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| 1 | Efficacy of endoluminal gastroplication in Japanese patients with proton pump inhibitor-resistant,non-erosive esophagitis显示文摘AIM:To evaluate the efficacy,safety,and long-term outcomes of endoluminal gastroplication(ELGP) in patients with proton pump inhibitor(PPI)-resistant,nonerosive reflux disease(NERD).METHODS:The subjects were NERD patients,diagnosed by upper endoscopy before PPI use,who had symptoms such as heartburn or reflux sensations two or more times a week even after 8 wk of full-dose PPI treatment.Prior to ELGP,while continuing full-dose PPI medication,patients' symptoms and quality of life(QOL) were assessed using the questionnaire for the diagnosis of reflux disease,the frequency scale for symptoms of gastro-esophageal reflux disease(FSSG),gastrointestinal symptoms rating scale,a 36-item short-form.In addition,24-h esophageal pH monitoring or 24-h intraesophageal pH/impedance(MII-pH) monitoring was performed.The Bard EndoCinch TM was used for ELGP,and 2 or 3 plications were made.After ELGP,all acid reducers were temporarily discontinued,and medication was resumed depending on the development and severity of symptoms.Three mo after ELGP,symptoms,QOL,pH or MII-pH monitoring,number of plications,and PPI medication were evaluated.Further,symptoms,number of plications,and PPI medication were evaluated 12 mo after ELGP to investigate long-term effects.RESULTS:The mean FSSG score decreased significantly from before ELGP to 3 and 12 mo after ELGP(19.1 ± 10.5 to 10.3 ± 7.4 and 9.3 ± 9.9,P < 0.05,respectively).The total number of plications decreased gradually at 3 and 12 mo after ELGP(2.4 ± 0.8 to 1.2 ± 0.8 and 0.8 ± 1.0,P < 0.05,respectively).The FSSG scores in cases with no remaining plications and in cases with one or more remaining plications were 4.4 and 2.7,respectively,after 3 mo,and 2.0 and 2.8,respectively,after 12 mo,showing no correlation to plication loss.On pH monitoring,there was no difference in the percent time pH < 4 from before ELGP to 3 mo after.Impedance monitoring revealed no changes in the number of reflux episodes or the symptom index for reflux events from before ELGP to 3 mo after,but the symptom sensitivity index decreased significantly 3 mo after ELGP(16.1 ± 12.9 to 3.9 ± 8.3,P < 0.01).At 3 mo after ELGP,6 patients(31.6%) had reduced their PPI medication by 50% or more,and 11 patients(57.9%) were able to discontinue PPI medication altogether.After 12 mo,3 patients(16.7%) were able to reduce the amount of PPI medication by 50% or more,and 12 patients(66.7%) were able to discontinue PPI medication altogether.A high percentage of cases with remaining plications had discontinued PPIs medication after 3 mo,but there was no difference after 12 mo.No serious complications were observed in this study.CONCLUSION:ELGP was safe,resulted in significant improvement in subjective symptoms,and allowed less medication to be used over the long term in patients with PPI-refractory NERD. | Kentaro Tokudome Yasushi Funaki Makoto Sasaki Shinya Izawa Yasuhiro Tamura Akihito Iida Naotaka Ogasawara Toshihiro Konagaya Yoshifumi Tokura Kunio Kasugai | 2012 | World Journal of Gastroenterology2012，18，41： | 5 |
| 2 | Pathophysiology of functional heartburn based on Rome Ⅲ criteria in Japanese patients显示文摘AIM:To investigate the pathophysiology of functional heartburn(FH) in Japanese patients.METHODS:A total of 111 patients with proton pump inhibitor(PPI)-refractory non-erosive gastroesophageal reflux disease underwent intraesophageal pressure testing and 24-h multichannel intraluminal impedancep H(24MII-p H) testing.The patients also completed several questionnaires while they were receiving the PPI treatment, including the questionnaire for the diagnosis of reflux disease(QUEST), the frequency scale for the symptoms of gastroesophageal reflux disease(FSSG), the gastrointestinal symptoms rating scale(GSRS), SF-36, and the Cornell Medical Index(CMI).The subjects were classified into FH and endoscopy-negative reflux disease(ENRD) groups based on the Rome Ⅲ criteria.RESULTS:Thirty-three patients with esophageal motility disorder were excluded from this study, while 22 patients with abnormal esophageal acid exposure time(p H-POS) and 34 with hypersensitive esophagus(HE) were included in the ENRD group.The FH group included 22 patients with no reflux involvement.Sex, age, and body mass index did not differ significantly between the groups.The mean SF-36 values were < 50(normal) for all scales in these groups, with no significant differences.The GSRS scores in these groups were not different and showed overlap with other gastrointestinal symptoms.The QUEST and the FSSG scores did not differ significantly between the groups.Neuroticism was diagnosed using the CMI questionnaire in 17 of the 78 included subjects within the p H-POS(n=4),HE(n=8),and FH(n=5)groups,with no significant differences.CONCLUSION:Clinical characteristics of the FH and PPI-refractory ENRD groups were similar.Therefore,esophageal function should be examined via manometry and 24MII-p H testing to differentiate between them. | Yasuhiro Tamura Yasushi Funaki Shinya Izawa Akihito Iida Yoshiharu Yamaguchi Kazunori Adachi Naotaka Ogasawara Makoto Sasaki Hiroshi Kaneko Kunio Kasugai | 2015 | World Journal of Gastroenterology2015，21，16： | 4 |
| 3 | Inhibition of gastric perception of mild distention by omeprazole in volunteers显示文摘AIM:To evaluate the effects of omeprazole on gastric mechanosensitivity in humans. METHODS:A double lumen polyvinyl tube with a plastic bag was introduced into the stomach of healthy volunteers under fluorography and connected to a barostat device. Subjects were then positioned so they were sitting comfortably, and the minimal distending pressure (MDP) was determined after a 30-min adaptation period. Isobaric distensions were performed in stepwise increments of 2 mmHg (2 min each) starting from the MDP. Subjects were instructed to score feel-ings at the end of every step using a graphic rating scale:0, no perception; 1, weak/vague; 2, weak but significant; 3, moderate/vague; 4, moderate but signifi-cant; 5, severe discomfort; and 6, unbearable pain. After this first test, subjects received omeprazole (20 mg, after dinner) once daily for 1 wk. A second test was performed on the last day of treatment. RESULTS:No adverse effects were observed. Mean MDP before and after treatment was 6.3 ± 0.3 mmHg and 6.2 ± 0.5 mmHg, respectively. One subject before and 2 after treatment did not reach a score of 6 at the maximum bag volume of 750 mL. After omeprazole, there was a significant increase in the distension pres-sure required to reach scores of 1 (P = 0.019) and 2 (P = 0.017) as compared to baseline. There were no changes in pressure required to reach the other scores after treatment. Two subjects before and one after omeprazole rated their abdominal feeling < 1 at MDP, and mean (± SE) abdominal discomfort scores at MDP were 0.13 ± 0.09 and 0.04 ± 0.04, respectively. Mean scores induced by each MDP + 2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 (mmHg) were 1.1 ± 0.3, 2.0 ± 0.4, 2.9 ± 0.5, 3.3 ± 0.4, 4.6 ± 0.3, 5.2 ± 0.3, 5.5 ± 0.2, 5.5 ± 0.3, 5.7 ± 0.3, and 5.4, respectively. After omepra-zole, abdominal feeling scores for the same incremental pressures over MDP were 0.3 ± 0.1, 0.8 ± 0.1, 2.0 ± 0.4, 2.8 ± 0.4, 3.8 ± 0.4, 4.6 ± 0.4, 4.9 ± 0.3, 5.4 ± 0.4, 5.2 ± 0.6, and 5.0 ± 1.0, respectively. A signif- icant decrease in feeling score was observed at intrabag pressures of MDP + 2 mmHg (P = 0.028) and + 4 mmHg (P = 0.013), respectively, after omeprazole. No significant score changes were observed at pres-sures ≥ MDP + 6 mmHg. CONCLUSION:Although the precise mechanisms are undetermined, the present study demonstrated that omeprazole decreases mechanosensitivity to mild gastric distension. | Akihito Iida Hiroshi Kaneko Toshihiro Konagaya Yasushi Funaki Kentaro Tokudome Shinya Izawa Yasuhiro Tamura Mari Mizuno Naotaka Ogasawara Makoto Sasaki Kunio Kasugai | 2012 | World Journal of Gastroenterology2012，18，39： | 3 |
| 4 | Phase I and pharmacokinetic study of nab-paclitaxel, nanoparticle albumin-bound paclitaxel, administered weekly to Japanese patients with solid tumors and metastatic breast cancer显示文摘 | Masashi Ando Kan Yonemori Noriyuki Katsumata Chikako Shimizu Taizo Hirata Harukaze Yamamoto Kenji Hashimoto Mayu Yunokawa Kenji Tamura Yasuhiro Fujiwara | 2012 | Cancer Chemotherapy and Pharmacology2012，，2： | 2 |
| 5 | Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines: implications for cell-based immunotherapy for patients with glioblastoma显示文摘 | Tsutomu Nakazawa Mitsutoshi Nakamura Young Soo Park Yasushi Motoyama Yasuo Hironaka Fumihiko Nishimura Ichiro Nakagawa Shuichi Yamada Ryosuke Matsuda Kentaro Tamura Tadashi Sugimoto Yasuhiro Takeshima Akiko Marutani Takahiro Tsujimura Noriko Ouji Yukiteru | 2014 | Journal of Neuro-Oncology2014，，1： | 1 |
| 6 | Three-dimensional ultrasound imaging of breast cancer by a real-time intraoperative navigation system显示文摘 | Tomoo Inoue Yasuhiro Tamaki Yoshinobu Sato Masahiko Nakamoto Shinichi Tamura Yoshio Tanji Tetsuya Taguchi Shinzaburo Noguchi | 2005 | Breast Cancer2005，，2： | 1 |
| 7 | Effects of Diet-Induced Moderate Weight Reduction on Intrahepatic and Intramyocellular Triglycerides and Glucose Metabolism in Obese Subjects显示文摘 | Fumihiko Sato Yoshifumi Tamura Hirotaka Watada Naoki Kumashiro Yasuhiro Igarashi Hiroshi Uchino Tadayuki Maehara Shinsuke Kyogoku Satoshi Sunayama Hiroyuki Sato Takahisa Hirose Yasushi Tanaka Ryuzo Kawamori | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，，8： | 1 |
| 8 | Masafumi Moil and Ikuo Takahashi, Simulation analyses of buildings damaged in the 1995 Kobe, Japan, Earthquake considering soil-structure interaction显示文摘 | Yasuhiro Hayashi Kazuo Tamura | 1991 | Earthquake engineering and structural dynamics 281991，，： | 1 |
| 9 | Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients显示文摘 | Kimie Sai Yoshiro Saito Keiko Maekawa Su-Ryang Kim Nahoko Kaniwa Tomoko Nishimaki-Mogami Jun-ichi Sawada Kuniaki Shirao Tetsuya Hamaguchi Noboru Yamamoto Hideo Kunitoh Yuichiro Ohe Yasuhide Yamada Tomohide Tamura Teruhiko Yoshida Yasuhiro Matsumura Atsush | 2010 | Cancer Chemotherapy and Pharmacology2010，，1： | 1 |
| 10 | Determination of hymexazol in agricultural products by GC-NPD 显示文摘 | Tamura Yasuhiro Takano Ichiro Kobayashi Maki | 2008 | Journal of the Food Hygienic Society of Japan2008，49，3： | 1 |
| 11 | Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer显示文摘 | Makiko Ono Hitoshi Tsuda Chikako Shimizu Sohei Yamamoto Tatsuhiro Shibata Harukaze Yamamoto Taizo Hirata Kan Yonemori Masashi Ando Kenji Tamura Noriyuki Katsumata Takayuki Kinoshita Yuichi Takiguchi Hideki Tanzawa Yasuhiro Fujiwara | 2012 | Breast Cancer Research and Treatment2012，，3： | 1 |
| 12 | Nitensidine A, a guanidine alkaloid from Pterogyne nitens , is a novel substrate for human ABC transporter ABCB1显示文摘 | Yasuhiro Tajima Hiroshi Nakagawa Ai Tamura Onat Kadioglu Kazuhiro Satake Yuji Mitani Hayato Murase Luis Octavio Regasini Vanderlan da Silva Bolzani Toshihisa Ishikawa Gert Fricker Thomas Efferth | 2014 | Phytomedicine2014，，3： | 1 |
| 13 | Porphyromonas gingivalis,a periodontal pathogen,impairs post-infarcted myocardium by inhibiting autophagosome–lysosome fusion显示文摘While several previous studies have indicated the link between periodontal disease (PD) and myocardial infarction (MI), theunderlying mechanisms remain unclear. Autophagy, a cellular quality control process that is activated in several diseases, includingheart failure, can be suppressed by Porphyromonas gingivalis (P.g.). However, it is uncertain whether autophagy impairment byperiodontal pathogens stimulates the development of cardiac dysfunction after MI. Thus, this study aimed to investigate therelationship between PD and the development of MI while focusing on the role of autophagy. Neonatal rat cardiomyocytes(NRCMs) and MI model mice were inoculated with wild-type P.g. or gingipain-deficient P.g. to assess the effect of autophagyinhibition by P.g. Wild-type P.g.-inoculated NRCMs had lower cell viability than those inoculated with gingipain-deficient P.g. Thisstudy also revealed that gingipains can cleave vesicle-associated membrane protein 8 (VAMP8), a protein involved in lysosomalsensitive factor attachment protein receptors (SNAREs), at the 47th lysine residue, thereby inhibiting autophagy. Wild-type P.g.-inoculated MI model mice were more susceptible to cardiac rupture, with lower survival rates and autophagy activity thangingipain-deficient P.g.-inoculated MI model mice. After inoculating genetically modified MI model mice (VAMP8-K47A) with wildtype P.g., they exhibited significantly increased autophagy activation compared with the MI model mice inoculated with wild-typeP.g., which suppressed cardiac rupture and enhanced overall survival rates. These findings suggest that gingipains, which arevirulence factors of P.g., impair the infarcted myocardium by cleaving VAMP8 and disrupting autophagy. This study confirms thestrong association between PD and MI and provides new insights into the potential role of autophagy in this relationship. | Yuka Shiheido-Watanabe Yasuhiro Maejima Shun Nakagama Qintao Fan Natsuko Tamura Tetsuo Sasano | 2023 | International Journal of Oral Science2023，15，4： | 0 |
| 14 | Influence of Zn Diffusion on Bandwidth and Extinction in MQW Electroabsorption Modulators Buried with Semi-Insulating InP显示文摘A comprehensive analysis of multi-quantum-well electroabsorption modulators buried with semi-insulating (SI)-InP is presented. We quantitatively demonstrate that suppression of Zn diffusion into the burying and optical core layers plays a key role in high-speed and high-extinction operation. | Takayuki Yamanaka Hideki Fukano Ken Tsuzuki Munehisa Tamura Ryuzo Iga Matsuyuki Ogasawara Yasuhiro Kondo Tadashi Saitoh | 2003 | 光学学报2003，23，S1： | 0 |
| 15 | Near-infrared polarimetry of the GG Tauri A binary system显示文摘A high angular resolution near-infrared image that shows the intensity of polarization for the GG Tau A binary system was obtained with the Subaru Telescope.The image shows a circumbinary disk scattering the light from the central binary. The azimuthal profile of the intensity of polarization for the circumbinary disk is roughly reproduced by a simple disk model with the Henyey-Greenstein phase function and the Rayleigh function, indicating there are small dust grains at the surface of the disk.Combined with a previous observation of the circumbinary disk, our image indicates that the gap structure in the circumbinary disk orbits counterclockwise, but material in the disk orbits clockwise. We propose that there is a shadow caused by material located between the central binary and the circumbinary disk. The separations and position angles of the stellar components of the binary in the past 20 yr are consistent with the binary orbit with a = 33.4 AU and e = 0.34. | Yoichi Itoh Yumiko Oasa Tomoyuki Kudo Nobuhiko Kusakabe Jun Hashimoto Lyu Abe Wolfgang Brandner Timothy D.Brandt Joseph C.Carson Sebastian Egner Markus Feldt Carol A.Grady Olivier Guyon Yutaka Hayano Masahiko Hayashi Saeko S.Hayashi Thomas Henning Klaus W.Hodapp Miki Ishii Masanori Iye Markus Janson Ryo Kandori Gillian R.Knapp Masayuki Kuzuhara Jungmi Kwon Taro Matsuo Michael W.McElwain Shoken Miyama Jun-Ichi Morino Amaya Moro-Martin Tetsuo Nishimura Tae-Soo Pyo Eugene Serabyn Takuya Suenaga Hiroshi Suto Ryuji Suzuki Yasuhiro H.Takahashi Naruhisa Takato Hiroshi Terada Christian Thalmann Daigo Tomono Edwin L.Turner Makoto Watanabe John Wisniewski Toru Yamada Satoshi Mayama Thayne Currie Hideki Takami Tomonori Usuda Motohide Tamura | 2014 | Research in Astronomy and Astrophysics2014，14，11： | 0 |
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