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| 1 | Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis显示文摘Anastomotic leakage(AL) is one of the most devastating complications after rectal cancer surgery. The double stapling technique has greatly facilitated intestinal reconstruction especially for anastomosis after low anterior resection(LAR). Risk factor analyses for AL after open LAR have been widely reported. However, a few studies have analyzed the risk factors for AL after laparoscopic LAR. Laparoscopic rectal surgery provides an excellent operative field in a narrow pelvic space, and enables total mesorectal excision surgery and preservation of the autonomic nervous system with greater precision. However, rectal transection using a laparoscopic linear stapler is relatively difficult compared with open surgery because of the width and limited performance of the linear stapler. Moreover, laparoscopic LAR exhibits a different postoperative course compared with open LAR, which suggests that the risk factors for AL after laparoscopic LAR may also differ from those after open LAR. In this review, we will discuss the risk factors for AL after laparoscopic LAR. | Kenji Kawada Yoshiharu Sakai | 2016 | World Journal of Gastroenterology2016，22，25： | 53 |
| 2 | One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent显示文摘瞄准:为了描述包含可扩充的金属的经皮的 transhepatic 插入的一个简单一步舞方法,在妨碍的黄疸的治疗使用的斯滕特氏印模膏(他们) 由 unresectable 恶意引起了。方法:由于 unresectable 恶意与妨碍的黄疸诊断的十四个病人在学习被包括。在这些病人的恶意是很先进的癌或老年的结果。经皮的 transhepatic 胆管造影术在 ultrasonographic 指导下面被执行。在有一个内部金属性的指南的一根导管是先进的进十二指肠以后,一他们被放在胆总管,在一个点之间在到肝的核的 Vater 和入口的乳头状的小突起以外的 1 厘米。在用就一个单身者跨越距离是困难的情况中他们,另外的斯滕特氏印模膏被放。一根排水导管在地方被离开充当一把止血钳子。在胆汁郁积和斯滕特氏印模膏明显的分辨率被证实以后,导管被移开 2 或 3 d 过程以后。结果:EMS 的一步舞插入与 24.4 min 的一过程平均数时间在所有病人被完成。从要求了 2 他们的病人, 4 需要一过程时间超过 30 min。导管的移动的吝啬的时间过程以后是 2.3 d。所有病人与 7.8 瞬间的一吝啬的后续时间死于恶意。没有 stent 相关的复杂并发症或斯滕特氏印模膏阻塞被遇到。结论:他们的一步舞经皮的 transhepatic 插入是为决定胆汁的阻塞和罐头有效地改进病人生命的质量的一个简单过程。 | Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Yoshiaki Mizuguchi Tetsuya Shimizu Shigeki Yokomuro Takayuki Aimoto Yoshiharu Nakamura Eiji Uchida Yasuo Arima Manabu Watanabe Eiichi Uchida Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，15： | 28 |
| 3 | The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells显示文摘 | Qian-mei ZHOU Song WANG Hui ZHANG Yi-yu LU Xiu-feng WANG Yoshiharu MOTOO Shi-bing SU | 2009 | Acta Pharmacologica Sinica2009，30，12： | 25 |
| 4 | 外来入侵杂草空心莲子草与本土杂草莲子草的化感作用潜力比较显示文摘为确定外来入侵杂草空心莲子草的化感作用潜力,以我国本土生长的莲子草为对照采用“三明治”生测法,测定了空心莲子草和莲子草及其不同器官对靶标莴苣和无芒稗根长和芽长的抑制率。结果表明,空心莲子草叶片处理对莴苣和无芒稗根长的抑制率分别为81%和51%,对莴苣和无芒稗芽长的抑制率分别为49%和48%,显著高于空白对照。但与莲子草相比,差异不显著。空心莲子草根系对莴苣的根长平均抑制率为54%,显著高于茎和叶片。随着样品用量增加,空心莲子草对莴苣根长的抑制率显著提高,其50mg叶片处理对莴苣根长的抑制率为83%,显著高于10mg处理的54%和30mg处理的61%。 | 余柳青 Yoshiharu FUJII 周勇军 张建萍 陆永良 玄松南 | 2007 | 中国水稻科学2007，21，1： | 17 |
| 5 | Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil显示文摘We report the case of a patient treated with living donor-related liver transplantation who suffered from osteomalacia during adefovir dipivoxil (ADV)-containing antiviral therapy for lamivudine-resistant hepatitis B virus infection. The patient had generalized bone pain,with severe hypophosphatemia after 20 mo of ADV therapy. Radiographic studies demonstrated the presence of osteomalacia. The peak plasma ADV level was 38 ng/mL after administration of ADV at 10mg/day. It was also found that ADV affected the metabolism of tacrolimus,a calcineurin-inhibitor,and caused an increase in the plasma levels of tacrolimus. The disability was reversed with the withdrawal of ADV and with mineral supplementation. ADV can cause an elevation of plasma tacrolimus levels,which may be associated with renal dysfunction. High levels of ADV and tacrolimus can cause nephrotoxicity and osteomalacia. This case highlights the importance of considering a diagnosis of osteomalacia in liver transplantation recipients treated with both ADV and tacrolimus. | Masami Minemura Yoshiharu Tokimitsu Kazuto Tajiri Yasuhiro Nakayama Kengo Kawai Hiroshi Kudo Katsuharu Hirano Yoshinari Atarashi Yutaka Yata Satoshi Yasumura Terumi Takahara Toshiro Sugiyama | 2010 | World Journal of Hepatology2010，2，12： | 13 |
| 6 | 一期前路病灶清除加植骨术治疗化脓性脊椎炎显示文摘 | 刘洪 Hirokazu Ishihara 马忠泰 Yoshiharu Kawaguchi | 2005 | 中华骨科杂志2005，25，11： | 12 |
| 7 | 水生生物型空心莲子草(Alternanthera philoxeroides)对环境因子的反应及与水稻的竞争显示文摘为明确环境因子对水生生物型空心莲子草生活力的影响以及空心莲子草与水稻的竞争关系,采用生物测定方法,分析了低温、干燥、盐碱、水层等因子对空心莲子草茎的活棵率、繁殖茎数和植株生物量的影响,还研究了不同种群密度的空心莲子草对水稻产量性状的影响。空心莲子草茎在4℃低温随后常温处理的活棵率达84%,而在-20℃随后常温处理后完全失去生活力;在含水量为30.2%时,空心莲子草茎的活棵率、繁殖茎数和植株鲜质量比鲜样(含水量93.5%)处理的分别下降了45%、33%和74%;0.1%盐碱水溶液处理就可使空心莲子草茎基本失去生活力;水生生物型空心莲子草茎在土壤湿润和不同水层条件下都能够成活和生长。在水稻100株/m2条件下,接种空心莲子草茎23~360株/m2使水稻减产43%~53%。 | 余柳青 Yoshiharu FUJII 周勇军 张建萍 陆永良 玄松南 | 2007 | 中国水稻科学2007，21，2： | 8 |
| 8 | A critical review on the chemical wear and wear suppression of diamond tools in diamond cutting of ferrous metals显示文摘Diamond tools play a critical role in ultra-precision machining due to their excellent physical and mechanical material properties,such as that cutting edge can be sharpened to nanoscale accuracy.However,abrasive chemical reactions between diamond and non-diamond-machinable metal elements,including Fe,Cr,Ti,Ni,etc,can cause excessive tool wear in diamond cutting of such metals and most of their alloys.This paper reviews the latest achievements in the chemical wear and wear suppression methods for diamond tools in cutting of ferrous metals.The focus will be on the wear mechanism of diamond tools,and the typical wear reduction methods for diamond cutting of ferrous metals,including ultrasonic vibration cutting,cryogenic cutting,surface nitridation and plasma assisted cutting,etc.Relevant commercially available devices are introduced as well.Furthermore,future research trends in diamond tool wear suppression are discussed and examined. | Guo Jiang Zhang Jianguo Pan Yanan Kang Renke Namba Yoshiharu Shore Paul Yue Xiaobin Wang Baorui Guo Dongming | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 7 |
| 9 | Does flexible small-diameter colonoscope reduce insertion pain during colonoscopy?显示文摘AIM It is well known that colonoscopy can bedifficult due to abdominal pain induced duringcolonoscope insertion,if sedative agents are notgiven.Recently,an extra-flexible,small-diameter colonoscope(CF-SV,Olympus Inc.,Japan)was developed in order to improve safetyand comfort.The aim of this study was toaccess the usefulness of the CF-SV.METHODS One hundred patients undergoingsigmoidoscopy were recruited and colonoscopywas performed by one experiencedcolonoscopist.First,a routine-type colonoscope(CF-2301)was inserted into the colon withoutsedation.When the patient complained ofabdominal pain(even if mild),the scope wasnot advanced further and was withdrawn afterthe anatomic location of its tip was determinedfluoroscopically.Then,the CF-SV was inserteduntil it reached the cecun or the site whereabdominal pain occurred.Previous abdominalsurgery and abdominal disease were consideredas unfavorable factors(UF)and the relationshipbetween abdominal pain and UF,age and genderwere investigated.Furthermore,the colonicinsertion pressures in 36 patients with abdominalpain were measured with a force gauge.RESULTS Thirty-four cases(34%)felt no painwith the CF-2301 and successful pancolon-0scopies to the cecum were performed.Sixty-six cases(66%)complained of abdominal pain.The procedure was painless for 47% of men and24% of women,respectively.The CF-2301 scopefailed to reach the sigmoid-descending colon junctions in 59(89.4%)of the 66 patientscomplaining of abdominal pain.However,CF-SVreached proximal area in 94.9% of those whofailed with CF-2301.The median pressure forpain-inducing was 700 g/cm^2.CONCLUSION Unsedated patients with UFwere prone to complain of pain when thestandard-type CF-2301 scope was used.Thenewly developed extra-flexible CF-SV is usefulfor the aged and for those with UF or being proneto suffer from abdominal pain.Sedative agentsmay be unnecessary if this new type ofcolonoscope is used. | Yoshiharu Uno Akihiro Munakata | 2000 | World Journal of Gastroenterology2000，6，5： | 7 |
| 10 | Pancreatitis-associated protein:From a lectin to an anti-inflammatory cytokine显示文摘Pancreatitis-associated protein (PAP) was discovered in the pancreatic juice of rats with acute pancreatitis. PAP is a 16 kDa secretory protein structurally related to the C-type lectins although classical lectin-related function has not been reported yet. Then, it was demonstrated that PAP expression may be activated in some tissues in a constitutive or injury- and inflammation-induced manner. More recently, it has been found that PAP acts as an anti-inflammatory factor in vitro and in vivo. PAP expression can be induced by several pro- and anti-inflammatory cytokines and by itself through a JAK/STAT3-dependent pathway. PAP is able to activate the expression of the anti-inflammatory factor SOCS3 through the JAK/STAT3-dependent pathway. The JAK/STAT3/SOCS3 pathway seems to be a common point between PAP and several cytokines. Therefore, it is reasonable to propose that PAP is a new anti- inflammatory cytokine. | Daniel Closa Yoshiharu Motoo Juan L Iovanna | 2007 | World Journal of Gastroenterology2007，13，2： | 6 |
| 11 | Pathophysiology of functional heartburn based on Rome Ⅲ criteria in Japanese patients显示文摘AIM:To investigate the pathophysiology of functional heartburn(FH) in Japanese patients.METHODS:A total of 111 patients with proton pump inhibitor(PPI)-refractory non-erosive gastroesophageal reflux disease underwent intraesophageal pressure testing and 24-h multichannel intraluminal impedancep H(24MII-p H) testing.The patients also completed several questionnaires while they were receiving the PPI treatment, including the questionnaire for the diagnosis of reflux disease(QUEST), the frequency scale for the symptoms of gastroesophageal reflux disease(FSSG), the gastrointestinal symptoms rating scale(GSRS), SF-36, and the Cornell Medical Index(CMI).The subjects were classified into FH and endoscopy-negative reflux disease(ENRD) groups based on the Rome Ⅲ criteria.RESULTS:Thirty-three patients with esophageal motility disorder were excluded from this study, while 22 patients with abnormal esophageal acid exposure time(p H-POS) and 34 with hypersensitive esophagus(HE) were included in the ENRD group.The FH group included 22 patients with no reflux involvement.Sex, age, and body mass index did not differ significantly between the groups.The mean SF-36 values were < 50(normal) for all scales in these groups, with no significant differences.The GSRS scores in these groups were not different and showed overlap with other gastrointestinal symptoms.The QUEST and the FSSG scores did not differ significantly between the groups.Neuroticism was diagnosed using the CMI questionnaire in 17 of the 78 included subjects within the p H-POS(n=4),HE(n=8),and FH(n=5)groups,with no significant differences.CONCLUSION:Clinical characteristics of the FH and PPI-refractory ENRD groups were similar.Therefore,esophageal function should be examined via manometry and 24MII-p H testing to differentiate between them. | Yasuhiro Tamura Yasushi Funaki Shinya Izawa Akihito Iida Yoshiharu Yamaguchi Kazunori Adachi Naotaka Ogasawara Makoto Sasaki Hiroshi Kaneko Kunio Kasugai | 2015 | World Journal of Gastroenterology2015，21，16： | 4 |
| 12 | Effect of Saikokeishito, a Kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts显示文摘OBJECTIVE: Saikokeishito(TJ-10) is a Kampo(traditional Japanese herbal) medicine, clinically used for hundreds of years in East Asia. Among its various mechanisms elucidated so far, TJ-10 inhibits the production of transforming growth factor-β1(TGF-β1) and development of pancreatic fi brosis in vivo. Oxidative damage of normal human dermal fi broblasts(NHDFs) in the corium is a cause of human dermal senescence. Our aim was to determine whether TJ-10 protects NHDFs from premature senescence by hydrogen peroxide(H2O2). METHODS: Premature senescence was induced in NHDFs by 200 μmol/L H2O2 for 4 h. Cell viability and the expressions of p53, AMP-activated protein kinase α1(AMPKα1), AMPKα2, and 14-3-3 protein sigma(14-3-3 σ) were measured in NHDFs treated with TJ-10 for 48 h before exposure to H2O2 for 4 h. RESULTS: Cell viability after treatment with 200 μmol/L H2O2 for 4 h was similar(about 80%) to after pre-treatment with TJ-10. Ascorbic acid as a control did not protect NHDFs from damage by 200 μmol/L H2O2. Treatment with 200 μmol/L H2O2 tended to up-regulate p53 and to down-regulate SIRT1 and AMPKα1, but had no effect on AMPKα2 and 14-3-3 σ expression. Pretreatment with TJ-10 inhibited H2O2-induced up-regulation of p53 and enhanced AMPKα1 expression. CONCLUSION: It is suggested that Saikokeishito has a protective effect on oxidative stressinduced senescence of NHDFs. | Takanobu Takata Yoshiharu Motoo Naohisa Tomosugi | 2014 | Journal of Integrative Medicine2014，12，6： | 4 |
| 13 | Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: A review from the international workshop for pulmonary functional imaging显示文摘Pulmonary contrast enhanced magnetic resonance angiography(CE-MRA) is useful for the primary diagnosis of pulmonary embolism(PE). Many sites have chosen not to use CE-MRA as a first line of diagnostic tool for PE because of the speed and higher efficacy of computerized tomographic angiography(CTA). In this review, we discuss the strengths and weaknesses of CEMRA and the appropriate imaging scenarios for the primary diagnosis of PE derived from our unique multiinstitutional experience in this area. The optimal patient for this test has a low to intermediate suspicion for PE based on clinical decision rules. Patients in extremis are not candidates for this test. Younger women(< 35 years of age) and patients with iodinated contrast allergies are best served by using this modality We discuss the history of the use of this test, recent technical innovations, artifacts, direct and indirect findings for PE, ancillary findings, and the effectiveness(patient outcomes) of CE-MRA for the exclusion of PE. Current outcomes data shows that CE-MRA and NM V/Q scans are effective alternative tests to CTA for the primary diagnosis of PE. | Nanae Tsuchiya Edwin JR van Beek Yoshiharu Ohno Hiroto Hatabu Hans-Ulrich Kauczor Andrew Swift Jens Vogel-Claussen Jürgen Biederer James Wild Mark O Wielpütz Mark L Schiebler | 2018 | World Journal of Radiology2018，10，6： | 4 |
| 14 | Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort显示文摘 | Kunitoshi Iseki Yoshiharu Ikemiya Taku Inoue Chiho Iseki Kozen Kinjo Shuichi Takishita | 2004 | American Journal of Kidney Diseases2004，，4： | 4 |
| 15 | Acupuncture improved lipid metabolism by regulating intestinal absorption in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD),in which abnormal lipid metabolism plays an important role in disease progression,has become a pandemic.Abnormal lipid metabolism,for example an increased fat intake,has been thought to be an initial factor leading to NAFLD.The small intestine is the main site of dietary lipid absorption.A number of clinical trials have shown that acupuncture has positive effects in the regulation of lipid metabolism,which is closely associated with the progression of NAFLD.We therefore hypothesized that,acupuncture can improve the conditions of NAFLD by regulating intestinal absorption of lipid.AIM To study the role of acupuncture treatment in the improvement of metabolic syndrome secondary to NAFLD by mouse model.METHODS 8-wk-old male C57BL/6J mice were fed a methionine-and choline-deficient diet for 3 wk.Then,all mice were separated randomly into acupoints group(AG)or non-acupoints group(NG)with high fat diet feeding.Needling treatment was performed at Zu san li,Guan yuan and Yong quan acupoints as acupuncture treatment to AG mice while non-acupoints place to NG mice.Finally,mice were anesthetized with an injection of ketamine-medetomidine and euthanized by exsanguination.RESULTS An apparent improvement of obesity was found in AG mice after acupuncture treatment.In AG mice,the body weight was much lower(22.6±1.2 g vs 28.1±1.0 g,P<0.005)in comparison to NG mice.The length of small intestine in AG mice was significantly shorter(26.7±2.3 cm vs 32.7±2.7 cm,P<0.005).A large amount of chyme was observed in the lumen of the AG small intestine.The expression of microsomal triglyceride transfer protein,apolipoprotein B and apolipoprotein C2 was downregulated.Triacylglycerols(TGs),total cholesterol and nonesterified fatty acid(NEFA)levels of the small intestinal tissue were significantly higher in AG mice,but the serum TGs and NEFA levels were reduced in AG mice.CONCLUSION These results indicate that acupuncture at Zu san li,Guan yuan and Yong quan suppressed lipid absorption by downregulating the expression of apolipoproteins in the small intestine. | Jia Han Xin Guo Xiang-Jin Meng Jing Zhang Reimon Yamaguchi Yoshiharu Motoo Sohsuke Yamada | 2020 | World Journal of Gastroenterology2020，26，34： | 4 |
| 16 | Scaffolds based therapy for osteochondral lesions of the talus:A systematic review显示文摘AIM To clarify the effectiveness of scaffold-based therapy for osteochondral lesions of the talus(OLT). METHODS A systematic search of MEDLINE and EMBASE databases was performed during August 2016 and updated in January 2017. Included studies were evaluated with regard to the level of evidence(LOE) and quality of evidence(QOE) using the Modified Coleman Methodology Score. Variable reporting outcome data, clinical outcomes, and the percentage of patients who returned to sport at previous level were also evaluated. RESULTS Twenty-eight studies for a total of 897 ankles were included; 96% were either LOE Ⅲ or Ⅳ. Studies were designated as either of poor or fair quality. There were 30 treatment groups reporting six different scaffold repair techniques: 13 matrix-induced autologous chondrocyte transplantation(MACT), nine bone marrow derived cell transplantation(BMDCT), four autologous matrixinduced chondrogeneis(AMIC), and four studies of other techniques. The categories of general demographics(93%) and patient-reported outcome data(85%) were well reported. Study design(73%), imaging data(73%), clinical variables(49%), and patient history(30%) were also included. The weighted mean American Orthopaedic Foot and Ankle Society(AOFAS) score at final follow-up was: 86.7 in MACT, 88.2 in BMDCT, and 82.3 in AMIC. Eight studies reported that a weighted mean of 68.3% ofpatients returned to a previous level of sport activity. CONCLUSION Scaffold-based therapy for OLT may produce favorable clinical outcomes, but low LOE, poor QOE, and variability of the data have confounded the effectiveness of this treatment. | Yoshiharu Shimozono Youichi Yasui Andrew W Ross Wataru Miyamoto John G Kennedy | 2017 | World Journal of Orthopedics2017，8，10： | 4 |
| 17 | Laparoscopic and endoscopic cooperative surgery for duodenal tumor resection显示文摘 | Fumitoshi Hirokawa Michihiro Hayashi Yoshiharu Miyamoto Mitsuhiro Asakuma Tetsunosuke Shimizu Koji Komeda Yoshihiro Inoue Eiji Umegaki Kazuhisa Uchiyama | 2014 | Endoscopy2014，，： | 3 |
| 18 | Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells显示文摘瞄准:为了调查基因的表示,在人的胰腺的癌症房间在导致 gemcitabine 的细胞毒性包含了。方法:一根人的胰腺的癌症房间线, PANC-1,是有教养的。1x10 (4 ) PANC-1 房间是在 96 井的 plated 微效价盘子。在为 24 h 被孵化以后, gemcitabine 在集中变化 2.5-1000 mg/L 被加到媒介。AlamarBlue 染料方法被用于细胞生长分析。DNA 破碎是用 DNA 破碎的份量上 assayed 连接酶的免疫吸着剂试金(ELISA ) 工具包。奶头和 TP53INP1 mRNA 表示与半量的分析用反向的抄写聚合酶链反应被决定。GSK-3beta 和 phospho-GSK-3beta 蛋白质的表示与西方的污点分析被检验。结果:为在到 gemcitabine 的 48-h 暴露以后的药的 IC50 是 16 mg/L。PANC-1 房间的生长被 gemcitabine 以一种集中依赖者方式(P<0.0001 ) 禁止,房间生长也在整个时间功课(P<0.0001 ) 被禁止。在在 48 h 的对待 gemcitabine 的组的 DNA 破碎率是 44.7% ,而它在未经治疗的组是 25.3% 。奶头 mRNA 表示在与 gemcitabine 被对待以后被减少,而 TP53INP1 mRNA 被 gemcitabine 处理增加。西方的污点分析证明 phospho- GSK-3beta (ser9 ) 被 gemcitabine 处理导致。结论:Gemcitabine 压制 PANC-1 房间增长并且导致 apoptosis。Apoptosis 被认为与抑制被联系奶头和 GSK-3beta,和 TP53INP1 和 pospho-GSK-3beta (ser9 ) 的激活。 | Pei-Hong Jiang Yoshiharu Motoo Norio Sawabu Toshinari Minamoto | 2006 | World Journal of Gastroenterology2006，12，10： | 3 |
| 19 | Traditional Japanese Medicine,Kampo:Its History and Current Status显示文摘Traditional Japanese medicine,Kampo,is used by over 80%of medical doctors in Japan.Owing to its high quality and safety,Kampo has been integrated into modern medicine,and there are 345 randomized controlled trials using Kampo in Japan as of 2010.Although there are a number of articles in top journals about basic science research,we can find only small numbers of high-quality clinical evidence.Since undergraduate education on Kampo has been established,integrative approach with the balanced combination of modern medicine and Kampo is expected to generate good clinical evidence in the near future. | Yoshiharu Motoo Takashi Seki Kiichiro Tsutani | 2011 | Chinese Journal of Integrative Medicine2011，17，3： | 3 |
| 20 | DATA CRYSTALLIZATION APPLIED FOR DESIGNING NEW PRODUCTS显示文摘它仅仅是能在数据被存储的真实世界的可见部分。为如此的不完全、组织病的数据,结晶的数据瞄准 at presenting 在包括 unobservable 事件的事件之中的隐藏的结构。,这被数据结晶化认识到哑巴项目,相应于 unobservable 事件的潜在的存在,被插入到给定的数据。有可见事件的这些哑巴项目和他们的关系被 applyingKeyGraph 与哑巴项目设想到数据,象灰尘涉及水分子的结晶化的形成的雪的结晶化一样。为调节要设想的结构的颗粒度水平,数据结晶化的工具与人在真实世界上理解重要情形的过程是综合的。这个基本方法被期望为机会发现的以前的方法带人到成功的决策的各种各样的真实世界领域适用。在这篇论文,我们在一个真实公司与 human-interactiveannealing (DCHA ) 把数据结晶化用于产品的设计。结果显示出它的效果到工业决策。 | Kenichi HORIE Yoshiharu MAENO Yukio OHSAWA | 2007 | Journal of Systems Science and Systems Engineering2007，16，1： | 3 |
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