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| 1 | Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR, the sponge of miR-520b显示文摘Bufalin, the major active component of the traditional Chinese medicine ChanSu obtained from the skin and parotid venom glands of toads, has long been known as an anticancer agent. Recent studies show that microRNAs (miRs) are involved in the anticancer activities of bufalin, while long non-coding RNAs (lncRNAs) are known to interact with miRNAs to regulate various biological functions. In this paper, we investigated the possible network related to the antimetastatic effect of bufalin in prostate cancer (PCa) cells. We demonstrated that bufalin (0.05?10 μM) dose-dependently suppressed the proliferation of prostate cancer DU145 and PC3 cells with IC50 values of 0.89 and 1.28 μM, respectively. Furthermore, bufalin treatment significantly suppressed the cell migration and invasion. To explore the role of lncRNAs in the antimetastatic activity of bufalin, we used an lncRNA microarray and found that HOX transcript antisense RNA (HOTAIR) was the most markedly downregulated lncRNA in bufalin-treated PCa cells. Overexpression of HOTAIR counteracted the suppressing effects of bufalin on DU145 and PC3 cells. We then predicted and verified that HOTAIR upregulated FGFR1 expression by sponging miR-520b in PCa cells. In 40 patients with PCa bone metastasis, we used in situ hybridization or immunohistochemical assay to assess the HOTAIR and FGFR1 expression, which revealed that both HOTAIR and FGFR1 expression were significantly higher in bone metastasis tissues than in the primary PCa tissues. In addition, the level of serum HOTAIR was positively associated with the levels of serum bone metabolic markers (CTx, OST, B-ALP and PINP) and may serve as a reasonable biomarker for PCa bone metastasis. Taken together, this is the first study revealing that HOTAIR promotes PCa bone metastasis, and bufalin may be a promising candidate for the treatment of this disease. | Jian-jun Zhang Xiao-hui Zhou Yan Zhou Yong-gang Wang Bin-zhi Qian Ai-na He Zan Shen Hai-yan Hu Yang Yao | 2019 | Acta Pharmacologica Sinica2019，40，9： | 13 |
| 2 | Associations between individual and environmental factors and habitual physical activity among older Chinese adults:A social–ecological perspective显示文摘Purpose: To examine, within a social–ecological framework, associations between multifaceted individual and environmental factors and habitual physical activity(HPA) among older Chinese adults.Methods: Through a mix of qualitative and quantitative methods, a survey instrument assessing various factors underlying 3 social–ecological dimensions of intrapersonal, interpersonal, and community and environmental resources was developed. Using a cross-sectional design, older adults(n = 1580, aged 67 ± 7 years) recruited from 10 communities in Shandong province completed the social–ecological survey of HPA. Data were analyzed using Partial Least Squares Path Modeling.Results: Factors related to intrapersonal(medical knowledge, motivation, physical function, sport skills, socioeconomic status, and education),interpersonal(social support, social activity, and social norms), and community and physical environmental resources(safety, capacity, availability of and access to physical activity facilities) were found to be significantly associated with older adults' participation in HPA.Conclusion: The findings provide an initial validation of a social–ecological approach to the study of HPA in China, suggesting that strategies aimed at promoting physical activity in older adults should address multiple levels of factors that may contribute to the likelihood of older Chinese adults being physically active. | Xiangren Yi Zachary Pope Zan Gao Shumei Wang Fang Pan Jingpeng Yan Meng Liu Peipei Wu Jingjing Xu Rui Wang | 2016 | Journal of Sport and Health Science2016，5，3： | 11 |
| 3 | Potato/Maize intercropping reduces infestation of potato tuber moth, Phthorimaea operculella(Zeller) by the enhancement of natural enemies显示文摘The potato tuber moth(PTM),Phthorimaea operculella(Zeller),is one of the most economically significant insect pests for potato in both field and storage worldwide.To evaluate the infestation,reduction of potato yield and the control efficacy for PTM,field tests were conducted in two seasons by intercropping of potato as the host plant with maize as a non-host plant of PTM.Three intercropping patterns were tested,which were 2 rows of potatoes with either 2,3,or 4 rows of maize(abbreviated 2 P:2 M,2 P:3 M,and 2 P:4 M),and the monocropped potato as the control,2 rows of potatoes,without maize,(abbreviated 2 P:0 M).Results showed that the population and infestation of PTM in the 2 P:3 M intercropping pattern was significantly lower than those in 2 P:2 M,2 P:4 M and the monocropping pattern of 2 P:0 M,due to the enhancement of natural enemies.Cumulative mines and tunneling in potato leaves in 2 P:3 M intercropping were significantly lower than those in 2 P:2 M and 2 P:4 M patterns.The population of parasitoids and the parasitism rate of PTM in intercropping pattern of 2 P:3 M were significantly higher than that in intercropping pattern of 2 P:2 M,2 P:4 M and monocropping pattern of 2 P:0 M.We conclude that the potato intercropped with maize reduced the adult and larva populations,and reduced the damage from PTM by enhancing the number of parasitoids and the level of parasitism.The greatest population density of parasitoids and parasitism rate were in the intercropping pattern of 2 rows of potatoes with 3 rows of maize.These data indicate that the host/non-host intercropping patterns can be used as a biological control tactic against PTM by enhancing the density of natural enemies in the agro-ecosystems. | ZHENG Ya-qiang ZHANG Li-min CHEN Bin YAN Nai-sheng GUI Fu-rong ZAN Qing-an DU Guang-zu HE Shu-qi LI Zheng-yue GAO Yu-lin XIAO Guan-li | 2020 | Journal of Integrative Agriculture2020，19，2： | 8 |
| 4 | Existence of Solutions of Boundary Value Problem Differential a Nonlinear Three-Point for Third-Order Ordinary Equations显示文摘In this paper,existence of solutions of third-order differential equation ■with nonlinear three-point boundary condition ■is obtained by embedding Leray-Schauder degree theory in upper and lower solutions method,where a,b,c ∈ R,a < b < c;f :[a,c]×R3 → R,g :R3 → R,h :R2 → R and I :R3 → R are continuous functions.The existence result is obtained by defining the suitable upper and lower solutions and introducing an appropriate auxiliary boundary value problem.As an application,an example with an explicit solution is given to demonstrate the validity of the results in this paper. | SHEN Jian He ZHOU Zhe Yan YU Zan Pin | 2009 | Journal of Mathematical Research and Exposition2009，29，1： | 6 |
| 5 | Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1显示文摘瞄准:严重痛苦的感觉神经病经常发生在 paclitaxel 化疗期间。,后来, paclitaxel 能激活桅杆房间和 basophils 橡黄素, polyphenolic flavonoid 在各种各样的植物包含了,它能明确地作为桅杆房间 stabilizer 禁止组织安版本。在这研究,我们探索橡黄素是否能改善导致 paclitaxel 的神经病的疼痛和阐明的位于 \O 下面 mechanisms.Methods:组织安版本上的橡黄素抑制被从白血病(RBL-2H3 ) 房间与 paclitaxel 刺激了的老鼠 basophilic 检测组织安版本在 vitro 验证(10 μ mol/L ) 。在里面在里面 vivo 实验,老鼠和老鼠收到了橡黄素(20, 40 mg·为 40 和 12 d 的 kg -1·d-1) 分别地。同时,动物与 paclitaxel 被注射(2 mg/kg, ip ) d 上的四次 1, 3, 5 和 7。热痛觉过敏和机械 allodynia 在不同时间点被评估。动物是 euthanized 和针的绳索,背面的根中心为分析 PKCε 被收获;并且 TRPV1 表示铺平。血浆组织安层次在 d 上在老鼠被估计 31 .Results:有橡黄素的预告的处理(3, 10, 30 μ mol/L ) 从在 vitro 的刺激 paclitaxel 的 RBL-2H3 房间的 dose-dependently 禁止的过多的组织安版本,和橡黄素管理显著地在对待 paclitaxel 的老鼠压制了高血浆组织安层次。橡黄素管理 dose-dependently 在对待 paclitaxel 的老鼠和老鼠为热痛觉过敏和机械 allodynia 提起了阀值。而且,橡黄素管理 dose-dependently 压制了 PKCε 的增加的表示层次;并且在对待 paclitaxel 的老鼠和老鼠的针的绳索和 DRG 的 TRPV1。而且,橡黄素管理可以禁止了 PKCε 的 translocation;从细胞质到在对待 paclitaxel 的 rats.Conclusion 的针的绳索和 DRG 的膜:我们的结果揭示导致 paclitaxel 的外部神经病的内在的机制并且为对待这个副作用表明橡黄素的治疗学的潜力。 | Wei GAO Yan ZAN Zai-jie Jim WANG Xiao-yu HU Fang HUANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 5 |
| 6 | Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling显示文摘PTEN, phosphatidylinositol-3-kinase/AKT 小径的一个否定管理者,是胰岛素发信号的一个重要调节的人。决定胰腺的 Pten 的新陈代谢的函数,我们产生了胰特定的 Pten 大美人(PPKO ) 鼠标。PPKO 老鼠扩大了胰并且提高了 acinar 房间的增长。他们也展出了低血糖症, hypoinsulinemia,和改变的氨基的新陈代谢。尤其是, PPKO 老鼠证明 streptozotocin (STZ ) 的推迟的发作导致了糖尿病,到 high-fat-diet (HFD ) 的偏导性的抵抗导致了糖尿病。在 PPKO 老鼠为抵抗调查机制到导致 HFD 的多糖症,我们在主要胰岛素应答的纸巾评估了 AKT phosphorylation:肝,肌肉,和脂肪。我们发现在胰的 Pten 损失引起在肝发信号的 AKT 的举起。AKT 和它的下游的底层 GSK3 尾的 phosphorylation 在 PPKO 老鼠的肝被增加,当没有 Pten 等位基因的可检测的切除, PTEN 水平在 PPKO 老鼠的肝被减少时。戏剧性地揭示的 Proteomics 分析减少了在 PPKO 老鼠的肝 78-kDa 铺平调整葡萄糖的蛋白质(GRP78 ) ,它可以也贡献用 HFD 喂的 PPKO 老鼠的更低的血葡萄糖水平。一起,我们的调查结果在新陈代谢的规定在肝揭示新奇回答到胰腺的缺点,把一种新尺寸加到理解糖尿病抵抗。 | Zan Tong Yan Fan Weiqi Zhang Jun Xu Jing Cheng Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，6： | 5 |
| 7 | Absorption characteristics of elemental mercury in mercury chloride solutions显示文摘Elemental mercury(Hg0) in flue gases can be efficiently captured by mercury chloride(Hg Cl2) solution. However, the absorption behaviors and the influencing effects are still poorly understood. The mechanism of Hg0 absorption by Hg Cl2 and the factors that control the removal were studied in this paper. It was found that when the mole ratio of Cl-to Hg Cl2 is 10:1, the Hg0 removal efficiency is the highest. Among the main mercury chloride species,Hg Cl3-is the most efficient ion for Hg0 removal in the Hg Cl2 absorption system when moderate concentrations of chloride ions exist. The Hg0 absorption reactions in the aqueous phase were investigated computationally using Moller–Plesset perturbation theory. The calculated Gibbs free energies and energy barriers are in excellent agreement with the results obtained from experiments. In the presence of SO32-and SO2, Hg2+reduction occurred and Hg0 removal efficiency decreased. The reduced Hg0 removal can be controlled through increased chloride concentration to some degree. Low p H value in Hg Cl2 solution enhanced the Hg0 removal efficiency, and the effect was more significant in dilute Hg Cl2 solutions. The presence of SO42-and NO3-did not affect Hg0 removal by Hg Cl2. | Yongpeng Ma Haomiao Xu Zan Qu Naiqiang Yan Wenhua Wang | 2014 | Journal of Environmental Sciences2014，26，11： | 4 |
| 8 | Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis显示文摘Hydrogen has been used to suppress tumor growth with considerable efficacy.Inhalation of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic routes of hydrogen administration.We have developed a topical delivery method of hydrogen at targeted sites through the degradation of magnesium-based biomaterials.However,the underlying mechanism of hydrogen’s role in cancer treatment remains ambiguous.Here,we investigate the mechanism of tumor cell apoptosis triggered by the hydrogen released from magnesium-based biomaterials.We find that the localized release of hydrogen increases the expression level of P53 tumor suppressor proteins,as demonstrated by the in vitro RNA sequencing and protein expression analysis.Then,the P53 proteins disrupt the membrane potential of mitochondria,activate autophagy,suppress the reactive oxygen species in cancer cells,and finally result in tumor suppression.The anti-tumor efficacy of magnesium-based biomaterials is further validated in vivo by inserting magnesium wire into the subcutaneous tumor in a mouse.We also discovered that the minimal hydrogen concentration from magnesium wires to trigger substantial tumor apoptosis is 91.2μL/mm^(3)per day,which is much lower than that required for hydrogen inhalation.Taken together,these findings reveal the release of H2 from magnesium-based biomaterial exerts its anti-tumoral activity by activating the P53-mediated lysosome-mitochondria apoptosis signaling pathway,which strengthens the therapeutic potential of this biomaterial as localized anti-tumor treatment. | Rui Zan Hao Wang Weijie Cai Jiahua Ni Berengere J.C.Luthringer-Feyerabend Wenhui Wang Hongzhou Peng Weiping Ji Jun Yan Jiazeng Xia Yang Song Xiaonong Zhang | 2022 | Bioactive Materials2022，7，3： | 3 |
| 9 | High expression of human serum albumin in milk of trans-genie mice directed by the goat β-casein gene promoter region显示文摘We have constructed a mammary gland expression vector that contained the goat β-casein gene pro-moter, 5’upstream regulatory region, exons 1, 2, intron 1 as well as the human serum albumin (hALB) mini-gene (including the full-long sequences of hALB cDNA and its intron 1). Injection of the vector into mouse tail veins showed that the recombinant construct was expressed only in mammary glands. The vector was microinjected into the mouse fertilized eggs, followed by transferring the eggs into the foster mice. 33 F0 mice were obtained. Of the 33, 8 mice (5 , 3 ) were transgenic with hALB gene integration identified by PCR as well as Southern blot hybridization. The integration rate was 24.2% (8/33). Western blot analysis showed that 3 female transgenic mice had hALB expression in their milk. The hALB contents in milk reached 3.54, 0.21 and 3.03 g/L, respectively. | HUANG Ying, HUANG Ying, HUANG Zan,YAN Jingbin, MA Zhanlu, SHENG Min,REN Zhaorui, ZENG Yitao & HUANG ShuzhenShanghai Institute of Medical Genetics, Shanghai Children’s Hospital, Shanghai 200040, China | 2001 | Chinese Science Bulletin2001，46，7： | 3 |
| 10 | An ultrahigh-sensitivity and selective sensing material for ethanol: α-/γ-Fe2O3 mixed-phase mesoporous nanofibers显示文摘为综合的一个过程 Fe 2 O 3 基于 electrospinning 和难模板的方法被建议以便 Fe 2 O 3 能与精确被定制。Mesoporous -Fe2O3,-/-Fe2O3, 和 -Fe2O3 nanofibers 能被改变合成参数成功地制作。扫描电子显微镜学,传播电子显微镜学, X 光检查衍射分析,拉曼光谱学,和氮 adsorptiondesorption 分析被用来描绘综合产品的结构。为与最高的乙醇反应准备 -/-Fe2O3 nanofibers 的最佳的锻烧条件通过察觉到乙醇的大小被决定。混合阶段材料比相应 purephase 展出了显著地更高的敏感。-/-Fe2O3 nanofibers 的优异察觉到乙醇的表演建议他们可能对在察觉到的酒精的使用合适。因此,为改进金属氧化物半导体的察觉到的表演的新奇策略是在一结构装配一样的金属氧化物的不同水晶的形式。最后,为比 -Fe2O3 和 -Fe2O3 的那些高的 -/-Fe2O3 的察觉到的性能负责的机制从 X 光检查光电子光谱学和抵抗大小根据数据被阐明。 | Shuang Yan Guangtao Zan Qingsheng Wu | 2015 | Nano Research2015，8，11： | 2 |
| 11 | Synthesis,characterization and experimental investigation of Cu-BTC as CO_2 adsorbent from flue gas显示文摘Porous Cu-BTC material was synthesized by the solvothermal method.Powder X-ray diffraction(PXRD) was used to test the phase purity of the synthesized material and investigate its structural stability under the influence of flue gas components.The thermal stability of the material was determined through thermal gravimetric(TG) analysis.Scanning electron microscopy(SEM) was employed to study the microstructure of the material.Cu-BTC was demonstrated not only to have high CO 2 adsorption capacity but also good selectivity of CO 2 over N 2 by means of packed bed tests.The adsorption capacity of Cu-BTC for CO 2 was about 69 mL/g at 22°C.The influence of the main flue gas components on the CO 2 capacity of the material were discussed as well. | Jiangkun Xie Naiqiang Yan Zan Qu Shijian Yang | 2012 | Journal of Environmental Sciences2012，24，4： | 2 |
| 12 | Enhanced simultaneous absorption of NO_(x) and SO_(2) in oxidation-reduction-absorption process with a compounded system based on Na_(2)SO_(3)显示文摘Oxidation of sulfite and competitive absorption existed in Na_(2)SO_(3) solution for simultaneous removal of NO_(x) and SO_(2),inhibited the long-term high-efficiency when used for practical applications.A matching strategy was developed to solve these problems.Antioxidants combination was used to retard the oxidation of antioxidant and enhance inhibition of S(IV)(tetravalent sulfur)oxidation.Hydroquinone(HQ)and sodium thiosulfate(ST)showed a positive synergistic effect on inhibition of S(IV)oxidation.When SO_(2) concentration was 500 and 2000 ppmV,the addition of 0.1 wt.%HQ and 1 wt.%ST decreased the percentage of S(IV)oxidized by oxygen by over 30%and 40%,respectively.Alkali(Na_(2)CO_(3))alleviated the competitive absorption between NO_(x) and SO_(2).Moreover,Na_(2)CO_(3) exhibited an enhancement effect on the absorption of NO_(x) and SO_(2) when coupled with anti-oxidants.While the increase of oxygen pressure accelerated the oxidation of S(IV),the anti-oxidants can retard the oxidation.The measurement of pH suggested the removal efficiency of NO_(x) highly depended on SO_(3)^(2-) concentration rather than pH.The further investigation of the mechanism suggested the match effect was related to the interaction between ST and the intermediate product of HQ.The match strategy holds a potential for application of SO_(3)^(2-) to denitration. | Sichao Li Wenjun Huang Haomiao Xu Kai Liu Jia-nan Wang Yaning Sun Zan Qu Naiqiang Yan | 2022 | Journal of Environmental Sciences2022，34，1： | 2 |
| 13 | Modeling of human colonic blood flow for a novel artificial anal sphincter system显示文摘A novel artificial anal sphincter system has been developed to simulate the normal physiology of the human anorectum. With the goal of engineering a safe and reliable device, the model of human colonic blood flow has been built and the relationship between the colonic blood flow rate and the operating occlusion pressure of the anorectum is achieved. The tissue ischemia is analyzed based on constitutive relations for human anorectum. The results suggest that at the planned operating occlusion pressure of less than 4 kPa the artificial anal sphincter should not risk the vascularity of the human colon. | Peng ZAN Guo-zheng YAN Hua LIU | 2008 | 浙江中西医结合杂志2008，18，9： | 1 |
| 14 | Development of simple sequence repeat markers and diversity analysis in alfalfa ( Medicago sativa L.)显示文摘 | Zan Wang Hongwei Yan Xinnian Fu Xuehui Li Hongwen Gao | 2013 | Molecular Biology Reports2013，，4： | 1 |
| 15 | Catalytic oxidation of ele- mental mercury over the modified catalyst Mn/T-A1203 at lower temperatures 显示文摘 | Li Jianfeng Yan Naiqiang Qu Zan | 2010 | Environmental Science Technology2010，44，1： | 1 |
| 16 | Analysis ofconformational motions and residue fluctuations for Escherich-ia coli ribose-binding protein revealed with elastic networkmodels显示文摘 | Li Hai Yan Cao Zan Xia Zhao Li Ling | 2013 | Int J Mol Sci2013，14，10： | 1 |
| 17 | Catalytic Ox- idation of Elemental Mercury over the Modified Catalyst Mn/a-A1203 at Lower Temperatures 显示文摘 | LI Jianfeng YAN Naiqiang QU Zan | 2009 | Environmental Science & Technology2009，44，1： | 1 |
| 18 | Catalytic oxidation of elemental mercury over the modified catalyst Mn/ct-A1203 at lower temperature 显示文摘 | LI Jianfeng YAN Naiqiang QU Zan | 2010 | Environmental Science & Technology2010，44，： | 1 |
| 19 | Coupling model and optimal combination scheme of water,fertilizer,dissolved oxygen and temperature in greenhouse tomato under drip irrigation显示文摘Water-fertilizer coupling technology has been widely used in the world.Poor soil aeration,low temperature or high temperature can affect the rate of nutrient uptake by crop roots.Aiming at the interaction between water,fertilizer,dissolved oxygen and temperature(WFOT)coupling model and irrigation flux of tomato in greenhouse,using these four factors with a five-level uniform-precision rotatable central composite design,a mathematical model was established among the four factors affecting tomato yield in a greenhouse,and the optimal combination scheme of WFOT was obtained.Within the test range,tomato yields increased with increasing irrigation quotas(X_(1)),fertilization amount(X_(2)),dissolved oxygen(X_(3))and geothermal pipe water temperature(X_(4)).The magnitude of the effect of each factor of WFOT on tomato yield was in the following order:X_(1),X_(2),X_(4),X_(3)(spring and summer),and X_(1),X_(3),X_(2),X_(4)(autumn and winter).The interaction between high water-low heat and low water-high heat were beneficial for yield increase(spring and summer),the high fertilizer-low heat and low fertilizer-high heat interactions were beneficial to yield increase(autumn and winter).If WFOT agronomic measures were adopted according to the 95%confidence interval,there was a 95%probability that the spring-summer tomato yield will be higher than 89902 kg/hm^(2).The WFOT coupling scheme was X_(1)of 4808-5091 m3/hm^(2),X_(2)(N-P_(2)O_(5)-K_(2)O)of 171-57-84 to 186-62-89 kg/hm^(2),X_(3)of 7.9-8.2 mg/L,and X_(4)of 34.9°C-37.0°C.There was a 95%probability of tomato yield higher than 85209 kg/hm^(2)in autumn and winter,and the WFOT coupling scheme was X_(1)of 5270-5416 m3/hm^(2),X_(2)(N-P_(2)O_(5)-K_(2)O)of 151-50-76 to 167-56-82 kg/hm^(2),X_(3)of 8.0-8.2 mg/L,and X_(4)of 34.1°C-36.2°C.Overall,and the model had a very good simulation effect,with application value.The relative error between spring-summer and autumn-winter yields ranged from 1.12%to 25.34%.The results of the study can provide a theoretical basis for improving the quality and efficiency of greenhouse tomatoes. | Zan Ouyang Juncang Tian Ce Zhao Xinfang Yan | 2021 | International Journal of Agricultural and Biological Engineering2021，14，6： | 1 |
| 20 | Green synthesis of graphene nanosheets/ZnO composites and electrochemical properties显示文摘 | Jun Wang Zan Gao Zhanshuang Li Bin Wang Yanxia Yan Qi Liu Tom Mann Milin Zhang Zhaohua Jiang | 2011 | Journal of Solid State Chemistry2011，，： | 1 |
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