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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | DNA Sequence Representation without Degeneracy显示文摘 | Stephen S Yau T | 2003 | Nucleic Acids Research2003，31，12： | 1 |
| 3 | Plurigenera of compact connected strongly pseudoconvex CR manifolds In memory of Salah Baouendi显示文摘Strongly pseudoconvex CR manifolds are boundaries of Stein varieties with isolated normal singularities.We introduce a series of new invariant plurigeneraδm,m∈Z+for a strongly pseudoconvex CR manifold.The main purpose of this paper is to present the following result:Let X1and X2be two compact strongly pseudoconvex embeddable CR manifolds of dimension 2n-1 3.If there is a non-constant CR morphism from X1to X2,thenδm(X2)δm(X1)whereδm(Xi)is the plurigeneus of Xi(see Definition 2.4). | LIN KePao YAU Stephen ZUO HuaiQing | 2015 | Science China Mathematics2015，58，3： | 1 |
| 4 | Spherical extension property no longer true for domains in algebraic variety with isolated singularity Dedicated to Professor YANG Lo on the occasion of his 70th birthday显示文摘Let D be a domain in Cn. It is known that if D is a simply connected bounded domain in C with spherical real analytic boundary D, then every local biholomorphic map at boundary as above extends to a biholomorphic map from D onto the unit ball in Cn. As a consequence, a local biholomorphic map between D1 and D2 where D1 and D2 are simply connected domains in Cn with spherical real analytic boundaries can extend to a global biholomorphic map from D1 onto D2. If the boundary is algebraic, the simply connected condition in the above result can be dropped. In this note, we show that the above phenomenon is no longer true if domains are in algebraic varieties with isolated singularities. | YAU Stephen S. T. | 2010 | Science China Mathematics2010，53，2： | 1 |
| 5 | The diffeomorphic types of the complements of arrangements in CP^3Ⅱ显示文摘For any arrangement of hyperplanes in CP^3,we introduce the soul of this arrangement. The soul,which is a pseudo-complex,is determined by the combinatorics of the arrangement of hyper- planes.In this paper,we give a sufficient combinatoric condition for two arrangements of hyperplanes to be diffeomorphic to each other.In particular we have found sufficient conditions on combinatorics for the arrangement of hyperplanes whose moduli space is connected.This generalizes our previous result on hyperplane point arrangements in CP^3. | YAU Stephen S-T | 2008 | Science China Mathematics2008，51，4： | 1 |
| 6 | Prediction of protein coding regions by the 3-base periodicity analysis of a DNA sequence显示文摘 | Changchuan Yin Stephen S.-T. Yau | 2007 | Journal of Theoretical Biology2007，，4： | 1 |
| 7 | The second pluri-genus of smoothable Gorenstein surface singularities显示文摘For complete intersection isolated surface singularities, Okuma gave a formula for the second plurigenus relating geometry genus, Milnor number and Tjurina number. We generalize Okuma’s theorem to Gorenstein smoothable surface singularities. | YAU Stephen S. T. | 2010 | Science China Mathematics2010，53，3： | 1 |
| 8 | Wavelet-Galerkin method for the Kolmogorov equation显示文摘 | Liang Z H Stephen S T Yau | 2004 | Mathematical and Computer Modelling2004，40，： | 1 |
| 9 | An adaptive middl'eware for context - sensitive communications for real - time applications in ubiquitous computing environments显示文摘 | Stephen S Yau Fariaz Karim | 2004 | Real - Time Systems2004，26，1： | 1 |
| 10 | Zs-Cyclic codes and quadratic residue codes 显示文摘 | CHIU M H STEPHEN S T Yau Yung Yu | 2000 | Advance in Ap- plied Mathematics2000，25，1： | 1 |
| 11 | Wavelet-Galerkin method for the Kolmogorov equation 显示文摘 | Liang Z H Yau Stephen S T | 2004 | Mathematical and Computer Modelling2004，40，： | 1 |
| 12 | Efficient audit service outsourcing for data integrity in clouds显示文摘 | Yan Zhu Hongxin Hu Gail-Joon Ahn Stephen S. Yau | 2011 | The Journal of Systems & Software2011，，5： | 1 |
| 13 | Reconfigurable context-sensitive middleware for pervasive computing显示文摘 | Stephen S Yau Fariaz Karim Yu Wang | 2002 | IEEE Pervasive Computing2002，1，3： | 1 |
| 14 | Prediction of protein coding regions by the 3-base periodicity analysis of a DNA sequence显示文摘 | Changchuan Yin Stephen S.-T. Yau | 2007 | Journal of Theoretical Biology2007，，4： | 1 |
| 15 | Acute Kidney Injury After Cardiac Surgery: Focus on Modifiable Risk Factors显示文摘 | Keyvan Karkouti Duminda N. Wijeysundera Terrence M. Yau Jeannie L. Callum Davy C. Cheng Mark Crowther Jean-Yves Dupuis Stephen E. Fremes Blaine Kent Claude Laflamme Andre Lamy Jean-Francois Legare C David Mazer Stuart A. McCluskey Fraser D. Rubens Corey S | 2009 | Circulation2009，，4： | 1 |
| 16 | Variation of complex structures and variation of Lie algebras显示文摘 | Craig Seeley Stephen S. -T. Yau | 1990 | Inventiones Mathematicae1990，，1： | 1 |
| 17 | 软件设计技术之概观显示文摘 | Stephen S. Yau Jeffery J. -P. Tsai 李辉 | 1987 | 计算机科学1987，，04： | 1 |
| 18 | The Oxford Classification of IgA Nephropathy: A Retrospective Analysis显示文摘 | Yau Timothy Korbet Stephen M Schwartz Melvin M Cimbaluk David J | 2011 | EN2011，，5： | 1 |
| 19 | A sharp estimate of positive integral points in6-dimensional polyhedra and a sharp estimate of smooth numbers显示文摘Inspired by Durfee Conjecture in singularity theory, Yau formulated the Yau number theoretic conjecture(see Conjecture 1.3) which gives a sharp polynomial upper bound of the number of positive integral points in an n-dimensional(n≥3) polyhedron. It is well known that getting the estimate of integral points in the polyhedron is equivalent to getting the estimate of the de Bruijn function ψ(x, y), which is important and has a number of applications to analytic number theory and cryptography. We prove the Yau number theoretic conjecture for n = 6. As an application, we give a sharper estimate of function ψ(x, y) for 5≤y < 17, compared with the result obtained by Ennola. | LIANG Andrew YAU Stephen ZUO Huai Qing | 2016 | Science China Mathematics2016，59，3： | 0 |
| 20 | The Hong Kong consensus statements on unresectable hepatocellular carcinoma:narrative review and update for 2021显示文摘Background and Objective:Hong Kong,like many parts of Asia,faces a high burden of hepatocellular carcinoma(HCC)caused by high endemic rates of hepatitis B virus infection.Hong Kong clinicians have developed a high level of expertise in HCC treatment across surgical,transarterial,ablative,radiotherapeutic and systemic modalities.This publication summarizes the latest evidence-based recommendations on how these modalities should be used.Methods:In two meetings held in 2020,a multidisciplinary panel of surgeons,oncologists and interventional radiologists performed a narrative review of evidence on the management of HCC,with an emphasis on treatment of HCC not amenable to surgical resection.Close attention was paid to new evidence published since the previous version of these statements in 2018.Key Content and Findings:The expert panel has formulated 60 consensus statements to guide the staging and treatment of unresectable HCC.Since the previous version of these statements,considerable additions have been made to the recommendations on use of targeted therapies and immunotherapies because of the large volume of new evidence.Conclusions:Our consensus statements offer guidance on how to select HCC patients for surgical or non-surgical treatment and for choosing among non-surgical modalities for patients who are not candidates for resection.In particular,there is a need for more evidence to aid physicians in the selection of second-line systemic therapies,as currently most data are limited to patients with disease progression on first-line sorafenib. | Tan-To Cheung Simon Chun-Ho Yu Stephen L.Chan Ronnie T.P.Poon Philip Kwok Ann-Shing Lee Anna Tai Derek Tam Chin-Cheung Cheung Tak-Wing Lai Nam-Hung Chia Ada Law Tracy Shum Yim-Kwan Lam Vince Lau Victor Lee Charing Chong Chung-Ngai Tang Thomas Yau | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 0 |
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