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| 1 | Controlling N-doping type in carbon to boost single-atom site Cu catalyzed transfer hydrogenation of quinoline显示文摘Single-atom site(SA)catalysts on N-doped carbon(CN)materials exhibit prominent performance for their active sites being M-Nx.Due to the commonly random doping behaviors of N species in these CN,it is a tough issue to finely regulate their doping types and clarify their effect on the catalytic property of such catalysts.Herein,we report that the N-doping type in CN can be dominated as pyrrolic-N and pyridinic-N respectively through compounding with different metal oxides.It is found that the proportion of distinct doped N species in CN depends on the acidity and basicity of compounded metal oxide host.Owing to the coordination by pyrrolic-N,the SA Cu catalyst displays an enhanced activity(two-fold)for transfer hydrogenation of quinoline to access the valuable molecule tetrahydroquinoline with a good selectivity(99%)under mild conditions.The higher electron density of SA Cu species induced by the predominate pyrrolic-N coordination benefits the hydrogen transfer process and reduces the energy barrier of the hydrogenation pathway,which accounts for the improved catalytic effeciency. | Jian Zhang Caiyan Zheng Maolin Zhang Yajun Qiu Qi Xu Weng-Chon Cheong Wenxing Chen Lirong Zheng Lin Gu Zhengpeng Hu Dingsheng Wang Yadong Li | 2020 | Nano Research2020，13，11： | 29 |
| 2 | Clinical features and treatment status of hemifacial spasm in China显示文摘 | Wang Lin Hu Xingyue Dong Hongjuan Wang Wenzhao Huang Yue Jin Lingjing Luo Yumin Zhang Weixi Lian Yajun Liang Zhanhua Shang Huifang Feng Yabo wu Yiwen Chen Jun Luo Weifeng Wan Xinhua | 2014 | Chinese Medical Journal2014，，5： | 20 |
| 3 | Groundwater hydrochemistry and isotope geochemistry in the Turpan Basin, northwestern China显示文摘The Turpan Basin is located in the arid zone of northwestern China and is a typical closed inland basin surrounded by high mountains. It is one of the most arid regions in the world and, as a result, the groundwater in this area is very important for both domestic and agricultural uses. In the present study, the relationships of major elements(K+, Na+, Ca2+, Mg2+, HCO3-, SO42- and Cl-) and environmental isotopes(δ18O, δ2H and T) in groundwater were analyzed to investigate the evolution of the regional hydrochemistry within the Turpan Basin. The hydrochemistry results demonstrate that groundwater with high total dissolved solids(TDS) concentration is dominated by sodium chloride(Na-Cl) and sodium sulfate(Na-SO4) type water, whereas that with low TDS concentration(typically from near mountain areas) is dominated by calcium bicarbonate(Ca-HCO3) type water. The evolution of groundwater hydrochemistry within the Turpan Basin is a result of calcium carbonate precipitation, evaporation concentration, cation exchange and dissolution of evaporites(i.e. halite, mirabilite and gypsum). Furthermore, evaporite dissolution associated with irrigation practice plays a key role in the groundwater salinization, especially in the central part of the basin. Environmental isotopes reveal that the groundwater is recharged by precipitation in the mountain areas and fast vertical infiltration of irrigation return flow. In the southern sub-basin the shallow groundwater and the deep groundwater is separated at a depth of about 40 m, with substantial differences in terms of hydrochemical and isotopic characteristics. The results are useful for decision making related to sustainable water resource utilization in the Turpan Basin and other regions in northwestern China. | Lu CHEN GuangCai WANG FuSheng HU YaJun WANG Liang LIU | 2014 | Journal of Arid Land2014，6，4： | 13 |
| 4 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 5 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 6 | 2.7 Ga Monzogranite on the Songnen Massif and Its Geological Implications显示文摘The formation and evolution of Songnen massif hasalways been a hot topic, and the presence of Precambrianbasement on the Songnen massif is still controversial: (1)Lacking of Pre-Paleozoic dating results, the Precambrianbasement on Songnen massif does not extend largelyaccording to the isotopic dating results of core frombasement, (2) the existence of gneiss from deep drill holesof the Songliao Basin makes some researchers considerthat Precambrian basement should exist on the Songnenmassif and another proof is that the geophysical featuresof gravity. | WU Xinwei ZHANG Chao ZHANG Yujin GUO Wei ZHANG Chao CUI Tianri YANG Yajun HU Jianfei SONG Wanbing | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 8 |
| 7 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 8 | Sedimentary geochemistry and provenance of the Lower and Middle Devonian Laojunshan Formation,the North Qilian Orogenic Belt显示文摘The Laojunshan Formation is a suite of molasse formed during the rapid uplift of the North Qilian Orogenic Belt (NQOB). Forty-one samples of sandstone have been collected from the Sunan and Minle sections in the western sector and the Gulang and Jingyuan sections in the eastern sector of the NQOB belt. Geochemical analyses of those samples indicated: 1) The MgO+Fe2O3T and Al2O3/SiO2 values are higher, and K2O/Na2O ratios are lower in the western sector than those in the eastern sector. 2) All of them are depleted in Nb and Ta elements. The samples from the western sector are depleted in Rb element and enriched with Sc, Co, Ni, V, and Cr elements in the Upper Crust-normalized patterns. However, those from the eastern sector are depleted in Sr without enrichments of Sc, Co, Ni, V, and Cr. 3) All of the samples display a right-inclined REE pattern af- ter Chondrite-normalized REE pattern. But LaN/YbN and Eu/Eu* ratios of the samples from the western sector are lower than those of the samples from the eastern sector. These geochemical characteristics suggest the prominent input of mafic clast with minor granitic rocks into the Sunan area, felsic clast into the Gulang and Jingyuan area, and both mafic and felsic clast into the Minle area. The angular shapes of gravels imply that these ill-sorted sediments were deposited near their sources without recy- cling. Geochemical features above also demonstrated that no major chemical weathering occurred for the western provenance, but deposits in the eastern sector resulted from low or middle degree chemical weathering. Evidences combining tectonic discriminations and comparisons with potential provenances revealed that sediments in the Sunan area were derived mainly from the North Qilian Continental arc, whereas sediments in the Minle, Gulang, and Jingyuan areas were derived not only from the North Qilian Continental arc but also from the basement of the Middle Qilian block. Integrated with the characteristics of development of Silurian and Devonian, these imply that the orogeny of NQOB is diachronous in the trending direction due to the oblique collision. | XU YaJun DU YuanSheng YANG JiangHai HUANG Hu | 2010 | Science China Earth Sciences2010，53，3： | 7 |
| 9 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 10 | Soil phosphorus availability and rice phosphorus uptake in paddy fields under various agronomic practices显示文摘Agronomic practices affect soil phosphorus(P) availability, P uptake by plants, and subsequently the efficiency of P use. A field experiment was carried out to investigate the effects of various agronomic practices(straw incorporation, paddy water management, nitrogen(N) fertilizer dose, manure application,and biochar addition) on soil P availability(e.g., soil total P(STP), soil available P(SAP), soil microbial biomass P(SMBP), and rice P uptake as well as P use efficiency(PUE)) over four cropping seasons in a rice-rice cropping system, in subtropical central China. Compared to the non-straw treatment(control,using full dose of chemical N fertilizer), straw incorporation increased SAP and SMBP by 9.3%–18.5% and 15.5%–35.4%, respectively;substituting half the chemical N fertilizer dose with pig manure and the biochar application increased STP, SAP, and SMBP by 10.5%–48.3%, 30.2%–236.0%, and 19.8%–72.4%,respectively, mainly owing to increased soil P and organic carbon inputs;adding a half dose of N and no N input(reduced N treatments) increased STP and SAP by 2.6%–7.5% and 19.8%–33.7%, respectively, due to decreased soil P outputs. Thus, soil P availability was greatly affected by soil P input and use. The continuous flooding water regime without straw addition significantly decreased SMBP by 11.4% compared to corresponding treatments under a mid-season drainage water regime. Total P uptake by rice grains and straws at the harvest stage increased under straw incorporation and under pig manure application, but decreased under the reduced N treatments and under biochar application at a rate of 48 t ha-1, compared to the control. Rice P uptake was significantly positively correlated with rice biomass, and both were positively correlated with N fertilizer application rates, SAP, SMBP, and STP. Phosphorus use efficiency generally increased under straw incorporation but decreased under the reduced N treatments and under the manure application(with excessive P input), compared to the control. These results showed that straw incorporation can be used to increase soil P availability and PUE while decreasing the use of chemical P fertilizers. When substituting chemical fertilizers with pig manure, excess P inputs should be avoided in order to reduce P accumulation in the soil as well as the environmental risks from non-point source pollution. | Bingshen JIANG Jianlin SHEN Minghong SUN Yajun HU Wenqian JIANG Juan WANG Yong LI Jinshui WU | 2021 | Pedosphere2021，31，1： | 6 |
| 11 | Research and development of new neodymium laser glasses显示文摘This work presents a brief introduction on three kinds of newly developed Nd^(3+)-doped laser glasses in Shanghai Institute of Optics and Fine Mechanics(SIOM), China. Two Nd^(3+)-doped phosphate glasses with lower thermal expansion coefficient and thermal shock resistance 4 times higher than that of N31 glass are developed for laser processing.Nd:Silicate and Nd:Aluminate glasses with peak emission wavelength at 1061 and 1065 nm, effective emission bandwidth of 34 and 50 nm, respectively, are developed for Exawatt-class laser system application. Fluorophosphate glasses with low nonlinear refractive index(n_2=0.6–0.86) and long fluorescence lifetime(430–510 μs) are investigated for the purpose of decreasing B integral in high-power laser system. The properties of all these glasses are presented and compared with those of commercial neodymium laser glasses. | Dongbing He Shuai Kang Liyan Zhang Lin Chen Yajun Ding Qianwen Yin Lili Hu | 2017 | High Power Laser Science and Engineering2017，5，1： | 6 |
| 12 | Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model显示文摘Background:The intestinal barrier integrity can be disrupted due to burn injury,which is responsible for local and systemic inflammatory responses.Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade at an early stage.Interleukin-17A(IL-17A)plays a critical role in inflammatory diseases.However,the role of IL-17A in the progression of burn-induced intestinal inflammation is poorly understood.In this study,we aimed to investigate the effect of IL-17A and associated pro-inflammatory cytokines that were deeply involved in the pathogenesis of burn-induced intestinal inflammatory injury,and furthermore,we sought to determine the early source of IL-17A in the intestine.Methods:Mouse burn model was successfully established with infliction of 30%total body surface area scald burn.The histopathological manifestation,intestinal permeability,zonula occludens-1 expression,pro-inflammatory cytokines were determined with or without IL-17A-neutralization.Flow cytometry was used to detect the major source of IL-17A^(+)cells in the intestine.Results:Burn caused intestinal barrier damage,increase of intestinal permeability,alteration of zonula occludens-1 expressions,elevation of IL-17A,IL-6,IL-1βand tumor necrosis factor-α(TNF-α),whereas IL-17A neutralization dramatically alleviated burn-induced intestinal barrier disruption,maintained zonula occludens-1 expression,and noticeably,inhibited pro-inflammatory cytokines elevation.In addition,we observed that the proportion of intestinal IL-17A^(+)Vγ4^(+)T subtype cells(but not IL-17A^(+)Vγ1^(+)T subtype cells)were increased in burn group,and neutralization of IL-17A suppressed this increase.Conclusions:The main original findings of this study are intestinal mucosa barrier is disrupted after burn through affecting the expression of pro-inflammatory cytokines,and a protective role of IL-17A neutralization for intestinal mucosa barrier is determined.Furthermore,Vγ4^(+)T cells are identified as the major early producers of IL-17A that orchestrate an inflammatory response in the burn model.These data suggest that IL-17A blockage may provide a unique target for therapeutic intervention to treat intestinal insult after burn. | Yajun Song Yang Li Ya Xiao Wengang Hu Xu Wang Pei Wang Xiaorong Zhang Jiacai Yang Yong Huang Weifeng He Chibing Huang | 2019 | Burns & Trauma2019，7，1： | 5 |
| 13 | The molecular diversity of arbuscular mycorrhizal fungi in the arsenic mining impacted sites in Hunan Province of China显示文摘Arbuscular mycorrhizal fungi(AMF) can establish a mutualistic association with most terrestrial plants even in heavy metal contaminated environments. It has been documented that high concentrations of toxic metals, such as arsenic(As) in soil could adversely affect the diversity and function of AMF. However, there are still gaps in understanding the community composition of AMF under long-term As contaminations. In the present study, six sampling sites with different As concentrations were selected in the Realgar mining area in Hunan Province of China. The AMF biodiversity in the rhizosphere soils of the dominant plant species was investigated by sequencing the nuclear small subunit ribosomal RNA(SSU rR NA) gene fragments using 454-pyrosequencing technique. A total of 11 AMF genera were identified,namely Rhizophagus, Glomus, Funneliformis, Acaulospora, Diversispora, Claroideoglomus, Scutellopora,Gigaspora, Ambispora, Praglomus, and Archaeospora, among which Glomus, Rhizophagus, and Claroideoglomus clarodeum were detected in all sampling sites, and Glomus was the dominant AMF genus in the Realgar mining area. Redundancy analysis indicated that soil pH, total As and Cd concentrations were the main factors influencing AMF community structure. There was a negative correlation between the AMF species richness and the total As concentration in the soil,but no significant correlation between the Shannon–Wiener index of the AMF and plants. Our study showed that high As concentrations can exert a selective effect on the AMF populations. | Yuqing Sun Xin Zhang Zhaoxiang Wu Yajun Hu Songlin Wu Baodong Chen | 2016 | Journal of Environmental Sciences2016，28，1： | 4 |
| 14 | A synthesis pattern of acoustic field produced by phased array based on the direct weighting of the controlled acoustic pressure显示文摘为了优化声学的地,有效地由分阶段执行的数组生产了,快速,以前建议的伪逆方法被简化。用到控制健全压力的振幅和阶段的赔偿的一个方法的健全压力的一个近似重量公式被介绍。一块多重焦点的地模式能被预先装置控制健全压力的价值基于伪逆矩阵算法获得。由 16 x 16 个方形的元素组成的一个分阶段执行的数组被用于数字模拟。声学的精力能有效地在需要的点被扔的结果表演,和声学的地能用健全压力的直接重量公式快速被综合。这研究可以为在超声过高热控制声学的地的分发提供一个有效方法。 | HU Jiwen QIAN Shengyou DING Yajun | 2012 | Chinese Journal of Acoustics2012，31，1： | 3 |
| 15 | Identification and bioinformatics analysis of lactate dehydrogenase genes from Echinococcus granulosus显示文摘Objective:To identify full length cDNA sequence of lactate dehydrogenase(LDH) from adult Echinococcus granulosus(E.granulosus) and to predict the structure and function of its encoding protein using bioinformatics methods.Methods:With the help of NCBI,EMBI, Expasy and other online sites,the open reading frame(ORF),conserved domain,physical and chemical parameters,signal peptide,epitope,topological structures of the protein sequences were predicted and a homology tertiary structure model was created:Vector NT1 software was used for sequence alignment,phylogenetic tree construction and tertiary structure prediction. Results:The target sequence was 1 233 bp length with a 996 bp biggest ORF encoding 331 amino acids protein with typical L-LDH conserved domain.It was confirmed as full length cDNA of LDH from E.granulosus and named as EgLDH(GenBank accession number:HM748917).The predicted molecular weight and isoelectric point of the deduced protein were 3 5516.2Da and 6.32 respectively.Compared with LDHs from Taenia solium,Taenia saginata asiatica,Spirometra erinaceieuropaei.Schistosoma japonicum,Clonorchis sinensis and human,it showed similarity of 86% ,85% ,55% ,58% ,58% and 53% ,respectively.EgLDH contained 3 putative transmembrane regions and 4 major epitopes(54aa-59aa.81aa-87aa,97aa-102aa,307aa-313aa),the latter were significant different from the corresponding regions of human LDH.In addition,some NAD and substrate binding sites located on epitopes 54aa-59aa and 97aa-102aa,respectively.Tertiary structure prediction showed that 3 key catalytic residues 105R,165D and 192H forming a catalytic center near the epitope 97aa-102aa,most NAD and substrate binding sites located around the center.Conclusions:The full length cDNA sequences of EgLDH were identified.It encoded a putative transmembrane protein which might be an ideal target molecule for vaccine and drugs. | Gang Lu Yajun Lu Lihua Li Lixian Wu Zhigang Fan Dazhong Shi Hu Wang Xiumin Han | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 2 |
| 16 | FRACTAL ANALYSES OF DIRECTIONAL SOLIDIFICATION BEHAVIOR OF A Ni-BASE SUPERALLOY显示文摘The morphology of solid/liquid interface of a directionally solidification process is describedby means of fractal analysis,and the relations among the fractal dimension of the solid/liq-uid interface,solidification rate,dendrite arm space and the phosphorus content of the test al-loys have been given.It was found that the increase of the solidification rate and the phos-phorus content of the test alloy will lead to a increase,following the regularity of exponentialfunction,in the fractal dimension of solid/liquid interface.Furthermore,by combining thefractal theory and the thermodynamic principle with the measured results,it has been provedthat the fractal dimension is not only a kind of simple geometrical parameter used in des-cribing irregular geometry,but also a state function depending the change of solidificationparameters and chemical compositions. | SUN Liling DONG Lianke ZHANG Jishan TANG Yajun ZHANG Jinghua HU Zhuangqi Institute of Metal Research,Academia Sinica,Shenyang,China SUN Liling,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，5： | 2 |
| 17 | Study on Soil Improvement Measure of Plant Landscape Construction in Saline and Alkaline Area in Tianjin显示文摘A detailed research in soil improving measure was conducted during the process of plants that were cultivated in Tianjin saline and alkaline area. The results showed that the commonly used measures could improve the soil, and also we got some useful advices and suggestions for plants cultivating in Tianjin saline and alkaline areas. | GENG Meiyun CHEN Yajun HU Haihui YU Lei | 2006 | Journal of Northeast Agricultural University(English Edition)2006，13，2： | 2 |
| 18 | Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms显示文摘Heart failure is the leading cause of death worldwide.Compound Danshen Dripping Pill(CDDP)or CDDP combined with simvastatin has been widely used to treat patients with myocardial infarction and other cardiovascular diseases in China.However,the effect of CDDP on hypercholesterolemia/atherosclerosis-induced heart failure is unknown.We constructed a new model of heart failure induced by hypercholesterolemia/atherosclerosis in apolipoprotein E(ApoE)and LDL receptor(LDLR)dual deficient(ApoE^(–/–)LDLR^(–/–))mice and investigated the effect of CDDP or CDDP plus a low dose of simvastatin on the heart failure.CDDP or CDDP plus a low dose of simvastatin inhibited heart injury by multiple actions including anti-myocardial dysfunction and anti-fibrosis.Mechanistically,both Wnt and lysine-specific demethylase 4A(KDM4A)pathways were significantly activated in mice with heart injury.Conversely,CDDP or CDDP plus a low dose of simvastatin inhibited Wnt pathway by markedly up-regulating expression of Wnt inhibitors.While the anti-inflammation and anti-oxidative stress by CDDP were achieved by inhibiting KDM4A expression and activity.In addition,CDDP attenuated simvastatin-induced myolysis in skeletal muscle.Taken together,our study suggests that CDDP or CDDP plus a low dose of simvastatin can be an effective therapy to reduce hypercholesterolemia/atherosclerosis-induced heart failure. | Yanfang Yang Ke Feng Liying Yuan Yuxin Liu Mengying Zhang Kaimin Guo Zequn Yin Wenjia Wang Shuiping Zhou He Sun Kaijing Yan Xijun Yan Xuerui Wang Yajun Duan Yunhui Hu Jihong Han | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 19 | Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection显示文摘Circulating peptide is a potential source of biomarkers for cancer detection.However,the existence of large molecular weight proteins in plasma have a disastrous effect on circulating peptides isolating and detecting.Herein,nanotrap fractionation following by mass spectrometry have been applied to quantify the levels of bradykinin (BK) and hydroxylated bradykinin (Hyp-BK) as a relative measure of KRAS-regulated prolyl-4-hydroxylase alpha-1 (P4HA1) which may serve as early diagnosis marker for pancreatic ductal adenocarcinoma (PDAC).We found that P4HA1 can be upregulated by KRASG12v,which is a PDAC driver mutation,using HPNE/KRAS and HPNE cells.And we revealed that P4HA1 is overexpressed in PDAC tumors,compared to normal and inflamed pancreatic tissues.RNA interference revealed that P4HA1 activity was primarily responsible for Hyp-BK production.Mass spectrometry analysis revealed that plasma Hyp-BK/BK ratio was higher in PDAC than pancreatitis patients and healthy controls,while the area under the receiver operating characteristic (ROC) curve (AUC) is 0.8209 (95%Cl,0.7269-0.9149).The Hyp-BK/BK association with PDAC was reproduced in another cohort,where this ratio was found to increase with advancing tumor stage.These novel findings paved the way for wider applications of Nanotrap coupled mass spectrometry as a powerful tool for revealing biosignatures from plasma. | Zaian Deng Zhen Zhao Bo Ning Jeffery Basilio Karen Mann Jie Fu Yajun Gu Yuanqing Ye Xifeng Wu Jia Fan Paul Chiao Tony Hu | 2019 | Nano Research2019，12，6： | 2 |
| 20 | Detrital zircon of 4.1 Ga in South China显示文摘One hadean zircon from the Cambrian sandstone in the southern part of South China has a U-Pb age of 4107±29 Ma with ε Hf(t) value similar to that of the homochronous depleted mantle and Hf model age of 4102±21 Ma.This demonstrates the existence of hadean crustal remnant in South China.A close match between the U-Pb age and Hf model age with the highly position ε Hf(t) value indicates the growth and immediate reworking of juvenile crust from the depleted mantle at ca 4.1 Ga.The prominent 'Pan-African' and Grenville zircons derived from the exotic sources were also found in the sample,which indicates a linking between South China and Gondwana in the Cambrian period.The southern part of South China has complex histories of crustal growth and tectonic evolution. | XU YaJun DU YuanSheng HUANG HongWei HUANG ZhiQiang HU LiSha ZHU YanHui YU WenChao | 2012 | Chinese Science Bulletin2012，57，33： | 2 |
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