|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis显示文摘 | Yongting Luo Hongxia Duan Yining Qian Liqun Feng Zhenzhen Wu Fei Wang Jing Feng Dongling Yang Zhihai Qin Xiyun Yan | 2017 | Cell Research2017，27，3： | 18 |
| 2 | FXYD6: a novel therapeutic target toward hepatocellular carcinoma显示文摘FXYD6, FXYD 领域包含离子运输管理者 6,被报导了影响 Na 的活动 < 啜 class= “ a-plus-plus ” >+/K+-ATPase 并且与心理疾病被联系。这里,我们证明 FXYD6 在 hepatocellular 癌(HCC ) 是起来调整的并且提高 HCC 房间的迁居和增长。FXYD6 的起来规定不仅断然随 Na 的增加相关 < 啜 class= “ a-plus-plus ” >+/K 有它发信号的下游的 Src 英皇家空军之阶级最低之兵的激活的 +-ATPase 而且坐标小径。更重要地,显著地由它的功能的抗体堵住 FXYD6 在老鼠禁止 xenografted HCC 肿瘤的生长潜力,显示 FXYD6 代表向 HCC 的一个潜在的治疗学的目标。总的来说,我们的结果在 HCC 前进建立 FXYD6 的一个关键角色并且建议指向 FXYD6 的治疗能向 HCC 病人有益于临床的治疗。 | Qian Gao Xiongfei Chen Hongxia Duan Zhaoqing Wang Jing Feng Dongling Yang Lina Song Ningxin Zhou Xiyun Yan | 2014 | Protein & Cell2014，5，7： | 7 |
| 3 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 4 | Recent advancements in metal-organic frameworks for green applications显示文摘A series of environmental and energy issues,such as global warming,water pollution,acid rain,and energy shortage,have to be settled urgently.Metal-organic frameworks(MOFs)are compounds consisting of metal ions or clusters coordinated to organic ligands,which show great promise for alleviating or mitigating these challenges owing to their outstanding physical and chemical properties.In this review,we summarize the recent advances of MOFs in the fields of green applications,including carbon capture,harmful gas removal,sewage treatment,and green energy storage.In addition,the challenges and prospects of the large-scale commercialized use of MOFs in handling environmental issues are also discussed. | Chongxiong Duan Yi Yu Jing Xiao Yuanyuan Li Pengfei Yang Fei Hu Hongxia Xi | 2021 | Green Energy & Environment2021，6，1： | 6 |
| 5 | CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases显示文摘Blood vessel dysfunction causes several retinal diseases,including diabetic retinopathy,familial exudative vitreoretinopathy,macular degeneration and choroidal neovascularization in pathological myopia.Vascular endothelial growth factor(VEGF)-neutralizing proteins provide benefits in most of those diseases,yet unsolved haemorrhage and frequent intraocular injections still bothered patients.Here,we identified endothelial CD146 as a new target for retinal diseases.CD146 expression was activated in two ocular pathological angiogenesis models,a laser-induced choroid neovascularization model and an oxygeninduced retinopathy model.The absence of CD146 impaired hypoxia-induced cell migration and angiogenesis both in cell lines and animal model.Preventive or therapeutic treatment with anti-CD146 antibody AA98 significantly inhibited hypoxia-induced aberrant retinal angiogenesis in two retinal disease models.Mechanistically,under hypoxia condition,CD146 was involved in the activation of NFκB,Erk and Akt signalling pathways,which are partially independent of VEGF.Consistently,anti-CD146therapy combined with anti-VEGF therapy showed enhanced impairment effect of hypoxia-induced angiogenesis in vitro and in vivo.Given the critical role of abnormal angiogenesis in retinal and choroidal diseases,our results provide novel insights into combinatorial therapy for neovascular fundus diseases. | Bai Xue Ping Wang Wenzhen Yu Jing Feng Jie Li Rulian Zhao Zhenglin Yang Xiyun Yan Hongxia Duan | 2022 | Science China(Life Sciences)2022，65，6： | 3 |
| 6 | Expression of nerve growth factor precursor, mature nerve growth factor and their receptors during cerebral ischemia-reperfusion injury显示文摘We investigated nerve growth factor precursor (proNGF) and mature NGF expression in ischemic and non-ischemic cortices after cerebral ischemia-reperfusion injury. In both ischemic and non-ischemic cortices, proNGF was found to be present in the extracellular space and cytoplasm. In addition, mature NGF was expressed in extracellular space, but with a very low signal. In ischemic cortex only, proNGF was significantly decreased, reaching a minimal level at 1 day. Mature NGF was increased at 4 hours, then reached a minimal level at 3 days. The p75 neurotrophin receptor (p75NTR) was significantly decreased after ischemia, and increased at 3 days after ischemia. These results confirmed that proNGF was the predominant form of NGF during the pathological process of cerebral ischemia-reperfusion injury. In addition, our findings suggest that ischemic injury may influence the conversion of proNGF to mature NGF, and that proNGF/p75NTR may be involved in reperfusion injury. | Guoqian He Jian Guo Jiachuan Duan Wenming Xu Ning Chen Hongxia Li Li He | 2011 | Neural Regeneration Research2011，6，22： | 3 |
| 7 | Establishment of a rhesus monkey model of middle cerebral artery ischemia and reperfusion using a microcatheter embolization method显示文摘Nonhuman primates are closest to humans in terms of lineage,and middle cerebral artery ischemia/reperfusion responses of nonhuman primates are most similar to ischemic stroke in humans.Therefore,nonhuman primates could be utilized to simulate the process of ischemic stroke in the human.Few studies,however,have reported the use of endovascular technology to establish a rhesus monkey stroke model.In the present study,seven adult,male,rhesus monkeys were selected and,following anesthesia,a microcatheter was inserted into one side of the middle cerebral artery via the femoral artery to block blood flow,thereby resulting in middle cerebral artery occlusion.After 2 hours,the microcatheter was withdrawn to restore the middle cerebral artery blood flow and to establish ischemia/reperfusion.Results from angiography and magnetic resonance angiography confirmed occlusion and reopening of the middle cerebral artery.Magnetic resonance imaging revealed the existence of ischemic brain lesions,and neurological examination showed sustained functional deficits following surgery.The rhesus monkey middle cerebral artery ischemia/reperfusion models established by microcatheter embolization had the advantage of non-craniotomy invasion and reproducibility.The scope and degree of ischemic damage using this model was controllable.Therefore,this nonhuman primate model is an ideal model for cerebral ischemia and reperfusion. | Jie Yang Jian Guo Hongbo Zheng Muke Zhou Li He Wenying Cao Li Xiao Jiachuan Duan Qiyong Gong Xiaoqi Huang Hongxia Li Li Wang Jingqiu Cheng | 2010 | Neural Regeneration Research2010，5，15： | 2 |
| 8 | miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV显示文摘 | Lipeng Qiu Hongxia Fan Wensong Jin Bao Zhao Yanzhong Wang Ying Ju Lizhao Chen Yu Chen Zhongping Duan Songdong Meng | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 2 |
| 9 | Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria显示文摘Cerebral malaria(CM)is a life-threatening diffuse encephalopathy caused by Plasmodium falciparum,in which the destruction of the blood–brain barrier(BBB)is the main cause of death.However,increasing evidence has shown that antimalarial drugs,the current treatment for CM,do little to protect against CM-induced BBB damage.Therefore,a means to alleviate BBB dysfunction would be a promising adjuvant therapy for CM.The adhesion molecule CD146 has been reported to be expressed in both endothelial cells and proinflammatory immune cells and mediates neuroinflammation.Here,we demonstrate that CD146 expressed on BBB endothelial cells but not immune cells is a novel therapeutic target in a mouse model of experimental cerebral malaria(eCM).Endothelial CD146 is upregulated during eCM development and facilitates the sequestration of infected red blood cells(RBCs)and/or proinflammatory lymphocytes in CNS blood vessels,thereby promoting the disruption of BBB integrity.Mechanistic studies showed that the interaction of CD146 and Galectin-9 contributes to the aggregation of infected RBCs and lymphocytes.Deletion of endothelial CD146 or treatment with the anti-CD146 antibody AA98 prevents severe signs of eCM,such as limb paralysis,brain vascular leakage,and death.In addition,AA98 combined with the antiparasitic drug artemether improved the cognition and memory of mice with eCM.Taken together,our findings suggest that endothelial CD146 is a novel and promising target in combination with antiparasitic drugs for future CM therapies. | Hongxia Duan Shuai Zhao Jianquan Xiang Chenhui Ju Xuehui Chen Irene Gramaglia Xiyun Yan | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
| 10 | Recent advances in the synthesis of nanoscale hierarchically porous metal–organic frameworks显示文摘Nanoscale hierarchically porous metal–organic frameworks(NHP-MOFs)have received unprecedented attention in many fields owing to their integration of the strengths of nanoscale size(<1μm)and hierarchical porous structure(micro-,meso-and/or macro-pores)of MOFs.This review focuses on recent advances in the main synthetic strategies for NHP-MOFs based on different metal ions(e.g.,Cu,Fe,Co,Zn,Al,Zr,and Cr),including the template method,composite technology,post-synthetic modification,in situ growth and the grind method.In addition,the mechanisms of synthesis,regulation techniques and the advantages and disadvantages of various methods are discussed.Finally,the challenges and prospects of the commercialisation of promising NHP-MOFs are also presented.The purpose of this review is to provide a road map for future design and development of NHP-MOFs for practical application. | Chongxiong Duan Kuan Liang Zena Zhang Jingjing Li Ting Chen Daofei Lv Libo Li Le Kang Kai Wang Han Hu Hongxia Xi | 2022 | Nano Materials Science2022，4，4： | 2 |
| 11 | CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis显示文摘 | Tianxia Jiang Jie Zhuang Hongxia Duan Yongting Luo Qiqun Zeng Kelong Fan Huiwen Yan Di Lu Zhongde Ye Junfeng Hao Jing Feng Dongling Yang Xiyun Yan | 2012 | Blood2012，，11： | 1 |
| 12 | ATP-regulation of antioxidant properties and phenolics in litchi fruit during browning and pathogen infection process显示文摘 | Chun Yi Yueming Jiang John Shi Hongxia Qu Sophia Xue Xuewu Duan Jingyu Shi Nagendra K. Prasad | 2009 | Food Chemistry2009，，1： | 1 |
| 13 | Effect of adenosine triphosphate on changes of fatty acids in harvested litchi fruit infected by Peronophythora litchii显示文摘 | Chun Yi Yueming Jiang John Shi Hongxia Qu Xuewu Duan Bao Yang Nagendra K. Prasad Ting Liu | 2009 | Postharvest Biology and Technology2009，，3： | 1 |
| 14 | A procedure of parameter inversion for a nonlinear constitutive model of soils with shield tunneling 显示文摘 | He Yu Li Shouju Duan Hongxia | 2011 | Computers & Mathematics with Applications2011，61，8： | 1 |
| 15 | Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: Roles in skeletal muscle growth and differentiation显示文摘 | Cunming Duan Hongxia Ren Shan Gao | 2010 | General and Comparative Endocrinology2010，，3： | 1 |
| 16 | Computational insight into novel molecular recognition mechanism of different bioactive GAs and the Arabidopsis receptor GID1A 显示文摘 | DUAN Hongxia LI Dongling LIU Hongchen | 2013 | J Mol Model2013，19，10： | 1 |
| 17 | China renewable energy development evaluation and structure optimiza- tion显示文摘 | Li Hong Dong Liang Duan Hongxia | 2011 | Resource Science2011，，33： | 1 |
| 18 | Effect of drought and ABA on growth, photosynthesis and antioxidant system of Cotinus coggygria seedlings under two different light conditions显示文摘 | Yan Li Hongxia Zhao Baoli Duan Helena Korpelainen Chunyang Li | 2010 | Environmental and Experimental Botany2010，，1： | 1 |
| 19 | Effect of drought andABA on growth, photosynthesis and antioxidant system of Cotinuscoggygria seedlings under two different light conditions显示文摘 | Li Yan Zhao Hongxia Duan Baoli | 2011 | Environmental and experimental botany2011，71，1： | 1 |
| 20 | miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV显示文摘 | Lipeng Qiu Hongxia Fan Wensong Jin Bao Zhao Yanzhong Wang Ying Ju Lizhao Chen Yu Chen Zhongping Duan Songdong Meng | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员