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| 1 | Advancedendoscopicsubmucosaldissectionwithtraction显示文摘Endoscopic submucosal dissection (ESD) has been established as a standard treatment for early stage gastric cancer (EGC) in Japan and has spread worldwide. ESD has been used not only for EGC but also for early esophageal and colonic cancers. However, ESD is as-sociated with several adverse events, such as bleeding and perforation, which requires more skill. Adequate tissue tension and clear visibility of the tissue to be dissected are important for effective and safe dissection. Many ESD methods using traction have been devel-oped, such as clip-with-line method, percutaneous trac-tion method, sinker-assisted method, magnetic anchor method, external forceps method, internal-traction method, double-channel-scope method, outerroute method, double-scope method, endoscopic-surgical-platform, and robot-assisted method. Each method has both advantages and disadvantages. Robotic endos-copy, enabling ESD with a traction method, will become more common due to advances in technology. In thenear future, simple, noninvasive, and effective ESD us-ing traction is expected to be developed and become established as a worldwide standard treatment for superficial gastrointestinal neoplasias. | Imaeda H Hosoe N Kashiwagi K Ohmori T Yahagi N Kanai T Ogata H | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 24 |
| 2 | 直肠上皮瘤行内镜黏膜下层切除术 | Fujishiro M. Yahagi N. Nakamura M. 程妍 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，10： | 21 |
| 3 | 流血和与内视镜的 submucosal 解剖联系的人工的胃的溃疡的管理显示文摘 Endoscopic submucosal dissection (ESD), an endoscopic procedure for the treatment of gastric epithelial neoplasia without lymph node metastases, spread rapidly, primarily in Japan, starting in the late 1990s. ESD enables en bloc resection of lesions that are difficult to resect using conventional endoscopic mucosal resection (EMR). However, in comparison to EMR, ESD requires a high level of endoscopic competence and a longer resection time. Thus, ESD is associated with a higher risk of adverse events, including intraoperative and postoperative bleeding and gastrointestinal perforation. In particular, because of a higher incidence of intraoperative bleeding with mucosal incision and submucosal dissection, which are distinctive endoscopic procedures in ESD, a strategy for endoscopic hemostasis, mainly by thermo-coagulation hemostasis using hemostatic forceps, is important. In addition, because of iatrogenic artificial ulcers that always form after ESD, endoscopic hemostasis and appropriate pharma-cotherapy during the healing process are essential. | Yosuke Muraki Shotaro Enomoto Mikitaka Iguchi Mitsuhiro Fujishiro Naohisa Yahagi Masao Ichinose | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，1： | 14 |
| 4 | Endoscopic mucosal resection and endoscopic submucosal dissection in the treatment of sporadic nonampullary duodenal adenomatous polyps显示文摘Although uncommon, sporadic nonampullary duodenal adenomas have a growing detection due to the widespread of endoscopy. Endoscopic therapy is being increasingly used for these lesions, since surgery, considered the standard treatment, carries significant morbidity and mortality. However, the knowledge about its risks and benefits is limited, which contributes to the current absence of standardized recommendations. This review aims to discuss the efficacy and safety of endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) in the treatment of these lesions. A literature review was performed, using the Pubmed database with the query: '(duodenum or duodenal)(endoscopy or endoscopic) adenoma resection', in the human species and in English. Of the 189 retrieved articles, and after reading their abstracts, 19 were selected due to their scientific interest. The analysis of their references, led to the inclusion of 23 more articles for their relevance in this subject. The increased use of EMR in the duodenum has shown good results with complete resection rates exceeding 80% and low complication risk(delayed bleeding in less than 12% of the procedures). Although rarely used in the duodenum, ESD achieves close to 100% complete resection rates, but is associated with perforation and bleeding risk in up to one third of the cases. Even though literature is insufficient to draw definitive conclusions, studies suggest that EMR and ESD are valid options for the treatment of nonampullary adenomas. Thus, strategies to improve these techniques, and consequently increase the effectiveness and safety of the resection of these lesions, should be developed. | Joana Marques Francisco Baldaque-Silva Pedro Pereira Urban Arnelo Naohisa Yahagi Guilherme Macedo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 13 |
| 5 | What are the latest developments in colorectal endoscopic submucosal dissection?显示文摘Endoscopic submucosal dissection (ESD) enables direct submucosal dissection so that even large early-stage gastrointestinal tumors can be resected en bloc . ESD has recently been applied to the colorectum since it was originally developed for use in the stomach. However, colorectal ESD is technically more difficult with an increased risk of perforation compared with gastric ESD. In addition, this procedure is seldom performed in Western countries. Consequently, further technical advances and the availability of a suitable clinical training system are required for the extensive use of colorectal ESD. In this topic highlight, we review the most recent developments in colorectal ESD. | Toshio Uraoka Yutaka Saito Naohisa Yahagi | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 8 |
| 6 | Cutting edge of endoscopic full-thickness resection for gastric tumor显示文摘Recently,several studies have reported local full-thickness resection techniques using flexible endoscopy for gastric tumors,such as gastrointestinal stromal tumors,gastric carcinoid tumors,and early gastric cancer(EGC). These techniques have the advantage of allowing precise resection lines to be determined using intraluminal endoscopy. Thus,it is possible to minimize the resection area and subsequent deformity. Some of these methods include:(1) classical laparoscopic and endoscopic cooperative surgery(LECS);(2) inverted LECS;(3) combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique; and(4) non-exposed endoscopic wall-inversion surgery. Furthermore,a recent prospective multicenter trial of the sentinel node navigation surgery(SNNS) for EGC has shown acceptable results in terms of sentinel node detection rate and the accuracy of nodal metastasis. Endoscopic full-thickness resection with SNNS is expected to become a treatment option that bridges the gap between endoscopic submucosal dissection and standard surgery for EGC. In the future,the indications for these procedures for gastric tumors could be expanded. | Tadateru Maehata Osamu Goto Hiroya Takeuchi Yuko Kitagawa Naohisa Yahagi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，16： | 4 |
| 7 | How to establish endoscopic submucosal dissection in Western countries显示文摘Endoscopic submucosal dissection(ESD) has been invented in Japan to provide resection for cure of early cancer in the gastrointestinal tract. Professional level of ESD requires excellent staging of early neoplasias with image enhanced endoscopy(IEE) to make correct indications for ESD,and high skills in endoscopic electrosurgical dissection. In Japan,endodiagnostic and endosurgical excellence spread through personal tutoring of skilled endoscopists by the inventors and experts in IEE and ESD. To translocate this expertise to other continents must overcome two fundamental obstacles:(1) inadequate expectations as to the complexity of IEE and ESD; and(2) lack of suitable lesions and master-mentors for ESD trainees. Leading endoscopic mucosal resection-proficient endoscopists must pioneer themselves through the long learning curve to proficient ESD experts. Major referral centers for ESD must arise in Western countries on comparable professional level as in Japan. In the second stage,the upcoming Western experts must commit themselves to teach skilled endoscopists from other referral centers,in order to spread ESD in Western countries. Respect for patients with early gastrointestinal cancer asks for best efforts to learn endoscopic categorization of early neoplasias and skills for ESD based on sustained cooperation with the masters in Japan. The strategy is discussed here. | Tsuneo Oyama Naohisa Yahagi Thierry Ponchon Tobias Kiesslich Frieder Berr | 2015 | World Journal of Gastroenterology2015，21，40： | 3 |
| 8 | Endoscopic removal of foreign bodies:A retrospective study in Japan显示文摘BACKGROUND The ingestion of foreign bodies(FBs)and food bolus impaction(FBI)in the digestive tract are commonly encountered clinical problems.Methods to handle such problems continue to evolve offering advantages,such as the avoidance of surgery,reduced cost,improved visualization,reduced morbidity,and high removal success rate.However,to date,no studies have evaluated the endoscopic management of FBs in Japan.AIM To elucidate level of safety and efficacy in the endoscopic management of FBs and FBI.METHODS A total of 215 procedures were performed at Keio University Hospital between November 2007 and August 2018.Data were collected from medical charts,and endoscopic details were collected from an endoscopic reporting system.Procedures performed with a flexible gastrointestinal endoscope were only taken into account.Patients who underwent a technique involving FB or FBI from the digestive tract were only included.Data on patient sex,patient age,outpatient,inpatient,FB type,FB location,procedure time,procedure type,removal device type,success,and technical complications were reviewed and analyzed retrospectively.RESULTS Among the 215 procedures,136(63.3%)were performed in old adults(≥60 years),180(83.7%)procedures were performed in outpatients.The most common type of FBs were press-through-pack(PTP)medications[72(33.5%)cases],FBI[47(21.9%)],Anisakis parasite(AP)[41(19.1%)cases].Most FBs were located in the esophagus[130(60.5%)cases]followed by the stomach[68(31.6%)cases].AP was commonly found in the stomach[39(57.4%)cases],and it was removed using biopsy forceps in 97.5%of the cases.The most common FBs according to anatomical location were PTP medications(40%)and dental prostheses(DP)(40%)in the laryngopharynx,PTP(48.5%)in the esophagus,AP(57.4%)in the stomach,DP(37.5%)in the small intestine and video capsule endoscopy device(75%)in the colon.A transparent cap with grasping forceps was the most commonly used device[82(38.1%)cases].The success rate of the procedure was 100%,and complication were observed in only one case(0.5%).CONCLUSION Endoscopic management of FBs and FBI in our Hospital is extremely safe and effective. | Kenji JL Limpias Kamiya Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Xi Sun Ryoichi Miyanaga Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Atsushi Nakayama Motohiko Kato Tadateru Maehata Rieko Nakamura Koichi Ueno Junichi Sasaki Yuko Kitagawa Naohisa Yahagi Haruhiko Ogata Takanori Kanai | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，1： | 3 |
| 9 | Percutaneous endoscopic gastrostomy under steadypressure automatically controlled endoscopy:First clinicalseries显示文摘AIM: To elucidate the safety of percutaneous endoscopic gastrostomy(PEG) under steady pressure automatically controlled endoscopy(SPACE) using carbon dioxide(CO_2).METHODS: Nine patients underwent PEG with a modified introducer method under conscious sedation. A T-tube was attached to the channel of an endoscope connected to an automatic surgical insufflator. The stomach was inflated under the SPACE system. The intragastric pressure was kept between 4-8 mmH g with a flow of CO_2 at 35 L/min. Median procedure time, intragastric pressure, median systolic blood pressure, partial pressure of CO_2, abdominal girth before and immediately after PEG, and free gas and small intestinal gas on abdominal X-ray before and after PEG were recorded. RESULTS: PEG was completed under stable pneumostomach in all patients, with a median procedural time of 22 min. Median intragastric pressure was 6.9 mmH g and median arterial CO_2 pressure before and after PEG was 42.1 and 45.5 Torr(NS). The median abdominal girth before and after PEG was 68.1 and 69.6 cm(NS). A mild free gas image after PEG was observed in two patients, and faint abdominal gas in the downstream bowel was documented in two patients.CONCLUSION: SPACE might enable standardized pneumostomach and modified introducer procedure of PEG. | Hiroyuki Imaeda Kiyokazu Nakajima Naoki Hosoe Masanori Nakahara Shinichiro Zushi Motohiko Kato Kazuhiro Kashiwagi Yasushi Matsumoto Kayoko Kimura Rieko Nakamura Norihito Wada Masahiko Tsujii Naohisa Yahagi Toshifumi Hibi Takanori Kanai Tetsuo Takehara Haruhiko Ogata | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 2 |
| 10 | Endoscopic Submucosal Dissection of Esophageal Squamous Cell Neoplasms显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Yasuhito Shimizu Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2006 | Clinical Gastroenterology and Hepatology2006，，6： | 2 |
| 11 | Outcomes of Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms in 200 Consecutive Cases显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 2 |
| 12 | Cold polypectomy techniques for diminutive polyps in the colorectum显示文摘 | Toshio Uraoka Hemchand Ramberan Takahisa Matsuda Takahiro Fujii Naohisa Yahagi | 2014 | Digestive Endoscopy2014，，： | 2 |
| 13 | Endoscopic submucosal dissection for nonampullary large superficial adenocarcinoma/adenoma of the duodenum: feasibility and long-term outcomes显示文摘 | Shu Hoteya Naohisa Yahagi Toshiro Iizuka Daisuke Kikuchi Toshifumi Mitani Akira Matsui Osamu Ogawa Satoshi Yamashita Tsukasa Furuhata Akihiro Yamada Ryusuke Kimura Kosuke Nomura Yasutaka Kuribayashi Mitsuru Kaise | 2013 | EIO2013，，01： | 2 |
| 14 | JGES guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection显示文摘 | Shinji Tanaka Hiroshi Kashida Yutaka Saito Naohisa Yahagi Hiroo Yamano Shoichi Saito Takashi Hisabe Takashi Yao Masahiko Watanabe Masahiro Yoshida Shin‐ei Kudo Osamu Tsuruta Ken‐ichi Sugihara Toshiaki Watanabe Yusuke Saitoh Masahiro Igarashi Takashi Toyon | 2015 | Digestive Endoscopy2015，，4： | 2 |
| 15 | Delayed bleeding after endoscopic submucosal dissection for non‐ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure: Analysis of risk factors显示文摘 | Shu Hoteya Mitsuru Kaise Toshiro Iizuka Osamu Ogawa Toshifumi Mitani Akira Matsui Daisuke Kikuchi Tsukasa Furuhata Satoshi Yamashita Akihiro Yamada Ryusuke Kimura Kousuke Nomura Yasutaka Kuribayashi Yoshifumi Miyata Naohisa Yahagi | 2015 | Digestive Endoscopy2015，，3： | 2 |
| 16 | Lathyrane diterpenes fromEuphorbia lathyris显示文摘 | H Itokawa Y Ichihara M Yahagi | 1990 | Phy tochemistry1990，29，6： | 1 |
| 17 | Successful endoscopic en bloc resection of a large laterally spreading turnout in the rectosimoid junction by endoscopic submucosal dissection显示文摘 | FUJISHIRO M YAHAGI N KAKUSHIMA N | 2006 | Gastrointestinal Endoscopy2006，1，： | 1 |
| 18 | Polyunsaturated fatty acids suppress sterol regulatory elementbinding protein lc promoter activity by inhibition of liver x receptor(LXR) binding to LXR response elements显示文摘 | YOSHIKAWA T SHIMANO H YAHAGI N | 2002 | Biological Chemisry2002，277，3： | 1 |
| 19 | Quasi-microwave-range inductors covered with Co-based magnetic thin films显示文摘 | SATIO T TSUTI K YAHAGI S | 1999 | IEEE Trans Magn1999，35，5： | 1 |
| 20 | Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression显示文摘 | Sekiya M Yahagi N Matsuzaka T | 2003 | Hepatology2003，38，6： | 1 |
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