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| 1 | Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/ reperfusion injury显示文摘目的: 进一步描绘膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的功能的角色在早、迟了(第二扇窗户) ischemic preconditioning (欧洲电脑生产厂商)- 并且 postconditioning (停靠港) 调停了对 ischemia/reperfusion (I/R ) 的 cardioprotection 损害。 | Sunny Yang XIANG Linda L YE Li-lu Marie DUAN Li-hui LIU Zhi-dong GE John A AUCHAMPACH Garrett J GROSS Dayue Darrel DUAN | 2011 | Acta Pharmacologica Sinica2011，32，6： | 9 |
| 2 | Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart显示文摘Cell therapy has been a promising strategy for cardiac repair after myocardial infarction(MI),but a poor ischemic environment and low cell delivery efficiency remain significant challenges.The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI,but it is unclear whether it could be used for human pluripotent stem cell(hiPSC)cultivation and provide a proper microenvironment for cell grafts against the ischemic environment.Herein,we developed a splenic extracellular matrix derived thermoresponsive hydrogel(SpGel).Proteomics analysis indicated that SpGel is enriched with proteins known to modulate the Wnt signaling pathway,cell-substrate adhesion,cardiac muscle contraction and oxidation-reduction processes.In vitro studies demonstrated that hiPSCs could be efficiently induced into endothelial cells(iECs)and cardiomyocytes(iCMs)with enhanced function on SpGel.The cytoprotective effect of SpGel on iECs/iCMs against oxidative stress damage was also proven.Furthermore,in vivo studies revealed that iEC/iCM-laden SpGel improved cardiac function and inhibited cardiac fibrosis of infarcted hearts by improving cell survival,revascularization and remuscularization.In conclusion,we successfully established a novel platform for the efficient generation and delivery of autologous cell grafts,which could be a promising clinical therapeutic strategy for cardiac repair and regeneration after MI. | Ge Guan Da Huo Yanzhao Li Xiaolin Zhao Yinghao Li Zhongliang Qin Dayu Sun Guanyuan Yang Mingcan Yang Ju Tan Wen Zeng Chuhong Zhu | 2021 | Bioactive Materials2021，6，12： | 2 |
| 3 | Delta-Sig- ma modulation for direct digital frequency synthesis 显示文摘 | Yang Dayu Dai Fa Foster Ni Weining | 2009 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2009，17，6： | 1 |
| 4 | A fusion model for CPU load prediction in cloud computing显示文摘 | Xu Dayu Yang Shanlin Luo He | 2013 | Journal of Networks2013，8，11： | 1 |
| 5 | Astragaloside IV derivative HHQ16 ameliorates infarctioninduced hypertrophy and heart failure through degradation of lncRNA4012/9456显示文摘Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction(MI)heart failure(HF).Here,we report a novel small molecule HHQ16,an optimized derivative of astragaloside IV,which effectively reversed infarction-induced myocardial remodeling and improved cardiac function by directly acting on the cardiomyocyte to reverse hypertrophy.The effect of HHQ16 was associated with a strong inhibition of a newly discovered Egr2-affliated transcript Inc9456 in the heart.While minimally expressed in normal mouse heart,Inc9456 was dramatically upregulated in the heart subjected to left anterior descending coronary artery ligation(LADL)and in cardiomyocytes subjected to hypertrophic stimulation.The critical role of Inc9456 in cardiomyocyte hypertrophy was confirmed by specific overexpression and knockout in vitro.A physical interaction between Inc9456 and G3BP2 increased NF-kB nuclear translocation,triggering hypertrophy-related cascades.HHQ16 physically bound to Inc9456 with a high-affinity and induced its degradation.Cardiomyocyte-specific Inc9456 overexpression induced,but knockout prevented LADL-induced,cardiac hypertrophy and dysfunction.HHQ16 reversed the effect of Inc9456 overexpression while lost its protective role when Inc9456 was deleted,further confirming Inc9456 as the bona fide target of HHQ16.We further identified the human ortholog of Inc9456,also an Egr2-affliated transcript,Inc4012.Similarly,Inc4012 was significantly upregulated in hypertrophied failing hearts of patients with dilated cardiomyopathy.HHQ16 also specifically bound to Inc4012 and caused its degradation and antagonized its hypertrophic effects.Targeted degradation of pathological increased Inc4012/lnc9456 by small molecules might serve as a novel promising strategy to regress infarction-induced cardiac hypertrophy and HF. | Jingjing Wan Zhen Zhang hennan Wu Saisai Tianbei Zang Ge Jin Qingyan Sun Pin Wang Xin Luan Yili Yang Xuelin Zhan Lingyu Linda Ye Dayue Darrel Duan Xia Liu Weidong Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 6 | Mapping the Brain-Wide Cholinergic Neurons Projecting to Skeletal Muscle in Mice by High-Throughput Light Sheet Tomography显示文摘Dear Editor,The cholinergic system plays an important role in regulating locomotion and motor functions by modulating neuronal activity[1].However,the anatomical relationships between the brain-wide cholinergic system and skeletal muscles remain unclear.To understand how this system modulates the activity of skeletal muscles,details of the pattern of cholinergic innervation and differences in the innervation of skeletal muscles are necessary.However,classical immunohistochemical methods are unable to test unequivocally whether a mapping exists in the connections from the brain to skeletal muscles. | Dayu Chen Xiaofeng Cheng Xiong Yang Yongsheng Zhang Zhigang He Qian Wang Guojie Yao Xiuli Liu Shaoqun Zeng Jincao Chen Hongbing Xiang | 2021 | Neuroscience Bulletin2021，37，2： | 0 |
| 7 | 储存环CSRm上的类硼Ar^(13+)离子的低能双电子复合实验研究显示文摘Based on the successful dielectronic recombination(DR)experiments with intermediate charge state ions of Belike Ar^(14+[1]) and Ca^(16+[2]) at the CSRm,we are preparing the precision spectroscopy of DR experiments with highly charged ions and even radioactive ions at the CSRe.A test electron-ion recombination experiment of Boron-like Ar13+ions was performed with a section of the new electron beam energy detuning system,which will be installed at the CSRe.Fig.1 presents the measured and also the calculated DR spectra for B-like Ar^(13+) from 0 to 3 eV.The experimental result indicates that the new detuning system is more stable and has a higher energy resolution than the previous detuning system used at the CSRm.It paves the way for the upcoming DR experiments with highly charged heavy ions at the CSRe.In addition,the flexible atomic code(FAC)was employed to calculate the DR resonance strengths of Boron-like Ar^(13+) to compare with the experimental result. | Huang Zhongkui Wen Weiqiang Wang Shuxing Li Shuang Wang Hanbing Nadir Khan Dou Lijun Zhu Xiaolong Mao Lijun Li Jie Ma Xiaoming Yin Dayu Mao Ruishi Yuan Youjin Yang Jiancheng Chen Chongyang Zhu Linfan Ma Xinwen | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 8 | 重离子存环CSRe上相对论能量类锂O^(5+)离子激光冷却实验研究显示文摘Laser cooling is one of the most promising techniques to achieve high phase-space densities or even crystalline beams for relativistic heavy ion beams at storage rings[1].Based on the success of laser cooling of C^(3+) at the ESR[2,3],and the experience of test laser cooling experiments at the CSRe[4],laser cooling of lithium-like O^(5+) ion beams with an relativistic energy of 275.7 MeV/u was achieved for the first time at the heavy-ion storage ring CSRe in Lanzhou,China.In the experiment,a CW laser system with a wavelength of 220 nm was used to match the optical transition of 2s1=2-2p1=2 of O^(5+)ions.In order to cool the relativistic ion beams with only one counterpropagating CW laser,the ion beams were bunched by applying a sinusoidal voltage to the RF-buncher system.Fig. | Wang Hanbing Wen Weiqiang Huang Zhongkui Zhang Dacheng Chen Dongyang Zhang Hongyi Hai Bang Zhao Dongmei Zhu Xiaolong Li Xiaoni Li Jie Mao lijun Mao Ruishi Zhao Tiecheng Wu Junxia Yin Dayu Yang Jiancheng Yuan Youjin Ma Xinwen | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 9 | 6-4 Longitudinal Electron Cooling Experiments at HIRFL-CSRe显示文摘The electron cooler was installed in one of the straight sections of CSRe which is used to provide high-qualitybeams for experiments. Longitudinally the dynamics of the cooling process have been studied for a series of electronbeam parameters and the friction force was measured with the aid of an RF-buncher for C6+ (122 MeV/u) and O8+(122 MeV/u) ions. The cooling time at different electron beam state have been measured, too. | Zhao He Mao Lijun Yang Xiaodong Li Jie Tang Meitang Ma Xiaoming Yan Tailai Shi Jian Yin Dayu Chai Weipin Sheng Lina Zhang Xiaohu Li Peng Zheng Wenheng Yang Jiancheng Yuan Youjin | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 10 | S1B-1 CLC-3 Chloride Channels in the Nervous System:Missed Targets in Cerebrovascular and Brain Diseases?显示文摘CLC-3 chloride(Cl-)channel,a member of an extended family of voltagegated CLC chloride channels and transporters,are ubiquitously expressed throughout the nervous system,including in the cerebrovascular smooth muscle cells(CVSMC)and neurons in the brain.CLC-3 chloride channels play critical roles in the regulation of vascular tone and cell volume regulation,migration,proliferation,and apoptosis.Remodeling of CLC-3 Cl-channels in CVSMC contributes significantly to the development of vascular pathology and remodeling and may be novel mechanisms for hypertension and stroke.Targeting Cl-channels may be a novel therapeutic strategy for the treatment of hypertension and stroke.CLC-3 Cl-channels are also involved in neuronal apoptosis and are important regulators of cell volume and hippocampal neuronal apoptosis.Expression of CLC-3 in the presynaptic vesicles determines quantal size of inhibitory transmission in the hippocampus through impact on GABAergic synaptic transmission.A distinct presynaptic CLC-3 dependent regulatory mechanism may represent a novel target for the regulation of synaptic vesicle acidification and filling.It extends the role of Cl-in inhibitory transmission from that of a postsynaptic permeant species to a presynaptic regulatory element.The CLC-3 Cl-channels are important targets for glioma and cancer therapy.CLC-3 channels(Cl.vol)/transporters may play important roles in the regulation of many cellular functions and integrate their physiological and pathological roles with multi-chloride channels,including TMEM16A(Cl.ca),CFTR at the phenomic level in the cerebrovascular and nervous system.Deep understandings of CLC-3 Cl-channels expression and function in the nervous system may provide novel molecular insights into the cerebrovascular disease and brain disease including brain cancers. | Dayue Darrel Duan Lingyu Linda Ye YANG Si-Jin | 2018 | 神经药理学报2018，8，4： | 0 |
| 11 | Dielectronic Recombination of Na-like Kr^(25+) at the CSRm显示文摘The absolute rate coefficients for dielectronic recombination(DR)of Na-like Kr^(25+) ions were measured by employing the electron-ion merged-beam technique at the heavy-ion storage ring CSRm.The measured DR spectrum covers the energy range of 0~70 eV. | Huang Zhongkui Wen Weiqiang Wang Shuxing Ma wanlu Wang Hanbing Nadir Khan Zhao Dongmei Zhu Xiaolong Mao Lijun Li Jie Ma Xiaoming Yin Dayu Mao Ruishi Yuan Youjin Yang Jiancheng Chen Chongyang Zhu Linfan Ma Xinwen | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 12 | Dielectronic Recombination of F-like Ni^(25+) at the CSRm显示文摘The absolute rate cofficients for dielectronic recombination(DR)of F-like Ni^(19+) ions were measured by employing the electron-ion merged-beam technique at the heavy-ion storage ring CSRm.The measured DR spectrum covers the energy range of 0~70 eV. | Wang Shuxing Huang Zhongkui Wen Weiqiang Wang Hanbing Nadir Khan Zhao Dongmei Zhu Xiaolong Mao Lijun Li Jie Ma Xiaoming Yin Dayu Mao Ruishi Yuan Youjin Yang Jiancheng Chen Chongyang Ma Xinwen Zhu Linfan | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 13 | Radiative Recombination Rates Enhancement at Low Energy Range in the Heavy Ion Storage Ring CSRm显示文摘Recombination of Ar^(14+),Ar^(15+),Ca^(16+) and Ni^(19+) ions with electrons has been investigated at low energy range at the CSRm.For each ion,the absolute recombination rate coefficients have been measured with electron-ion collision energies from 0 to 1000 meV which include the radiative recombination(RR)and also dielectronic recombination(DR)processes.In order to interpret the measured results. | Khan Nadir Huang Zhongkui Wen Weiqiang Wang Shuxing Wang Hanbing Ma Wanlu Zhu Xiaolong Zhao Dongmei Zhu Linfan Mao Lijun Li Jie Ma Xiaoming Tang Meitang Yin Dayu Yang Weiqing Yang Jiancheng Yuan Youjin Ma Xinwen | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 14 | Evaluation of Tung Oil(Vernicia fordii(Hemsl.))for Controlling Termites显示文摘In worldwide,the use of chemical pesticides to protect wood has been greatly restricted.In recent years,a large number of researchers devoted to the search for natural,safe and non-polluting bioactive chemical compounds from plants as an alternative to synthetic organic chemical preservative.In Chinese folk,tung oil can be used as paint for wooden furniture to protect them from pests.This study aimed to evaluate the chemical compositions of raw and heated tung oil and their activity against termite.In choice bioassays,weight loss of wood treated with 5%raw or heated tung oil after 4 weeks was significantly less than that of the control group.In no-choice bioassays,there was a significant difference in termite survival and wood weight loss on raw and heated tung oil-treated wood.When tung oil-treatment concentrations increased to 5%,wood weight loss was less than 10%.There was no significant difference in termite survival and wood weight loss between raw and heated tung oil-treated wood.Survival of termites in both tung oil wood treatments was significantly lower than that in the starvation control after 4 weeks.Raw and heated tung oil significantly improved the resistance of pine wood to termites,and have the potential for the development of natural wood preservatives. | Hangtian Li Siying Li Hui Lu Jingjing Zhang Xi Yang Dayu Zhang Yike Zhang Yongjian Xie | 2022 | Journal of Botanical Research2022，4，3： | 0 |
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