produced from Tan Sat Measurements显示文摘1.The need for global carbon monitoring from space and the Tan Sat mission Global warming is a major problem,for which carbon dioxide(CO_2 )is the main greenhouse gas involved in heating the troposphere.However,the poor availability of global CO_2 measurements makes it difficult to estimate CO_2 emissions accurately.Satellite measurements would be very helpful for understanding the global CO_2 flux distribution if the CO_2 column-averaged dry-air mole fraction(XCO_2 ) | Dongxu YANG Yi LIU Zhaonan CAI Xi CHEN Lu YAO Daren LU | 2018 | Advances in Atmospheric Sciences2018，35，6： | 16 |
| 7 | A model and experimental study of phosphate uptake kinetics in algae:Considering surface adsorption and P-stress显示文摘Phosphorus is an important limiting nutrient in many ecosystems.Consequently,there is increasing interest on phosphate uptake and algal growth due to the increasing frequency and magnitude of algal blooms induced by eutrophication.The co-existence of surface adsorbed and intracellular phosphorus pools indicate that phosphate uptake by phytoplankton is,to some extent,a two-stage kinetic process.However,almost all previous uptake models considered the internal uptake stage only and ignored the possible impact of surface adsorption.In this article,a two-stage kinetic uptake model considering both surface adsorption and P-stress on phosphate uptake by algae was constructed and compared to conventional one-stage models,based on experimental data on short-term uptake kinetics of a green algae S.quadricauda.Results indicated that with suitable parameters,the two-stage uptake model not only fit the experimental data better,but also gave more reasonable and realistic explanations to the phosphate uptake process.The results are meaningful as surface-adsorption of phosphate may affect the uptake process of phosphate and assist in understanding realistic phosphate uptake kinetics in phytoplankton. | Bo Yao Beidou Xi Chunming Hu Shouliang Huo Jing Su Hongliang Liu | 2011 | Journal of Environmental Sciences2011，23，2： | 15 |
| 8 | Relation among p130Cas,E-cadherin and β-catenin expression,clinicopathologic significance and prognosis in human hepatocellular carcinoma显示文摘BACKGROUND:p130Cas(p130Crk-associated substance) is a junction protein that is important to the adhesion between cytoskeleton and extracellular matrix.Also the adhesion molecules E-cadherin andβ-catenin play important roles in the invasiveness of carcinoma.This study was undertaken to investigate the effects of p130Cas E-cadherin andβ-catenin on the invasion,metastasis and prognosis of hepatocellular carcinoma(HCC). METHODS:Immunohistochemistry was used to evaluate the expression of p130Cas,E-cadherin,andβ-catenin in 40 patients with HCC.All patients were followed up postoperatively,and the relationship between expression and clinicopathological prognostic parameters was analyzed RESULTS:The positive expression rates of p130Cas and E-cadherin in HCC tissue(n=40)were 62.50%and 55.00% but in normal liver tissue 10%,and 100%,respectively (P<0.05).The abnormal expression rate ofβ-catenin in HCC tissue was 70%,while in normal liver tissue it was 13.33%(P<0.05).The positive rate of p130Cas was correlated with lymph node invasion,pathological stage TNM stage,and a worse prognosis,but not with gender age,HBV infection,hepatic cirrhosis,alpha-fetoprotein (AFP)level before operation,and tumor diameter Similarly,the expression of E-cadherin andβ-catenin was correlated with lymph node invasion,pathological stage,TNM stage,and worse prognosis,but not with gender,age,HBV infection,hepatic cirrhosis,AFP level before operation,and tumor size.Correlations were found between p130Cas and abnormal E-cadherin/β-catenin expression(P<0.001 and<0.05,respectively).CONCLUSIONS:In HCC,there is a negative correlation between the positive expression of p130Cas and the normal expression of the adhesion molecules E-cadherin/β-catenin, and p130Cas plays important roles in the invasion, metastasis and prognosis of HCC.p130Cas may be involved in alterating the structure and function of E-cadherin/ β-catenin,by regulating tyrosine phosphorylation via the p130Cas-Src signal pathway. | Cheng Guo,Qing-Guang Liu,Wei Yang,Zheng-Liang Zhang and Ying-Min Yao Department of Hepatobiliary Surgery,First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710061, China | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，5： | 15 |
| 9 | Effect of Qingfei Mixture (清肺合剂) on Pediatric Mycoplasma Pneumoniae Pneumonia with Phlegm Heat Obstructing Fei (Lung) Syndrome显示文摘Objective: To explore the effect and mechanism of Qingfei Mixture(清肺合剂), a Chinese medicine, in treating mycoplasma pneumonia(MP) in MP patients and rat model. Methods: A total of 46 MP children with phlegm heat obstructing Fei(Lung) syndrome were randomly assigned to two groups by the method of random number table, with 23 children in each group. The control group was treated with intravenous infusion of azithromycin; the treatment group received intravenous infusion of azithromycin and oral administration of Qingfei Mixture. The treatment course was 7 days. Major symptoms and minor symptoms were observed and scored before and after treatments. A rat model of MP was also established. A total of 120 wistar rats were randomly divided into 5 groups: a normal group, infection group, Qingfei Mixture treatment group, azithromycin treatment group, and Qingfei Mixture + azithromycin treatment group. Each group contained 24 rats, from which every 6 were euthanatized 1, 3, 7 and 14 days after infection. MP DNA in pulmonary tissue homogenates was detected using real-time fluorescence quantitative polymerase chain reaction. Pathology was assessed after hematoxylin(HE) staining and lung tissue pathology scores were determined in pulmonary tissue. Transmission electron microscopic detection and electronic image analysis were performed on lung tissue 3 days after infection. Interleukin(IL)-17 was detected in serum using enzymelinked immunosorbent assay(ELISA) 7 days after infection. Results: In the clinical study, both control and the treatment group showed improved results on removing symptoms of phlegm heat syndrome compared to the control group(P<0.05). In animal experiments, On the 7th day after MP infection, as detected by electron microscopy, the pulmonary capillary basement membranes of the azithromycin + Qingfei Mixture treatment group were much thinner than those of the azithromycin or Qingfei mixture treatment groups(P<0.05). The level of serum IL-17 in the azithromycin + Qingfei Mixture treatment group was lower than that in the azithromycin or Qingfei Mixture groups(P<0.01). Conclusion: Both Qingfei Mixture and azithromycin have therapeutic effects on mycoplasma pneumoniae pneumonia, but the combination of both agents had the greatest effect. | YANG Ai-jun XI Kun YAO Yan-qing DING Ying-xue YANG Li-jun CUI Hong | 2017 | Chinese Journal of Integrative Medicine2017，23，9： | 15 |
| 10 | Two Comparable Earthquakes Produced Greatly Different Coseismic Landslides:The 2015 Gorkha,Nepal and 2008 Wenchuan,China Events显示文摘The 2015 Gorkha Earthquake in Nepal and the 2008 Wenchuan Earthquake in China occurred at the south and southeast margins of the Tibetan Plateau, respectively. Both earthquakes had similar magnitudes of Mw 7.8 and 7.9, caused catastrophic loss of life and damage to property, and generated tens of thousands of landslides. Comparisons of pre- and post-quake satellite images supported by field investigations show that the Gorkha Earthquake triggered at least 2 064 large landslides(defined as covering an area ≥10 000 m^2) over a ~35 600 km^2 region with a volume of(444–584)×10~6(average 509×10~6) m^3 and total area of 44.78×10~6 m^2. In contrast, the Wenchuan Earthquake triggered 25 580 large landslides over a region of ~44 000 km^2 with a volume of(7 128–9 479)×10~6(average 8 219×10~6) m^3 and a total area of about 670.65×10~6 m^2. Several controlling factors including topographic relief, slope steepness, and regional peak ground acceleration(PGA) were investigated to try to explain the great differences between the number, volume and area of the coseismic landslides associated with the two similar earthquakes. We found that the differences primarily arose from an unexpected factor, the dip angle of the seismogenic fault. This discovery should aid understanding the failure mechanisms of quake-triggered landslides, and suggests that more factors should be taken into consideration in estimating coseismic landslide volumes from earthquake magnitudes. | Chong Xu Xiwei Xu Yingying Tian Lingling Shen Qi Yao Xueqiang Huang Junxue Ma Xi Chen Siyuan Ma | 2016 | Journal of Earth Science2016，27，6： | 14 |
| 11 | Splenic hamartoma: case report and review of literature显示文摘脾的 hamartoma 是由正常脾的元素的异常混合物组成的良性的畸形性。近似有肿瘤的病人的一半由尸体或脾切除术偶然无征状、诊断。肿瘤相关的肾的 hematological anddermatological 畸形能被肿瘤的移动对待。与包括额外膜的 glomerulonephritis, membrano-proliferativeglomerulonephritis 和肾的腺癌的肾的疾病有关的脾的 hamartoma 以前被报导了。在 2002 年 12 月,我们与由偶然检测的肾的骨盆的石头复杂的脾的 hamartoma 对待一个病人 byultrasonography。 | JIA Hong-bo LI Ying-ping HAN De-en LIU Yao ZHANG Bin WU De-quan CHEN Xi JIANG Ying ZHENG Long-xian DU Jin-rong JIANG Xue-hai | 2006 | Chinese Medical Journal2006，，16： | 13 |
| 12 | Evolution Characteristics of Government-Industry-University-Research Cooperative Innovation Network for China's Agriculture and Influ- encing Factors: Illustrated According to Agricultural Patent Case显示文摘Under the special background of China, the cooperative innovation between different government-industry-university-research institutes plays an increasingly important role in the agricultural field. However, the existing literature has paid little attention to it. Considering the cooperation patents, published in the agriculture field stemming from the Full-text Database of China Patents as the study object, the spatial and institutional attribute of the authors as the data source, and by combining the social network and spatial econometrics analysis, this paper analyzes the structure evolution characteristics of cooperative innovation networks of agricultural government-industry-university-research institute in the city level of China in 1985–2014, based on the triple helix theory, with the influence factors discussed. This shows that, 1) since 1985, China's agricultural innovation level has been substantially increased, but the development degree of the cooperative innovation network is low, and the patent cooperation mainly relies on authors in the same unit; 2) enterprises play a leading role in the agricultural cooperative innovation. The effect of the government and hybrid organizations driven by the government is not obvious; 3) the cooperative innovation in the province and city dominates, and a multi-pole pattern has been formed. The cooperative innovation network structure evolves from a single helix empty core and double helix multi core to a double helix hierarchical network; 4) the city's science, education funding and personnel investment are key factors determining the agricultural cooperative innovation, while the agricultural development of the city presents slight negative impacts on it. The spatial mismatch of supply and demand is present in the technical cooperative innovation of China's agriculture. Therefore, the science enhancement and education investment to big agricultural provinces should be promptly implemented. | LI Erling YAO Fei XI Jiaxin GUO Chunyang | 2018 | Chinese Geographical Science2018，28，1： | 13 |
| 13 | Geochemistry of the subduction-related magmatic rocks in the Dahong Mountains, northern Hubei Province--Constraint on the existence and subduction of the eastern Mianlüe oceanic basin显示文摘The existence and subduction of the eastern Mianl黣 oceanic basin in the south Qinling belt are keys to understand the Qinling orogen. Based on geological mapping, several volcanic slices have been identified in Tumen, Zhoujiawan, Xiaofu and Yuantan areas, which distribute in the northern margin of the Dahong Mountains (DHM), and thrust into the Sanli-gang-Sanyang fault. These slices consist mainly of diabases, basaltic-andesitic lavas, pyroclastic rocks and a minor tuff. The geochemistry of the basalts, andesites,and diabases is characterized by depleting in Nb and Ta, enriching in Th and LILE (e.g.K, Rb, Ba), and undifferentiating in HFSE. These geochemical characteristics suggest that the original magma of these rocks was derived from a mantle wedge above a subduction zone, and formed in an island-arc setting in Carboniferous-early Triassic. Comparing with the ophiolites and island-arc volcanic rocks in Mianxian-Leyang area to the west, it is reasonable to consider that there had been an oceanic basin connecting with the Mianle ancient ocean to the westward, distributing along the south edge of the Tongbai-Dabie block. In view of the ophiolite in Huashan area and these island-arc volcanic rocks along the north of the Dahong Mountains, it is suggested that there had been a plate tectonic evolutionary history with oceanic basin rifting and subduction in this region. | DONG Yunpeng, ZHANG Guowei, ZHAO Xia, YAO Anping & LIU Xiaoming The Key Laboratory of Continental Dynamics, Ministry of Education, Department of Geology, Northwest University, Xi抋n 710069,China | 2004 | Science China Earth Sciences2004，47，4： | 12 |
| 14 | Study on interaction between microtubule associated protein tau and prion protein显示文摘Microtubule-associated protein tau is considered to play roles in many neurodegenera-tive diseases including some transmissible spongiform encephalopathies.To address the possible molecular linkage of prion protein(PrP) and tau,a GST-fusion segment of human tau covering the three-repeat region and various PrP segments was used in the tests of GST pull-down and immuno-precipitation.We found tau protein interacted with various style prion proteins such as native prion protein(PrPC) or protease-resistant isoform(PrPSc) .Co-localization signals of tau and PrP were found in the CHO cell tranfected with both PrP and tau gene.The domain of interaction with tau was located at N-terminal of PrP(residues 23 to 91) .The evidence of molecular interactions between PrP and tau protein highlights a potential role of tau in the biological function of PrP and the pathogenesis of TSEs. | HAN Jun1,ZHANG Jin1,2,YAO Hailan1,3,WANG Xiaofan1,LI Feng1,CHEN Lan1,4,GAO Chen1,GAO Jianmei1,NIE Kai1,ZHOU Wei1 & DONG Xiaoping11.State Key Laboratory for Infectious Diseases Prevention and Control,National Institute for Viral Disease Control and Pre-vention,Chinese Center for Disease Control and Prevention,Beijing 100052,China 2.School of Medicine,Xi’an Jiao-Tong University,Xi’an 710061,China 3.Tong-Ji Medical College,Hua-Zhong University of Science and Technology,Wuhan 430030,China 4.National Laboratory of Medical Molecular Biology,Institute of Basic Medical Science,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China | 2006 | Science China(Life Sciences)2006，49，5： | 10 |
| 15 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 16 | Outcomes of the national programme on prevention of mother-to-child transmission of hepatitis B virus in China,2016-2017显示文摘Background:In addition to providing free hepatitis B vaccine(HBvacc)series to all infants in China since 2005,the national programme on prevention of mother-to-child transmission(PMTCT)of hepatitis B virus(HBV)started providing free hepatitis B immunoglobulin for all new-borns born to hepatitis B surface-antigen(HBsAg)positive mothers in 2010.However,few studies have evaluated the effectiveness of the PMTCT programme.Therefore,we aimed to investigate the outcomes of the programme and identify associated factors.Method:Using a cross-sectional study design,we collected data on 4112 pairs of HBsAg-positive mothers and their children aged 7-22 months in four representative provinces through interviews and medical record review.We tested HBsAg and hepatitis B surface antibody(anti-HBs)of children by enzyme-linked immunosorbent assay at designated maternal and child hospital laboratories.We used logistic regression to analyse factors associated with child HBsAg and anti-HBs positivity.Results:Thirty-five children were HBsAg positive,indicating the mother-to-child transmission(MTCT)rate was 0.9%(0.6-1.1%).The anti-HBs positive rate was 96.8%(96.3-97.4%).Children receiving HBvacc between 12 and 24h of birth were 2.9 times more likely to be infected than those vaccinated in less than 12 h(adjusted odds ratio[aOR]=2.9,95%confidence interval[CI]:1.4-63,P=0.01).Maternal hepatitis B e-antigen(HBeAg)positivity was associated with higher MTCT rate(aOR=79.1,95%Cl:10.8-580.2,P<0.001)and lower anti-HBs positive rate(aOR=0.4,95%CI:03-0.6,P<0.001).Children with low birth weight(LBW)were 60%less likely to be anti-HBs positive than those with normal birth weight(aOR=0A,95%CI:02-0.8,P=0.01).Conclusions:The MTCT rate was lower than the 2030 WHO elimination goal,which implies the programme is on track to achieve this target.As earlier HBvacc birth dose(HBvcc-BD)was associated with lower MTCT rate,we suggest that the PMTCT programme work with the Expanded Programme on Immunization(EPI)to modify the current recommendation for early HBvcc-BD to a requirement Our finding that LBW was associated with lower anti-HBs positivity points to the need for further studies to understand factors associated with these risks and opportunities for program strengthening.The programme needs to ensure providing essential test to identify HBeAg-positive mothers and their infants and provide them with appropriate medical care and follow-up. | Ya-Ping Qiao Min Su Yao Song Xiao-Yan Wang Zhen Li Yan-Lin Li Li-Xia Dou Qian Wang Katrina Hann Guo-Min Zhang Xiao-Na Huang Yu-Ning Yang Xi Jin Ai-Ling Wang | 2019 | Infectious Diseases of Poverty2019，8，4： | 10 |
| 17 | Use of Xinfeng capsule to treat abarticular pathologic changes in patients with rheumatoid arthritis显示文摘OBJECTIVE: To observe the influence of Xinfengcapsule(XFC) on abarticular pathologic changes(APCs) and other indices of patients with rheumatoid arthritis(RA) and explore the mechanism of action of XFC in improving such changes.METHODS: Three-hundred RA patients were divided randomly into a treatment group(n=150) and control group(n=150). A normal control(NC)group(n=90) was also created. Changes in cardiac function, pulmonary function, anemia indices and platelet parameters of RA patients were measured.Curative effects of the two groups were compared,and comparison carried out with the NC group.RESULTS: In 300 RA patients, late diastolic peak flow velocity(A peak) was much higher(P<0.01)and early diastolic peak flow velocity(E peak), E/A,and left ventricular fraction shortening much lower(P<0.01) than those in the NC group. Vital capacity(VC), forced vital capacity in one second, forced vital capacity(FVC), maximal voluntary ventilation(MVV), maximal expiratory flow in 50% of VC(FEF50) and FEF75 were lowered remarkably(P<0.05 or P<0.01). Platelet count(PLT), plateletcrit(PCT) and mean platelet volume(MPV) increased markedly(P<0.05 or P<0.01), and hemoglobin(Hb)level decreased significantly(P<0.05). After XFC treatment, the A peak and PLT and PCT were much lower(P<0.05), and E/A and the number of red blood cells as well as Hb level were much higher(P<0.05), as were FVC, MVV and FEF50(P<0.05 or P<0.01), in the treatment group than those in the NC group. Total score of pain and swelling in joints,uric-acid level and high-sensitivity C-reactive protein level were much lower, and superoxide dismutase level as well as the number of CD4 +CD25+ regulation T cells(Treg) and CD4+CD25+CD127- Treg were much higher(P<0.05 or P<0.01)in the treatment group than those in the NC group.CONCLUSION: RA patients with pathologic changes in joints also suffer from lower cardiac and pulmonary functions and from parameters of anemia and platelet factors. XFC can improve the symptoms of RA patients, ameliorate their cardiac and pulmonary functions and reduce the parameters of anemia and platelet factors. XFC lowers the immune inflammatory reaction to improve APCs in RA patients. | Jian Liu Yunxiang Cao Chuanbing Huang Yuan Wang Xi Chen Wandong Zhang Guizhen Wang Haixia Fan Yao Ge Ruilian Chen Ruikai Zong Yajun Qi Yue Sun Yifei Liu Fang Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 10 |
| 18 | Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China显示文摘 | Hua Yang Xiao-Chuan Li Chen Yao Jing-He Lang Hang-Mei Jin Ming-Rong Xi Gang Wang Lu-Wen Wang Min Hao Yan Ding Jie Chen Jian-Qing Zhang Lu Han Cheng-Xiu Guo Xiang Xue Yan Li Jian-Hua Zheng Man-Hua Cui Huai-Fang Li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-Hua Huang Qing Liu Ya-Li Zhuang Xiang-Hua Huang Gen-Hai Zhu Ou-Ping Huang Li-Na Hu Mu-Jun Li Hong-Lin Zhou Jing-Hui Song Lan Zhu | 2017 | Chinese Medical Journal2017，，22： | 10 |
| 19 | Clinical and experimental study of effect of Raondix Salviae Militiorhiza and other blood-activating and stasis-eliminating Chinese herbson hemodynamics of portal hypertension显示文摘INTRODUCTIONTherehasbeennolonglastingandsideeffectsfreedrugstolowertheportalhypertensioninpatientswithlivercirrhosissofar.Th... | YAO Xi Xian, CUI Dong Lai, SUN Yu Feng and LI Xiao Tian | 1998 | World Journal of Gastroenterology1998，4，5： | 10 |
| 20 | First-in-man Implantation of the XINSORB Bioresorbable Sirolimus-eluting Scaffold in China显示文摘To the Editor:A 35-year-old man who smoked for 15 years suffered from chest pain 12 days ago before admission.He was diagnosed as myocardial infarction.Thrombolytic therapy was given consequently.The electrocardiogram showed sub-acute inferior wall myocardial infarction.Echocardiogram showed attenuated constriction of the inferior wall with an ejection fraction of 59%.On September 5,2013,he was treated with a XINSORB scaffold in right coronary artery (RCA). | Jia-Hui Chen Yi-Zhe Wu Li Shen Feng Zhang Zhi-Feng Yao Jia-Sheng Yin Meng Ji Qi-Bing Wang Lei Ge Ju-Ying Qian Xi Hu Jian Xie Jun-Bo Ge | 2015 | Chinese Medical Journal2015，，9： | 10 |
您所在的机构暂未开通此部分的功能，请联系管理员