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| 1 | Hydration Mechanism of Sulphoaluminate Cement显示文摘The feasibility of sulphoaluminate cement (SAC) utilization in support mortar was studied. Setting time and strength of as-received sulphoaluminate cement (SAC) paste were examined, hydration kinetics behavior was determined through Isothermal Calorimeter, and hydration mechanism was investigated by X-Ray diffraction analysis (XRD) and field emission scanning electron microscopy analysis(FSEM). Results showed that as-received SAC contained 61% of anhydrous calcium sulfate (3CA·CaSO4) and dicalcium silicate (C2S). The strength after 1 day or 3 days grew to 68.6% or 85.7% of that after 28 days respectively, while most of hydration heat was released within 1 day. The emergency of three exothermic peaks at acceleration stage was found and hydration kinetics model was established choosing the terminal time of the first exothermic peak at accelerating stage as the beginning of accelerating stage. XRD analysis suggested that large amount of ettringite (AFt) was produced at early age and FSEM observation revealed that ettringite (AFt) formed in sulphoaluminate cement (SAC) paste was characterized of different morphology which was proved to be caused by different ion concentrations. | 何真 YANG Huamei LIU Meiyan | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，1： | 13 |
| 2 | Genome-wide detection of additional fetal chromosomal abnormalities by cell-free DNA testing of 15,626 consecutive pregnant women显示文摘Cell-free DNA(cfDNA) testing for common fetal trisomies(T21, T18, T13) is highly effective. However, the usefulness of cfDNA testing in detecting other chromosomal abnormalities is unclear. We evaluated the performance of cfDNA testing for genome-wide abnormalities, and analyzed the incremental yield by reporting extra abnormalities. We performed genome-wide cfDNA testing in 15,626 consecutive pregnancies prospectively enrolled in this study. cfDNA testing results were reported and counseling was given depending on the presence of extra chromosomal abnormalities. cfDNA testing identified 190 cases(1.2%)of chromosomal abnormalities including 100 common trisomies and 90 additional abnormalities. By expanding the cfDNA reporting range to genome-wide abnormalities, the false positive rate increased to 0.39%(P<0.001) and positive predictive value(PPV) was reduced to 65.58%(P=0.42). However, the detection yield increased from 0.44% to 0.65%(P=0.014), and cfDNA testing detected 38.61%(39/101) additional abnormalities with no ultrasound and biochemical screening findings. cfDNA testing outperformed biochemical screening by showing 60 times higher true positive rate and fewer false negative results.Genome-wide cfDNA testing significantly increased the diagnostic yield by detecting extra abnormalities, especially those without diagnostic indications. Genome-wide cfDNA testing has fewer false positive and false negative results compared with biochemical screening. | Hong Yao Ya Gao Jia Zhao Rong Zhang Huixin Xu Huamei Hu Yanmei Luo Yuying Yuan Meili Fu Hongyun Zhang Hui Jiang Wei Wang Huanming Yang Jian Wang Zhiqing Liang Fang Chen | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 3 | Rock magnetic properties and palaeomagnetic results of sediments from a stone implement layer in the Bose Basin, Guangxi显示文摘Directional samples were taken to study rock magnetism and palaeomagnetic records from the Dong- sheng profile, which is 5 m thick and on the northwest edge of the Bose Basin. Mineralogy and rock magnetism of typical samples indicate that coarse granular titanomagnetite, and fine-grained hematite, superparamagnetic maghemite formed by pedogenesis are in the sediment, which has undergone many transformative processes during different stages of pedogenesis. Parallel samples were taken for thermal demagnetization (TH) (0 to 680℃) and alternating field (AF) demagnetization (0 to 80 mT) respectively. Experimental results of these two kinds of demagnetization illustrate that there are two or more magnetic components in the samples. Intensity of NRM decreases by almost 60% to 90% rapidly when the temperature ranges from 100℃ to 350℃, with a steady magnetic component. It is impossible to analyze the magnetic components at high temperature because those fluctuate widely when the temperature is higher than 400℃. Steady magnetic components from 100℃ to 350℃ indicate that the remanence was mainly carried by fine-grained hematite formed by pedogenesis, reflecting a change in the geomagnetic field while the magnetite was being oxidized into hematite by chemical weathering after deposition. The formative age of the sediments cannot be obtained by magnetic methods in this profile. | YANG XiaoQiang ZHU ZhaoYu ZHANG YiNan LI HuaMei ZHOU WenJuan YANG Jie | 2008 | Science China Earth Sciences2008，51，3： | 2 |
| 4 | Hydro-Abrasive Erosion of Concrete Incorporated with Nano-SiO_2, Super-Fine Slag or Rubber Powder显示文摘In this paper, we investigates the concretes respectively incorporated with 5%(m︰m) nano-SiO2(NS), 40%(m︰m) super- fine slag(SS), as well as 40%(m︰m) SS combining 20% replacement of sand volume with RP. The tested mechanical properties include compressive strength, abrasion resistant strength, and elastic modulus. The results indicate that among these concretes, the SS-RP concrete has the highest abrasion resistant strength with increment ratios of 1.71 and 1.35 at 28 days and 90 days, respectively; the SS concrete has the highest compressive strength with increment ratios of 2.03 and 1.95 at 28 days and 90 days, respectively; the elastic modulus of SS-RP concrete significantly decrease compared with the SS concrete and is slightly higher than that of the reference concrete. It is concluded that NS, SS, and RP all can improve the abrasion resistance of concrete, and it will be significantly improved when SS combining RP is incorporated. | HE Zhen CHEN Xiaorun YANG Huamei CAI Xinhua | 2013 | Wuhan University Journal of Natural Sciences2013，18，6： | 2 |
| 5 | Hydration Mechanism of Sulphoaluminate Cement显示文摘 | Zhen He Yang Huamei Liu Meiyan | 2014 | Journal of Wuhan University:Materials Science2014，29，2： | 1 |
| 6 | Hydration Mechanism of Silica Fume- sulphoaluminate Cement显示文摘Setting time and strength of sulphoaluminate rapid hardening cement(SAC) incorporated in the presence and absence of silica fume(SF) were determined. Combined with the techniques of isothermal calorimeter, XRD and FSEM, the hydration kinetics of the two systems and the effect mechanism of SF on SAC were investigated. The experimental results showed that SF was proved to be beneficial for SAC system, in terms of setting time and late strength gain. Evidence of accelerator effect of silica fume was found during the first 8 hours of hydration. The formation of AFt was accelerated and the microstructure of the hydration products grew denser with incorporation of SF. SF was proved to play the role of dispersion and setting control at early age and had a greater contribution to later strength due to the increment of crystal nucleation point and the pozzolanic activity. Therefore, SF can be used to not only control the hydration kinetics of SAC, but also develop the late strength and improve the microstructure. | HE Zhen YANG Huamei HU Shuguang LIU Meiyan | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，6： | 1 |
| 7 | Advancements in understanding mechanisms of hepatocellular carcinoma radiosensitivity:A comprehensive review显示文摘Primary liver cancer is a significant health problem worldwide.Hepatocellular carcinoma(HCC)is the main pathological type of primary liver cancer,accounting for 75%-85%of cases.In recent years,radiotherapy has become an emerging treatment for HCC and is effective for various stages of HCC.However,radiosensitivity of liver cancer cells has a significant effect on the efficacy of radiotherapy and is regulated by various factors.How to increase radiosensitivity and improve the therapeutic effects of radiotherapy require further exploration.This review summarizes the recent research progress on the mechanisms affecting sensitivity to radiotherapy,including epigenetics,transportation and metabolism,regulated cell death pathways,the microenvironment,and redox status,as well as the effect of nanoparticles on the radiosensitivity of liver cancer.It is expected to provide more effective strategies and methods for clinical treatment of liver cancer by radiotherapy. | Gaoyuan Yang Huamei Yan Yongchang Tang Feng Yuan Mingbo Cao Yupeng Ren Yuxuan Li Zhiwei He Xiaorui Su Zhicheng Yao Meihai Deng | 2023 | Chinese Journal of Cancer Research2023，35，3： | 1 |
| 8 | High resolution magnetostratigraphy and deposition cycles in the Nihewan Basin (North China) and their significance for stone artifact dating显示文摘 | Li Huamei Yang Xiaoqiang Friedrich Heller Li Haitao | 2008 | Quaternary Research2008，，2： | 1 |
| 9 | Synthe- ses and crystal structures of ferrocene-containing enamino- nes and their copper complexes 显示文摘 | Shi Yaocheng Yang Huamei Shen Wenbin | 2004 | Polyhedron2004，23，1： | 1 |
| 10 | Effect of coral sand on the mechanical properties and hydration mechanism of magnesium potassium phosphate cement mortar显示文摘Damaged structures on coral islands have been spalling and cracking due to the dual corrosion of tides and waves.To ensure easy access to aggregate materials,magnesium potassium phosphate cement(MKPC)and coral sand(CS)are mixed to repair damaged structures on coral islands.However,CS is significantly different from land-sourced sand in mineral composition,particle morphology,and strength.This has a substantial impact on the hydration characteristics and macroscopic properties of MKPC mortar.Therefore,in this study we investigated the compressive strength,interfacial mechanical properties,and corrosion resistance of MKPC CS mortar.Changes in the morphology,microstructure,and relative contents of hydration products were revealed by scanning electron microscope-energy dispersive spectrometer(SEM-EDS)and X-ray diffraction(XRD).The results indicated that the compressive strength increased linearly with the interfacial micro-hardness,and then stabilized after long-term immersion in pure water and Na2SO4 solution,showing excellent corrosion resistance.Compared with MKPC river sand(RS)mortar,the hydration products of CS mortar were an intermediate product 6KPO2·8H2O with a relative content of 3.9%at 1 h and 4.1%at 12 h.The hydration product MgKPO_(4)·6H_(2)O increased rapidly after 7-d curing,with an increased growth rate of 1100%.Our results showed that CS promoted the nucleation and formation of hydration products of MKPC,resulting in better crystallinity,tighter overlapping,and a denser interfacial transition zone.The results of this study provide technical support for applying MKPC mortar as a rapid repair material for damaged structures on coral islands. | Hao LIU Huamei YANG Houzhen WEI Jining YU Qingshan MENG Rongtao YAN | 2024 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2024，25，2： | 0 |
| 11 | 胃癌细胞色素氧化酶CYP3A4基因多态性与含紫杉醇方案化疗敏感相关性的研究(英文)显示文摘Objective: The aim of the study was to investigate the relationship between susceptibility of paclitaxel-based regimen and gene polymorphisms of cytochrome oxidase CYP3A4 for advanced gastric cancer. Methods: Peripheral venous blood sample of 53 advanced gastric cancer patients were enrolled to test the mutation of CYP3A4 gene by denaturing high performance liquid chromatography(DHPLC) and DNA sequencing. The relation between the efficacy of paclitaxel-based regimen and CYP3A4 gene polymorphisms was further analyzed. Results: DHPLC indicated that among the 53 patients, 21 cases showed biomodal type(mutation) and 32 cases were of unimodal type(wild-type). Sequencing results showed that the deletion mutation was found at the 27 th basic group of C in exon 10 of CYP3A4 gene. The response rate(RR) and disease control rate(DCR) of wild-type group were 40.6% and 84.4%, while in mutation group they were 33.3% and 85.7%, respectively, with no significances between the two groups(P > 0.05). Of all 53 cases, the median progression-free survival(PFS) was 6.5 months(95% CI: 3.576–9.424 months), and the median overall survival(OS) was 11.0 months(95% CI: 6.955–15.045 months). The median PFS and OS in wild-type group had no differences compared with those in mutation group(7.0 months vs. 7.0 months, P > 0.05; 10.0 months vs. 14.0 months, P > 0.05). Between wild-type and mutation groups, the median PFS of patients applied with oxaliplatin containing regimen and the median OS in patients applied with/without oxaliplatin had no significant differences(P > 0.05), while the median PFS in patients received non-oxaliplatin regime had statistical differences(P = 0.024). The median PFS and OS in patients receiving 3-drug or 2-drug regimes had no correlation with CYP3A4 gene polymorphisms. The adverse effects in the two groups were mild, mainly in grades 1–2. The common adverse effects were anorexia, nausea/vomiting and leucopenia. Conclusion: Deletion mutation was located in the 27 th basic group of C in exon 10 of CYP3A4 gene. Paclitaxel-based regime has a trend to prolong the OS of advanced gastric cancer with mutation type. | Jianwei Yang Yan Meng Ying Su Zeng Chen Wei Gao Jinyuan Lin Jing Jia Huamei Lin | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，10： | 0 |
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