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| 1 | Early Paleozoic granitic magmatism related to the processes from subduction to collision in South Altyn, NW China显示文摘Four episodes of granitic rocks at 517, 501–496, 462–451, and 426–385 Ma occurred in the South Altyn subduction-collision complex. The first episode of granite emplacement predates the formation of the ophiolite type mafic rock(?500 Ma), and the three subsequent episodes can be temporally correlated to high-pressure(HP) to ultrahigh-pressure(UHP) metamorphism at ca. 500 Ma, retrograde granulite-facies metamorphism at ca. 450 Ma, and amphibolite-facies metamorphism at ca. 420 Ma, respectively. A comprehensive study of these granitic rocks, along with the regional geological background, mafic-ultramafic rocks, and HP-UHP metamorphism, indicates that the four episodes of granitic magmatism are sequentially derived from the partial melting of the earlier subducted oceanic crust at 517 Ma, the thickened continental crust due to continental subduction at ca. 500 Ma, the mid-upper crust in response to slab breakoff at ca. 450 Ma, and the tectonic transition from contraction to extension at ca. 420 Ma. The formation age of 517 Ma for oceanic adakite provides a direct constraint on the time of the oceanic subduction in South Altyn. In addition, there is a ca. 10 Myr interval between the oceanic subduction to the continental deep subduction, suggesting that the Early Paleozoic tectonic evolution might have been a successive process in South Altyn. The four episodes of formation of granitic rocks, mafic-ultramafic rocks, and HP-UHP metamorphic rocks have fully recorded the tectonic evolution, beginning with the oceanic subduction, followed by continental subduction, and later exhumation during the Early Paleozoic in South Altyn. | LIU Liang KANG Lei CAO YuTing YANG WenQiang | 2015 | Science China Earth Sciences2015，58，9： | 25 |
| 2 | Enhanced rectification, transport property and photocurrent generation of multilayer ReSe2/MoS2 p-n heterojunctions显示文摘 | Xiaoting Wang Le Huang Yuting Peng Nengjie Huo Kedi Wu Congxin Xia Zhongming Wei Sefaattin Tongay Jingbo Li | 2016 | Nano Research2016，9，2： | 16 |
| 3 | Geochemistry and Zircon U-Pb Dating of Changshagou Adakite from the South Altyn UHPM Terrane: Evidence of the Partial Melting of the Lower Crust显示文摘Changshagou adakite, an outcrop in the middle segment of the South Altyn Tagh ultra-high pressure metamorphism(UHPM) terrane, contains medium-K cal-alkaline and weakly peraluminous compositions(Si O2 = 66.79% to 68.65%, Al2O3 = 17.48% to 18.31%, K2 O + Na2 O = 6.32% to 6.88%, K2O/Na2 O = 0.25 to 0.33, A/CNK = 1.01 to 1.06). This outcrop is also enriched with large ion lithophile elements but with depleted high-field strength elements(HFSE) showing clearly negative Nb, Ta, and Ti anomalies. REE distribution patterns show a positive anomaly of Eu(δEu = 1.15 to 1.31) and weakly enriched with LREE compared with HREE(LREE/HREE = 1.02 to 4.20). Experimental results and several characteristics, including relatively low Nb/Ta ratios(6.03 to 8.45) and high Sr, Sr/Y,(La/Yb)N and low Y and Yb, which indicate the presence of residual garnet and the absence of plagioclase in the source region, show that adakite may form at a pressure ranging from 1.2 GPa to 1.5 GPa and at a temperature of approximately 900°C. Low Cr, Ni, and Mg# values, trace element patterns, and Si O2–Mg# and Si O2–Mg O diagrams indicate that rocks are formed by the partial melting of a thickened lower continental crust. LA-ICP-MS in situ U-Pb dating yields two group ages: 503.1 ± 1.7 Ma(core) and 453.1 ± 3.0 Ma(rim). The Th/U ratios of the core and the rim are 0.11 to 0.40 and 0.03 to 0.07, respectively. Considering the zircon CL image characteristics, Th/U ratios, and previous studies on regional UHPM rocks, adakite formed at 503.1 ± 1.7 Ma and underwent a tectothermal event as a result of the break-off of the Altyn deep subducted continental crust at 453.1 ± 3.0 Ma. | KANG Lei LIU Liang WANG Chao CAO Yuting YANG Wenqiang WANG Yawei LIAO Xiaoying | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 15 |
| 4 | Improved threshold retracker for satellite altimeter waveform retracking over coastal sea显示文摘数据质量是为到测地学和海洋学的卫星的申请的一个关键因素。因为高度表波形被地形学和环境污染严重污染,测高法的精确性在沿海的区域被限制。那么波形沤飘动被需要为更好的精确性计算地球物理的数据记录(GDR ) 的范围修正。在这篇论文,新波形沤 racker 说出改进阀值沤 racker (国际互联网广播台) 被提出。ret racker 首先基于在波形检测的前缘造亚波形,然后决定每前缘的中点计算折磨范围修正的ret ,最后从一个海洋潮模式从一个本地 geopotential 模型和潮高度根据大地水准面波动计算引用的海表面高度,并且把它与所有作比较沤折磨范围决定最好的。作为测试, Geosat 美国通用汽车公司的高度表波形是沤在台湾沿海的区域附近飘动。结果比 -5-pa-rameter 功能试穿方法和阀值方法的更好证明国际互联网广播台方法的那精确性是 two times,并且三比 GDR 的更好预定。国际互联网广播台能高效地改进沿海的海区域的测高法精确性。 | GUO Jinyun HWANG Cheiway CHANG Xiaotao LIU Yuting | 2006 | Progress in Natural Science:Materials International2006，16，7： | 14 |
| 5 | Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer显示文摘Cloning of macaque monkeys by somatic cell nucleus transfer(SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases. Here, we report the feasibility of this approach by SCNT of fibroblasts from a macaque monkey(Macaca fascicularis), in which a core circadian transcription factor BMAL1 was knocked out by clustered regularly interspaced short palindromic repeat/Cas9 gene editing(see accompanying paper).Out of 325 SCNT embryos transferred into 65 surrogate monkeys, we cloned five macaque monkeys with BMAL1 mutations in both alleles without mosaicism, with nuclear genes identical to that of the fibroblast donor monkey. Further peripheral blood m RNA analysis confirmed the complete absence of the wild-type BMAL1 transcript. This study demonstrates that the SCNT approach could be used to generate cloned monkeys from fibroblasts of a young adult monkeys and paves the way for the development of macaque monkey disease models with uniform genetic backgrounds. | Zhen Liu Yijun Cai Zhaodi Liao Yuting Xu Yan Wang Zhanyang Wang Xiaoyu Jiang Yuzhuo Li Yong Lu Yanhong Nie Xiaotong Zhang Chunyang Li Xinyan Bian Mu-ming Poo Hung-Chun Chang Qiang Sun | 2019 | National Science Review2019，6，1： | 14 |
| 6 | Genome-wide Identification and Classification of HSF Family in Grape, and Their Transcriptional Analysis under Heat Acclimation and Heat Stress显示文摘Heat stress is one of the most serious threats in viticulture. Heat shock transcription factors(HSFs) have been proven to be the most important transcriptional factor family in the plant response to heat. In this study, a total of 19 putative HSF genes(VHSFs) were identified from the 12 × Vitis vinifera Pinot Noir PN4002 genome, and their chromosomal location, phylogenetic tree, exon-intron structure and conserved motifs were also analyzed. In addition, these HSFs transcriptional profiles in Vitis vinifera 'Jingxiu'(weak heat tolerance) and Vitis davidii 'Tangwei'(strong heat tolerance) under heat stress(47℃) and heat acclimation(38℃) were presented. Only VHSF01, VHSF05, VHSF15 and VHSF18 among 19 VHSFs showed different transcriptional models in these two genotypes under the same treatment, suggesting that these four VHSFs may be important factors which result in a thermotolerance difference between 'Jingxiu' and 'Tangwei'. This study provides novel insights into the response of 19 VHSFs to heat stress in the grape and suggests that potential key VHSFs in grape thermotolerance have great implications for molecular breeding in grapes. | LIU Guotian CHAI Fengmei WANG Yi JIANG Jinzhu DUAN Wei WANG Yuting WANG Fangfang LI Shaohua WANG Lijun | 2018 | Horticultural Plant Journal2018，4，4： | 13 |
| 7 | Numerical simulation and experimental investigation of natural convection heat transfer of molten salt around fine wire显示文摘In order to get the natural convection heat transfer mechanism of molten salt, the experimental investigation of natural convective heat transfer of LiNO3was studied after it was simulated by numerical calculation. Experiment was carried out on the nat-ural convection heat transfer of air and water around the fine wire using the method of Joule heating. The results showed that the natural convection heat transfer of air and water around the fine wire agreed well with Fand's correlation. Based on the aforementioned experiment, the natural convection heat transfer of molten salt LiNO3was studied by experiment and the same results were got. Therefore, the natural convection heat transfer of molten salt can be calculated by Fand's correlation, which takes into consideration the effect of viscosity dissipation. | LU YuanWei LI XiaoLi LI Qiang WU YuTing MA ChongFang | 2013 | Science China(Technological Sciences)2013，56，7： | 13 |
| 8 | Observational study of the circulation in the southern South China Sea显示文摘CTD data from two oceanographic survey cruises, conducted by 'Shiyan No.3' R/V during two reversing monsoons, were employed to calculate and analyze the distributions of temperature, salinity and geopotential anomaly in the southern South China Sea (SSCS). Based on these distributions, the horizontal structures of the SSCS circulation are described systematically. Study results show that the SSCS circulation structure could be classified as a two-layer (the upper and the lower) pattern, and that the main circulation in the upper layer (0-400 m) is driven by the South China Sea monsoons and is opposite in direction to the reversal of the monsoons. The distributions of principal current systems and their features are presented. Two important local phenomena, local eddy and oceanic front, were observed. | Fang Wendong Guo Zhongxin Huang Yuting | 1998 | Chinese Science Bulletin1998，43，11： | 13 |
| 9 | 3D bioprinting: an emerging technology full of opportunities and challenges显示文摘 | Bin Zhang Yichen Luo Liang Ma Lei Gao Yuting Li Qian Xue Huayong Yang Zhanfeng Cui | 2018 | Bio-Design and Manufacturing2018，1，1： | 13 |
| 10 | Impacts of temperature and precipitation on runoff in the Tarim River during the past 50 years显示文摘The relationship between climate change and water resources in the Tarim River was analyzed by combining the temperature,precipitation and streamflow data from 1957 to 2007 from the four headstreams of the Tarim River (Aksu,Hotan,Yarkant and Kaidu rivers) in the study area.The long-term trend of the hydrological time series including temperature,precipitation and streamflow were studied using correlation analysis and partial correlations analysis.Holt double exponential smoothing was used to fit the trends between streamflow and the two climatic factors of Aksu River,Hotan River and Yarkant River.The streamflow of the main stream was forecasted by Autoregressive Integrated Moving Average Model (ARIMA) modeling by the method of time series analysis.The results show that the temperature experienced a trend of monotonic rising.The precipitation and runoff of the four headstreams of the Tarim River increased,while the inflow to the headstreams increased and the inflow into the Tarim River decreased.Changes of temperature and precipitation had a significant impact on runoff into the four headstreams of the Tarim River: the precipitation had a positive impact on water flow in the Aksu River,Hotan River and Kaidu River,while the temperature had a positive impact on water flow in the Yarkant River.The results of Holt double exponential smoothing showed that the correlation between the independent variable and dependent variable was relatively close after the model was fitted to the headstreams,of which only the runoff and temperature values of Hotan River showed a significant negative correlation.The forecasts by the ARIMA model for 50 years of annual runoff at the Allar station followed the pattern of the measured data for the same years.The short-term forecasts beyond the observed series adequately captured the pattern in the data and showed a decreasing tendency in the Tarim River flow of 3.07% every ten years.The results showed that global warming accelerated the water recharge process of the headstreams.The special hydrological characteristics of the arid area determined the significant association between streamflow and the two climatic factors studied.Strong glacier retreat is likely to bring a series of flood disasters within the study area. | YuTing FAN YaNing CHEN WeiHong LI HuaiJun WANG XinGong LI | 2011 | Journal of Arid Land2011，3，3： | 13 |
| 11 | mTOR/miR-145-regulated exosomal GOLM1 promotes hepatocellular carcinoma through augmented GSK-3b/MMPs显示文摘Golgi membrane protein 1(GOLM1/GP73)is a serum marker of hepatocellular carcinoma(HCC).We have previously shown that mTOR promoted tumorigenesis of HCC through stimulating GOLM1 expression.In this study,we demonstrated that the mammalian target of rapamycin(mTOR)was a negative regulator of microRNA-145(miR-145)expression.miR-145 inhibited GOLM1 expression by targeting a coding sequence of GOLM1 gene.GOLM1 and miR-145 were inversely correlated in human HCC tissues.GOLM1-enriched exosomes activated the glycogen synthase kinase-3β/matrix metalloproteinases(GSK-3β/MMPs)signaling axis of recipient cells and accelerated cell proliferation and migration.In contrast,miR-145 suppressed tumorigenesis and metastasis.We suggest that mTOR/miR-145/GOLM1 signaling pathway should be targeted for HCC treatment. | Xiaochen Gai Bufu Tang Fangming Liu Yuting Wu Fang Wang Yanling Jing Fuqiang Huang Di Jin Ling Wang Hongbing Zhang | 2019 | Journal of Genetics and Genomics2019，46，5： | 13 |
| 12 | Development of a soil-plant-atmosphere continuum model (HDS-SPAC) based on hybrid dual-source approach and its verification in wheat field显示文摘HDS-SPAC,a new soil-plant-atmosphere continuum(SPAC) model,is developed for simulating water and heat transfer in SPAC.The model adopts a recently proposed hybrid dual source approach for soil evaporation and plant transpiration partitioning.For the above-ground part,a layer approach is used to partition available energy and calculate aerodynamic resistances,while a patch approach is used to derive sensible heat and latent heat fluxes from the two sources(soil and vegetation).For the below-ground part,soil water and heat dynamics are described by the mixed form of Richards equation,and the soil heat conductivity equation,respectively.These two parts are coupled through ground heat flux for energy transfer,root-zone water potential-dependent stomatal resistance,and surface soil water potential-dependent evaporation for water transfer.Evaporation is calculated from the water potential gradient at soil-atmosphere interface and aerodynamic resistance,and transpiration is determined using a Jarvis-type function linking soil water availability and atmospheric conditions.Some other processes,such as canopy interception and deep percolation,are also considered in the HDS-SPAC model.The hybrid dual-source approach allows HDS-SPAC to simulate heat and water transfer in an ecosystem with a large range of vegetation cover change temporally or spatially.The model was tested with observations at a wheat field in North China Plain over a time of three months covering both wet and dry conditions.The fractional crop covers change from 30% to over 90%.The results indicated that the HDS-SPAC model can estimate actual evaporation and transpiration partitioning and soil water content and temperature over the whole range of tested vegetation coverage. | YANG YuTing SHANG SongHao GUAN Huade | 2012 | Science China(Technological Sciences)2012，55，10： | 12 |
| 13 | Hydrological and water cycle processes of inland river basins in the arid region of Northwest China显示文摘The increasing shortage in water resources is a key factor affecting sustainable socio-economic development in the arid region of Northwest China(ARNC). Water shortages also affect the stability of the region's oasis ecosystem. This paper summarizes the hydrological processes and water cycle of inland river basins in the ARNC, focusing on the following aspects: the spatial-temporal features of water resources(including air water vapor resources, runoff, and glacial meltwater) and their driving forces; the characteristics of streamflow composition in the inland river basins; the characteristics and main controlling factors of baseflow in the inland rivers; and anticipated future changes in hydrological processes and water resources. The results indicate that:(1) although the runoff in most inland rivers in the ARNC showed a significant increasing trend, both the glaciated area and glacial ice reserves have been reduced in the mountains;(2) snow melt and glacier melt are extremely important hydrological processes in the ARNC, especially in the Kunlun and Tianshan mountains;(3) baseflow in the inland rivers of the ARNC is the result of climate change and human activities, with the main driving factors being the reduction in forest area and the over-exploitation and utilization of groundwater in the river basins; and(4) the contradictions among water resources, ecology and economy will further increase in the future. The findings of this study might also help strengthen the ecological, economic and social sustainable development in the study region. | CHEN Yaning LI Baofu FAN Yuting SUN Congjian FANG Gonghuan | 2019 | Journal of Arid Land2019，11，2： | 12 |
| 14 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 15 | Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis显示文摘Gouty arthritis is a very familiar inflammatory arthritis.Controlling inflammation is the key to preventing gouty arthritis.However,colchicine,the most highly represented drug used in clinical practice,has strict contraindications owing to some severe side effects.Curcumin(Cur),a natural anti-inflammatory drug,has demonstrated good safety and efficacy.However,the rapid degradation,poor aqueous solubility,and low bioavailability of Cur limit its therapeutic effect.To strengthen the effectiveness and bioavailability of Cur.Cur loaded tetrahedral framework nucleic acids(Cur-TFNAs)were synthesized to deliver Cur.Compared with free Cur,Cur-TFNAs exhibit a preferable drug stability,good biocompatibility(CCK-8 assay),ease of uptake(immunofluorescence),and higher tissue utilization(in vivo biodistribution).Most importantly,Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression.Therefore,we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases. | Mei Zhang Xiaolin Zhang Taoran Tian Qi Zhang Yuting Wen Junyao Zhu Dexuan Xiao Weitong Cui Yunfeng Lin | 2022 | Bioactive Materials2022，7，2： | 10 |
| 16 | A novel preparation of nanosized hexagonal Mg(OH)2 as a flame retardant显示文摘 | Yongbin Chen Tao Zhou Huaxiong Fang Simin Li Yuting Yao Bailin Fan Jian Wang | 2016 | Particuology2016，14，1： | 10 |
| 17 | Crack monitoring method based on Cu coating sensor and electrical potential technique for metal structure显示文摘Advanced crack monitoring technique is the cornerstone of aircraft structural health monitoring.To achieve real-time crack monitoring of aircraft metal structures in the course of service,a new crack monitoring method is proposed based on Cu coating sensor and electrical potential difference principle.Firstly,insulation treatment process was used to prepare a dielectric layer on structural substrate,such as an anodizing layer on 2A12-T4 aluminum alloy substrate,and then a Cu coating crack monitoring sensor was deposited on the structure fatigue critical parts by pulsed bias arc ion plating technology.Secondly,the damage consistency of the Cu coating sensor and2A12-T4 aluminum alloy substrate was investigated by static tensile experiment and fatigue test.The results show that strain values of the coating sensor and the 2A12-T4 aluminum alloy substrate measured by strain gauges are highly coincident in static tensile experiment and the sensor has excellent fatigue damage consistency with the substrate.Thirdly,the fatigue performance discrepancy between samples with the coating sensor and original samples was investigated.The result shows that there is no obvious negative influence on the fatigue performance of the 2A12-T4 aluminum alloy after preparing the Cu coating sensor on its surface.Finally,crack monitoring experiment was carried out with the Cu coating sensor.The experimental results indicate that the sensor is sensitive to crack,and crack origination and propagation can be monitored effectively through analyzing the change of electrical potential values of the coating sensor. | Hou Bo He Yuting Cui Ronghong Gao Chao Zhang Teng | 2015 | Chinese Journal of Aeronautics2015，28，3： | 10 |
| 18 | Electrochemical synthesis of nitric acid from air and ammonia through waste utilization显示文摘Commercial nitric acid(HNO3) and ammonia(NH3) are mostly produced through the Ostwald process and the Haber-Bosch process, respectively. However, high energy demand and enormous greenhouse gas accompy these processes. The development of economical and green ways to synthesize HNO3 and NH3 is highly desirable for solving the global energy and environmental crisis. Here, we present two energy-efficient and environmentally friendly strategies to synthesize HNO3 and NH3 at distributed sources, including the electrocatalytic oxidation of N2 in air to HNO3 and the electrocatalytic reduction of residual NO3- contamination in water to NH3. The isotope-labeling studies combined with theoretical calculation reveal the reaction path of the two proposed strategies, confirming the origin of the electrochemical products. Importantly, the electrooxidation-generated NO3- ions may also serve as reactants for the electroreduction synthesis of NH3 in the future. Our work may open avenues for energy-efficient and green production of HNO3 and NH3 at distributed sources. | Yuting Wang Yifu Yu Ranran Jia Chao Zhang Bin Zhang | 2019 | National Science Review2019，6，4： | 10 |
| 19 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 20 | Targeting and exploitation of tumor-associated neutrophils to enhance immunotherapy and drug delivery for cancer treatment显示文摘Neutrophils,the most abundant leukocytes in human blood,are essential fighter immune cells against microbial infection.Based on the finding that neutrophils can either restrict or promote cancer progression,tumor-associated neutrophils(TAN)are classified into anti-tumor N1 and pro-tumor N2 subsets.One of the major mechanisms underlying the tumor-promoting function of N2-TANs is suppression of adaptive immune cells,in particular,cytotoxic T lymphocytes.Currently,no established methodologies are available that can unequivocally distinguish immunosuppressive TANs and granulocytic/polymorphonuclear myeloid-derived suppressor cells(G/PMN-MDSC).In view of the critical role of PMN-MDSCs in immune evasion and resistance to cancer immunotherapy,as established from data obtained with diverse cancer models,therapeutic strategies targeting these cells have been actively developed to enhance the efficacy of immunotherapy.Here,we have reviewed the available literature on strategies targeting PMN-MDSCs and summarized the findings into four categories:(1)depletion of existing PMN-MDSCs,(2)blockade of the development of PMNMDSCs,(3)blockade of PMN-MDSC recruitment,(4)inhibition of immunosuppressive function.Owing to their high mobility to inflamed organs and ability to trespass the blood-brain barrier,neutrophils are outstanding candidate carriers in nanoparticle-based therapies.Another attractive application of neutrophils in cancer therapy is the use of neutrophil membrane-derived nanovesicles as a surrogate of extracellular vesicles for more efficient and scalable drug delivery.In the second part of the review,we have highlighted recent advances in the field of neutrophil-based cancer drug delivery.Overall,we believe that neutrophil-based therapeutics are a rapidly growing area of cancer therapy with significant potential benefits. | Yuting Zhang Guoqiang Liu Miaomiao Sun Xin Lu | 2020 | Cancer Biology & Medicine2020，17，1： | 9 |
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