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| 1 | Toward New-Generation Intelligent Manufacturing显示文摘 | Zhou Ji Li Peigen Zhou Yanhong Wang Baicun Zang Jiyuan Meng Liu | 2018 | Engineering2018，4，1： | 224 |
| 2 | Antidepressant-like effect of essential oil of Perilla frutescens in a chronic, unpredictable, mild stress-induced depression model mice显示文摘Perilla frutescens(Perilla leaf), a garnishing vegetable in East Asian countries, as well as a plant-based medicine, has been used for centuries to treat various conditions, including depression. Several studies have demonstrated that the essential oil of P. frutescens(EOPF) attenuated the depressive-like behavior in mice. The present study was designed to test the anti-depressant effects of EOPF and the possible mechanisms in an chronic, unpredictable, mild stress(CUMS)-induced mouse model. With the exposure to stressor once daily for five consecutive weeks, EOPF(3, 6, and 9 mg·kg-1) and a positive control drug fluoxetine(20 mg·kg-1) were administered through gastric intubation to mice once daily for three consecutive weeks from the 3rd week. Open-field test, sucrose consumption test, tail suspension test(TST), and forced swimming test(FST) were used to evaluate the behavioral activity. The contents of 5-hydroxytryptamine(5-HT) and its metabolite, 5-hydroxyindoleacetic acid(5-HIAA), in mouse hippocampus were determined by HPLC–ECD. Serum interleukin(IL)-1, IL-6, and tumor necrosis factor(TNF)-α levels were evaluated by enzyme-linked immunosorbent assay(ELISA). The results showed that CUMS significantly decreased the levels of 5-HT and 5-HIAA in the hippocampus, with an increase in plasma IL-6, IL-1β, and TNF-α levels. CUMS also reduced open-field activity, sucrose consumption, as well as increased immobility duration in FST and TST. EOPF administration could effectively reverse the alterations in the concentrations of 5-HT and 5-HIAA; reduce the IL-6, IL-1β, and TNF-α levels. Moreover, EOPF could effectively reverse alterations in immobility duration, sucrose consumption, and open-field activity. However, the effect was not dose-dependent. In conclusion, EOPF administration exhibited significant antidepressant-like effects in mice with CUMS-induced depression. The antidepressant activity of EOPF might be related to the relation between alteration of serotonergic responses and anti-inflammatory effects. | JI Wei-Wei LI Rui-Peng LI Meng WANG Shu-Yuan ZHANG Xian NIU Xing-Xing LI Wei YAN Lu WANG Yang FU Qiang MA Shi-Ping | 2014 | Chinese Journal of Natural Medicines2014，12，10： | 26 |
| 3 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 4 | Diagnosis and treatment of congenital choledochal cyst: 20 years' experience in China显示文摘AIM To summarize the experience of diagnosis and treatment of congenital choledochal cyst in the past 20years ( 1980 2000).``METHODS The clinical data of 108 patients admitted from 1980 to 2000 were analyzed retrospectively.RESULTS Abdominal pain, jaundice and abdominal mass were presented in most child cases. Clinical symptoms in adult cases were non-specific, resulting in delayed diagnosis frequently. Fifty-seven patients (52.7%) had coexistent pancreatiobiliary disease. Carcinoma of the biliary duct occurred in 18 patients (16.6%). Ultrasonic examination was undertaken in 94 cases, ERCP performed in 46 cases and CT in 71 cases. All of the cases were correctly diagnosed before operation. Abnormal pancreatobiliary duct junction was found in .39 patients.Before 1985 the diagnosis and classification of congenital choledochal cyst were established by ultrasonography preoperatively and confirmed during operation, the main procedures were internal drainage by cyst enterostomy.After 1985, the diagnosis was established by ERCP and CT. and cystectomy with Roux-en-Y hepaticojejunostomy was the conventional procedures. In 1994, we reported a new and simplified operative procedure in order to reduce the risk of choledochal cyst malignancy. Postoperative complication was mainly retrograde infection of biliary tract, which could be controlled by the administration of antibiotics, there was no perioperative mortality.``CONCLUSION The concept in diagnosis and treatment of congenital choledochal cyst has obviously been changed greatly. CT and ERCP were of great help in the classification of the disease. Currently, cystectomy with Roux-en-Y hepaticojejunostomy is strongly recommended as the choice for patients with type I and type Ⅳ cysts.Piggyback orthotopic liver transplantation is indicated in type \ cysts (Carolis disease) with frequently recurrent cholangitis. | Liu-Bin Shi~1 Shu-You Peng~1 Xing-Kai Meng~1 Cheng-Hong Peng~1 Ying-Bin Liu~1 Xiao-Peng Chen~1 Zhen-Ling Ji~2 De-Tong Yang~2 Huai-Ren Chen~2 1 Department of Surgery,The Second Affiliated hospital of Zhejiang University School of Medicine,Hangzhou 310009,China2 Department of Surgery,Affiliated Zhongda Hospital of Southeast University,Nanjing 210009,China | 2001 | World Journal of Gastroenterology2001，7，5： | 18 |
| 5 | The Frattini Subalgebra of Restricted Lie Superalgebras显示文摘在现在的论文,我们学习限制谎言 superalgebra 的 Frattini subalgebra (L,[p ]) 。我们首先看那是否 L = A 1 鈯? A 2 鈯?鈯? A n 一,然后? p (L)=? p (一 1 )+? p (一 2 )+?+? p ( n ),在每 A i 是 L 的 p 鈥搃d eal 的地方。我们然后获得二结果:F (L)=?(L)= J (L)= L (1 ) 如果并且仅当 L 是 nilpotent;如果 L 是可解决的, F p (L) 和 F (L) 是 L 的 nilpotent 理想。另外,必要、足够的条件被作出对有利的裁决 ? p 鈥揻r ee 限制了谎言 superalgebras。最后,我们讨论 E 鈥損鈥搑e stricted 谎言 superalgebras 和 E 鈥搑e stricted 谎言 superalgebras 的关系。关键词限制了谎言 superalgebras - E 鈥損鈥搑e stricted 谎言 superalgebras - Frattini p 鈥搒u balgebra -蠁 p 鈥揻r ee - p 鈥揺l ementary 先生(2000 ) 题目分类 17B40 - 17B50 由中国(资助号码 10271076 ) | Liang Yun CHEN Dao Ji MENG Yong Zheng ZHANG | 2006 | Acta Mathematica Sinica,English Series2006，22，5： | 18 |
| 6 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 7 | GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats显示文摘Hydrogen sulfide(H_2S) is a gasotransmitter that regulates cardiovascular functions.The present study aimed to determine the protective effect of slow-releasing H_2S donor GYY4137 on myocardial ischemia and reperfusion(I/R) injury and to investigate the possible signaling mechanisms involved.Male Sprague-Dawley rats were treated with GYY4137 at 12.5 mg/(kg·day),25 mg/(kg·day) or 50 mg/(kg·day) intraperitoneally for7 days.Then,rats were subjected to 30 minutes of left anterior descending coronary artery occlusion followed by reperfusion for 24 hours.We found that GYY4137 increased the cardiac ejection fraction and fractional shortening,reduced the ischemia area,alleviated histological injury and decreased plasma creatine kinase after myocardial I/R.Both H_2S concentration in plasma and cystathionine-γ-lyase(CSE) activity in the myocardium were enhanced in the GYY4137 treated groups.GYY4137 also decreased malondialdehyde and myeloperoxidase levels in serum,attenuated superoxide anion level and suppressed phosphorylation of mitogen activated protein kinases in the myocardium after I/R.Meanwhile,GYY4137 increased the expression of Bcl-2 but decreased the expression of Bax,caspase-3 activity and apoptosis in the myocardium.The data suggest that GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis. | Guoliang Meng Jing Wang Yujiao Xiao Wenli Bai Liping Xie Liyang Shan Philip K Moore Yong Ji | 2015 | The Journal of Biomedical Research2015，29，3： | 18 |
| 8 | Thiolactone copolymer donor gifts organic solar cells a 16.72% efficiency显示文摘Since 1995,bulk-heterojunction organic solar cells consisting of one or two organic donors and one or two organic acceptors have been fighting for high power conversion efficiencies(PCEs)and good stability[1].Until recent years,this next-generation photovoltaic technology starts to offer decent PCEs,shedding the light on commercialization,and attracting great attention again[2-14].Compared w让h the continuously emerging highperformance nonfullerene acceptors,high-performance donors are rare. | Ji Xiong Ke Jin Yufan Jiang Jianqiang Qin Tan Wang Jinfeng Liu Qishi Liu Haili Peng Xiongfeng Li Anxin Sun Xianyi Meng Lixiu Zhang Ling Liu Wenting Li Zhimin Fang Xue Jia Zuo Xiao Yaqing Feng Xiaotao Zhang Kuan Sun Shangfeng Yang Shengwei Shi Liming Ding | 2019 | Science Bulletin2019，64，21： | 17 |
| 9 | Methane–air explosion characteristics with different obstacle configurations显示文摘To investigate the flame and overpressure characteristics of methane–air explosion with different obstacle configurations,an experimental study has been conducted,taking account of the number of obstacles,obstacle distance from ignition source,and stream-wise and cross-wise obstacle positions.The results show that the flame speed and peak overpressure increase with the increasing number of obstacles,while the time to reach the peak is not fully determined by it.And the configuration having the farthest obstacle produces a higher overpressure and takes a longer time to reach the peak,but a slower flame propagation speed is obtained.Similar explosion characteristics are also observed in the configurations with two obstacles fixed at different stream-wise positions.Furthermore,the experimental results demonstrate that the peak overpressures and flame speeds in configurations with central or staggered obstacles are relatively higher,which should to be avoided in practical processes to minimize the risk associated with methane–air explosion. | Wen Xiaoping Yu Minggao Ji Wentao Yue Meng Chen Junjie | 2015 | International Journal of Mining Science and Technology2015，25，2： | 16 |
| 10 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 11 | Current understanding of coronary artery calcification显示文摘冠的动脉石灰化(CAC ) 在有冠的心疾病(CHD ) 的病人是高度流行的并且与主要不利心血管的事件被联系。有 CAC— 的二种公认的类型;他们的内层、中间的石灰化,和各个有特定的风险因素。关于脉管的石灰化的机制的几个理论被提出了,并且我们当前相信脉管的石灰化是一个活跃、调整过程。CAC 能通常与严重 CHD,和这无征状的现象在病人被发现使 CAC 的早诊断重要。冠的计算 tomographic angiography 是主要 noninvasive 工具检测钙化的损害。由得分的冠的动脉石灰化的测量是为在在中间的风险的无征状的成年人的心血管的风险评价的一个合理度量标准。迄今为止, CAC 的有效医疗没被识别。经皮的冠的干预的几策略与 CAC,但是与不能令人满意的结果被用于 CHD 病人。CAC 的预后仍然是 CHD 病人的一个主要问题。因此,关于 CAC 的机制的更多的细节需要被阐明以便改进 CAC 的理解和治疗。 | Wei LIU Yue ZHANG Cheuk-Man YU Qing-Wei JI Meng CAI Ying-Xin ZHAO Yu-Jie ZHOU | 2015 | Journal of Geriatric Cardiology2015，12，6： | 15 |
| 12 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 13 | Experimental investigation of shale imbibition capacity and the factors influencing loss of hydraulic fracturing fluids显示文摘Spontaneous imbibition of water-based fracturing fluids into the shale matrix is considered to be the main mechanism responsible for the high volume of water loss during the flowback period. Understanding the matrix imbibition capacity and rate helps to determine the fracturing fluid volume, optimize the flowback design, and to analyze the influences on the production of shale gas.Imbibition experiments were conducted on shale samples from the Sichuan Basin, and some tight sandstone samples from the Ordos Basin. Tight volcanic samples from the Songliao Basin were also investigated for comparison. The effects of porosity, clay minerals, surfactants, and KCl solutions on the matrix imbibition capacity and rate were systematically investigated. The results show that the imbibition characteristic of tight rocks can be characterized by the imbibition curve shape, the imbibition capacity, the imbibition rate, and the diffusion rate. The driving forces of water imbibition are the capillary pressure and the clay absorption force. For the tight rocks with low clay contents,the imbibition capacity and rate are positively correlated with the porosity. For tight rocks with high clay content,the type and content of clay minerals are the most important factors affecting the imbibition capacity. The imbibed water volume normalized by the porosity increases with an increasing total clay content. Smectite and illite/smectite tend to greatly enhance the water imbibition capacity.Furthermore, clay-rich tight rocks can imbibe a volume ofwater greater than their measured pore volume. The average ratio of the imbibed water volume to the pore volume is approximately 1.1 in the Niutitang shale, 1.9 in the Lujiaping shale, 2.8 in the Longmaxi shale, and 4.0 in the Yingcheng volcanic rock, and this ratio can be regarded as a parameter that indicates the influence of clay. In addition,surfactants can change the imbibition capacity due to alteration of the capillary pressure and wettability. A 10wt% KCl solution can inhibit clay absorption to reduce the imbibition capacity. | Hong-Kui Ge Liu Yang Ying-Hao Shen Kai Ren Fan-Bao Meng Wen-Ming Ji Shan Wu | 2015 | Petroleum Science2015，12，4： | 13 |
| 14 | The electromagnetic wave experiment for CSES mission: Search coil magnetometer显示文摘The seismic activities on the Earth can produce a disturbance of the electromagnetic field and particles in the ionosphere. The search coil magnetometer(SCM) mounted on China Seismo-Electromagnetic satellite(CSES) is designed to measure the magnetic field fluctuation of low frequency electromagnetic waves in the frequency range of 10 Hz–20 k Hz. The SCM comprises a three-axis search coil sensor mounted on a 4.5 m boom and an electronic box inside satellite module. The sampling rate of the SCM is 51.2 k Hz and the time resolution of the power spectrum density(PSD) is 2 s. The frequency resolution is 12.5 Hz.There are three operation modes: survey, detailed survey and calibration. In the survey mode, the SCM can provide a PSD in the whole frequency range of 10 Hz–20 k Hz and wave forms in the low frequency range below 2 k Hz while in the detailed survey mode the SCM can provide both PSD and wave forms in the whole frequency range of 10 Hz–20 k Hz. The sensitivity of the SCM instrument is 5.0×10^(-4) n T Hz^(-1/2) at 10 Hz, 5.0×10^(–5) n T Hz^(-1/2) at 200 Hz, 3.4×10^(-5) n T Hz^(-1/2) at 2 k Hz and 1.1×10^(-4) n T Hz^(-1/2) at 20 k Hz. The telemetry rate is ~0.85 Mbps in the survey mode and ~3.0 Mbps in the detailed survey mode. The phase difference between three axes can be made generally with a precision of less than 1.0°. The dynamic range of the SCM instrument is over 100 d B. The orthogonality of three mechanical axes of search coil senor is better than 0.13°. The performance of SCM can satisfy the requirement of scientific objectives of CSES mission. | CAO JinBin ZENG Li ZHAN Feng WANG ZuoGui WANG Yan CHEN Yu MENG QingChun JI ZhanQiang WANG PengFei LIU ZhongWei MA LingYu | 2018 | Science China(Technological Sciences)2018，61，5： | 13 |
| 15 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 16 | A new CFAR ship target detection method in SAR imagery显示文摘Many ship target detection methods have been developed since it was verified that ship could be imaged with the space-based SAR systems. Most developed detection methods mostly emphasized ship detection rate but not computation time. By making use of the advantages of the K-distribution CFAR method and two-parameter CFAR method,a new CFAR ship target detection algorithm was proposed. In that new method,we use the K-distribution CFAR method to calculate a global threshold with a certain false-alarm rate. Then the threshold is applied to the whole SAR imagery to determine the possible ship target pixels,and a binary image is given as the preliminary result. Mathematical morphological filter are used to filter the binary image. After that step,we use the two-parameter CFAR method to detect the ship targets. In the step,the local sliding window only works in the possible ship target pixels of the SAR imagery. That step avoids the statistical calculation of the background pixels,so the method proposed can much improve the processing speed. In order to test the new method,two SAR imagery with different background were used,and the detection result shows that that method can work well in different background circumstances with high detection rate. Moreover,a synchronous ship detection experiment was carried out in Qingdao port in October 28,2005 to verify the new method and one ENVISAT ASAR imagery was acquired to detect ship targets. It can be concluded from the experiment that the new method not only has high detection rate,but also is time-consuming,and is suitable for the operational ship detection system. | JI Yonggang ZHANG Jie MENG Jummin ZHANG Xi | 2010 | Acta Oceanologica Sinica2010，29，1： | 13 |
| 17 | Relationship between expressions of E-cadherin and alpha-catenin and biological behaviors of human pancreatic cancer显示文摘OBJECTIVES: To investigate the expressions of E-eadherin and alpha-catenin in pancreatic carcinomaand their relationship with biological behaviors, and clarify the mechanism of invasion and metastasis ofpancreatic cancer.METHODS: The expressions of E-eadherin and alpha-catenin was examined in 47 patients withinfiltrative ductal adenocarcinoma of the pancreas and 12 specimens of normal pancreatic tissues byimmunohistochemical technique (PicTureTM two-step method). Proliferation cell nuclear antigen(PCNA) was tested as an index of the proliferation degree of pancreatic cancer cells.RESULTS: The immunoreactivity of E-cadherin and alpha-catenin was expressed by normal ductal andacinar cells with strong membranous staining at the intercellular border in 12 specimens of normalpancreatic tissues. The abnormal rate of E-cadherin expression in pancreatic cancer was 53.2% (25/47),and it was significantly related to differentiation, high proliferation degree and lymph node and livermetastases (P<0.O1, 0.05, 0.05 and O.01, respectively). 61.7% patients with pancreatic cancer(29/47) showed abnormal expression of alpha-catenin. There was a good correlation amongalpha-catenin expression, histological grade, and lymph node and liver metastases (P<0.05, 0.05 and0.01, respectively). No significant association was found among abnormal expressions of E-cadherin andalpha-catenin, tumor size, invasion, and 1-year survival rate of patients ( P>0.05, all). There was apositive relationship between the expressions of E-cadherin and alpha-catenin in the 47 patients withpancreatic cancer (P<O.O1, r=0.88).CONCLUSIONS: Pancreatic cancer likely occurs in case of the inactivation of E-cadherin andalpha-catenin genes and abnormal expression of proteins, which significantly correlate with tumorigenesis,proliferation, differentiation, and lymph node or liver metastasis of pancreatic cancer. | Yu-Jun Li Yun-Xiao Meng Xiang-Rui Ji the Department of Pathology. Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，2： | 12 |
| 18 | Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma:a single-center,single-arm,phase 2 study显示文摘Advanced intrahepatic cholangiocarcinoma(ICC)has a dismal prognosis.Here,we report the efficacy and safety of combining toripalimab,lenvatinib,and gemcitabine plus oxaliplatin(GEMOX)as first-line therapy for advanced ICC.Thirty patients with pathologically confirmed advanced ICC received intravenous gemcitabine(1 g/m2)on Days 1 and 8 and oxaliplatin(85 mg/m2)Q3W for six cycles along with intravenous toripalimab(240 mg)Q3W and oral lenvatinib(8 mg)once daily for one year.The expression of programmed death-ligand 1(PD-L1)and genetic status was investigated in paraffin-embedded tissues using immunohistochemistry and whole-exome sequencing(WES)analysis.The primary endpoint was the objective response rate(ORR).Secondary outcomes included safety,overall survival(OS),progression-free survival(PFS),disease control rate(DCR)and duration of response(DoR).As of July 1,2022,the median follow-up time was 23.5 months,and the ORR was 80%.Twenty-three patients achieved partial response,and one achieved complete response.Patients(21/30)with DNA damage response(DDR)-related gene mutations showed a higher ORR,while patients(14/30)with tumor area positivity≥1(PD-L1 staining)showed a trend of high ORR,but without significant difference.The median OS,PFS,and DoR were 22.5,10.2,and 11.0 months,respectively.The DCR was 93.3%.Further,56.7%of patients experienced manageable grade≥3 adverse events(AEs),commonly neutropenia(40.0%)and leukocytopenia(23.3%).In conclusion,toripalimab plus lenvatinib and GEMOX are promising first-line regimens for the treatment of advanced ICC.A phase-III,multicenter,double-blinded,randomized study to validate our findings was approved by the National Medical Products Administration(NMPA,No.2021LP01825). | Guo-Ming Shi Xiao-Yong Huang Dong Wu Hui-Chuan Sun Fei Liang Yuan Ji Yi Chen Guo-Huan Yang Jia-Cheng Lu Xian-Long Meng Xin-Ying Wang Lei Sun Ning-Ling Ge Xiao-Wu Huang Shuang-Jian Qiu Xin-Rong Yang Qiang Gao Yi-Feng He Yang Xu Jian Sun Zheng-Gang Ren Jia Fan Jian Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 12 |
| 19 | Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy显示文摘瞄准: 估价 Vam3 (Amurensis H ) 的功效, resveratrol 的二聚的衍生物,在禁止香烟导致烟的 autophagy。 | Ji SHI Ning YIN Ling-ling XUAN Chun-suo YAO Ai-min MENG Qi HOU | 2012 | Acta Pharmacologica Sinica2012，33，7： | 12 |
| 20 | Elevated IL-37 levels in the plasma of patients with severe coronary arterycalcification显示文摘Background Coronary artery calcification (CAC) is a predictor of cardiovascular events and plaque burden and is closely associatedwith chronic inflammation. Intedeukin (IL)-37 is a newly discovered member of the IL-1 family and is considered an anti-inflammatorycytokine. Our recent study on mice indicated that IL-37 could attenuate atherosclerosis and vascular calcification, which suggests that IL-37could be associated with the development of atherosclerosis and related diseases. The aim of this study was to investigate if IL-37 plays arole in the progression of CAC in patients. Methods Two hundred participants with suspected cardiovascular disease were recruited. Thelevels of plasma IL-37, osteoprotegerin (OPG), hypersensitive C-reactive protein (hsCRP) together with other biochemical parameters weremeasured, and a coronary calcium assessment was carried out by multi-detector row CT. A score of 〈 10 AU (Agatston units) denotes anabsence of CAC, a score of 11-100 AU denotes mild CAC, 101-400 denotes moderate CAC, and 〉 400 AU denotes severe CAC. ResultsOur initial data showed that there were no apparent differences in plasma IL-37 levels among patients with or without mild or moderate CAC.However, IL-37 levels were significantly increased in patients with severe CAC (P 〈 0.001). Similar results were observed for plasma OPGand hsCRP levels. When IL-37 levels in patients with severe calcification were compared with that in all of the other non-severe CAC groups,it became apparent that there was a significant positive correlation between IL-37 level and severe CAC (r = 0.360, P 〈 0.001; OR = 1.033)using Spearrnan's correlation and binary logistic regression analysis. Conclusions This study demonstrates that the anti-inflammatory cy-tokine IL-37 is associated with high coronary calcium levels, suggesting that IL-37 expression may be caused by the activation ofinf/amma-tion and that IL-37 might become a predictor of severe CAC in the future, which requires further investigation. | Meng CHAI Hai-Tao ZHANG Yu-Jie ZHOU Qing-Wei JI Qing YANG Yu-Yang LIU Ying-Xin ZHAO Dong-Mei SHI Wei LIU Li-Xia YANG Lin-Lin ZHANC Jing LIANG | 2017 | Journal of Geriatric Cardiology2017，14，5： | 11 |
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