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| 1 | A complex network approach to topology control problem in underwater acoustic sensor networks显示文摘 | Liu Linfeng Liu Ye Zhang Ningshen | 2013 | IEEE Transactions on Parallel and Distributed Systems2013，，1： | 1 |
| 2 | Comprehensive Model Construction and Simulation for Superconducting Electrodynamic Suspension Train显示文摘With the advantages of levitation/guidance self-stability,large levitation gap,and high lift-to-drag ratios,superconducting electrodynamic suspension(SC-EDS)train is becoming a viable candidate for the high-speed and ultra-high-speed rail transportation.In order to provide the basis for designing the optimization and control strategy,this paper establishes a comprehensive model for the SC-EDS train,which considers the dynamics of the bogie and car body in all directions.The obtained model reveals the complex coupling and feedback relationships among the variables,which cannot be described by the existing local models of the SC-EDS train.Simulation examples under different parameters and initial conditions are presented and discussed to demonstrate the potential use of the model given in this paper. | Linfeng Liu Hao Ye Wei Dong Junfeng Cui | 2023 | Complex System Modeling and Simulation2023，3，3： | 0 |
| 3 | Changing profile of lung cancer clinical characteristics in China:Over 8-year population-based study显示文摘Background:Although examinations and therapies for bronchial lung cancer,also called lung cancer(LC),have become more effective and precise,the morbidity and mortality of LC remain high worldwide.Describing the changing profile of LC characteristics over time is indispensable.This study aimed to understand the changes in real-world settings of LC and its characteristics in China.Methods:In this study,119,785 patients were enrolled from 2012 to 2020 in the Shanghai Pulmonary Hospital.The patients’medical records were extracted from the hospital’s database.Demographic characteristics,general clinicopathological information,and blood coagulation indices at the initial diagnoses were analyzed using the Kruskal-Wallis,Nemenyi,chi-squared,and Bonferroni tests.Changes in demographic characteristics during the 8-year study period,namely dynamic changes among different stages and different pathological types,were evaluated.Results:The percentages of female(from 38.50%[323/839]in 2012 to 48.29%[5112/10,585]in 2020)and non-smoking LC(from 69.34%[475/685]to 80.48%[8055/10,009])patients increased significantly during the study period,with a trend toward a younger age at diagnosis(from 3.58%[30/839]to 8.99%[952/10,585]).Over the study period,the proportion and absolute number of lung adenocarcinoma cases increased(from 67.97%[433/637]to 76.31%[6606/8657])while the proportion of lung squamous cell carcinoma decreased(from 21.19%[135/637]to 12.08%[1046/8657]).Comprehensive driver gene mutation examination became more common,and epidermal growth factor receptor(EGFR)mutation occurred more frequently in female vs.male(62.03%[12793/20625]vs.29.90%[8207/27,447])and non-smoking vs.smoking(53.54%[17,203/32,134]vs.23.73%[3322/13,997])patients(both P<0.001).The distribution of the common driver genes differed among different stages of LC.EGFR mutation was detected most frequently at each stage,and other driver gene alterations were more common in advanced stages(P<0.001).The combination of chemotherapy,targeted ther-apy,and immunotherapy,as a comprehensive management regimen,gradually became predominant over the study period(P<0.001).A hypercoagulable state was shown in advanced-stage LC patients and patients with the anaplastic lymphoma kinase fusion,indicated by significantly elevated levels of d-dimer,fibrinogen,and fibrinogen degradation products.Conclusions:This study comprehensively depicted the changing characteristics of Chinese LC patients over an 8-year period to provide preliminary insights into LC treatment.Trial registration:ClinicalTrials.gov,NCT05423236. | Kandi Xu Hao Wang Simin Li Lishu Zhao Xinyue Liu Yujin Liu Li Ye Xiaogang Liu Linfeng Li Yayi He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，3： | 0 |
| 4 | Replacement of Flake Graphite in Aluminacarbon Refractories by Hexagonal Boron Nitride显示文摘Three kinds of composite alumina refractories were prepared with tabular alumina( 3- 1 and 1- 0 mm) as aggregates, tabular alumina powder, α-Al2O3 micropowder,and Si powder as matrix,adding 3 mass%hexagonal boron nitride( h-BN), 3 mass% flake graphite and 10 mass% flake graphite, respectively.Cold physical properties,hot modulus of rupture,oxidation resistance,thermal shock resistance and slag corrosion resistance of the specimens were compared. The results show that:( 1) physical properties and hot modulus of rupture of Al2O3- h-BN refractories are slightly different from those of low carbon Al2O3- C refractories,but better than those of traditional Al2O3- C refractories with 10 mass% graphite;( 2) Al2O3- h-BN refractories have better thermal shock resistance and oxidation resistance than the carbon containing refractories,while similar slag resistance with low carbon Al2O3- C refractories;( 3) h-BN can replace flake graphite as a starting material for the preparation of composite alumina refractories,considering the overall properties of the material. | LIANG Feng XUE Zhengliang ZHAO Lei FANG Wei YE Linfeng LEI Zhongxing | 2014 | China's Refractories2014，23，4： | 0 |
| 5 | New spray and wait protocol with node activity in heterogeneous delay tolerant networks显示文摘The spray and wait protocol is a classic copy-limited spraying protocol in delay tolerant networks, in which, the binary spray mode can be improved for heterogeneous delay tolerant networks. In this article, a new conception of node activity was defined to weigh the importance of nodes in aspect of message dissemination in the whole network. A new spray and wait protocol with node activity was proposed to improve the performance in heterogeneous delay tolerant networks. A mathematical model used under varieties of the spraying protocols was also proposed to analyze the expected delay of the protocol. Simulations show that the spray token proportion with node activity is optimal and the new protocol is of better performance than other related protocols. Therefore, this protocol has high efficiency and good scalability. | Wu Jiagao Ye Ke Zhu Yiji Liu Linfeng | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，2： | 0 |
| 6 | RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis显示文摘Hantaan virus(HTNV)is a rodent-borne virus that causes hemorrhagic fever with renal syndrome(HFRS),resulting in a high mortality rate of 15%.Interferons(IFNs)play a critical role in the anti-hantaviral immune response,and IFN pretreatment efficiently restricts HTNV infection by triggering the expression of a series of IFNstimulated genes(ISGs)through the Janus kinase-signal transducer and activator of transcription 1(JAK-STAT)pathway.However,the tremendous amount of IFNs produced during late infection could not restrain HTNV replication,and the mechanism remains unclear.Here,we demonstrated that receptor-interacting protein kinase 3(RIPK3),a crucial molecule that mediates necroptosis,was activated by HTNV and contributed to hantavirus evasion of IFN responses by inhibiting STAT1 phosphorylation.RNA-seq analysis revealed the upregulation of multiple cell death-related genes after HTNV infection,with RIPK3 identified as a key modulator of viral replication.RIPK3 ablation significantly enhanced ISGs expression and restrained HTNV replication,without affecting the expression of pattern recognition receptors(PRRs)or the production of type I IFNs.Conversely,exogenously expressed RIPK3 compromised the host's antiviral response and facilitated HTNV replication.RIPK3^(-/-)mice also maintained a robust ability to clear HTNV with enhanced innate immune responses.Mechanistically,we found that RIPK3 could bind STAT1 and inhibit STAT1 phosphorylation dependent on the protein kinase domain(PKD)of RIPK3 but not its kinase activity.Overall,these observations demonstrated a noncanonical function of RIPK3 during viral infection and have elucidated a novel host innate immunity evasion strategy utilized by HTNV. | Yue Si Haijun Zhang Ziqing Zhou Xudong Zhu Yongheng Yang He Liu Liang Zhang Linfeng Cheng Kerong Wang Wei Ye Xin Lv Xijing Zhang Wugang Hou Gang Zhao Yingfeng Lei Fanglin Zhang Hongwei Ma | 2023 | Virologica Sinica2023，38，5： | 0 |
| 7 | STING strengthens host anti-hantaviral immunity through an interferon-independent pathway显示文摘Hantaan virus(HTNV),the prototype virus of hantavirus,could escape innate immunity by restraining type I interferon(IFN)responses.It is largely unknown whether there existed other efficient anti-hantaviral tactics in host cells.Here,we demonstrate that the stimulator of interferon genes(STING)strengthens the host IFNindependent anti-hantaviral immunity.HTNV infection activates RIG-I through IRE1-XBP 1-mediated ER stress,which further facilitates the subcellular translocation and activation of STING.During this process,STING triggers cellular autophagy by interacting with Rab7A,thus restricting viral replication.To note,the anti-hantaviral effects of STING are independent of canonical IFN signaling.Additionally,neither application of the pharmacological antagonist nor the agonist targeting STING could improve the outcomes of nude mice post HTNV challenge in vivo.However,the administration of plasmids exogenously expressing the mutant C-terminal tail(ΔCTT)STING,which would not trigger the type I IFN responses,protected the nude mice from lethal HTNV infection.In summary,our research revealed a novel antiviral pathway through the RIG-I-STING-autophagy pathway,which offered novel therapeutic strategies against hantavirus infection. | Kerong Wang Jian Zhang Yongheng Yang Yue Si Ziqing Zhou Xudong Zhu Sushan Wu He Liu Hui Zhang Liang Zhang Linfeng Cheng Wei Ye Xin Lv Yingfeng Lei Xijing Zhang Shilin Cheng Lixin Shen Fanglin Zhang Hongwei Ma | 2023 | Virologica Sinica2023，38，4： | 0 |
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