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| 1 | New insights of epithelial-mesenchymal transition in cancer metastasis显示文摘上皮间充质的转变(EMT ) 在胚胎的形态发生,心发展,长期的退化纤维变性,和癌症转移期间是关键步。几个不同特点被 EMT 传送了,包括房间活动性,侵略海角,到 apoptosis 的抵抗,和干细胞的一些性质。许多信号小径贡献了 EMT 的正式就职,例如转变生长 factor-β , Wnt,刺猬,槽口,和原子 factor-κB。在最后几年,增加证据证明了 EMT 在肿瘤前进和转移起一个必要作用。理解 EMT 的分子的机制让一个伟人在解开完成变形串联并且可以为变形疾病导致新奇干预。 | Yadi Wu Binhua P. Zhou | 2008 | Acta Biochimica et Biophysica Sinica2008，40，7： | 57 |
| 2 | Current Status and Challenge of Pseudorabies Virus Infection in China显示文摘Pseudorabies(PR),also called Aujeszky's disease,is a highly infectious disease caused by pseudorabies virus(PRV).Without specific host tropism,PRV can infect a wide variety of mammals,including pig,sheep,cattle,etc.,thereby causing severe clinical symptoms and acute death.PRV was firstly reported in China in 1950s,while outbreaks of emerging PRV variants have been documented in partial regions since 2011,leading to significant economic losses in swine industry.Although scientists have been devoting to the design of diagnostic approaches and the development of vaccines during the past years,PR remains a vital infectious disease widely prevalent in Chinese pig industry.Especially,its potential threat to human health has also attracted the worldwide attention.In this review,we will provide a summary of current understanding of PRV in China,mainly focusing on PRV history,the existing diagnosis methods,PRV prevalence in pig population and other susceptible mammals,molecular characteristics,and the available vaccines against its infection.Additionally,promising agents including traditional Chinese herbal medicines and novel inhibitors that may be employed to treat this viral infection,are also discussed. | Lei Tan Jun Yao Yadi Yang Wei Luo Xiaomin Yuan Lingchen Yang Aibing Wang | 2021 | Virologica Sinica2021，36，4： | 34 |
| 3 | 炎症--加速癌症转移的驱动力显示文摘肿瘤微环境在癌变中发挥重要作用,这一点已经得到越来越多的共识。炎症组分存在并有助于肿瘤增殖、血管生成、转移以及对激素和化疗的抵抗。本文聚焦炎症在肿瘤转移中的作用。我们关注促炎因子特别是细胞因子在肿瘤转移中的作用。了解炎症促进肿瘤转移的机制将为癌症治疗带来创新性的突破。 | Yadi WU Binhua P.ZHOU 丁燕(翻译) 南娟(翻译) 刘谦(校对) | 2009 | 中国肺癌杂志2009，12，11： | 26 |
| 4 | Esophageal cancer:Epidemiology,risk factors and screening显示文摘More than 600,000 people are diagnosed with esophageal cancer(EC)every year globally,and the five-year survival rate of EC is less than 20%.Two common histological subtypes of EC,esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC),have great geographical variations in incidence rates.About half of the world’s EC was diagnosed in China and a majority of which belong to ESCC.Globally,the overall incidence rate of EC is decreasing.In some high-risk Asian regions,such as China,the incidence rate of ESCC has generally declined,potentially due to economic growth and improvement of diet habits.In some European high-income countries and the United States,the decline is mainly attributed to the decrease in smoking and drinking.The risk factors of EC are not well understood,and the importance of environmental and genetic factors in the pathogenesis is also unclear.The incidence and mortality of advanced EC can be reduced through early diagnosis and screening.White light endoscopy is still the gold standard in the current screening technology.This article reviews the epidemiology,risk factors,and screening strategies of EC in recent years to help researchers determine the most effective management strategies to reduce the risk of EC. | Jiang Li Jianguo Xu Yadi Zheng Ya Gao Siyi He He Li Kaiyong Zou Ni Li Jinhui Tian Wanqing Chen Jie He | 2021 | Chinese Journal of Cancer Research2021，33，5： | 12 |
| 5 | The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis显示文摘Panax notoginseng,a perennial herb of the genus Panax in the family Araliaceae,has played an important role in clinical treatment in China for thousands of years because of its extensive pharmacological effects.Here,we report a high-quality reference genome of P.notoginseng,with a genome size up to 2.66 Gb and a contig N50 of 1.12 Mb,produced with third-generation PacBio sequencing technology.This is the first chromosome-level genome assembly for the genus Panax.Through genome evolution analysis,we explored phylogenetic and whole-genome duplication events and examined their impact on saponin biosynthesis.We performed a detailed transcriptional analysis of P.notoginseng and explored genelevel mechanisms that regulate the formation of characteristic tubercles.Next,we studied the biosynthesis and regulation of saponins at temporal and spatial levels.We combined multi-omics data to identify genes that encode key enzymes in the P.notoginseng terpenoid biosynthetic pathway.Finally,we identified five glycosyltransferase genes whose products catalyzed the formation of different ginsenosides in P.notoginseng.The genetic information obtained in this study provides a resource for further exploration of the growth characteristics,cultivation,breeding,and saponin biosynthesis of P.notoginseng. | Zhouqian Jiang Lichan Tu Weifei Yang Yifeng Zhang Tianyuan Hu Baowei Ma Yun Lu Xiuming Cui Jie Gao Xiaoyi Wu Yuru Tong Jiawei Zhou Yadi Song Yuan Liu Nan Liu Luqi Huang Wei Gao | 2021 | Plant Communications2021，2，1： | 11 |
| 6 | Dosimetric evaluation of VMAT radiation therapy technique for breast cancer after conservative surgery based on three different types of multileaf collimators显示文摘Objective Radiotherapy combined with conservative surgery plays an important role in the treatment of early-stage breast cancer. Volumetric modulated arc therapy(VMAT) has been introduced into clinical practice. The purpose of this study was to investigate the dosimetric effects of different multileaf collimators(MLC) on VMAT radiotherapy plans for treating breast cancer.Methods Fifteen breast cancer patients who were treated using a conventional technique in our department were selected to participate in this retrospective analysis. VMAT plans based on three types of Elekta MLCs [Beam Modulator(BM) with 4-mm leaf width, Agility with 5-mm leaf width and MLCi2 with 10-mm leaf width] were independently generated for each patient. Plan comparisons were performed based on dose-volume histogram(DVH) analysis including dosimetric parameters such as the homogeneity index(HI), conformity index(CI), Dmax, Dmin, and Dmean for the planning treatment volume(PTV), in addition to dose-volume parameters for the organs at risk(OARs). The delivery efficiency of the three types of MLCs was compared in terms of the beam delivery time and the monitor units(MUs) per fraction for each plan. Results Both target uniformity and conformity were improved in plans for Agility and BM MLC compared with the plan using MLCi2. The mean HI decreased from 1.14 for MLCi2 to 1.13 for BM and 1.10 for Agility, while the mean CI increased from 0.68 for MLCi2 to 0.73 for BM and 0.75 for Agility. Furthermore, at both low and high dose levels, smaller volumes of ipsilateral lung, heart, contralateral lung, and breast were irradiated with Agility MLC than with the other two types of MLCs. The delivery time with Agility MLC was reduced by 10.8% and 32.1%, respectively, compared with that for MLCi2 and BM.Conclusion Our results indicate that the Agility MLC exhibits a dosimetric advantage and a significant improvement in delivery efficiency for the treatment of breast cancer using VMAT. | Fuli Zhang Weidong Xu Huayong Jiang Yadi Wang Junmao Gao Qingzhi Liu | 2018 | Oncology and Translational Medicine2018，4，5： | 4 |
| 7 | Hierarchical grain size and nanotwin gradient microstructure for improved mechanical properties of a non-equiatomic CoCrFeMnNi high-entropy alloy显示文摘This study explored a multi-mechanism approach to improving the mechanical properties of a Co CrFe Mn Ni high-entropy alloy through non-equiatomic alloy design and processing.The alloy design ensures a single-phase face-centered cubic structure while lowering the stacking fault energy to encourage the formation of deformation twins and stacking faults by altering the equiatomic composition of the alloy.The processing strategy applied helped create a hierarchical grain size gradient microstructure with a high nanotwins population.This was achieved by means of rotationally accelerated shot peening(RASP).The non-equiatomic Co Cr Fe Mn Ni high-entropy alloy achieved a yield strength of 750 MPa,a tensile strength of 1050 MPa,and tensile uniform elongation of 27.5%.The toughness of the alloy was 2.53×10^(10)k J/m^(3),which is about 2 times that of the same alloy without the RASP treatment.The strength increase is attributed to the effects of grain boundary strengthening,dislocation strengthening,twin strengthening,and hetero-deformation strengthening associated with the heterogeneous microstructure of the alloy.The concurrent occurrence of the multiple deformation mechanisms,i.e.,dislocation deformation,twining deformation and microband deformation,contributes to achieving a suitable strain hardening of the alloy that helps to prevent early necking and to assure steady plastic deformation for high toughness. | Zibing An Shengcheng Mao Yinong Liu Hao Zhou Yadi Zhai Zhiyong Tian Cuixiu Liu Ze Zhang Xiaodong Han | 2021 | Journal of Materials Science & Technology2021，，33： | 3 |
| 8 | Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program显示文摘Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline comorbidity, and family history.Conclusions: Significant gender differences in the risk of lung cancer were discovered in China non-smokers. Existing risk factors did not explain the excess lung cancer risk of all non-smoking men, and the internal causes for the excess risk still need to be explored;most known risk factors were more harmful to non-smoking women;further exploring the causes of the sex difference would help to improve the prevention and screening programs and protect the non-smoking males from lung cancers. | Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin Xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu Yongjie Xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 9 | Experiment and simulation study of emergency evacuation during violent attack in classrooms显示文摘In recent years,as a disaster,terrorist attacks have occurred throughout the world.However,emergency evac-uation behaviors during these incidents were not clear,and the traditional emergency plans were not suitable for such incidents.In this paper,evacuation behaviors under armed assault attack in a classroom were studied based on evacuation experiments.A total of 103 participants took part in three experiments.In each experiment,the attacker’s attacking route was set differently to study the impact of the attacking route on evacuation be-haviors.Pre-evacuation delay,panic of the evacuees,exit choices,evacuation time,and evacuees’trajectories in the experiments were all analyzed.The results of the experiments showed that when a terrorist attack occurs,there is a long delay before evacuation,and most of the evacuees were in the state of“observation”before they moved.When one of the participants started to evacuate or shout,other participants would begin to recognize the danger and escape quickly.These three experiments showed that the route of the attacker had a significant impact on the routes and exit choices of the evacuees.Rather than searching for the nearest exit,the primary purpose of evacuees was to keep a safe distance from the attacker.The average speed of the evacuees in these three experiments was 1.07 m/s,0.81 m/s,and 0.84 m/s,respectively.The density distribution during the crowd evacuation process was uneven,with the highest density occurring at the area from the seats to the aisles.The research can provide data support for the design of emergency plans and the computer simulation of the armed assault attack. | Ning Ding Yihang Ma Dapeng Dong Yadi Wang | 2021 | Journal of Safety Science and Resilience2021，2，4： | 2 |
| 10 | Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates显示文摘Emerging SARS-CoV-2 variants and the gradually decreasing neutralizing antibodies over time post vaccination have led to an increase in incidents of breakthrough infection across the world.To investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain(RBD)(PS-RBD)and whole inactivated virus particle vaccine(IV)against the variant strains,in this study,rhesus macaques were immunized with PS-RBD or IV vaccine,followed by a Beta variant(B.1.351)challenge.Although neutralizing activity against the Beta variant was reduced compared with that against the prototype,the decreased viral load in both upper and lower respiratory tracts,milder pathological changes,and downregulated inflammatory cytokine levels in lung tissues after challenge demonstrated that PS-RBD and IV still provided effective protection against the Beta variant in the macaque model.Furthermore,PS-RBD-induced macaque sera possessed general binding and neutralizing activity to Alpha,Beta,Delta,and Omicron variants in our study,though the neutralizing antibody(NAb)titers declined by varying degrees,demonstrating potential protection of PS-RBD against current circulating variants of concern(VOCs).Interestingly,although the IV vaccine-induced extremely low neutralizing antibody titers against the Beta variant,it still showed reduction for viral load and significantly alleviated pathological change.Other correlates of vaccine-induced protection(CoP)like antibody-dependent cellular cytotoxicity(ADCC)and immune memory were both confirmed to be existing in IV vaccinated group and possibly be involved in the protective mechanism. | Qian He Qunying Mao Xiaozhong Peng Zhanlong He Shuaiyao Lu Jialu Zhang Fan Gao Lianlian Bian Chaoqiang An Wenhai Yu Fengmei Yang Yanan Zhou Yun Yang Yanyan Li Yadi Yuan Xujia Yan Jinghuan Yang Xing Wu Weijin Huang Changgui Li Junzhi Wang Zhenglun Liang Miao Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 11 | Comparison of the effects of two typesof multileaf collimators on tumor control probabilityin radiotherapy for breast cancer after conservativesurgery based on the EUD model显示文摘Objective To compute and compare the tumor control probability(TCP) of volumetric modulated arc therapy(VMAT) for breast cancer after conservative surgery based on two types of multileaf collimator(MLC) through a retrospective planning study.Methods For a group of 9 patients diagnosed with left breast cancer,VMAT plan based on Agility MLC and beam modulator(BM) MLC were designed.The prescription dose was 50 Gy covering at least 95% of the planning target volume,2 Gy per fraction.TCPs were calculated according to dose-volume histogram(DVH) analysis.Results The TCP of the BM VMAT plan was slightly higher than that of the Agility VMAT plan(94.61% vs 94.23%) but was inferior with respect to delivery efficiency;the delivery time was reduced for Agility VMAT plan by 35% compared to BM VMAT plan.Conclusion For breast cancer radiation therapy after conservative surgery,BM VMAT plans provide slightly higher TCP while the delivery of Agility VMAT plans is significantly faster than the BM VMAT plans. | Fuli Zhang Yadi Wang Weidong Xu Huayong Jiang Junmao Gao Qingzhi Liu Na Lu Diandian Chen Bo Yao Jun Hou Heliang He Jianping Chen | 2017 | Oncology and Translational Medicine2017，3，2： | 2 |
| 12 | Multi-Cluster Feature Selection Based on Isometric Mapping显示文摘Dear editor,This letter presents an unsupervised feature selection method based on machine learning.Feature selection is an important component of artificial intelligence,machine learning,which can effectively solve the curse of dimensionality problem.Since most of the labeled data is expensive to obtain. | Yadi Wang Zefeng Zhang Yinghao Lin | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，3： | 2 |
| 13 | Effect of luteolin on xanthine oxidase: Inhibition kinetics and interaction mechanism merging with docking simulation显示文摘 | Jiakai Yan Guowen Zhang Yuting Hu Yadi Ma | 2013 | Food Chemistry2013，，4： | 2 |
| 14 | Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe显示文摘Carboxylesterase 1(CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and iso form-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity,sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CESl activities in several biological systems including tissue preparations,living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research. | Lele Ding Zhenhao Tian Jie Hou Tongyi Dou Qiang Jin Dandan Wang Liwei Zou Yadi Zhu Yunqing Song Jingnan Cui Guangbo Ge | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 15 | Kinetics and mechanism of thermal degradation of vegetable-tanned leather fiber显示文摘Thermal degradation of vegetable-tanned leather fiber(VLF)was investigated by thermogravimetric analysis aiming to know the exact kinetics and degradation mechanism.The thermogravimetric(TG)and differential thermogravimetric(DTG)curves showed that decomposition of the VLF occurs mainly in the range of 150-600℃,and the latter exhibits asymmetrical peak with a pronounced shoulder.The decomposition process was first analyzed by deconvolution of the experimental DTG curves,followed by reconstruction of the weight loss profiles of two individual processes.Several common isoconversional approaches were applied to calculate the activation energy over a wide range of conversion for the sample,including modified Kissinger-Akahira-Sunose(MKAS),Friedman,and Flynn-Wall-Ozawa.The average activation energy of vegetable-tanned leather fiber was found to be 241.9 kJ mol^(−1) by MKAS method.The activation energy values obtained for the pseudocomponents representing highly-crosslinked and low-crosslinked collagen in VLF were given as 190.6 and 124.8 kJ mol^(−1),respectively.Generalized master plots results suggested that the reaction mechanism for highly-crosslinked collagen follows the random nucleation and growth process at conversion values lower than 0.5.When the conversion is higher than 0.5,the mechanism tends to random scission model.For low-crosslinked collagen,the degradation is mainly governed by random nucleation and nuclei growth.The gaseous products of VLF thermal degradation were analyzed with an online-coupled TG-Fourier transform infrared spectroscopy system. | Jie Liu Lan Luo Yadi Hu Fang Wang Xuejing Zheng Keyong Tang | 2019 | Journal of Leather Science and Engineering2019，1，1： | 2 |
| 16 | N^(6)-methyladenosine Steers RNA Metabolism and Regulation in Cancer显示文摘As one of the most studied ribonucleic acid(RNA)modifications in eukaryotes,N^(6)-methyladenosine(m^(6)A)has been shown to play a predominant role in controlling gene expression and influence physiological and pathological processes such as oncogenesis and tumor progression.Writer and eraser proteins,acting opposite to deposit and remove m^(6)A epigenetic marks,respectively,shape the cellular m^(6)A landscape,while reader proteins preferentially recognize m^(6)A modifications and mediate fate decision of the methylated RNAs,including RNA synthesis,splicing,exportation,translation,and stability.Therefore,RNA metabolism in cells is greatly influenced by these three classes of m^(6)A regulators.Aberrant expression of m^(6)A regulators has been widely reported in various types of cancer,leading to cancer initiation,progression,and drug resistance.The close links between m^(6)A and cancer shed light on the potential use of m^(6)A methylation and its regulators as prognostic biomarkers and drug targets for cancer therapy.Given the notable effects of m^(6)A in reversing chemoresistance and enhancing immune therapy,it is a promising target for combined therapy.Herein,we summarize the recent discoveries on m^(6)A and its regulators,emphasizing their influences on RNA metabolism,their dysregulation and impacts in diverse malignancies,and discuss the clinical implications of m^(6)A modification in cancer. | Shenghua Dong Yutong Wu Yadi Liu Hengyou Weng Huilin Huang | 2021 | Cancer Communications2021，41，7： | 2 |
| 17 | Preoperative Diagnosis of Solitary Fibrous Tumor of the Kidney with Percutaneous Fine Needle Biopsy and Management with Laparoscopic Partial Nephrectomy: One Case Report and Literatures Review显示文摘Introduction Solitary fibrous tumor (SFT) of the kidney is a rare spindle cell neo-plasm and all reported SFTs of the kidney were diagnosed throughpathological examination | Liaoyuan Li Yadi He Xin Gao Ming Yang Haibin Zhang Yuanyuan Xu Wenfeng Xu | 2008 | Chinese Journal of Clinical Oncology2008，5，6： | 2 |
| 18 | Boron and nitrogen dual-doped carbon as a novel cathode for high performance hybrid ion capacitors显示文摘Hybrid ion capacitors have been considered as a very attractive energy source with high energy density and power density since it combines both merits of lithium ion batteries and supercapacitors. However,their commercial application has been limited by the mismatch of charge-storage capacity and electrode kinetics between the capacitor-type cathode and battery-type anode. Herein, B and N dual-doped 3D superstructure carbon cathode is prepared through a facile template method. It delivers a high specific capacity, excellent rate capability and good cycling stability due to the B, N dual-doping, which has a profound effect in control the porosity, functional groups, and electronic conductivity for the carbon cathode. The hybrid ion capacitors using B, N dual-doping carbon cathode and prelithiated graphite anode show a high energy density of 115.5 Wh/kg at 250 W/kg and remain about 53.6 Wh/kg even at a high power density of 10 kW/kg. Additionally, the novel hybrid device achieves 76.3% capacity retention after 2000 cycles tested at 1250 W/kg power density. Significantly, the simultaneous manipulation of heteroatoms in carbon materials provides new opportunities to boost the energy and power density for hybrid ion capacitors. | Jiangmin Jiang Ping Nie Shan Fang Yadi Zhang Yufeng An Ruirui Fu Hui Dou Xiaogang Zhang | 2018 | Chinese Chemical Letters2018，29，4： | 1 |
| 19 | C3d enhanced DNA vaccination induced humoral immune response to glycoprotein C of pseudorabies virus显示文摘 | Tiezhu Tong Huiying Fan Yadi Tan Shaobo Xiao Jieyu Ling Huanchun Chen Aizhen Guo | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
| 20 | Contribution to the study of the effect of the interspecificity on a two nutrients competition model显示文摘 | Fethi Borsali Karim Yadi | 2015 | International Journal of Biomathematics2015，8，1： | 1 |
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