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| 1 | Organ-specific efficacy in advanced non-small cell lung cancer patients treated with first-line single-agent immune checkpoint inhibitors显示文摘Background:Response to immune checkpoint inhibitors(ICIs)is affected by multiple factors.This study aimed to explore whether sites of metastasis are associated with clinical outcomes of ICIs in advanced non-small-cell lung cancer(NSCLC)patients.Methods::The data of NSCLC patients with high programmed death-ligand 1 expression and good performance status receiving first-line ICIs monotherapy from Guangdong Provincial People’s Hospital between May 2019 and July 2020 were retrospectively analyzed.Metastatic sites included liver,bone,brain,adrenal gland,pleura,and contralateral lung.Progression-free survival(PFS)and overall survival(OS)were compared between different metastatic sites and metastatic burden by the Kaplan-Meier method.Organ-specific disease control rate(OSDCR)of different individual metastatic sites was evaluated.Results:Forty NSCLC patients meeting the criteria were identified.The presence of liver metastasis was significantly associated with shorter PFS(3.1 vs.15.5 months,P=0.0005)and OS(11.1 months vs.not reached,P=0.0016).Besides,patients with bone metastasis tend to get shorter PFS(4.2 vs.15.5 months,P=0.0532)rather than OS(P=0.6086).Moreover,the application of local treatment could numerically prolong PFS in patients with brain metastasis(15.5 vs.4.3 months,P=0.1894).More metastatic organs involved were associated with inferior PFS(P=0.0052)but not OS(P=0.0791).The presence of liver metastasis or bone metastasis was associated with more metastatic organs(Phi[φ]:0.516,P=0.001).The highest OSDCR was observed in lung(15/17),and the lowest in the liver(1/4).Conclusions:Metastases in different anatomical locations may be associated with different clinical outcomes and local tumor response to ICIs in NSCLC.ICIs monotherapy shows limited efficacy in patients with liver and bone metastasis,thus patients with this type of metastasis might require more aggressive combination strategies. | Jiayi Deng Ming Gao Qing Gou Chongrui Xu Honghong Yan Mingyi Yang Jiakang Li Xiaorong Yang Xuewu Wei Qing Zhou | 2022 | Chinese Medical Journal2022，，12： | 2 |
| 2 | Probing Hg evasion from surface waters of two Chinese hyper/meso-eutrophic reservoirs显示文摘 | Xuewu Fu Xinbin Feng Qi Wan Bo Meng Haiyu Yan Yanna Guo | 2010 | Science of the Total Environment2010，，23： | 1 |
| 3 | Molecular cloning and identification of full-length cDNA encoding hjgh afinity Fc receptor for bovine IgG(FcγRI)显示文摘 | Yuhe Yan Xuewu Li Aiping Wang | 2000 | Veterinary Immunology and Immunopathology2000，75，： | 1 |
| 4 | Synthesis of ultralarge-pore FDU-12 silica with face-centered cubic structure显示文摘 | HUANG Liang YAN Xuewu KRUK M | 2010 | Langrnuir2010，26，14： | 1 |
| 5 | Effect of Hydro- thermal Conditions on the Synthesis of Siliceous MCM-48 in Mixed Cationic-Anionic Surfactants Systems 显示文摘 | Chen Fengxi Yan Xuewu Li Quanzhi | 1998 | Stud SurfSci Catal1998，117，： | 1 |
| 6 | Molecular cloning and identification of full - length cDNA encoding high afinity Fc receptor for bovine IgG (FcγRI)显示文摘 | Yuhe Yan Xuewu Li Aiping Wang et ol | 2000 | Veterinary Immunology and Immunopathology2000，75，： | 1 |
| 7 | Hydro- craking of Heavy Oil Using Zeolites Y/A1-SBA-15 Composites a Catalyst Supports 显示文摘 | Zhang Xuejun Zhang Fuqiang Yan Xuewu | 2008 | J Porous Mater2008，15，2： | 1 |
| 8 | Hydro- cracking of heavy oil using zeolites Y/AI-SBA-15 composites as catalyst supports显示文摘 | Zhang Xuejun Zhang Fuqiang Yan Xuewu | 2008 | J Porous Mater2008，15，： | 1 |
| 9 | TI'F1 - induced apoptosis of HepG -2 cells through a mitochondrial pathway 显示文摘 | Li Yan Lei Bian Zhang Xuewu | 2011 | Oncology Reports2011，，26： | 1 |
| 10 | Inhibition of tumor angiogene- sis by TTFI from extract of herbal medicine显示文摘 | Li Yan Xiaowan Li Zhang Xuewu | 2011 | World J Gastroenterol2011，17，44： | 1 |
| 11 | Study on the morphological regulation mechanism of hollow silica microsphere prepared via emulsion droplet template显示文摘The morphology regulation of hollow silica microspheres is significant for their properties and applications. In this paper, hollow silica microspheres were formed through the hydrolysis and condensation reaction of tetraethyl orthosilicate(TEOS) at the interface of the emulsion droplet templates composed of liquid paraffin and TEOS, followed by dissolving paraffin with ethanol. The effects of various factors including the emulsifier structure and content, TEOS content, catalyst type, and the ethanol content in the continuous water phase on the particle size, shell thickness and morphology of the prepared hollow silica microspheres were studied in detail. The results show that the diffusion and contact of TEOS and water molecules as well as the hydrolysis condensation reaction of TEOS at the oil-water interface are two critical processes for the synthesis and morphological regulation of hollow silica microspheres. Cationic emulsifier with a hydrophobic chain of appropriate length is the prerequisite for the successful synthesis of hollow silica microspheres. The ethanol content in water phase is the dominant factor to determine the average diameter of hollow microspheres, which can vary from 96 nm to 660 nm with the increase of the volume ratio of alcohol-water from 0 to 0.7. The silica wall thickness varies with the content and the hydrophobic chain length of the emulsifier, TEOS content, and the activity of the catalyst. The component of the soft template will affect the morphology of the silica wall. When the liquid paraffin is replaced by cyclohexane, hollow microspheres with fibrous mesoporous silica wall are fabricated. This work not only enriches the basic theory of interfacial polymerization in the emulsion system, but also provides ideas and methods for expanding the morphology and application of hollow silica microspheres. | Chu Zhao Zhiqing Ge Zhuoni Jiang Shuo Yan Jingjing Shu Mozhen Wang Xuewu Ge | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
| 12 | Kinetic study of transverse electron-scale interface instability in relativistic shear flows显示文摘Interfacial magnetic field structures induced by transverse electron-scale shear instability(mushroom instability)are found to be strongly associated with electron and ion dynamics,which in turn will influence the development of the instability itself.We find that high-frequency electron oscillations are excited normal to the shear interface.Also,on a larger time scale,the bulk of the ions are gradually separated under the influence of local magnetic fields,eventually reaching an equilibrium related to the initial shear conditions.Wepresent a theoretical model of this behavior.Such separation on the scale of the electron skin depth will prevent different ions from mixing and will thereafter restrain the growth of higher-order instabilities.We also analyze the role of electron thermal motion in the generation of the magnetic field,and we find an increase in the instability growth rate with increasing plasma temperature.These results have potential for providing a more realistic description of relativistic plasma flows. | Peilin Yao Hongbo Cai Xinxin Yan Wenshuai Zhang Bao Du Jianmin Tian Enhao Zhang Xuewu Wang Shaoping Zhu | 2020 | Matter and Radiation at Extremes2020，5，5： | 0 |
| 13 | Preparation and performance of novel magnetic phase-change-microcapsule-supported Bi_(2)WO_(6)catalyst显示文摘The design and synthesis of novel photocatalyst with self-temperature control function is an important topic in the field of advanced environmental functional materials.In this work,submicron-sized magnetic phase change microcapsules composed of paraffin core and Fe_(3)O_(4)-loaded silica shell are prepared,on which the Bi_(2)WO_(6)crystals is grown in situ through hydrothermal reaction to obtain novel magnetic phase-change-microcapsule-supported Bi_(2)WO_(6)catalyst(MP@FS/BWO).The MP@FS/BWO has a paraffin encapsulation ratio of 57.1%,and the phase change enthalpy of 105.1 J/g in a temperature range of 50–60℃,which endows the MP@FS/BWO with a certain self-temperature regulation ability.MP@FS/BWO shows excellent catalytic performance in the decomposition of rhodamine B under the simulated sunlight irradiation.After the light source is turned off,it still has good catalytic ability by maintaining high temperature due to its temperature control function based on the phase transition process.The MP@FS/BWO can be easily recycled by magnetic separation and shows good structural stability and reusability.This work provides a new idea for the development of long-effect and energy-saving outdoor photocatalysts. | Zhuoni Jiang Zhiqing Ge Shuo Yan Jingjing Shu Mozhen Wang Xuewu Ge | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 14 | Numerical simulation and experimental research on oscillation performance of disc-type jet oscillator显示文摘Based on active flow control technology,the two wall jets attached to a standard cylindrical surface due to the Coanda effect will output a detached jet when they collide.The direction of the output jets produced by this collision is very sensitive to small changes in the two wall jets.Therefore,a new type of curved-wall supersonic compressible disc-type jet oscillator is proposed by using the oscillating feedback jet as the source of wall separation.Through monitoring the internal flow field,the jet core’s pressure attenuation,the jet’s amplitude,and the wall pressure are analyzed.The results show that the disc-type jet oscillator model with a double-bend inlet has the best performance.After adding a multi-pipe outlet structure to the model,the oscillators with various disc diameters were simulated at different inlet pressures and air inlet frequencies to the wall-off control port.The oscillation performance of the disc jet oscillator is better when the diameter of the disc is 32 mm and 20 mm,and the included angle between the wall-off control port and the horizontal direction is 45°.Two kinds of oscillators of the same diameter as the model are experimentally studied,and the results prove the feasibility of the disc-type jet oscillator. | Wutekuer NUERMAIMAITI Xuewu LIU Pengze YAN Zongrui WANG Dapen HU | 2023 | Chinese Journal of Aeronautics2023，36，10： | 0 |
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