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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Detection of Recurrence in Patients with Rectal Cancer:PET/CT after Abdominoperineal or Anterior Resection显示文摘 | Einat ES Yoav P Hedva L | 2004 | Radiology2004，232，9： | 1 |
| 3 | Use of a linear stapler in pharyngeal closure after total laryn- gectomy显示文摘 | YOAV P T ROMAN R ROLF B | 1990 | Operative Techniques in Otolaryngology- Head and Neck Surgery1990，1，： | 1 |
| 4 | Detection of recurrence in patients with rectal cancer:PET/CT after abdominoperineal or anterior resection 显示文摘 | Einat ES Yoav P Hedva L | 2004 | Radiology2004，232，9： | 1 |
| 5 | Hydrodynamic cavitation and boiling in refrigerant (R-123) flow inside microchannels 显示文摘 | Brandon S All K Yoav P | 2007 | Int J Heat Mass Transfer2007，50，1314： | 1 |
| 6 | Gas-liquid two phase flow across a bank of micropillars显示文摘 | Santosh K Yoav P | 2007 | Physics of Fluids2007，19，4： | 1 |
| 7 | Condensation heat transfer in square, triangular, and semi-circular mini-channels显示文摘 | MELANIE D LEE H J YOAV P | 2012 | International Journal of Heat and Mass Transfer2012，55，： | 1 |
| 8 | Coronary artery bypass grafting without cardiopulmony bypass in impaired left ventricular function显示文摘 | Yaron M Leonid S Yoav P | 1997 | Ann Thorac Surg1997，63，： | 1 |
| 9 | Malic acid accumulation by Aspergillus flavus显示文摘 | Yoav P Barak A Scrutton MC | 1989 | Applied Microbiology and Biotechnology1989，30，2： | 1 |
| 10 | Human specific loss of olfactory receptor genes显示文摘 | Yoav G Orna M Svante P | 2003 | Proc Natl Acad Sci U S A2003，100，： | 1 |
| 11 | Geomorphic changes leading to natural desertification versus anthropogenic land conservation in an arid environment, the Negev Highlands, Israel显示文摘 | Yoav A Naomi P Joseph P | 2006 | Geomorphology2006，82，： | 1 |
| 12 | Effects of pin fin shape and configuration on the single-phase heat transfer characteristics of jet impingement on micro pin fins 显示文摘 | SIDY N YOAV P MICHAEL K L | 2014 | International Journal of Heat and Mass Transfer2014，70，： | 1 |
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