|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 2 | Acoustic sound speed profile inversion based on orthogonal matching pursuit显示文摘The estimation of ocean sound speed profiles(SSPs)requires the inversion of an acoustic field using limited observations.Such inverse problems are underdetermined,and require regularization to ensure physically realistic solutions.The empirical orthonormal function(EOF)is capable of a very large compression of the data set.In this paper,the non-linear response of the sound pressure to SSP is linearized using a first order Taylor expansion,and the pressure is expanded in a sparse domain using EOFs.Since the parameters of the inverse model are sparse,compressive sensing(CS)can help solve such underdetermined problems accurately,efficiently,and with enhanced resolution.Here,the orthogonal matching pursuit(OMP)is used to estimate range-independent acoustic SSPs using the simulated acoustic field.The superior resolution of OMP is demonstrated with the SSP data from the South China Sea experiment.By shortening the duration of the training set,the temporal correlation between EOF and test sets is enhanced,and the accuracy of sound velocity inversion is improved.The SSP estimation error versus depth is calculated,and the 99%confidence interval of error is within±0.6 m/s.The 82%of mean absolute error(MAE)is less than 1 m/s.It is shown that SSPs can be well estimated using OMP. | Qianqian Li Juan Shi Zhenglin Li Yu Luo Fanlin Yang Kai Zhang | 2019 | Acta Oceanologica Sinica2019，38，11： | 4 |
| 3 | CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases显示文摘Blood vessel dysfunction causes several retinal diseases,including diabetic retinopathy,familial exudative vitreoretinopathy,macular degeneration and choroidal neovascularization in pathological myopia.Vascular endothelial growth factor(VEGF)-neutralizing proteins provide benefits in most of those diseases,yet unsolved haemorrhage and frequent intraocular injections still bothered patients.Here,we identified endothelial CD146 as a new target for retinal diseases.CD146 expression was activated in two ocular pathological angiogenesis models,a laser-induced choroid neovascularization model and an oxygeninduced retinopathy model.The absence of CD146 impaired hypoxia-induced cell migration and angiogenesis both in cell lines and animal model.Preventive or therapeutic treatment with anti-CD146 antibody AA98 significantly inhibited hypoxia-induced aberrant retinal angiogenesis in two retinal disease models.Mechanistically,under hypoxia condition,CD146 was involved in the activation of NFκB,Erk and Akt signalling pathways,which are partially independent of VEGF.Consistently,anti-CD146therapy combined with anti-VEGF therapy showed enhanced impairment effect of hypoxia-induced angiogenesis in vitro and in vivo.Given the critical role of abnormal angiogenesis in retinal and choroidal diseases,our results provide novel insights into combinatorial therapy for neovascular fundus diseases. | Bai Xue Ping Wang Wenzhen Yu Jing Feng Jie Li Rulian Zhao Zhenglin Yang Xiyun Yan Hongxia Duan | 2022 | Science China(Life Sciences)2022，65，6： | 3 |
| 4 | Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression. | Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，2： | 2 |
| 5 | Polyethylene glycol-modified cobalt sulfide nanosheets for high-performance photothermal conversion and photoacoustic/magnetic resonance imaging显示文摘 | Zhenglin Li Zhuo Li Lei Chen Ying Hu Shaoshan Hu Zhaohua Miao Ye Sun Flemming Besenbacher Miao Yu | 2018 | Nano Research2018，11，5： | 2 |
| 6 | Energy-efficient and security-optimized AES hardware design for ubiquitous computing显示文摘Ubiquitous computing must incorporate a certain level of security.For the severely resource con-strained applications,the energy-efficient and small size cryptography algorithm implementation is a critical prob-lem.Hardware implementations of the advanced encryption standard (AES) for authentication and encryption are presented.An energy consumption variable is derived to evaluate low-power design strategies for battery-powered devices.It proves that compact AES architectures fail to optimize the AES hardware energy,whereas reducing invalid switching activities and implementing power-optimized sub-modules are the reasonable methods.Implemen-tations of different substitution box (S-Boxes) structures are presented with 0.25 μm 1.8 V CMOS (complementary metal oxide semiconductor) standard cell library.The comparisons and trade-offs among area,security,and power are explored.The experimental results show that Galois field composite S-Boxes have smaller size and highest security but consume considerably more power,whereas decoder-switch-encoder S-Boxes have the best power char-acteristics with disadvantages in terms of size and security.The combination of these two type S-Boxes instead of homogeneous S-Boxes in AES circuit will lead to optimal schemes.The technique of latch-dividing data path is analyzed,and the quantitative simulation results demonstrate that this approach diminishes the glitches effectively at a very low hardware cost. | Chen Yicheng Zou Xuecheng Liu Zhenglin Han Yu Zheng Zhaoxia | 2008 | Journal of Systems Engineering and Electronics2008，19，4： | 2 |
| 7 | Aggregation behavior of juvenile Neptunea cumingii and eff ects on seed production显示文摘Neptunea cumingii is an important nutrition-rich economic species in China.Juveniles of N.cumingii suff er from high mortality at low temperatures,which has proved a limiting factor in raising seedlings in artifi cial habitats.Previous research has shown that N.cumingii displays aggregation behavior in response to adverse environmental changes.Therefore,we determined the eff ects of temperature,food,size of juvenile snails,substratum type,and density of juvenile snails on the aggregation behavior of N.cumingii.Results show that,at a low(4°C)or a high(22°C)temperature,juvenile snails adjusted to the inhospitable environment by exhibiting increased aggregation behavior.However,their aggregation behaviors diff ered at these two temperatures.There was no signifi cant diff erence in the aggregation rate,but the typical aggregation size was larger at 4°C than at 22°C.At 10°C or 16°C,aggregation behavior of juvenile snails reduced.Aggregation increased in the satiation treatment at 10°C and 16°C.Small-sized juveniles tended to have higher aggregation rates(92.22%)and a larger typical aggregation size.More juveniles were distributed in the bottom of shaded substrata.A larger typical aggregation size or higher density signifi cantly reduced the mortality of juvenile snails at a low temperature(4°C).These results broaden our understanding of gastropod aggregation behavior and can be used to develop and improve commercial breeding strategies and resource recovery for N.cumingii. | YU Zhenglin HU Zhi SONG Hao XU Tao YANG Meijie ZHOU Cong ZHANG Tao | 2020 | Journal of Oceanology and Limnology2020，38，5： | 2 |
| 8 | Assembling SnO Nanosheets into Microhydrangeas: Gas Phase Synthesis and Their Optical Property显示文摘Large scale SnO microhydrangeas are obtained successfully through thermally evaporating of SnO_2 powder wrapped by a filter paper at 1050 and using gold coated Si wafer as the substrate. The as-obtained SnO microhydrangeas are consisted of many thin nanosheets with the thicknesses of 30-60 nm and the diameters of 500-600 nm. A vapor-liquid-solid(VLS) growth mechanism for the as-synthesized SnO microhydrangeas was proposed based on experimental results. Photoluminescence spectrum(PL) shows that there is a strong sharp ultraviolet emission peak at 390 nm, revealing that these three-dimensional SnO microhydrangeas may have potential applications in optoelectronic fields. | Zhenglin Zhang Jing Wang Zhou Yu Fengyu Qu Xiang Wu | 2012 | Nano-Micro Letters2012，4，4： | 1 |
| 9 | The characteristic of sound propagation in deep water and underwater source localization in the direct zone显示文摘The multiple-path sound propagation in deep water is conducive to source localization of an underwater target.The transmission losses(TLs) and broadband pulse multiple-path propagation characteristics from a deep receiver is analyzed by using the experimental data from deep water area in the South China Sea(SCS).The results indicate that the width of the direct zone near the bottom of 4300 m water depth is about 30 km.The TLs in the direct zone near the bottom are much less than those in the shadow zone.It is meaningful for underwater sound source detection.Moreover,the time delay between the direct path and the bottomsurface-reflected path for a receiver near the bottom decreases monotonically with the source range.According to the linear relationship between the time delay of multipath and source range,a source localization method is presented to estimate the range of underwater target.The experimental results show that the estimated ranges are consistent with the global position system(GPS) measurements,and the mean square error of the estimation results is less than 0.28 km. | WANG Mengyuan LI Zhenglin WU Shuanglin QIN Jixing YU Yanxin | 2019 | Chinese Journal of Acoustics2019，38，4： | 1 |
| 10 | Sound speed profile inversion using a horizontal line array in shallow water显示文摘It is better to use a simple configuration to enhance the applicability of ocean environment inversion in shallow water.A matched-field inversion method based on a horizontal line array(HLA)is used to retrieve the variation of sound speed profile.The performance of the inversion method is verified in the South China Sea in June,2010.An HLA laid at bottom was used to receive signals from a bottom-mounted transducer.Inverted mean sound speed profiles from 9-hour long acoustic signals are in good agreement with measurements from two temperature chains at the sites of the source and receiver.The results show that an HLA can be used to monitor the variability of shallow-water sound speed profile. | LI ZhengLin HE Li ZHANG RenHe LI FengHua YU YanXin LIN Peng | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 1 |
| 11 | Erratum to:CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases显示文摘Erratum to:Sci China Life Sciences,Volume 65,Issue 6:1157-1170(2022),http://gffzzd3cc09b8251d45dfs9fcq66bocoou6kw5.ffgz.tsg.suse.edu.cn/10.1007/s11427-021-2020-0This paper contains four errors in Figure 4 and Figure 5.In Figure 4C,the image labeled as'1%O_(2)+IgG ctrl'is incorect.This image is another one for 1%O_(2) group.We provide a new image as follows for 1%O_(2)+IgG ctrl group.This new image does not affect the conclusion of this article. | Bai Xue Ping Wang Wenzhen Yu Jing Feng Jie Li Rulian Zhao Zhenglin Yang Xiyun Yan Hongxia Duan | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 12 | Dynamic human retinal pigment epithelium(RPE)and choroid architecture based on single-cell transcriptomic landscape analysis显示文摘The retinal pigment epithelium(RPE)and choroid are located behind the human retina and have multiple functions in the human visual system.Knowledge of the RPE and choroid cells and their gene expression profiles are fundamental for understanding retinal disease mechanisms and therapeutic strategies.Here,we sequenced the RNA of about 0.3 million single cells from human RPE and choroids across two regions and seven ages,revealing regional and age differences within the human RPE and choroid.Cell–cell interactions highlight the broad connectivity networks between the RPE and different choroid cell types.Moreover,the transcription factors and their target genes change during aging.The coding of somatic variations increases during aging in the human RPE and choroid at the single-cell level.Moreover,we identified ELN as a candidate for improving RPE degeneration and choroidal structure during aging.The mapping of the molecular architecture of the human RPE and choroid improves our understanding of the human vision support system and offers potential insights into the intervention targets for retinal diseases. | Lulin Huang Lin Ye Runze Li Shanshan Zhang Chao Qu Shujin Li Jie Li Mu Yang Biao Wu Ran Chen Guo Huang Bo Gong Zheng Li Hongjie Yang Man Yu Yi Shi Changguan Wang Wei Chen Zhenglin Yang | 2023 | Genes & Diseases2023，10，6： | 0 |
| 13 | Transfer Ionization Processes in Collisions between S^(q+) and H_2, He显示文摘Molecular H2 is extensively existing in interstellar plasma and play an important role in various charge exchange processes. Collisions between multiply charged S ions and H2, atomic H and He are key processes in investigation of the plasma related to Jupiter. The present work is focusing on the mechanism of collisions between Sq and H2, He. Although both the targets have two electrons, the outgoing channels are quite different, because molecular hydrogen can undergo dissociation and Coulombic explosion after charge transfer: | Wang Zhenglin Ma Xinwen Wei Baoren Chen Ximen Liu Huiping Yang Zhihu Yu Deyang Lu Rongchun Liu Zhaoyuan | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 14 | Deep Sc-RNA sequencing decoding the molecular dynamic architecture of the human retina显示文摘The human retina serves as a light detector and signals transmission tissue.Advanced insights into retinal disease mechanisms and therapeutic strategies require a deep understanding of healthy retina molecular events.Here,we sequenced the m RNA of over 0.6 million single cells from human retinas across six regions at nine different ages.Sixty cell sub-types have been identified from the human mature retinas with unique markers.We revealed regional and age differences of gene expression profiles within the human retina.Cell-cell interaction analysis indicated a rich synaptic connection within the retinal cells.Gene expression regulon analysis revealed the specific expression of transcription factors and their regulated genes in human retina cell types.Some of the gene’s expression,such as DKK3,are elevated in aged retinas.A further functional investigation suggested that over expression of DKK3 could impact mitochondrial stability.Overall,decoding the molecular dynamic architecture of the human retina improves our understanding of the vision system. | Lulin Huang Runze Li Lin Ye Shanshan Zhang Huaping Tian Mingyan Du Chao Qu Shujin Li Jie Li Mu Yang Biao Wu Ran Chen Guo Huang Ling Zhong Hongjie Yang Man Yu Yi Shi Changguan Wang Houbin Zhang Wei Chen Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，3： | 0 |
| 15 | Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution显示文摘The Revised International Staging System(R-ISS)is a simple and powerful prognostic tool for multiple myeloma(MM).However,heterogeneity in R-ISS stage is still poorly characterised,hampering improvement of treatments.We used single-cell RNA-seq to examine novel cellular heterogeneity and regular networks in nine MM patients stratified by R-ISS.Plasma cells were clustered into nine groups(P1–P9)based on gene expression,where P1–P5 were almost enriched in stage III.PDIA6 was significantly upregulated in P3 and LETM1was enriched in P1,and they were validated to be upregulated in the MM cell line and in 22 other patients’myeloma cells.Furthermore,in progression,PDIA6 was newly found and verified to be activated by UQCRB through oxidative phosphorylation,while LETM1 was activated by STAT1 via the C-type lectin receptor-signalling pathway.Finally,a subcluster of monocytes was exclusively found in stage III specifically expressed chemokines modulated by ATF3.A few ligand-receptor pairs(CCL3/CCL5/CCL3L1-CCR1)were obviously active in monocyte-plasma communications in stage III.Herein,this study identified novel molecules,networks and crosstalk pairs in different R-ISS stages of MM,providing significant insight for its prognosis and treatment. | Ling Zhong Xiao Yang Yu Zhou Jialing Xiao Huan Li Jiang Tao Qian Xi Chen Chu Chenglong Li Xi Yang Chen Yang Yi Zhang Ping Shuai Yuping Liu Man Yu Yi Shi Jiang Hu Wei Zhang Bo Gong Zhenglin Yang | 2022 | Science China(Life Sciences)2022，65，9： | 0 |
| 16 | Molecular response and developmental speculations in metamorphosis of the veined rapa whelk,Rapana venosa显示文摘Metamorphosis is the short developmental stage characterized by dramatic ontogenetic changes that occurs in most animals.However,this important process remains largely unclear in marine invertebrates.In this study,we performed the sequential RNA sequencing of a representative mollusk,the rapa whelk(Rapana venosa),that is undergoing metamorphosis and conducted differential gene expression analysis and weighted gene co-expression network analysis(WGCNA)to investigate the overall and dynamic transcriptome responses.The results revealed that the expression of cytochrome P4502A and 3A were upregulated during metamorphosis,while the expression of H/ACA ribonucleoproteins increased 4 h after metamorphosis induction(M4 stage),indicating that R.venosa mainly responded to the pelagobenthic changes.At the M24 stage,the enrichment of V-type proton ATPase and insulin indicated the complete development of secretory organs and initiation of hormone secretion.Furthermore,at the M48 stage,the enrichment of zinc metalloproteinase and conotoxin indicated a well-developed predation system that requires exogenous nutrition.Finally,during the PL stage,the genes associated with growth control were highly enriched,implying that R.venosa had completed metamorphosis and has entered the period of rapid growth.Therefore,our study provides useful transcriptomic resources for R.venosa and contributes new insights that may assist in elucidating the mechanisms underlying metamorphosis in marine invertebrates. | Pu SHI Hao SONG Jie FENG Meijie YANG Zhenglin YU Zhi HU Cong ZHOU Haizhou LI Tao ZHANG | 2023 | Integrative Zoology2023，18，3： | 0 |
| 17 | Settlement and metamorphosis of R apana venosa(Gastropoda: Muricidae) with implications for artificial culture显示文摘The rapa whelk Rapana venosa transforms from a phytophagous larva to a camivorous juvenile after settlement and metamorphosis.The high mortality rate and low metamorphosis rate(<1%)of larvae are among the key factors limiting the recovery of the resources ofR.venosa.We studied these two processes and showed that the larva has the ability to settle and metamorphose in the middle and late 4 spiral whorl period,and the use of substrates(scallop shells with oysters)can significantly improve the settlement and metamorphosis rate of larvae.The presence of darkness,juvenile bivalve shellfish,and oyster polysaccharide could effectively increase the rates of larval settlement and metamorphosis.Our findings broaden the understanding of settlement and metamorphosis in gastropods and can be used to improve population control,resource recovery and commercial breeding strategies for R.venosa. | YU Zhenglin YANG Meijie SONG Hao HU Zhi ZHOU Cong WANG Xiaolong LI Haizhou ZHANG Tao | 2020 | Journal of Oceanology and Limnology2020，38，1： | 0 |
| 18 | A genetic variant in IL-6 lowering its expression is protective for critical patients with COVID-19显示文摘Critical coronavirus disease 2019(COVID-19)is associated with high mortality and potential genetic factors have been reported to be involved in the development of critical COVID-19.We performed a genome-wide association study to identify the genetic factors responsible for developing critical COVID-19.632 critical patients with COVID-19 and 3021 healthy controls from the Chinese population were recruited.First,we identified a genome-wide significant difference of IL-6 rs2069837(p=9.73×10^(−15),OR=0.41)between 437 critical patients with COVID-19 and 2551 normal controls in the discovery cohort. | Bo Gong Lulin Huang Yongquan He Wen Xie Yi Yin Yi Shi Jialing Xiao Ling Zhong Yi Zhang Zhilin Jiang Fang Hao Yu Zhou Huan Li Li Jiang Xingxiang Yang Xiangrong Song Yan Kang Lin Tuo Yi Huang Ping Shuai Yuping Liu Fang Zheng Zhenglin Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员