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| 1 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 2 | Effects of cerium substitution on phase components, microstructures and magnetic properties of Nd-Fe-Ti-B alloy显示文摘(Nd(1-x)Cex)(12)Fe(77)Ti5B6(x=0,0.2,0.3,0.4,0.6,0.8)alloys were prepared by melt-spinning and annealing techniques.The phase constitutions,microstructures and magnetic properties were investigated by powder X-ray diffraction(XRD),a differential scanning calorimeter(DSC),a vibrating sample magnetometer(VSM)and a transmission electron microscope(TEM).It is found that with the increase of Ce content,the coercivity of the(Nd(1-x)Cex)(12)Fe(77)Ti5B6 alloys reaches maximum first and then decreases.The maximum coercivity reaches 18.5 kOe obtained in the sample of 20%Ce substituted which is 34%higher than the Ce-free sample.TEM results reveal that the micro structure refinement effect is responsible for the coercivity improvement.This phenomenon implies that in some cases,Ce and Ti co-doping is more beneficial to improving of the coercivity than Ti single doping in Nd-Fe-B alloys.With further Ce addition,magnetic properties deteriorate due to the formation of CeFe2 and TbCu7-type phases. | Haijun Peng Yang Luo Yakun Dou Xinyuan Bai Wenlong Yan Dunbo Yu Yuanfei Yang Shulin Diao | 2019 | Journal of Rare Earths2019，37，8： | 4 |
| 3 | Current Status and Future Perspective of Immunotherapy in Gastrointestinal Cancers显示文摘Gastrointestinal(GI)cancers represent a major public health problem worldwide.Due to the late detection and high heterogeneity of GI cancers,traditional treatments,including surgery,radiotherapy,chemotherapy,and targeted therapy,have shown limited effects,and the overall prognosis of these patients remains poor.Recently,immunotherapy,involving programmed cell death-1(PD-1)and its ligand(PD-L1),has shown promising efficacy in several solid cancers and seems to have become a potential treatment option for GI cancers This review focuses on data on the development of immunotherapy-based clinical trials in esophageal cancer,gastric cancer,and colorectal cancer.The predictive biomarkers and combination strategies in clinical trials and translational medicine are also discussed.Finally,prospects for immunotherapy in the treatment of GI cancers are described.Although only a small proportion of patients with GI cancers respond to PD-1/PD-L1 blockade,we strongly believe that precision immunotherapy might improve the overall survival of many more GI cancer patients in the future. | Zhihao Lu Zhi Peng Chang Liu Zhenghang Wang Yakun Wang Xi Jiao Jian Li Lin Shen | 2020 | The Innovation2020，1，2： | 1 |
| 4 | The application study of dual-energy CT nonlinearblending technique in pulmonary angiography显示文摘Objective This study aimed to explore the feasibility of enhancing image quality in computed tomography(CT) pulmonary angiography (CTPA) and reducing radiation dose using the nonlinear blending (NLB)technique of dual-energy CT.Methods A total of 61 patients scheduled for CTPA were enrolled, and 30 patients underwent dual-energyscanning. Nonlinear blending images (NLB group) and three groups of linear blending images (LB group,80 kV group, and 140 kV group) were reconstructed after scanning;31 patients underwent single-energyscanning (120 kV group). The CT values and standard deviations of the pulmonary trunk, left and rightpulmonary arteries, and ipsilateral back muscle at the bifurcation level of the left and right pulmonaryarteries were measured. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the fivegroups were calculated. The subjective image quality of the five groups was assessed. The radiation dosesof the dual- and single-energy groups were recorded and calculated.Results The CNR and SNR values of blood vessels in the NLB group were significantly higher than thosein the LB, 140 kV, and 80 kV groups (CNR of pulmonary artery trunk: t = 3.50, 4.06, 7.17, all P < 0.05;SNRof pulmonary trunk: t = 3.76, 4.71, 6.92, all P < 0.05). There were no statistical differences in the CNR andSNR values between the NLB group and 120 kV group (P > 0.05). The effective radiation dose of the dualenergygroup was lower than that of the single-energy group (t = –4.52, P < 0.05). The subjective scores ofimages in the NLB group were the highest (4.28 ± 0.74).Conclusion The NLB technique of dual-energy CT can improve the image quality of CTPA and reducethe radiation dose, providing more reliable imaging data for the clinical diagnosis of pulmonary embolism. | Siqi Yi Peng Zhou Yakun He Changjiu He Shibei Hu | 2023 | Oncology and Translational Medicine2023，9，1： | 0 |
| 5 | Constructing built-in electric field in graphitic carbon nitride hollow nanospheres by co-doping and modified in-situ Ni_(2)P for broad spectrum photocatalytic activity显示文摘The construction of built-in electric field is generally considered as an effective strategy to enhance photocatalytic performance due to its significant role in charge separation.Herein,a built-in electric field within g-C_(3)N_4 hollow nanospheres co-doped with sulfur and oxygen and modified in-situ Ni_(2)P is proposed.Ni_(2)P/SO-HC_(3)N_4 exhibits significantly enhanced board spectrum photocatalytic properties for hydrogen precipitation(5.21 mmol h^(-1)g^(-1))and photocatalytic Cr(VI)reduction without the use of noble metal.It also achieves high photocatalytic sterilization activity and remarkable stability when used to completely inactivate E.coli(10~7)in 60 min under Vis-NIR light irradiation.The enhanced performance is attributed to the formation of a curved hollow sphere structure,which promotes the electron transfer between the inner and outer layers.In addition,co-doping inhibits the recombination of photogenerated carriers,and the built-in electric field recombined with Ni_(2)facilitates the electron transfer between the composite interfaces.This design strategy demonstrates an original method of devising multifunctional photocatalysts with enhanced activity and stability. | Linlin Zhang Wenxing Peng YaKun Li Rui Qin Dong Yue Chengjun Ge Jianjun Liao | 2021 | Journal of Materials Science & Technology2021，，31： | 0 |
| 6 | Learning conditional photometric stereo with high-resolution features显示文摘Photometric stereo aims to reconstruct 3D geometry by recovering the dense surface orientation of a 3D object from multiple images under differing illumination.Traditional methods normally adopt simplified reflectance models to make the surface orientation computable.However,the real reflectances of surfaces greatly limit applicability of such methods to real-world objects.While deep neural networks have been employed to handle non-Lambertian surfaces,these methods are subject to blurring and errors,especially in high-frequency regions(such as crinkles and edges),caused by spectral bias:neural networks favor low-frequency representations so exhibit a bias towards smooth functions.In this paper,therefore,we propose a self-learning conditional network with multiscale features for photometric stereo,avoiding blurred reconstruction in such regions.Our explorations include:(i)a multi-scale feature fusion architecture,which keeps high-resolution representations and deep feature extraction,simultaneously,and(ii)an improved gradient-motivated conditionally parameterized convolution(GM-CondConv)in our photometric stereo network,with different combinations of convolution kernels for varying surfaces.Extensive experiments on public benchmark datasets show that our calibrated photometric stereo method outperforms the state-of-the-art. | Yakun Ju Yuxin Peng Muwei Jian Feng Gao Junyu Dong | 2022 | Computational Visual Media2022，8，1： | 0 |
| 7 | TMK:A crucial piece of the acid growth puzzle显示文摘Plant cells have relatively high turgor pressure driving cell expan-sion,which is restricted by the cell wall.How plant cells grow in an intrinsically controlled manner is an intriguing question,and the phytohormone auxin(indole-3-acetic acid,IAA)plays a vital reg-ulatory role.The auxin-mediated acid growth theory was pro-posed decades ago,whereas the underlying mechanisms were not fully elucidated.Plasma membrane(PM)H+-ATPases,also called Arabidopsis AUTOINHIBITED H+ATPASEs(AHAs),are proton pumps majorly responsible for regulating cell growth in plants.Based on our current understandings of the acid growth theory,auxin stimulates AHA proteins and thus promotes proton(H+)efflux,which thereby acidifies the apoplast to activate cell wall-modifying enzymes,such as expansins,eventually softening the cell wall to accommodate cell expansion(Duet al.,2020).Activated AHA proteins also cause PM hyperpolarization,enabling solute and water uptake to increase turgor pressure driving cell expansion(Duet al.,2020).Hence,how auxin activates PM H^(+)-ATPases is central to the acid growth theory.However,that was until now not fully understood. | Yakun Peng Shutang Tan | 2021 | Molecular Plant2021，14，12： | 0 |
| 8 | Chemical inhibition of Arabidopsis PIN-FORMED auxin transporters by the anti-inflammatory drug naproxen显示文摘The phytohormone auxin plays central roles in many growth and developmental processes in plants.Development of chemical tools targeting the auxin pathway is useful for both plant biology and agriculture.Here we reveal that naproxen,a synthetic compound with anti-inflammatory activity in humans,acts as an auxin transport inhibitor targeting PIN-FORMED(PIN)transporters in plants.Physiological experiments indicate that exogenous naproxen treatment affects pleiotropic auxin-regulated developmental processes.Additional cellular and biochemical evidence indicates that naproxen suppresses auxin transport,specifically PIN-mediated auxin efflux.Moreover,biochemical and structural analyses confirm that naproxen binds directly to PIN1 protein via the same binding cavity as the indole-3-acetic acid substrate.Thus,by combining cellular,biochemical,and structural approaches,this study clearly establishes that naproxen is a PIN inhibitor and elucidates the underlying mechanisms.Further use of this compound may advance our understanding of the molecular mechanisms of PIN-mediated auxin transport and expand our toolkit in auxin biology and agriculture. | Jing Xia Mengjuan Kong Zhisen Yang Lianghanxiao Sun Yakun Peng Yanbo Mao Hong Wei Wei Ying Yongxiang Gao Jiri Friml Jianping Weng Xin Liu Linfeng Sun Shutang Tan | 2023 | Plant Communications2023，4，6： | 0 |
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