|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein显示文摘AIM To compare the therapeutic effect andsignificances of multimodality treatment forhepatocellular carcinoma (HCC) with tumorthrombi in portal vein (PVTT).METHODS HCC patients (n = 147) with tumortrombi in the main portal vein or the first branchof portal vein were divided into four groups bythe several therapeutic methods. There wereconservative treatment group in 18 out ofpatients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAl)group in 18 patients (group B), in whompostoberative chemoembolization was doneperiodically; group of removal of HCC with PVTTin 79 (group C) and group of transcatheterhepatic arterial chemoembolization (TACE) orHAl and/or portal vein infusion (PVI) afteroperation in 32 (group D).RESULTS The median survival period was 12months in our series and the 1-, 3-, and 5-yearsurvival rates were 44.3%, 24.5% and 15.2%,respectively. The median survival times were 2,5, 12 and 16 months in group A, B, C and D,respectively. The 1-, 3- and 5-year survival rateswere 5.6%, 0% and 0% in group A; 22.2%,5.6% and 0% in group B; 53.9%, 26.9% and16.6% in group C; 79.3%, 38.9% and 26.8% ingroup D, respectively. Significant differenceappeared in the survival rates among the groups(P<0.05).CONCLUSION Hepatic resection with removalof tumor thrombi and HCC should increase thecurative effects and be encouraged for theprolongation of life span and quality of life forHCC patients with PVTT, whereas the besttherapeutic method for HCC with PVTT is withregional hepatic chemotherapy orchemoemblization after hepatic resection withremoval of tumor thrombi. | Jia Fan Zhi Quan Wu Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 80 |
| 2 | No-reflow protection and long-term efficacy for acute myocardial infarction with Tongxinluo: a randomized double-blind placebo- controlled multicenter clinical trial (ENLEAT Trial)显示文摘在紧急情况以后的背景没有回流为尖锐的圣片断举起的经皮的冠的干预(一种总线标准) 心肌的梗塞(STEMI ) 与严重预后有关。这研究的目的是评估 Tongxinluo 的功效,繁体中文药,在在为 219 个病人全部的 STEMI.Methods A 的紧急情况一种总线标准以后的没有回流和梗塞区域上(女性 31 ,14%)从九个临床的中心为 STEMI 经历紧急情况一种总线标准连续地在这被注册使随机化,双窗帘,控制安慰剂, multicenter 对2009年5月的从2007年1月的临床的试用。所有病人随机被划分成 Tongxinluo 在装载的组(n=108 ) 和控制组(n=111 ) ,给定的 Tongxinluo 或安慰剂在紧急情况一种总线标准前分别地为 2.08 g 开 asprin 300 mg 和 clopidogrel 300 mg 一起,然后为在一种总线标准以后的六个月三倍每日的 1.04 g。圣片断举起被心电图在住院记录并且 1, 2, 6, 12,在冠的汽球膨胀到以后的 24 个小时评估心肌的没有流动;在有静态的单个光子的排放的 STEMI 计算了断层摄影术( SPECT )决定在那里的梗塞 area.Results 不是在性别的统计意义以后, 17 个片断的心肌的灌注分数在白天 7 和白天 180 上被评估,年龄经过历史,胸疼痛, onset-to-reperfusion 时间, Killip 分类,就在一种总线标准前后的 TIMI 流动等级,在药治疗的任何一个在follow 在上面期间例如 statin ,-blocker,血管收缩素变换酶禁止者( ACEI )或血管收缩素 rece 在与在 6 个小时的控制组相比的 Tongxinluo 组有重要的圣片断恢复((-0.22????????????????????????????? 慰桴灯票楳汯杯捩污吗?? | ZHANG Hai-tao JIA Zhen-hua ZHANG Jian YE Zan-kai YANG Wei-xian TIAN Yue-qin JIA Xuan LI Wei WU Yi-ling YANG Yue-jin | 2010 | Chinese Medical Journal2010，，20： | 69 |
| 3 | Serum vaspin level in relation to postprandial plasma glucose concentration in subjects with diabetes显示文摘背景 Vaspin 是与肥胖和胰岛素 sensitivity.However 有关的最新识别的 adipocytokine ,它在人的 pathophysiologic 角色大部分留下我们的学习的 unknown.The 目的 123 个题目是在中国 adults.Methods A 调查在浆液 vaspin 水平和葡萄糖新陈代谢或肥胖之间的关系全部的,包括有正常葡萄糖忍耐( NGT )的 84 个题目和有糖尿病的 39 个题目,在这 study.Anthropometric 被注册参数,腹的胖区域。 | YE Yin HOU Xu-hong PAN Xiao-ping LU Jun-xi JIA Wei-ping | 2009 | Chinese Medical Journal2009，，21： | 40 |
| 4 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 5 | Evaluation of the yield and nitrogen use efficiency of the dominant maize hybrids grown in North and Northeast China显示文摘Breeding high-yielding and nutrient-efficient cultivars is one strategy to simultaneously resolve the problems of food security,resource shortage,and environmental pollution.However,the potential increased yield and reduction in fertilizer input achievable by using high-yielding and nutrient-efficient cultivars is unclear.In the present study,we evaluated the yield and nitrogen use efficiency(NUE) of 40 commercial maize hybrids at five locations in North and Northeast China in 2008 and 2009.The effect of interaction between genotype and nitrogen(N) input on maize yield was significant when the yield reduction under low-N treatment was 25%-60%.Based on the average yields achieved with high or low N application,the tested cultivars were classified into four types based on their NUE:efficient-efficient(EE) were efficient under both low and high N inputs,high-N efficient(HNE) under only high N input,low-N efficient(LNE) under only low N input,and nonefficient-nonefficient under neither low nor high N inputs.Under high N application,EE and HNE cultivars could potentially increase maize yield by 8%-10% and reduce N input by 16%-21%.Under low N application,LNE cultivars could potentially increase maize yield by 12%.We concluded that breeding for N-efficient cultivars is a feasible strategy to increase maize yield and/or reduce N input. | CHEN FanJun FANG ZenGuo GAO Qiang YE YouLiang JIA LiangLiang YUAN LiXing MI GuoHua ZHANG FuSuo | 2013 | Science China(Life Sciences)2013，56，6： | 27 |
| 6 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 7 | Progress of Air Pollution Control in China and Its Challenges and Opportunities in the Ecological Civilization Era显示文摘China’s past economic growth has substantially relied on fossil fuels,causing serious air pollution issues.Decoupling economic growth and pollution has become the focus in developing ecological civilization in China.We have analyzed the three-decade progress of air pollution controls in China,highlighting a strategic transformation from emission control toward air quality management.Emission control of sulfur dioxide(SO2)resolved the deteriorating acid rain issue in China in 2007.Since 2013,control actions on multiple precursors and sectors have targeted the reduction of the concentration of fine particulate matter(PM2.5),marking a transition to an air-quality-oriented strategy.Increasing ozone(O3)pollution further requires O3 and PM2.5 integrated control strategies with an emphasis on their complex photochemical interactions.Fundamental improvement of air quality in China,as a key indicator for the success of ecological civilization construction,demands the deep de-carbonization of China’s energy system as well as more synergistic pathways to address air pollution and global climate change simultaneously. | Xi Lu Shaojun Zhang Jia Xing Yunjie Wang Wenhui Chen Dian Ding Ye Wu Shuxiao Wang Lei Duan Jiming Hao | 2020 | Engineering2020，6，12： | 24 |
| 8 | Robot-assisted one-stage resection of rectal cancer with liver and lung metastases显示文摘The Da Vinci Surgical System may help to overcome some of the difficulties of laparoscopy for complicated abdominal surgery.The authors of this article present a case of robot-assisted, one-stage radical resection of three tumors, including robotic anterior resection for rectal cancer, segmental hepatectomy for liver metastasis, and wedge-shaped excision for lung metastasis.A 59-year-old man with primary rectal cancer and liver and lung metastases was operated upon with a one-stage radical resection approach using the Da Vinci Surgical System.Resection and anastomosis of rectal cancer were performed extracorporeally afterundocking the robot.The procedure was successfully completed in 500 min.No surgical complications occurred during the intervention and postoperative period, and no conversion to laparotomy or additional trocars were required.To the best of our knowledge, this is the first case of simultaneous resection for rectal cancer with liver and lung metastases using the Da Vinci Surgery System to be reported.The procedure is feasible and safe and its main advantages for patient are avoiding repeated operation, reducing surgical trauma, shortening recovery time, and early implementation of postoperative adjuvant therapy. | Jian-Min Xu Ye Wei Xiao-Ying Wang Hong Fan Wen-Ju Chang Li Ren Wei Jiang Jia Fan Xin-Yu Qin | 2015 | World Journal of Gastroenterology2015，21，9： | 23 |
| 9 | Therapeutic effect of Zijin capsule in liver fibrosis in rats显示文摘TherapeuticefectofZijincapsuleinliverfibrosisinratsCAIDaYongZHAOGang,CHENJiaChun,YEGanMei,BINGFeiHongandFANBuWuSubjecth... | CAI Da Yong, ZHAO Gang, CHEN Jia Chun, YE Gan Mei, BING Fei Hong and FAN Bu Wu | 1998 | World Journal of Gastroenterology1998，4，3： | 20 |
| 10 | Magnetic records of heavy metal pollution in urban topsoil in Lanzhou,China显示文摘This study is a systematic analysis of the magnetic characteristics and heavy metal elements in soil samples collected from Lanzhou City,China.The 117 surface soil samples were measured to study the feasibility and effectiveness of environmental magnetism for evaluating heavy metal pollution in urban soils.Results of the study indicate that low-coercivity magnetite dominates the magnetic properties in the samples.The high values of the soil magnetic mineral concentration parameters and low values of magnetic particle size parameters are distributed throughout the northern area of Xigu District,the industrial zones of the eastern section of Chengguan District and the districts of the narrow sections connecting Chengguan District and the other three districts;these parameters are fundamentally consistent with the distribution of the high values of the Pollution Load Index and Nemerow Pollution Index.Semi-quantitative studies which use the environmental magnetic method to monitor pollution of heavy metals(such as As,Cr,Cu,Ni,Pb,Zn,and Fe) have shown that when xlf≤35×10-8 m 3 kg-1,it is unpolluted;when 35≤xlf <150×10-8 m3 kg-1,it is moderately polluted to unpolluted;when 150≤xlf <365×10-8 m 3 kg-1,it is moderately polluted;when 365≤xlf <750×10-8 m3 kg-1,fd %<2.7 and ARM /SIRM<0.2×10-3m A-1,it is moderately to highly polluted;when xlf ≥750×10-8 m3 kg-1,xfd %<2.7 and xARM/SIRM<0.2×10-3m A-1,it is highly polluted.The region of moderately to highly polluted distribution is caused by industry and vehicles,showing that the change of pollution in Lanzhou City bears the trend of 'vehicle emission + industrial'. | WANG Bo XIA DunSheng YU Ye JIA Jia XU ShuJing | 2013 | Chinese Science Bulletin2013，58，3： | 19 |
| 11 | Expression of the CXCL12/CXCR4 and CXCL16/CXCR6 axes incervical in traepithelial neoplasia and cervical cancer显示文摘The chemokine CXCL12 is highly expressed in gynecologic tumors and is widely known to play a biologically relevant role in tumor growth and spread. Recent evidence suggests that CXCL16, a novel chemokine, is overexpressed in inflammation-associated tumors and mediates pro-tumorigenic effects of inflammation in prostate cancer. We therefore analyzed the expression of CXCL12 and CXCL16 and their respective receptors CXCR4 and CXCR6 in cervical intraepithelial neoplasia (CIN) and cervical cancer and further assessed their association with clinicopathologic features and outcomes. Tissue chip technology and immunohistochemistry were used to analyze the expression of CXCL12, CXCR4, CXCL16, and CXCR6 in healthy cervical tissue (21 cases), CIN (65 cases), and cervical carcinoma (60 cases). The association of protein expression with clinicopathologic features and overall survival was analyzed. These four proteins were clearly detected in membrane and cytoplasm of neoplastic epithelial cells, and their distribution and intensity of expression increased as neoplastic lesions progressed through CIN1, CIN2, and CIN3 to invasive cancer. Furthermore, the expression of CXCR4 was associated significantly with the histologic grade of cervical carcinoma, whereas the expression of CXCR6 was associated significantly with lymph node metastasis. In Kaplan-Meier analysis, patients with high CXCR6 expression had significantly shorter overall survival than did those with low CXCR6 expression. The elevated co-expression levels of CXCL12/CXCR4 and CXCL16/CXCR6 in CIN and cervical carcinoma suggest a durative process in cervical carcinoma development. Moreover, CXCR6 may be useful as a biomarker and a valuable prognostic factor for cervical cancer. | Yu Huang Jia Zhang Zhu-Mei Cui Jing Zhao Ye Zheng | 2013 | Chinese Journal of Cancer2013，32，5： | 18 |
| 12 | P53 immunohistochemical scoring:an independent prognostic marker for patients after hepatocellular carcinoma resection显示文摘AIM: To confirm if p53 mutation could be a routinepredictive marker for the prognosis of hepatocellularcarcinoma (HCC) patients.METHODS: Two hundreds and forty-four formalin-fixedparaffin-embedded tumor samples of the patients with HCCreceiving liver resection were detected for nuclearaccumulation of p53. The percent of P53 immunoreactivetumor cells was scored as 0 to 3 + in P53 positive region ( <10% -, 10-30 % +, 31-50 % + +, > 50 % + + + ).Proliferating cell nuclear antigen (PCNA) and someclinicopathological characteristics, including patients' sex,preoperative serum AFP level, tumor size, capsule,vascular invasion (both visual and microscopic ), andEdmondson grade were also evaluated.RESULTS: In univariate COX harzard regression modelanalysis, tumor size, capsule status, vascular invasion,and p53 expression were independent factors that wereclosely related to the overall survival (OS) rates of HCCpatients. The survival rates of patients with 3 + for P53expression were much lower than those with 2 + or + forP53 expression. Only vascular invasion ( P < 0.05 ) andcapsule ( P < 0.01 ) were closely related to the disease-freesurvival (DFS) of HCC patients. In multivariate analysis, p53overexpression (RI 0. 5456, P < 0. 01 ) was the mostsignificant factor associated with the OS rates of patientsafter HCC resection, while tumor size (RI 0.5209, P< 0.01),vascular invasion (RI 0.5271, P < 0.01 ) and capsule (RI-0.8691, P<0.01) were also related to the OS. However, onlytumor capsular status was an independent predictive factor( P< 0.05) for the DFS. No significant prognostic value wasfound in PCNA-LI, Edmondson's grade, patients' sex andpreoperative serum AFP level.CONCLUSION: Accumulation of p53 expression, as well estumor size, capsule and vascular invasion, could bevaluable markers for predicting the prognosis of HCCpatients after resection. The quantitativeimmunohistochemical scoring for P53 nuclear accumulationmight be more valuable for predicting prognosis of patientsafter HCC resection than the common qualitative analysis. | Lun-Xiu Qin Zhao-You Tang Zeng-Chen Ma Zhi-Quan Wu Xin-Da Zhou Qing-Hai Ye Yuan Ji Li-Wen Huang Hu-Liang Jia Hui-Chuan Sun Lu Wang,Liver Cancer Institute and Zhongshan Hospital,Fudan University,Shanghai,China | 2002 | World Journal of Gastroenterology2002，8，3： | 18 |
| 13 | Buyang Huanwu Decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: In vitro evidences显示文摘Buyang Huanwu Decoction(BYHWD) is a well-known traditional Chinese medicine prescription which is used to treat ischaemic stroke and stroke-induced disabilities. However, the exact mechanism underlying BYHWD's amelioration of ischaemic stroke and its effective constituents remain unclear. The present study aimed to identify the effective constituents of BYHWD and to further explore its action mechanisms in the amelioration of ischaemic stroke by testing the activities of 15 absorbable chemical constituents of BYHWD with the same methods under the same conditions. The following actions of these 15 compounds were revealed: 1) Ferulic acid, calycosin, formononetin, astrapterocarpan-3-O-β-D-glucoside, paeonol, calycosin-7-O-β-D-glucoside, astraisoflavan-7-O-β-D-glucoside, ligustrazine, and propyl gallate significantly suppressed concanavalin A(Con A)-induced T lymphocyte proliferation; 2) Propyl gallate, calycosin-7-O-β-D-glucoside, paeonol, and ferulic acid markedly inhibited LPS-induced apoptosis in RAW264.7 cells; 3) Propyl gallate and formononetin significantly inhibited LPS-induced NO release; 4) Hydroxysafflor yellow A and inosine protected PC12 cells against the injuries caused by glutamate; and 5) Formononetin, astragaloside IV, astraisoflavan-7-O-β-Dglucoside, inosine, paeoniflorin, ononin, paeonol, propyl gallate, ligustrazine, and ferulic acid significantly suppressed the constriction of the thoracic aorta induced by KCl in rats. In conclusion, the results from the present study suggest that BYHWD exerts its ischaemic stroke ameliorating activities by modulating multiple targets with multiple components. | ZHANG Wei-Wei XU Feng WANG Ding YE Jia CAI Shao-Qing | 2018 | Chinese Journal of Natural Medicines2018，16，3： | 16 |
| 14 | Persistence of hepatitis B vaccine immune protection and response to hepatitis B booster immunization显示文摘AbstractAIMToidentifythepersistenceofimmuneprotectionofChinamade,plasmaderivedhepatitisBvaccineafterinfancyimmunizationandt... | LI Hui 1, LI Rong Cheng 2, LIAO Su Su 1, YANG Jin Ye 2, ZENG Xian Jia 1 and WANG Shu Sheng 2 | 1998 | World Journal of Gastroenterology1998，4，6： | 15 |
| 15 | High CO methanation activity on zirconia-supported molybdenum sulfide catalyst显示文摘In this study, different methods were used to prepare MoO3/ZrO2 catalysts for sulfur resistant methanation reaction. It was found that MoO3/ZrO2 catalyst prepared by one-step co-precipitation method achieved high methanation performance. CO conversion could reach up to90% on 25 wt% MoO3/ZrO2 catalyst, much higher than that on the conventional 25 wt% MoO3/Al2O3 catalyst. The Mo-based catalysts were characterized by XRF, XRD, Raman, BET, TEM and H2-TPR etc. It was found that MoO3 particles were highly dispersed on ZrO2 support for 25 wt% MoO3/ZrO2 catalyst prepared at 65-85℃ because of its relatively larger pore size, which contributed to a high CO conversion.Meanwhile, when MoO3 loading exceeded the monolayer coverage, the formed crystalline MoO3 and ZrMo2O8might block the micropores of the catalyst and make the methanation activity declined. These results are useful for preparing highly efficient catalyst for CO methanation process. | Zhenhua Li Ye Tian Jia He Baowei Wang Xinbin Ma | 2014 | Journal of Energy Chemistry2014，23，5： | 15 |
| 16 | Non-invasive ventilation improves hemorheology status in hypoxemic patients with acute myocardial infarction after PCI显示文摘血氧不足有时在经皮的冠的干预(一种总线标准) 以后与尖锐心肌的梗塞(AMI ) 在病人发生在紧急情况房间里,甚至在那些与常规高流动的氧吸入的管理。现在的学习是在与 AMI 和 hypoxemia.MethodsThis 在病人改进血氧内容和 hemorheology 评估非侵略的通风(NIV ) 的有效性的 of 未来的学习与 AMI 注册了 50 个连续合格病人(72.3 ??? 折?? | Xi-Fu WANG Ming YE Dong YAN Hui-Min ZHANG Ping JIA Xue-Jun REN Yu-Jie ZENG | 2017 | Journal of Geriatric Cardiology2017，14，4： | 15 |
| 17 | Safety,tolerability,and pharmacokinetics of VV116,an oral nucleoside analog against SARS-CoV-2,in Chinese healthy subjects显示文摘VV116(JT001)is an oral drug candidate of nucleoside analog against SARS-CoV-2.The purpose of the three phase I studies was to evaluate the safety,tolerability,and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subjects,as well as the effect of food on the pharmacokinetics and safety of VV116.Three studies were launched sequentially:Study 1(single ascending-dose study,SAD),Study 2(multiple ascending-dose study,MAD),and Study 3(food-effect study,FE).A total of 86 healthy subjects were enrolled in the studies.VV116 tablets or placebo were administered per protocol requirements.Blood samples were collected at the scheduled time points for pharmacokinetic analysis.116-N1,the metabolite of VV116,was detected in plasma and calculated for the PK parameters.In SAD,AUC and Cmax increased in an approximately dose-proportional manner in the dose range of 25–800 mg.T_(1/2)was within 4.80–6.95 h.In MAD,the accumulation ratio for Cmax and AUC indicated a slight accumulation upon repeated dosing of VV116.In FE,the standard meal had no effect on Cmax and AUC of VV116.No serious adverse event occurred in the studies,and no subject withdrew from the studies due to adverse events.Thus,VV116 exhibited satisfactory safety and tolerability in healthy subjects,which supports the continued investigation of VV116 in patients with COVID-19. | Hong-jie Qian Yu Wang Meng-qi Zhang Yuan-chao Xie Qing-qing Wu Li-yu Liang Ye Cao Hua-qing Duan Guang-hui Tian Juan Ma Zhuo-bing Zhang Ning Li Jing-ying Jia Jing Zhang Haji Akber Aisa Jing-shan Shen Chen Yu Hua-liang Jiang Wen-hong Zhang Zhen Wang Gang-yi Liu | 2022 | Acta Pharmacologica Sinica2022，43，12： | 13 |
| 18 | Focal nodular hyperplasia of the liver in 86 patients显示文摘BACKGROUND: Focal nodular hyperplasia (FNH), the second most common benign hepatic tumor after hemangioma, is characterized by a stellate central scar and hyperplastic nodules. Although some large FNH may be associated with significant symptoms, more frequently they are discovered incidentally on physical examination or the work-up of unrelated symptoms. Since its nature and pathogenesis are still controversial, accurate diagnosis of FNH based on clinical presentation and radiographic studies is difficult. The purpose of this study was to explore the diagnosis and treatment of FNH. METHODS: Eighty-six FNH patients confirmed patholo- gically were treated at the Liver Cancer Institute in our hospital from 1996 to 2006. Their clinical manifestions, imaging presentation, pathological findings, and surgical results were analyzed retrospectively. RESULTS: Of the 86 patients with 99 foci, 54 were male and 32 female, with a mean age of 37 years. Eighty patients had a single solitary focus and 6 had multiple foci. Tumor diameter was less than 5 cm in 69 patients, 5-10 cm in 15, and more than 10 cm in 2. The overall rate of correct preoperative diagnosis was 59.3% (51/86) including 32.9% (26/79) by color Doppler flow imaging (CDFI), 60.3% (35/58) by CT, and 77.4% (24/31) by MRI. All the 86 patients underwent resection with good curative effect.CONCLUSIONS: CT and MRI are important diagnostic methods for FNH but it is difficult to make a definite preoperative diagnosis for partial classical and all non- classical FNH patients. We suggest that patients with clinical symptoms or with indefinite diagnosis should accept surgical removal. | Shen, Ying-Hao Fan, Jia Wu, Zhi-Quan Ma, Zeng-Chen Zhou, Xin-Da Zhou, Jian Qiu, Shuang-Jian Qin, Lun-Xiu Ye, Qin-Hai Sun, Hui-Chuan Huang, Xiao-Wu Tang, Zhao-You | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，1： | 13 |
| 19 | Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury显示文摘Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury. | Zhi Li Wei Zhao Wei Liu Ye Zhou Jingqiao Jia Lifeng Yang | 2014 | Neural Regeneration Research2014，9，24： | 13 |
| 20 | Key parameter estimation for radar rotating object imaging with multi-aspect observations显示文摘Rotating object model is commonly used for imaging analysis in high resolution radars such as the inverse synthetic aperture radar (ISAR). For a rotating object, it is known that multi-aspect observations can improve cross-range resolution with the known imaging geometry. For the non-cooperative rotating object with unknown imaging geometry, this paper proposes an integrated scheme to estimate the key parameters, e.g., the rotating velocity and the aspect angle difference between every two observations. Furthermore, convolution back-projection (CBP) method is applied to provide fused imaging result with improved resolution. Also, the accuracy of the ultimate parameter estimation is analyzed, which is strongly related with several important factors like position extraction error of scattering centers and so on. Finally, the results of numerical experiments are provided to demonstrate the effectiveness of the proposed method. | YE ChunMao, XU Jia , PENG YingNing & WANG XiuTan Department of Electronic Engineering, Tsinghua University, Beijing 100084, China | 2010 | Science China(Information Sciences)2010，53，8： | 12 |
您所在的机构暂未开通此部分的功能，请联系管理员