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    题名 作者 年代 出处 被引量
1The state-of-the-art synthetic strategies for SAPO-34 zeolite catalysts in methanol-to-olefin conversion显示文摘Methanol-to-olefin(MTO)conversion has proven to be one of the most successful non-petrochemical routes for producing light olefins.Silicoaluminophosphate(SAPO)zeolite SAPO-34 is one of the best industrial catalysts for MTO conversion,but suffers from rapid deactivation due to the inherent diffusion bottleneck limited by the narrow eight-ring pore openings.To improve the MTO performance,considerable synthetic efforts have been devoted to decrease the crystal size of zeolites or introduce secondary larger pores in zeolite crystals to form hierarchical structures.This review mainly focuses on presenting the state-of-the-art synthetic strategies for nanosized and hierarchical SAPO-34 catalysts with excellent MTO performance.Furthermore,the industrialization of SAPO-34 catalysts for the MTO reaction,and some current problems and future prospects for the synthesis of SAPO-34 catalysts,are also pointed out.We expect that this review can not only shed some light on the preparation of SAPO-34 catalysts,but also stimulate the future development of high-performance SAPO-34 catalysts to meet the increasing demands of the chemical industry.Qiming Sun Zaiku Xie Jihong Yu 2018National Science Review2018,5,4:22
2Cerium-tannic acid passivation treatment on galvanized steel显示文摘A novel cerium-tannic acid passivation treatment was performed on galvanized steel. The corrosion resistance of cerium-tannic passivated samples was tested by dropping test with 0.5 wt.% CuSO4 aqueous solution. The mass loss per unit area of passivated samples was measured after the corrosion in 0.5 mol/L NaCl + 0.005 mol/L H2SO4 at room temperature for 96 h. The electrochemical behaviors of cerium, tannic acid, and cerium-tannic acid passivated samples on galvanized steel in 0.5 mol/L NaCl solution were investigated by polarization curves and electrochemical impendence spectra. The corrosion equivalent circuit was established according to the impedance characteristics. The results show that cerium-tannic acid treated samples exhibit better corrosion resistance than the sole cerium or tannic acid treated samples under the same condition. The mechanism of synergistic effect for cerium-tannic acid passivation on galvanized steel was discussed.LIU Guangming YU Fei YANG Liu TIAN Jihong DU Nan 2009Rare Metals2009,28,3:9
3Effect of Squeeze Casting on Microstructure and Mechanical Properties of Hypereutectic Al-xSi Alloys显示文摘The effect of squeeze casting on microstructure and mechanical properties of hypereutectic Al-xS i alloys(x = 15, 17.5, 22 wt%) was investigated in this study. Results show that microstructure of the hypereutectic Al-x Si alloys was obviously improved by squeeze casting. The amount of coarse primary Si phase decreased, while that of ?ne primary α-Al dendrites increased with the increase of squeeze casting pressure. Due to the decrease of coarse primary Si particles, cracking of the matrix was reduced, whilst the?ne microstructure, and mechanical properties of the squeeze casting alloys were improved. Compared with gravity casting alloys, mechanical properties of the hypereutectic Al-xS i alloys solidi?ed at 600 MPa were improved signi?cantly. Hardness of the squeeze casting hypereutectic Al-(15, 17.5, 22 wt%) Si alloys was improved by 15.91%, 12.23%, 17.48%, ultimate tensile strength was improved by 37.85%, 32.27%, 22.74%,and elongation was improved by 55.83%, 167.86%, 126.76%, respectively. Due to the uniform distribution of Si phases in squeeze casting Al-x Si alloys, their wear resistance was markedly enhanced.Runxia Li Lanji Liu Lijun Zhang Jihong Sun Yuanji Shi Baoyi Yu 2017Journal of Materials Science & Technology2017,33,4:8
4Luminescence anti-counterfeiting:From elementary to advanced显示文摘Luminescence anti-counterfeiting derives from the easily changeable luminescence behaviors of luminescence materials under the regulation of various external stimuli(such as excitation light,chemical reagent,heat,and mechanical force,etc.)and luminescence lifetime,which plays an important role in preventing forgery of currency,artworks,and product brands.According to the numbers of changes of anti-counterfeiting labels under various regulation conditions,luminescence anti-counterfeiting can be classified into three levels from elementary to advanced:single-level anti-counterfeiting,double-level anti-counterfeiting,and multilevel anti-counterfeiting.In this review,the recent achievements in luminescence anti-counterfeiting are summarized,and the regulation of various factors to anti-counterfeiting labels is discussed.Finally,existing problems,future challenges,and possible development directions are proposed in order to realize facile,quick,low-cost,environmentally friendly,and difficult-to-replicate advanced luminescence anti-counterfeiting.Xiaowei Yu Hongyue Zhang Jihong Yu 2021Aggregate2021,2,1:4
5Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety.Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian 2018Journal of Traditional Chinese Medicine2018,38,4:4
6Differentiation of neuron-like cells from mouse parthenogenetic embryonic stem cells显示文摘Parthenogenetic embryonic stem cells have pluripotent differentiation potentials,akin to fertilized embryo-derived embryonic stem cells.The aim of this study was to compare the neuronal differentiation potential of parthenogenetic and fertilized embryo-derived embryonic stem cells.Before differentiation,karyotype analysis was performed,with normal karyotypes detected in both parthenogenetic and fertilized embryo-derived embryonic stem cells.Sex chromosomes were identified as XX.Immunocytochemistry and quantitative real-time PCR detected high expression of the pluripotent gene,Oct4,at both the mRNA and protein levels,indicating pluripotent differentiation potential of the two embryonic stem cell subtypes.Embryonic stem cells were induced with retinoic acid to form embryoid bodies,and then dispersed into single cells.Single cells were differentiated in N2 differentiation medium for 9 days.Immunocytochemistry showed parthenogenetic and fertilized embryo-derived embryonic stem cells both express the neuronal cell markers nestin,βIII-tubulin and myelin basic protein.Quantitative real-time PCR found expression of neurogenesis related genes(Sox-1,Nestin,GABA,Pax6,Zic5 and Pitx1) in both types of embryonic stem cells,and Oct4 expression was significantly decreased.Nestin and Pax6 expression in parthenogenetic embryonic stem cells was significantly higher than that in fertilized embryo-derived embryonic stem cells.Thus,our experimental findings indicate that parthenogenetic embryonic stem cells have stronger neuronal differentiation potential than fertilized embryo-derived embryonic stem cells.Xingrong Yan Yanhong Yang Wei Liu Wenxin Geng Huichong Du Jihong Cui Xin Xie Jinlian Hua Shumin Yu Liwen Li Fulin Chen 2013Neural Regeneration Research2013,8,4:4
7THEORY AND EXPERIMENTAL INVESTIGAION OF FLEXURAL WAVE PROPAGATION IN THIN RECTANGULAR PLATE WITH PERIODIC STRUCTURE显示文摘With the idea of the phononic crystals, a thin rectangular plate with two-dimensional peri-odic structure is designed. Flexural wave band structures of such a plate with infinite structure arecalculated with the plane-wave expansion (PWE) method, and directional band gaps are found in theΓX direction. The acceleration frequency response in the ΓX direction of such a plate with finitestructure is simulated with the finite element method and verified with a vibration experiment. Thefrequency ranges of sharp drops in the calculated and measured acceleration frequency responsecurves are in basic agreement with those in the band structures. Thin plate is a widely used componentin the engineering structures. The existence of band gaps in such periodic structures gives a new ideain vibration control of thin plates.Wen Jihong Yu Dianlong Wang Gang Zhao Hongang Liu Yaozong 2005Chinese Journal of Mechanical Engineering2005,18,3:4
8Roles of Hydroxyl Groups during Side-Chain Alkylation of Toluene with Methanol over Zeolite Na-Y: A Density Functional Theory Study显示文摘Xu Li Junran Lu Yi Li Jihong Yu 2017Chinese Journal of Chemistry2017,35,5:3
9Help from space:grant-free massive access for satellite-based IoT in the 6G era显示文摘The Sixth-Generation(6G)standard for wireless communications is expected to realize ubiquitous coverage for massive Internet of Things(IoT)networks by 2030.Satellite-based communications are recognized as a highly promising technical enabler to satisfy IoT service requirements in the 6G era.This study analyzes multiple access technologies,which are essential for the effective deployment of satellite-based IoT.First,we thoroughly investigate the existing research related to massive access,including information-theory considerations as well as Non-Orthogonal Multiple Access(NOMA)and Random Access(RA)technologies.Then,we explore the influence of the satellite transmission environment on multiple access technologies.Based on this study,a Non-orthogonal Massive Grant-Free Access(NoMaGFA)scheme,which reaps the joint benefits of RA and NOMA,is proposed for asynchronous transmissions in satellite-based IoT to achieve improved system throughput and enhance the system robustness under varying traffics.Finally,we identify some important and interesting future developments for satellite-based IoT,including waveform design,transceiver design,resource allocation,and artificial intelligence-enhanced design.Neng Ye Jihong Yu Aihua Wang Rongrong Zhang 2022Digital Communications and Networks2022,8,2:3
10Surface‑Enhanced Raman Scattering Fiber Probe Based on Silver Nanocubes显示文摘Surface-enhanced Raman scattering(SERS)provides a novel method for low concentration molecular detection.The performances were highly dependent on the sizes,geometries and distributions of metal nanostructures.Here,highly sensitive SERS fber probe based on silver nanocubes(Ag NCs)was fabricated,by assembled nanostructures on planar and tapered fber tips.Ag NCs were synthesized by polyol method,and controlled by reductant content,reaction temperatures and crystal growth durations.Tapered fbers with diferent cone angles were prepared by chemical etching.The electromagnetic distribution simulation indicated that nanocubes had stronger electric feld between two cubes and vertex corners than nanosphere,under 532 nm laser excitation.The intensity could reach 53.52 V/m,for cubes with 70 nm edge length.The SERS performance of probes was characterized using crystal violet analyte.The detectable lowest concentration could reach 10^(-9) and 10^(-10) M for planar and tapered fber probes,respectively.The corresponding enhancement factor could be 9.02×10^(7) and 6.22×10^(8).The relationship between SERS peak intensities and analyte concentrations showed well linear,which indicated both fber probes could be applied for both qualitative and quantitative analysis.Furthermore,optimal cone angle of tapered fber SERS probe was 8.3°.The tapered fber SERS probes have highly sensitive activity and great potential in substance detection.Miao Yu Qihang Tian Guangyuan He Kaimin Cui Jihong Zhang 2021Advanced Fiber Materials2021,3,6:3
11Tailoring Porosity and Titanium Species of TS-1 Zeolites via Organic Base-assisted Sequential Post-treatment显示文摘The exploration of high-efficient catalysts based on hierarchical Ti-containing zeolites with optimized active titanium species distribution is of great value in enhancing the epoxidation of bulky olefins. Herein, hierarchical TS-1(MFI) zeolite with an extra-large external surface area(210 m2/g) and highly active octahedral- coordinated Ti species was prepared via organic base-assisted sequential post-treatment. Such a catalyst afforded a high turnover number value(TON, 114) in 1-octene epoxidation reaction, which was over twice than that(53) of the untreated conventional microporous TS-1 parent. According to the detailed characterization results, we revealed the hierarchical porosity construction effect of tetrapropylamonium hydroxide(TPAOH) treatment(first step) and the octahedral-coordinated Ti species fabrication effect of ethylamine(EA) treatment(second step) under hydrothermal condition. Such a facile post-treatment strategy reported in this work may provide guidance for the rational synthesis of TS-1 zeolite with enhanced catalytic activity.XU Wenjing LI Li ZHANG Tianjun YU Jihong 2022Chemical Research in Chinese Universities2022,38,1:2
12Preface to Special Issue on Zeolite Materials and Catalysis显示文摘沸石是有分子的尺寸的常规隧道和笼子的水晶的多微孔的材料。由于他们的唯一的结构和酸的性质,自从 1950 年代末,他们广泛地在石油化学、化学的工业被使用了。例如,沸石在催化裂开和 hydrocracking.Faujasites 是的液体被用作催化剂第一分子的筛申请了催化目的。今天, FAU 仍然是在催化转变使用的最重要的沸石结构类型。工业上重要的沸石综合地被生产。尽管工业催化剂从 FAU, MFI,粗腐殖质, FER 和 BEA 被拉的大多数组织类型,也有世界范围的尝试综合改进沸石结构,作文,和物理性质怎么影响催化转变的理解的新结构类型。现在,沸石拓扑学的 225 种类型被国际沸石协会(IZA-SC ) 的结构委员会识别了,包括超过 40 自然地发生的沸石 frameworks.This 特刊是 “Zeolite 材料和 Catalysis” 的 state-of-art 的更改它盖住沸石和他们的催化反应的合成和描述。一评论, 2 通讯,和 13 篇研究文章在这期特刊被包括。评论纸集中于最近的进展在固态沸石(冯登) 的 NMR 描述。通讯面对表面活化剂用像板的形态学盖住 SAPO-5 沸石的没有溶剂的合成(小凤寿, Xiangju Meng ) 并且进为催化申请的 Al 免费的贝它沸石框架的铈原子的加入(Naijia Guan,戴维莉) 。研究文章与 Eni 碳硅酸盐的为残余裂开的 FCC 催化剂添加剂(于继宏),合成和描述在 Si/Ga 系统准备了的不同硅石/氧化铝比率集中于 ZSM-5 沸石的利用( Giuseppe Bellussi , Michela Bellettato ),从用 bifunctional 的葡萄糖的 5-Hydroxymethyl 糠醛的一个壶合成[ Sn ,艾尔]贝它催化剂(吴鹏),为甲烷 aromatization 的 Mo/HZSM-5 的激活( 埃米尔·J·M 。Hensen ) ,从胶体的 nanocrystalline 先锋(宋维国) 装配的订的 mesoporous silicalite-1 沸石, cyclohexanone 的异构的氧化由钛硅酸盐沸石 TS-1 催化:联合试验性并且 DFT 研究(邹晓东), zeolitic imidazolate 框架的 ionothermal 合成和合成溶解结晶化机制( Zhijian Tian ),用单个micropore模板的层次地结构化的 ZSM-5 沸石的一个壶合成(史建林, Zile Hua ), N 的地点和取向,在由X光检查同步加速器衍射和分子的建模( Sankar Gopinathan )的 AEI 框架的 N-diisopropyl ethylamine 模板,反应上的锌种类的影响国际著名研究写的论文的高质量在这个高度令人激动的研究区域组织将显示这期特刊为未来研究 activity.We 快车的一本好参考书我们对所有作者的真诚的感谢。Jihong Yu Feng-Shou Xiao Avelino Corma 2015催化学报2015,36,6:2
13On efficient key tag writing in RFID-enabled IoT显示文摘Dear editor,Radio-frequency identification(RFID) can provide data in an energy-efficient and low-cost way for data-driven intelligent decisions in emerging Industrial IoT [1]. In RFID systems, tags store information of physical objects and can be attached to these objects [2–5]. Tags can capture energy in the RF signal of a nearby RFID reader for data transmission [6].Pengfei ZHANG Hao LIU Jihong YU 2021Science China(Information Sciences)2021,64,6:2
14Research Advances of Epidemiological Characteristics and Diagnosis Technology of Rabies Virus显示文摘Rabies is a zoonosis caused by rabies virus,which has been characterized by infection of central nervous system. Rabies virus,which can cause fatal infections in humans and other mammals,has the characteristic of neurotropism,and the mortality caused by rabies is almost 100%. Routine diagnosis of rabies include clinical symptoms,while a final diagnosis depends on laboratory diagnostic methods,such as etiological diagnosis,serological diagnosis and molecular biological diagnosis. As a zoonotic infectious disease,rabies presents a global distribution situation,and the deaths caused by rabies virus infection in China ranks the second place in the world. Therefore,strengthening the recognition of disease etiology and epidemiology is very important to comprehensive prevention measures of rabies. The author mainly introduced the research progress on pathogen,epidemiology and diagnosis technology of rabies virus at home and abroad. In addition,the advantages and disadvantages of various methods were compared respectively,in order to provide a scientific basis for further study and rapid diagnosis of rabies.Sun Yu Ma Shichun Wang Xiaoying Wei Wei Su Zenghua Ma Jihong Xie Qiao Xu Yi Dong Hao Shi Jianzhong 2015Animal Husbandry and Feed Science2015,7,4:2
15Analysis of the relationship between bile duct and duodenal microbiota reveals that potential dysbacteriosis is the main cause of primary common bile duct stones显示文摘Bacteria play an important role in the formation of primary Common Bile Duct(CBD)stones.However,the composition and function of the microbiota of bile duct in patients with primary CBD stones remained to be explored.We utilized the 16S rRNA gene high-throughput sequencing technology to analyze the microbial diversity and community composition of biliary and duodenal microbiota in 15 patients with primary CBD stones and 4 patients without biliary tract diseases.Alpha diversity analysis showed that the microbiota richness was similar in bile and intestinal fluid;Beta diversity analysis showed that there were differences in the composition between biliary microbiota and the duodenal microbiota,but the abundance of the main groups showed similarities.The composition of the biliary microbiota from gallstone patients was more complex,as was the duodenal microbiota.Proteobacteria and Firmicutes were the dominant bacteria at phylum level,accounting for at least 75%of the total reads in each subgroup.Pseudomonas and EscherichiaShigella were the major genus among subgroups,but Escherichia-Shigella had increased abundance in duodenal microbiota with primary choledocholithiasis,which may play an important role in stone formation.It is noteworthy that Clostridiumsensu_stricto,Lachnospiraceae_UCG-008,Butyrivibrio and Roseburia which could produce short chain fatty acids(SCFAs),were significantly decreased in biliary microbiota with primary CBD stones(p<0.05).Our study provided new insights into the compositional of normal biliary microbiota.The micro-ecology of biliary and duodenal in patients with stones is complex and closely related,and there is a potential for dysbacteriosis.The decrease in abundance of certain major acid-producing bacteria affects the health of the biliary tract and thus leads to the formation of stones.Zhitang Lyu Tingting Yu Lichao Zhang Xiaona Xu Yijun Zhang Jihong Li Zhirong Li Wei Zhang Senlin Hou 2021Synthetic and Systems Biotechnology2021,6,4:2
16Layer-by-Layer Approach to Superhydrophobic Zeolite Antireflective Coatings显示文摘因为他们能最大化底层的轻发射度, Antireflection 表面和涂层吸引了可观的兴趣。在这个工作,沸石 antireflective (ZAR ) 涂层经由 layer-by-layer (LBL ) 被准备 MFI 类型沸石 silicalite-1 和聚合电解质的汇编。一微 -- 并且 macroporous 层次结构被获得它贡献沸石涂层的 antireflective 性质。石英上的涂层的发射度能在 650 nm 象 99.3% 一样高完成的光。而且, superhydrophobic ZAR 涂层能被化学修正与 1H,1H,2H,2H-perfluorooctyl-triethoxysilane 获得。这个工作证明沸石作为高透明的 superhydrophobic 涂层是优秀候选人。Jianan Zhang Jihong Yu 2018Chinese Journal of Chemistry2018,36,1:2
17Study on the vibration band gap and vibration attenuation property of phononic crystals显示文摘Phononic crystals (PCs) are functional materials with periodic structures and elas- tic wave (vibration) band gaps, where propagation of vibrations with frequencies within band gaps is forbidden. PCs with finite periods can restrain the propagation of vibrations with frequencies in band gaps and thus has vibration attenuation property. Worldwide, many institutions and researchers are engaged in the re- search of PCs, however, studies on the vibration attenuation property of PCs are still limited. In this paper, we report our study of band gaps and vibration attenua- tion properties of 1) a simplified PC—periodic mass-spring structures, 2) longitu- dinal vibration of one-dimensional (1D-), 2D-, 3D-PCs, and 3) the flexural vibration of 1D- and 2D-PCs. These studies provide a foundation for the applications of PCs in vibration attenuation.WEN JiHong WANG Gang YU DianLong ZHAO HongGang LIU YaoZong WEN XiSen 2008Science China(Technological Sciences)2008,51,1:2
18Synthesis, Characterization and Catalytic Properties of Zeolite [B, Al, Ga, Fe]-ZSM-5显示文摘Zeolite [B,Al, Ga, Fe]-ZSM-5, containing several heteroatoms, was synthesized for the first time under. hydrothermal conditions. Characterization of the sample using various techniques such as XRD, IR, ESR, TG-DTA, SEM and XRF indicates that the heteroatoms are located in the framework, similar to the situations of the heteroatoms present in the zeolites [B]-, [Al]-, [Ga]- and [Fe]-ZSM-5. The study of the catalytic properties for reactions of cracking and dehydrogenation of ethylbenzene reveals that the heteroatoms function independently and there are no mutual interactions between the heteroatoms.Liu Xinsheng, Yu Jihong, Kan Qubin and Ding Hong (Synthetic and Catalytic Chemistry Institute of Jilin University, Changchun) 1991Chemical Research in Chinese Universities1991,7,3:2
19Polymerization of methyl methacrylate catalyzed by mono-/bis-salicylaldiminato nickel(Ⅱ) complexes and methylaluminoxane显示文摘Two types of salicylaldiminato-based nickel complexes,mono-ligated Ni(II)complexes([O-C_(6)H_(4)-o-C(H)=N-Ar]Ni(PPh_(3))(Ph)(5),[O-(3,5-Br_(2))C_(6)H_(2)-o-C(H)=N-Ar]Ni(PPh_(3))(Ph)(6),[O-(3-t-Bu)C_(6)H_(3)-o-C(H)=N-Ar]Ni(PPh_(3))(Ph)(7))and bis-ligated Ni(II)complexes([O-(3,5-Br_(2))C_(6)H_(2)-o-C(H)=N-Ar]_(2)Ni(8),[O-(3,5-Br_(2))C_(6)H_(2)-o-C(H)=N-2-C_(6)H_(4)(PhO)]_(2)Ni(9),Ar=2,6-C_(6)H_(3)(i-Pr)_(2))were synthesized and characterized by Fourier transform infrared spectroscopy(FT-IR),nuclear magnetic resonance(NMR),mass spectrography(MS)and elemental analysis(EA).In the presence of methylaluminoxane(MAO)as cocatalyst,all the nickel complexes exhibited high activities for the polymerization of methyl methacrylate(MMA)and syndiotactic-rich poly(methyl methacrylate)(PMMA)was obtained.The complexes with less bulky substituents on salicylaldiminato framework possessed higher activities,while with the same salicylaldiminato,the mono-ligated nickel complexes showed higher catalytic activity than bis-ligated ones.Jihong LU Danfeng ZHANG Qian CHEN Buwei YU 2011Frontiers of Chemical Science and Engineering2011,5,1:2
20Low concentrations of the recombinant toxin protein rLj-RGD3 suppress TNF-a-induced human renal carcinoma cell invasion显示文摘肾的房间癌(RCC ) 的一个特点侵略由 gelatinase 酶的本地生产是细胞外的矩阵(ECM ) 的降级。矩阵 metalloproteinase-9 (MMP-9 ) 导致了癌症房间侵略是在癌症的枢轴的步之一转移。它被报导了那个肿瘤坏死因素 --(TNF-) , MMP-9 的一个管理者,能在人的肾的癌房间导致侵略。在我们的实验室的以前的工作显示出那 rLj-RGD3,从 Lampetra 装饰用的梨树的口腔的腺分泌物的 recombinant RGD (ArgGlyAsp ) 毒素蛋白质,拥有反肿瘤活动。在这研究,我们证明 rLj-RGD3 压制了 TNF -- 在 786-0 房间(人的肾的癌房间) 的导致的 MMP-9 分泌物。在 TNF 上调查 rLj-RGD3 的规章的效果 -- 导致的 MMP-9 分泌物,我们预先对待有 rLj-RGD3 的房间。有趣地, rLj-RGD3 没在 MMP 的组成的分泌物上有重要效果。然而, rLj-RGD3 的低集中减少了 TNF -- 导致的 MMP-9 分泌物。功能的研究表明 rLj-RGD3 导致了 apoptosis 并且显著地禁止了 786-0 房间的增长,迁居,和侵略。而且,在房间的肌动朊建筑学与 rLj-RGD3 预先对待被聚集并且瓦解。我们的调查结果建议 rLj-RGD3 可以在肾的癌症被用作潜在的药治疗。Minli Jin Rong Xiao Jihong Wang Xin Liu Yu Liu Zhuang Xue Li Lv Yuanyuan Zheng Qingwei Li 2013Acta Biochimica et Biophysica Sinica2013,45,5:2
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