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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 3 | Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury显示文摘Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ- | Lanzhi He Ping Yin Yakun Meng Jinfa Tang Tingting He Ming Niu Yuming Guo Yun Zhu Jing Jing Chunyu Li Zhijie Ma Jiabo Wang Zhaofang Bai Xiaohe Xiao | 2017 | Science Bulletin2017，62，11： | 29 |
| 4 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 5 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 6 | Investigation of open channel flow with unsubmerged rigid vegetation by the lattice Boltzmann method显示文摘The aquatic vegetation can significantly affect the flow structure,the sediment transport,the bed scour and the water quality in rivers,lakes,reservoirs and open channels.In this study,the lattice Boltzmann method(LBM)is applied in the two-dimensional numerical simulation of the flow structure in a flume with rigid vegetation.A multi-relaxation time model is applied to improve the stability of the numerical scheme for flows with a high Reynolds number.The vegetation induced drag force is added in the lattice Boltzmann equation model in order to improve the simulation accuracy and an algorithm of the multi-relaxation time is developed.Numerical simulations are performed for a wide range of flow and vegetation conditions and are validated by comparing with the laboratory experiments.Analysis of the simulated and experimentally measured flow Helds shows that the numerical simulation can satisfactorily reproduce the laboratory experiments,indicating that the proposed lattice Boltzmann model enjoys a high accuracy for simulating the flow-vegetation interaction in open channels. | He-fang Jing Yin-juan Cai Wei-hong Wang Yakun Guo Chun-guang Li Yu-chuan Bai | 2020 | Journal of Hydrodynamics2020，32，4： | 5 |
| 7 | Microwave-hydrothermal preparation of a graphene/hierarchy structure MnO_2 composite for a supercapacitor显示文摘Graphene/hierarchy structure manganese dioxide(GN/MnO_2) composites were synthesized using a simple microwave-hydrothermal method.The properties of the prepared composites were analyzed using field emission scanning electron microscopy(FE-SEM),X-ray diffraction(XRD),transmission electron microscopy(TEM),and X-ray photoelectron spectroscopy(XPS) measurements.The electrochemical performances of the composites were analyzed using cyclic voltammetry,electrochemical impedance spectrometry(EIS),and chronopotentiometry.The results showed that GN/MnO_2(10wt% graphene) displayed a specific capacitance of 244F/gat a current density of 100mA/g.An excellent cyclic stability was obtained with a capacity retention of approximately 94.3% after 500 cycles in a 1 mol/L Li_2SO_4 solution.The improved electrochemical performance is attributed to the hierarchy structure of the manganese dioxide,which can enlarge the interface between the active materials and the electrolyte.The preparation route provides a new approach for hierarchy structure graphene composites;this work could be readily extended to the preparation of other graphene-based composites with different structures for use in energy storage devices. | Zhong Chen Jianling Li Yu Chen Yakun Zhang Guofeng Xu Jun Yang Ye Feng | 2014 | Particuology2014，12，4： | 4 |
| 8 | The construction of personalized virtual landslide disaster environments based on knowledge graphs and deep neural networks显示文摘Virtual Landslide Disaster environments are important for multilevel simulation,analysis and decision-making about Landslide Disasters.However,in the existing related studies,complex disaster scene objects and relationships are not deeply analyzed,and the scene contents are fixed,which is not conducive to meeting multilevel visualization task requirements for diverse users.To resolve the above issues,a construction method for Personalized Virtual Landslide Disaster Environments Based on Knowledge Graphs and Deep Neural networks is proposed in this paper.The characteristics of relationships among users,scenes and data were first discussed in detail;then,a knowledge graph of virtual Landslide Disaster environments was established to clarify the complex relationships among disaster scene objects,and a Deep Neural network was introduced to mine the user history information and the relationships among object entities in the knowledge graph.Therefore,a personalized Landslide Disaster scene data recommendation mechanism was proposed.Finally,a prototype system was developed,and an experimental analysis was conducted.The experimental results show that the method can be used to recommend intelligently appropriate disaster information and scene data to diverse users.The recommendation accuracy stabilizes above 80%–a level able to effectively support The Construction of Personalized Virtual Landslide Disaster environments. | Yunhao Zhang Jun Zhu Qing Zhu Yakun Xie Weilian Li Lin Fu Junxiao Zhang Jianmei Tan | 2020 | International Journal of Digital Earth2020，13，12： | 3 |
| 9 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 10 | SOME NEW DATA AND FORMULAS FOR RESISTANCE FLOW IN FLUVIAL OPEN CHANNELS显示文摘Flow resistance in fluvial open channels, especially in steep gravel-bed channels, still presents challenges to researchers and engineers.This article presents some new data from both the flume experiments and field measurements.Data analysis using the divided hydraulic radius approach shows that the relative roughness plays a significant role in the bed form resistance.A new set of formulas that incorporate the relative roughness are proposed.As compared with several existing formulas, the proposed formulas can be used to better estimate the bed form resistance. | YANG Sheng-fa HU Jiang LI Dan-xun WANG Xing-kui GUO Yakun | 2011 | Journal of Hydrodynamics2011，23，4： | 2 |
| 11 | Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice显示文摘Due to the rapid spread of coronavirus disease 2019(COVID-19),there is an urgent requirement for the development of additional diagnostic tools for further analysis of the disease.The isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reeptor-binding domain[RBD]with high afinity to neutralize the virus and block the angiotensin-converting enzyme 2-(ACE2-)RBD interaction.Here,we introduce a novel nanobody-based radiotracer named^(68)Ga-Nb1159.The radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in vivo.Predinical positron emission tomography(PET)studies of Ga-Nb1159 in mice revealed is rapid dearance from circulation and robust uptake into the renal and urinary systems.Fortunately,^(68)Ga-Nb1159 could speifcally reveal the distribution of the RBD in mice.This sudy also helped to evaluate the pharmacodynamic efects of the neutralizing nanobody.Moreover,^(68)Ga-Nb1159 may be a promising l0ol lo explore the distribution of the RBD and improve the understanding of the virus.In particular,this study identified a novel molecular radioagent and established a reliable evaluation method for speifially investigating the RBD through noninvasive and visual PET technology. | Song Liu Guanghui Li Lei Ding Jin Ding Qian Zhang Dan Li Xingguo Hou Xiangxing Kong Jing Zou Shiming Zhang Hongbin Han Yakun Wan Zhi Yang Hua Zhu | 2022 | Research2022，，2： | 2 |
| 12 | Current Status and Future Perspective of Immunotherapy in Gastrointestinal Cancers显示文摘Gastrointestinal(GI)cancers represent a major public health problem worldwide.Due to the late detection and high heterogeneity of GI cancers,traditional treatments,including surgery,radiotherapy,chemotherapy,and targeted therapy,have shown limited effects,and the overall prognosis of these patients remains poor.Recently,immunotherapy,involving programmed cell death-1(PD-1)and its ligand(PD-L1),has shown promising efficacy in several solid cancers and seems to have become a potential treatment option for GI cancers This review focuses on data on the development of immunotherapy-based clinical trials in esophageal cancer,gastric cancer,and colorectal cancer.The predictive biomarkers and combination strategies in clinical trials and translational medicine are also discussed.Finally,prospects for immunotherapy in the treatment of GI cancers are described.Although only a small proportion of patients with GI cancers respond to PD-1/PD-L1 blockade,we strongly believe that precision immunotherapy might improve the overall survival of many more GI cancer patients in the future. | Zhihao Lu Zhi Peng Chang Liu Zhenghang Wang Yakun Wang Xi Jiao Jian Li Lin Shen | 2020 | The Innovation2020，1，2： | 1 |
| 13 | Tunnel vision optimization method for VR flood scenes based on Gaussian blur显示文摘The visualization of flood disasters in virtual reality(VR)scenes is useful for the representation and sharing of disaster knowledge and can effectively improve users’cognitive efficiency in comprehending disaster information.However,the existing VR methods of visualizing flood disaster scenes have some shortcomings,such as low rendering efficiency and poor user experience.In this paper,a tunnel vision optimization method for VR flood scenes based on Gaussian blur is proposed.The key techniques are studied,such as region of interest(ROI)calculation and tunnel vision optimization considering the characteristics of the human visual system.A prototype system has been developed and used to carry out an experimental case analysis.The experimental results show that the number of triangles drawn in a flood VR scene is reduced by approximately 30%–40%using this method and that the average frame rate is stable at approximately 90 frames per second(fps),significantly improving the efficiency of scene rendering and reducing motion sickness. | Lin Fu Jun Zhu Weilian Li Qing Zhu Bingli Xu Yakun Xie Yunhao Zhang Ya Hu Jingtao Lu Pei Dang Jigang You | 2021 | International Journal of Digital Earth2021，14，7： | 1 |
| 14 | Application of radiofrequency ablation for splenic preservation显示文摘 | Yakun Wu Lili Wan Peizhi Li Yinglin Zhang Min Li Jianping Gong Wei Zhang | 2014 | Journal of Surgical Research2014，，： | 1 |
| 15 | Effects of temperature and atmosphere component on quality of stored jujube fruit显示文摘 | LIN Li TIAN Shiping WAN Yakun et at | 2004 | Acta Botanica Sinica2004，46，8： | 1 |
| 16 | Three-dimensional numerical simulation of compound meandering open channel flow by the Reynolds stress model 显示文摘 | Jing Hefang Guo Yakun Li Chunguang | 2009 | International Journal for Numerical Methods in Fluids2009，59，： | 1 |
| 17 | 乳腺癌Metadherin基因表达的实时荧光定量方法的建立及初步应用(英文)显示文摘Objective:The aim of this study was to detect the expression level of Metadherin (MTDH) in peripheral blood of the breast cancer patients by real-time fluorescence quantitative polymerase chain reaction (PCR),and to explore the relationship between expression of Metadherin gene in the patients peripheral blood and the clinic-pathological features in breast cancer. Methods:Real-time fluorescence quantitative polymerase chain reaction was employed to determine the expression level of Metadherin gene in 80 peripheral blood samples of breast cancer patients and healthy donors. Results:The expression of Metadherin gene in breast cancer patients peripheral blood were positive,in which 34 breast cancer patients were highly expressed,accounting for 55.7%,while the expression of Metadherin gene in normal females peripheral blood were negative,there was statistical significance (Ratio = 2.02±0.81,P < 0.05); Ratio of the Metadherin expression in breast cancer patients peripheral blood and the glyceraldehyde-3-phosphate dehydrogenase expression was 1.15 ± 0.36. REST software analysis showed that the expression of Metadherin gene was significantly up-regulated in breast cancer. Conclusion:The SYBR Green I quantitative real-time polymerase chain reaction method can successfully detect the expression level of Metadherin gene. Expression level of Metadherin gene in breast cancer patients peripheral blood is closely related to survival,and it maybe involved in the development of breast cancer and used as an indicator of prognosis. | Bing Li Zhaozhe Liu Xiaodong Xie Yakun Wang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，6： | 1 |
| 18 | Electropolymerization of Ni(salen) on carbon nanotube carrier as a capacitive material by pulse potentiostatic method显示文摘The composites of poly[Ni(salen)] and multi-walled carbon nanotube(MWCNT) were synthesized by pulse potentiostatic method.The composites were characterized by field emission scanning electron microscopy,Fourier transform infrared spectra,and electrochemical impedance spectroscopy.The wrapping of carbon nanotubes with poly[Ni(salen)] varied significantly with anodic pulse duration.Variance of structure of poly[Ni(salen)] caused by anodic pulse duration affected the ability of absorption to solvent molecules or solvated ions,which was indicated by ν(C≡N) intensity.The ability to store/release charge of poly[Ni(salen)] caused by redox switching was evaluated in the form of low-frequency capacitance.Correlations of chargetransfer resistance/ionic diffusion resistance with potential and anodic pulse duration were investigated. | LI JianLing GAO Fei ZHANG YaKun KANG FeiYu WANG XinDong YE Feng YANG Jun | 2012 | Science China Chemistry2012，55，7： | 1 |
| 19 | An Integrated Research Framework for Effect of EWOM显示文摘With the development of the electronic commerce, the electronic word-of-mouth(e WOM)has become important reference information for consumer shopping. EWOM has attracted considerable interest from researchers in the past decade. In this paper, a research review is conducted and an integrated framework is proposed on the effect of e WOM. The effect of e WOM are influenced by its characteristics, communicators, and other factors. The characteristics of e WOM include the source,the volume and the valence. The communicators of e WOM refer to the sender, the receiver and the relationship between them. In addition, dispersion and consistency, persistence and observability,anonymity and deception, and community engagement are related factors for the effect of e WOM. | Jie LI Wenyi XUE Fang YANG Yakun LI | 2017 | Journal of Systems Science and Information2017，8，4： | 1 |
| 20 | Construction, characterization and application of a genomewide promoter library in Saccharomyces cerevisiae显示文摘倡导者们是批评元素控制基因表示,但是能在各种各样的生长条件下面不同地表现。这里,我们报导一个染色体宽的倡导者图书馆,在 Saccharomyces cerevisiae 的每个本国的倡导者在被克隆的构造黄在上游荧光灯蛋白质(YFP ) 记者基因。九个图书馆任意地在细菌被定义并且集合。倡导者的产生水池能被准备并且也作为 centromeric plasmids 转变了成酵母紧张或集成于在酶的处理之上的一个 genomic 地点。使用荧光激活房间排序,我们基于 YFP 荧光紧张分类酵母紧张并且任意地把全部图书馆划分了成 12 箱,代表对强壮的倡导者弱。几个强壮的倡导者从最活跃的箱被识别,他们的活动是在不同生长条件下面的 assayed。最后,这些倡导者被使用在木糖利用驱使基因的表示改进发酵效率。一起,这个图书馆能提供一个快答案在自定义生长条件下面识别并且利用需要的倡导者。 | Ting Yuan Yakun Guo Junkai Dong Tianyi Li Tong Zhou Kaiwen Sun Mei Zhang Qingyu Wu Zhen Xie Yizhi Cai Limin Cao Junbiao Dai | 2017 | Frontiers of Chemical Science and Engineering2017，11，1： | 1 |
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