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| 1 | Efficacy and safety of sunitinib in the treatment of metastatic renal cell carcinoma显示文摘背景酷氨酸 kinase 禁止者(TKI ) sunitinib,为变形肾的房间癌(RCC ) 的第一线治疗的首先指向的代理人,指向脉管的 endothelial 生长因素(VEGF ) 小径。如果高血压是有效预兆的 factor.Methods,这研究的目的是在对待变形清楚房间的 RCC 调查 sunitinib 的功效和安全并且证实有变形 RCC 的 36 个病人的一个总数在 2008 年 6 月和 2010 年 12 月之间被注册。在他们之中, 29 个案例是第一线治疗, 7 个案例在首要的 cytokine 或 sorafinib 治疗上的前进。所有病人的病理被证实在清楚的房间类型占优势。Sunitinib 单音治疗在每日的口头的治疗的重复 6 星期的周期被管理 4 个星期,到 2 个星期列在后面离开在 34 个病人;并且 3 个病人连续地与 37.5 mg/d 被管理直到疾病前进或不能接受的毒性发生了。全面反应率和安全被评估。我们根据中部的后续是的血压 level.Results 把病人划分了成组 A 和组 B 15 个月(10 个周期,范围 1.5-30.0 月(1-20 周期)) 。十个病人(29.4 ) 完成了部分回答(PR ) ;23 个病人(67.6 ) 表明了持续 2 个周期的稳定的疾病(SD ) 。十七个病人(50 ) 在后续期间得了进步疾病(PD ) 。中部的没有前进的幸存(PFS ) 是 15 个月(范围 3.0-28.5 ) 月。9 个病人的一个总数死了;全面幸存没被到达;死亡病人的中部的幸存时间是 13 个月(范围 7-24 ) 月。最普通的不利事件是手脚症候群(77.8 ) , thrombocytopenia (75.0 ) ,高血压(61.1 ) 和腹泻(46.0 ) 。最不利的事件由治疗打断是可逆的。22 个病人(61.1 ) 得了高血压;并且高血压与很长时间被联系到疾病前进和长全面的幸存(P=0.004, 0.000,分别地) 这研究的结果表明的 .Conclusions 功效和可管理的不利事件与变形清楚的房间 RCC 为病人在首要或第二线的治疗作为一个单个代理人 sunitinib 介绍。进一步,联系 sunitinib 的高血压可以是为在变形 RCC 的治疗功效的一个强壮的预兆的标记。 | LI Xue-song WU Xiang ZHAO Peng-ju HUANG Li-hua SONG Yi GONG Kan SHEN Cheng YU Wei SONG Gang ZHAO Zheng ZHANG Zheng ZHANG Qian WANG Gang HE Zhi-song ZHOU Li-qun JIN Jie | 2011 | Chinese Medical Journal2011，，18： | 17 |
| 2 | Improved corrosion resistance and thermal stability of sintered Nd-Fe-B magnets with holmium substitution显示文摘The effects of Ho substitution for Nd on the microstructure, corrosion resistance and thermal stability of the Nd-Fe-B magnets were investigated. The(Nd,Ho)-O phase was formed with increasing Ho substitution. The results of potentiodynamic polarization and highly accelerated stress test show improved corrosion resistance with increasing Ho substitution. The optimum mass loss 0.29 mg/cm^2 is achieved.Moreover, the average temperature coefficients for remanence and coercivity in the range of 25-150℃are both closer to zero, indicating improved thermal stability. The mechanisms for the improved corrosion resistance and thermal stability are discussed in relation to the microstructure featuring the(Nd,Ho)-O phase. | Jinghui Di Shuai Guo Ling Chen Pengpeng Yi Guangfei Ding Kan Chen Ming Li Don Lee Aru Yan | 2018 | Journal of Rare Earths2018，36，8： | 11 |
| 3 | MAGNETIC RESONANCE IMAGING CHARACTERISTICS AND SURGICAL RESULTS OF ADRENOCORTICOTROPIN-SECRETING PITUITARY ADENOMAS显示文摘Objective To evaluate magnetic resonance imaging(MRI)characteristics and surgical results of adrenocorticotropin(ACTH)-secreting pituitary adenomas.Methods MRI characteristics and relationship between MRI positive rate and surgical results of 266 patients with pathologically confirmed Cushing's disease were analyzed retrospectively.All patients underwent thin-section sagittal and coronal scans of the pituitary gland before and after administration of gadolinium-diethylene triamine pentaacetic acid(Gd-DTPA)on a 1.5 Tesla MRI scanner,and dynamic enhanced MRI was performed in 39 patients.All patients underwent transsphenoidal adenomectomy.Endocrinological examinations and assessments were performed.Results Preoperative MRI revealed normal results in 41(15.4%)cases,microadenoma in 179(67.3%),macroadenoma in 42(15.8%),and huge adenoma in 4(1.5%).Pituitary apoplexy was found in 13(4.9%)cases.Positive rate of ACTH-secreting adenomas was 84.6%(225/266)on MRI scans,and that of small microadenomas was 87.2%(34/39)on dynamic enhanced MRI scans.Preoperative endocrinological tests of 199 cases supported the diagnosis of typical Cushing's disease,while the other 67 cases had atypical endocrinological results.The endocrinological cure rate,remission rate,and inefficacy rate were 85.7%,7.9%,and 6.4%,respectively.There was no difference in the initial endocrinological cure rate between the patients with positive and normal MRI results(90% vs.87.8%,P=0.904).Conclusions Enhanced coronal pituitary MRI is helpful for preoperative localization of ACTH-secreting pituitary microadenoma.Dynamic enhanced MRI may improve detection rate of microadenoma.There is no marked difference in the surgical results for patients with preoperative MRI results indicating presence or absence of microadenoma. | Bing Xing Kan Deng Zu-yuan Ren Chang-bao Su Ren-zhi Wang Yi Yang Wen-bin Ma Yong-ning Li | 2008 | Chinese Medical Sciences Journal2008，23，1： | 9 |
| 4 | Evaluation of efficacy and safety of sunitinib regimen in 22 patients with metastatic renal cell carcinoma: at least 12-month follow-up显示文摘 | ZHANG Cui-jian ZHAO Peng-ju LI Xue-song ZHAO Jing HUANG Li-hua SONG Yi GONG Kan SHEN Cheng YU Wei SONG Gang ZHAO Zheng ZHANG Zheng ZHANG Qian HE Zhi-song JIN Jie ZHOU Li-qun | 2013 | Chinese Medical Journal2013，，15： | 7 |
| 5 | WSS25, a sulfated polysaccharide, inhibits RANKL-induced mouse osteoclast formation by blocking SMAD/ID1 signaling显示文摘目的: WSS25 是从 Gastrodia elata 双性人的根茎提取的 sulfated 多糖,它被发现绑在骨头形态基因蛋白质 2 (BMP-2 ) 在 hepatocellular 癌症房间。因为 BMP-2 可以调整骨破折和造骨细胞,这里,我们在 ovariectomized 老鼠在 vitro 和骨头损失在 osteoclastogenesis 上调查了 WSS25 的效果。 | Cheng CHEN Yi QIN Jian-ping FANG Xin-yan NI Jian YAO Hai-ying WANG Kan DING | 2015 | Acta Pharmacologica Sinica2015，36，9： | 6 |
| 6 | Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation显示文摘许多干细胞人口被他们的本地微型环境(壁龛) 紧调整,它包括 stromal 房间的不同类型。然而,很少对壁龛亚群并列地由决定干细胞命运的机制被知道。这里,我们识别那 Yki,关键河马小径部件,为护卫房间(EC ) 是必要的在在果蝇卵巢支持 germline 区别的功能。我们发现那个刺猬(Hh ) 发信号首先从帽子房间发出,支持 EC 的功能肘脉 interruptus (Ci ) ,表明受动器的 Hh,禁止河马 kinase 的行为串联活动。机械学地,我们发现 Ci 竞争地与 Hpo 交往并且损害表明复杂形成的 Hpo-Wts,从而支持的 Yki 原子本地化。Ci 的行动保证发信号在 EC 反对 Sd/Tgi/Vg-mediated 缺省压抑的有效 Yki。这研究揭开解释壁龛房间的亚群怎么协调经由表明串音的 Hh 河马决定干细胞命运的机制,并且提高我们发信号的 oncogenic Yki/YAP 的机械学的规定的理解。 | Chaoyi Li Lijuan Kan Yan Chen Xiudeng Zheng Weini Li Wenxin Zhang Lei Cao Xiaohui Lin Shanming Ji Shoujun Huang Guoqiang Zhang Xiaohui Liu Yi Tao Shian Wu Dahua Chen | 2015 | Cell Research2015，25，10： | 5 |
| 7 | Translational Regulation of Plant Response to High Temperature by a Dual-Function tRNAHls Guanylyltransferase in Rice显示文摘As sessile organisms,plants have evolved numerous strategies to acclimate to changes in environmental temperature.However,the molecular basis of this acclimation remains largely unclear.In this study we identified a tRNAHis guanylyltransferase,AET1,which contributes to the modification of pre-tRNAH,s and is required for normal growth under high-temperature conditions in rice.Interestingly,AET1 possibly interacts with both RACK1A and elF3h in the endoplasmic reticulum.Notably,AET1 can directly bind to OsARF mRNAs including the uORFs of OsARF19 and OsARF23,indicating that AET1 is associated with translation regulation.Furthermore,polysome profiling assays suggest that the translational status remains unaffected in the aet1 mutant,but that the translational efficiency of OsARF19 and OsARF23 is reduced;moreover,OsARF23 protein levels are obviously decreased in the aet1 mutant under high temperature,implying that AET1 regulates auxin signaling in response to high temperature.Ourfindings provide new insights into the molecular mechanisms whereby AET1 regulates the environmental temperature response in rice by playing a dual role in tRNA modification and translational control. | Ke Chen Tao Guo Xin-Min Li Yi-Min Zhang Yi-Bing Yang Wang-Wei Ye Nai-Qian Dong Chuan-Lin Shi Yi Kan You-Huang Xiang Hai Zhang Ya-Chao Li Ji-Ping Gao Xuehui Huang Qiang Zhao Bin Han Jun-Xiang Shan Hong-Xuan Lin | 2019 | Molecular Plant2019，12，8： | 4 |
| 8 | Molecular regulation and genetic control of rice thermal response显示文摘Global warming threatens food security.Rice(Oryza sativa L.),a vital food crop,is vulnerable to heat stress,especially at the reproductive stage.Here we summarize putative mechanisms of high-temperature perception(via RNA secondary structure,the phyB gene,and phase separation)and response(membrane fluidity,heat shock factors,heat shock proteins,and ROS(reactive oxygen species)scavenging)in plants.We describe how rice responds to heat stress at different cell-component levels(membrane,endoplasmic reticulum,chloroplasts,and mitochondria)and functional levels(denatured protein elimination,ROS scavenging,stabilization of DNA and RNA,translation,and metabolic flux changes).We list temperature-sensitive genetic male sterility loci available for use in rice hybrid breeding and explain the regulatory mechanisms associated with some of them.Breeding thermotolerant rice species without yield penalties via natural alleles mining and transgenic editing should be the focus of future work. | Yi Kan Hong-Xuan Lin | 2021 | The Crop Journal2021，9，3： | 4 |
| 9 | Preparation of multihollow P(St-MAA) particles by sequence soap-free/soap emulsion polymerization and followed by stepwise alkali/acid posttreatment显示文摘The effects of ionic emulsifier, sodium dodecylbenzene sulfate (SDBS), on the formation of the multihollow structures in sub-micron sized polymer particles produced by alkali/acid posttreatment were investigated. The original latex particles with narrow size distribution were synthesized by a new sequence emulsifier-free/emulsifier emulsion copolymerization of styrene (St) and methacrylic acid (MAA). Results indicated that the pore size decreased and the pore number increased with the increase of SDBS amount, and the morphology of the posttreated latex particles was also significantly influenced by the introducing time of SDBS in the preparation of the original latex particles, and a suitable introducing time was 3 h of polymerization. | Rong Long Li Cheng You Kan Ze Ping Li Yi Du Yan Nan Cui | 2007 | Chinese Chemical Letters2007，18，6： | 3 |
| 10 | Verticillium dahliae Secretory Effector PevD1 Induces Leaf Senescence by Promoting ORE1-Mediated Ethylene Biosynthesis显示文摘Leaf senescence,the final stage of leaf development,is influenced by numerous internal and environmental signals.So far,how biotic stresses such as pathogen infection regulate leaf senescence is unclear.Here,we found that the premature leaf senescence caused by a soil-borne vascular fungus Verticillium dahliae in Arabidopsis was impaired by the mutation of a protein elicitor from V.dahliae 1(PevD1).Constitutive or inducible overexpression of PevD1 accelerated Arabidopsis leaf senescence.A senescence-associated NAC transcription factor,ORE1,was targeted by PevD1.PevD1 interacted with and stabilized ORE1 protein by disrupting its interaction with the RING-type ubiquitin E3 ligase NLA.Mutation of ORE1 suppressed the premature senescence caused by overexpressing PevD1.Overexpression of ORE1 or PevD1 led to enhanced ethylene production,and ORE1 mediated PevD1-induced ethylene biosynthesis by directly binding to the ACS6 promoter.Loss-of-function of ACSs suppressed V.dahliae-induced leaf senescence in ORE1-overexpressing plants.Interestingly,PevD1 also interacted with Gossypium hirsutum ORE1(GhORE1),and virus-induced gene silencing of GhORE1 delayed V.dahliae-triggered leaf senescence in cotton,indicative of the existence of a conserved mechanism in plants.Altogether,our study demonstrates that V.dahliae induces leaf senescence by secreting the effector PevD1 to regulate the ORE1-ACS6 cascade,providing new insight into biotic stress-induced senescence in plants. | Yi Zhang Yuhan Gao Hou-Ling Wang Chengcheng Kan Ze Li Xiufen Yang Weilun Yin Xinli Xia Hong Gil Nam Zhonghai Li Hongwei Guo | 2021 | Molecular Plant2021，14，11： | 2 |
| 11 | Near-zero-dispersion soliton and broadband modulational instability Kerr microcombs in anomalous dispersion显示文摘The developing advances of microresonator-based Ker cavity solitons have enabled versatile applications ranging from communication,signal processing to high-precision measurements.Resonator dispersion is the key factor determining the Kerr comb dynamics.Near the zero group-velocity-dispersion(GVD)regime,low-noise and broadband microcomb sources are achievable,which is crucial to the application of the Kerr soliton.When the GVD is almost vanished,higher-order dispersion can significantly affect the Kerr comb dynamics.Although many studies have investigated the Kerr comb dynamics near the zero-dispersion regime in microresonator or fiber ring system,limited by dispersion profles and dispersion perturbations,the near-zero-dispersion soliton structure pumped in the anomalous dispersion side is still elusive so far.Here,we theoretically and experimentally investigate the microcomb dynamics in fiber-based Fabry-Perot microresonator with ultra-small anomalous GVD.We obtain 2/3-octave-spaning microcombs with~10 GHz spacing,>84 THz span,and>8400 comb lines in the modulational instability(MI)state,without any external nonlinear spectral broadening.Such widely-spanned Ml combs are also able to enter the soliton state.Moreover,we report the first observation of anomalous-dispersion based near-zero-dispersion solitons,which exhibits a local repetition rate up to 8.6 THz,an individual pulse duration<100 fs,a span>32 THz and>3200 comb lines.These two distinct comb states have their own advantages.The broadband MI combs possess high conversion efficiency and wide existing range,while the near-zero-dispersion soliton exhibits relatively low phase noise and ultra-high local repetition rate.This work complements the dynamics of Kerr cavity soliton near the zero-dispersion regime,and may stimulate cross-disciplinary inspirations ranging from dispersion-controlled microresonators to broadband coherent comb devices. | Zeyu Xiao Tieying Li Minglu Cai Hongyi Zhang Yi Huang Chao Li Baicheng Yao Kan Wu Jianping Chen | 2023 | Light(Science & Applications)2023，12，2： | 2 |
| 12 | Anα/βhydrolase family member negatively regulates salt tolerance but promotes flowering through three distinct functions in rice显示文摘Ongoing soil salinization drastically threatens crop growth,development,and yield worldwide.It is therefore crucial that we improve salt tolerance in rice by exploiting natural genetic variation.However,many salt-responsive genes confer undesirable phenotypes and therefore cannot be effectively applied to practical agricultural production.In this study,we identified a quantitative trait locus for salt tolerance from the African rice species Oryza glaberrima and named it as Salt Tolerance and Heading Date 1(STH1).We found that STH1 regulates fatty acid metabolic homeostasis,probably by catalyzing the hydrolytic degradation of fatty acids,which contributes to salt tolerance.Meanwhile,we demonstrated that STH1 forms a protein complex with D3 and a vital regulatory factor in salt tolerance,OsHAL3,to regulate the protein abundance of OsHAL3 via the 26S proteasome pathway.Furthermore,we revealed that STH1 also serves as a co-activator with the floral integrator gene Heading date 1 to balance the expression of the florigen gene Heading date 3a under different circumstances,thus coordinating the regulation of salt tolerance and heading date.Notably,the allele of STH1 associated with enhanced salt tolerance and high yield is found in some African rice accessions but barely in Asian cultivars.Introgression of the STH1HP46 allele from African rice into modern rice cultivars is a desirable approach for boosting grain yield under salt stress.Collectively,our discoveries not only provide conceptual advances on the mechanisms of salt tolerance and synergetic regulation between salt tolerance and flowering time but also offer potential strategies to overcome the challenges resulted from increasingly serious soil salinization that many crops are facing. | You-Huang Xiang Jia-Jun Yu Ben Liao Jun-Xiang Shan Wang-Wei Ye Nai-Qian Dong Tao Guo Yi Kan Hai Zhang Yi-Bing Yang Ya-Chao Li Huai-Yu Zhao Hong-Xiao Yu Zi-Qi Lu Hong-Xuan Lin | 2022 | Molecular Plant2022，15，12： | 2 |
| 13 | Synthesis and properties of soap-free poly(methyl methacrylate-ethyl acrylate-methacrylic acid) latex particles prepared by seeded emulsion polymerization显示文摘 | KANG Kai KAN Cheng-you DU Yi | 2005 | Europen Polymer Journal2005，，41： | 1 |
| 14 | Synthesis and properties of soap-free poly (methyl methacrylate- ethyl acrylate-methacrylic acid) latex particles prepared by seeded emulsion polymerization显示文摘 | KANG KAI KAN CHENG-YOU DU YI | 2005 | European Polymer Journal2005，41，3： | 1 |
| 15 | Low-carbon energy policy and ambient air pollution in Shanghai, China: A health-based economic assessment显示文摘 | Changhong Chen Bingheng Chen Bingyan Wang Cheng Huang Jing Zhao Yi Dai Haidong Kan | 2006 | Science of the Total Environment2006，，： | 1 |
| 16 | Enhanced photocatalytic activities of TiO 2 nanocomposites doped with water-soluble mercapto-capped CdTe quantum dots显示文摘 | Yue-Sheng Li Feng-Lei Jiang Qi Xiao Ran Li Kan Li Mei-Fang Zhang Ai-Qing Zhang Shao-Fa Sun Yi Liu | 2010 | Applied Catalysis B Environmental2010，，1： | 1 |
| 17 | Structural optimization of an automobile roof structure using equivalent static loads显示文摘 | Jeong S Yi S Kan C | 2008 | Proc Inst Mech Engineers Part D: J Automobile Engineering2008，222，11： | 1 |
| 18 | 显示文摘 | Liao Yi Su Zhongmin Kan Yuhe | 2005 | Theochem J Mol Struct2005，731，： | 1 |
| 19 | Influences of Electrolytes on the Soap-free Emulsion Copolymerization of St-MMA-AA显示文摘Monodisperse functional polymer microspheres with different particle size and with clean surface were prepared by batch soap-free emulsion polymerization of styrene, methyl methacrylate and acrylic acid in the presence of salts, and the influences of type and amount of electrolytes on polymerization process and particle morphology were investigated. Results showed that there was a critical concentration for different electrolyte to make polymerization process and the resultant emulsion stable, and the particle size increased with the increase of electrolyte concentration. The effect of metal ions was Ca2+>>K+>Na+>Li+,and the effect of haloids was Br>Cl>F. | Rong Long LI Cheng You KAN Yi DU Ze Ping LI | 2006 | Chinese Chemical Letters2006，17，11： | 1 |
| 20 | Detection of diverse viruses in alimentary specimens of bats in Macao显示文摘Bats carry a variety of viruses, and some of them cause public health problems. Macao, which is famous for its gambling industry, has a complex population structure. The globalization in such an international metropolis has enhanced the chance of disease transmission. Therefore, surveillance of zoonotic viruses is necessary for the early warning of potential emerging infectious diseases.Here, we report the first surveillance of bat viruses in Macao. In this study, we collected 1004 samples involving 10 bat species from 7 sites from April 2015 to May 2016, and examined the presence of viruses using nucleic acid-based methods. Coronaviruses, adenoviruses and paramyxoviruses were detected in these samples, with a high prevalence of coronaviruses. While,none was positive for hepatitis A virus, hepatitis E virus or hantavirus. Co-infections are not common in those bat species, but coronavirus HKU6 and adenovirus can be found commonly occurred in Myotis ricketti. | Jie Liang Xing-Lou Yang Bei Li Qi Liu Qin Zhang Hui Liu Hon-Pio Kan Kai-Chin Wong Si-Nga Chek Xiangyang He Xingwen Peng Zheng-Li Shi Yi Wu Libiao Zhang | 2017 | Virologica Sinica2017，32，3： | 1 |
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